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BSPST:形变监测仪器故障分类算法

计算机工程与应用 2024年第18期60卷 306-315页

作者：吴晓赢邓红霞胡玉良李颖穆慧敏太原理工大学计算机科学与技术学院太原030024 山西省地震局山西地震台太原030021

针对现有形变监测仪器发生故障时故障类别难以准确分类的问题,提出了一种基于最大区分子序列(Shapelet)转换的时间序列分类算法(best qualify Shapelet Transform,BSPST)。为了提升Shapelet质量,利用布隆过滤器和相似度匹配保留一组高... 详细信息

针对现有形变监测仪器发生故障时故障类别难以准确分类的问题,提出了一种基于最大区分子序列(Shapelet)转换的时间序列分类算法(best qualify Shapelet Transform,BSPST)。为了提升Shapelet质量,利用布隆过滤器和相似度匹配保留一组高质量的候选Shapelet来构建分类模型,BSPST利用布隆过滤器筛选出同类别中重复的符号聚合近似(symbolic aggregation approximation,SAX)单词。随后通过位图中标记的单词来评价SAX单词的重复度,以此去除类别中相似的SAX单词。最终将处理后的符号聚合近似单词转化为高质量的Shapelet。通过Shapelet转换技术,对数据进行转换。最后采取集成分类器进行分类。根据地震形变仪器故障数据建立了7个地震设备故障数据集,并结合东安格利亚大学和加州大学河滨分校时间序列分类仓库中选取的44个数据集和具代表性的最先进的方法进行了充分的实验验证。结果表明,BQST算法在分类精度、分类速度上稳居前列,有效解决了形变监测仪器的故障分类问题。

关键词：故障诊断时间序列分类最大区分子序列形变仪器

六味地黄二至丸合剂影响髓源性抑制细胞与乳腺癌肺转移的相关性

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中国实验方剂学杂志 2024年第20期30卷 37-45页

作者：郑里翔郭子锋郭慧文王晓敏许传铭胡玉亮江西中医药大学南昌330004 江西省南昌市新建区人民医院南昌330100

目的:探讨六味地黄二至丸合剂(合剂)通过调节髓源性抑制细胞(MDSCs)募集抑制自发乳腺癌小鼠肺转移进程的机制。方法:SPF级10月龄的昆明种小鼠雌种鼠380只,每3 d触诊乳腺部位1次。饲养6个月后仍未触摸到肿块的小鼠作为空白组,发瘤后的小... 详细信息

目的:探讨六味地黄二至丸合剂(合剂)通过调节髓源性抑制细胞(MDSCs)募集抑制自发乳腺癌小鼠肺转移进程的机制。方法:SPF级10月龄的昆明种小鼠雌种鼠380只,每3 d触诊乳腺部位1次。饲养6个月后仍未触摸到肿块的小鼠作为空白组,发瘤后的小鼠随机分为模型组、紫杉醇组(0.01 g·kg^(-1),腹腔注射,隔日1次,22 d)、六味地黄丸组(0.65 g·kg^(-1)·d^(-1),灌胃)、二至丸组(5.41 g·kg^(-1)·d^(-1),灌胃)及六味地黄丸二至丸合剂组(6.05 g·kg^(-1)·d^(-1),灌胃),小鼠肿块直径达到15 mm左右时,进行安乐死,剥离肿瘤和肺组织。记录发瘤小鼠生存期、瘤组织质量及肺转移率。苏木素-伊红(HE)染色观察小鼠肿瘤与肺组织病理形态变化,免疫荧光(IF)检测淋巴细胞抗原6复合物位点G6D(Ly6G)、CD11抗原样家族成员B(CD11b)双染MDSCs细胞检测各组小鼠MDSCs在组织中的分布。蛋白免疫印迹法(Western blot)检测小鼠肿瘤组织中基质金属蛋白酶-9(MMP-9)、转化生长因子-β(TGF-β)、锌指转录因子1(Snail1)、E-钙黏蛋白(E-cadherin)与小鼠肺组织中CC基序趋化因子9(CCL9)、CC基序趋化因子受体1(CCR1)的蛋白表达。结果:造模期间,与模型组比较,紫杉醇组与中药给药组小鼠存活中位天数增多,瘤重、肺转移率和肺部结节评分均明显减低(P<0.05,P<0.01),HE染色可见紫杉醇组和合剂组肿瘤细胞坏死增多。在原位肿瘤组织中,与模型组比较,紫杉醇组与中药给药组MDSCs荧光强度均明显下降(P<0.05,P<0.01)。在转移肺组织中,与空白组比较,模型组MDSCs荧光强度显著增加(P<0.01);与模型组比较,紫杉醇组与中药给药组MDSCs荧光强度均显著下降(P<0.01)。在原位肿瘤组织中,与空白组比较,模型组MMP-9、TGF-β、Snail1蛋白表达量均显著增多(P<0.01),E-cadherin表达量显著较少(P<0.01);与模型组比较,紫杉醇组与中药给药组MMP-9、TGF-β、Snail1蛋白表达量均明显减低(P<0.05,P<0.01),E-cadherin蛋白表达显著升高(P<0.01);且合剂组中TGF-β、Snail1蛋白表达均明显低于六味地黄丸组、二至丸组(P<0.05)。在转移肺组织中,与空白组比较,模型组CCL9与CCR1表达量均显著增加(P<0.01);与模型组比较,紫杉醇组与中药给药组各给药组CCL9与CCR1表达量均明显降低(P<0.05,P<0.01)。结论:六味地黄二至丸合剂抑制自发性乳腺癌小鼠肿瘤生长,延长其生存时间,减少肺转移的发生,其机制可能是通过减少MDSCs在原位肿瘤及肺组织内的募集,调节EMT相关分子的表型及CCL9/CCR1表达,从而抑制乳腺癌的肺转移。

关键词：六味地黄二至丸合剂乳腺癌肺转移髓源性抑制细胞(MDSCs) 上皮间充质转化(EMT)相关蛋白表达 CC基序趋化因子9(CCL9)/CC基序趋化因子受体1(CCR1)蛋白表达

内蒙古三级甲等医院高年资护士职业生涯成功水平现状及其影响因素研究

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中华护理教育 2024年第2期21卷 204-211页

作者：钟永芳赵改梅胡玉亮韩锁成张小萍赵泽英贾丽霞王雄英安海兵鄂尔多斯应用技术学院内蒙古自治区鄂尔多斯市017000 鄂尔多斯市中心医院中山大学附属第六医院广州市510655

目的了解内蒙古三级甲等医院高年资护士职业生涯成功水平现状,并分析其影响因素。方法于2021年12月—2022年3月,采用一般资料调查表、职业生涯成功量表对3 317名内蒙古三级甲等医院高年资护士进行问卷调查。结果共回收有效问卷3 088... 详细信息

目的了解内蒙古三级甲等医院高年资护士职业生涯成功水平现状,并分析其影响因素。方法于2021年12月—2022年3月,采用一般资料调查表、职业生涯成功量表对3 317名内蒙古三级甲等医院高年资护士进行问卷调查。结果共回收有效问卷3 088份。3 088名高年资护士职业生涯成功得分为(31.22±6.70)分;多元线性逐步回归分析结果显示,科室为儿科(以内科为参照)、工资待遇满意度、身体状况、院外进修培训情况、参与科研项目情况、对自身工作状态的满意程度、对未来职业发展的担忧情况、有无职业生涯规划、最想去的科室或岗位为行政科室(以无为参照)或辅助科室(以无为参照)、工作中最大的挑战为职业发展不明确(以体力不足为参照)或对领导方式不满意(以体力不足为参照)为内蒙古三级甲等医院高年资护士职业生涯成功水平的影响因素(P<0.05),共解释职业生涯成功水平25.7%的变异度。结论内蒙古三级甲等医院高年资护士职业生涯成功处于中等偏下水平,且受多种因素影响。护理管理者应关注高年资护士群体,针对其职业生涯成功水平影响因素精准施策,进而提高其职业生涯成功水平。

关键词：高年资护士职业生涯成功现状调查影响因素分析

Restless legs syndrome following the use of ziprasidone: a case report

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General Psychiatry 2020年第2期33卷 111-113页

作者： Cuizhen Zhu Ran Bi yuliang hu hui Zhou Daomin Zhu Brian Isaacson Qingwei Li Yezhe Lin Department of Sleeping Disorder Anhui Mental Health CenterHefeiAnhuiChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong UniversitySchool of MedicineShanghaiChina School of Public Health Schulich School of Medicine and DentistryLondonOntarioCanada Departm ent of Psychiatry and Psychology Mayo Clinic School of Graduate Medical EducationRochesterMinnesotaUSA Shanghai Mental Health Center ShanghaiChina Psychiatry Department AtlantiCare Regional Medical CenterAtlantic CityNew JerseyUSA Department of Psychiatry University of Rochester Medical CenterRochesterNew YorkUSA

Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of *** there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of *** present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and *** patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/*** potential causative medications and differential diagnoses that could have caused similar symptoms were *** should be aware of the potential for ziprasidone-induced *** and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS.

关键词： doses Dopamine medication

Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment

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General Psychiatry 2019年第3期32卷 107-118页

作者： huijuan Zhang Yao Wang yuliang hu Yikang Zhu Tian hong Zhang Jijun Wang Ke Ma Chuan Shi Xin Yu Chunbo Li Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai China Peking University Institute of Mental Health Sixth Hospital Beijing China National Clinical Research Center for Mental Disorders Peking University Sixth Hospital Beijing China Key Laboratory of Mental Health Ministry of Health Peking University Beijing China Institute of Psychology and Behavioral Science Shanghai Jiao long University Shanghai China

Background Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function of Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it is not clear about the level and pattern of cognitive impairment among this population. Aim To provide a meta-analysis systematically analysing studies of neurocognitive function using MCCB in Chinese patients with FES. Methods An independent literature search of both Chinese and English databases up to 13 March 2019 was conducted by two reviewers. Standardised mean difference (SMD) was calculated using the random effects model to evaluate the effect size. Results 56 studies (FES=3167, healthy controls (HC)=3017) were included and analysed. No study was rated as 'high quality' according to Strengthening the Reporting of Observational Studies in Epidemiology. Compared with HCs, Chinese patients with FES showed impairment with large effect size in overall cognition (SMD=-1.60,95% Cl -1.82 to -1.38,厂=67%) and all seven cognitive domains, with the SMD ranging from -0.87 to -1.41. In nine MCCB subtests, patients with FES showed significant difference in Symbol Coding (SMD=-1.90), Trail Making Test (TMT)(SMD=-1.36), Continuous Performance Test-Identical Pairs (SMD=-1.33), Hopkins Verbal Learning Test (SMD=-1.24), Brief Visuospatial Memory Test (SMD=-1.18), Mazes (SMD=-1.16), Category Fluency (SMD=-1.01), Spatial Span (SMD=-0.69) and Mayer-Salovey-Caruso Emotional Intelligence Test (SMD=-0.38). Conclusions Our meta-analysis demonstrates that Chinese patients with FES show neurocognitive deficits across all seven MCCB cognitive domains and all nine subtests, particularly in two neurocognitive domains: speed of processing and attention/vigilance, with the least impairment shown in social cognition. Symbol Coding and TMT may be the most sensitive tests to detect cognitive deficit in Chinese patients with FES.

关键词： Meta-analysis cognitive function first-episode schizophrenia

Stability Test of Naomai Xingshen Capsules

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Medicinal Plant 2022年第4期13卷 19-21,33页

作者： Congyan ZENG Xiaoyan PANG yuliang hu Xiaofang XIN Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine Zhongshan 528400China

[Objectives]To explore the stability of Naomai Xingshen Capsules.[Methods]Accelerated test and long-term test were carried out to investigate the changes in properties,identification,moisture,disintegration time and microbial limit of Naomai Xingshen Capsules.[Results]There were basically no changes in all indicators for the three batches of samples(after 6-month accelerated test and 24-month long-term test),and they all met the requirements of quality standards.[Conclusions]The preparation of Naomai Xingshen Capsules is stable and reliable,and the stability test provides a reliable basis for its expiration date.

关键词： Naomai Xingshen Capsules Accelerated test Long-term test Stability

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网络公共信息资源获取的选择与规划分析

图书情报知识 2005年第6期22卷 74-77页

作者：胡宇梁浙江商业职业技术学院杭州310053

本文从网络公共信息获取方式及其比较入手,分析了网络公共信息资源获取的必要性、充分性和网络公共信息服务开展所要涉及的问题,并就我国网络公共信息服务体系的调整提出了相应的建议和对策。

关键词：信息服务信息资源公共性

Estimation of Potential Risk of Reservoir-Induced Earthquake for the Proposed Hydroelectric Project on the Yangtze Gorges

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Earthquake Research in China 1995年第4期9卷 42-51页

作者： hu yuliang,Zhao Meng,hu Ping,Ma Wentao,Yang Qingyuan,and Chen Xiancheng Institute of Geology,State Seismological Bureau,Beijing 100029,China

The proposed hydroelectric project on the Yangtze Gorges will be one of the largest power stations in the *** problem of induced seismicity to the project has attracted much attention throughout China and the world.A research program has been carried out by the State Seismological Bureau of *** on the size of the reservoir and the lithology,geological structure,permeability,stress state,and previous seismicity in the region,the potential risk of reservoir-induced seismicity has been *** results suggest that,after impoundment in the reservoir area,the possibility of induced seismicity cannot be completely ruled *** areas with potential risk may be in some gorges composed of karstified carbonate and plutonic granite around the dam ***,the magnitude is expected to be limited owing to the small dimension of the induced seismogenic faults.

关键词： seismic risk evaluation reservoir earthquake Yangtze Gorge project

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带状疱疹后遗神经痛的相关危险因素分析

中国实用神经疾病杂志 2015年第11期18卷 20-22页

作者：胡于良四川内江市第一人民医院内江641000

目的探讨带状疱疹后遗神经痛的相关危险因素。方法选择我院2012-07—2014-07诊治的带状疱疹患者213例。按是否出现神经痛分为带状疱疹后神经痛组和带状疱疹后无神经痛组。比较2组性别、年龄、焦虑或抑郁状态、皮疹部位、急性期疼痛程度... 详细信息

目的探讨带状疱疹后遗神经痛的相关危险因素。方法选择我院2012-07—2014-07诊治的带状疱疹患者213例。按是否出现神经痛分为带状疱疹后神经痛组和带状疱疹后无神经痛组。比较2组性别、年龄、焦虑或抑郁状态、皮疹部位、急性期疼痛程度,对各主要研究因素进行单因素分析,对差异有统计学意义的因素再进行多因素Logistic回归分析。结果单因素分析显示,2组患者年龄≥50岁、女性、有焦虑或抑郁状态、急性期重度疼痛4个因素上,差异有统计学意义(P0.05)。多因素Logistic回归分析显示,年龄≥50岁、女性、急性期重度疼痛进入回归模型(P<0.05)。结论年龄≥50岁、女性、急性期重度疼痛为影响带状疱疹后遗神经疼痛的独立危险因素,重视高年龄、女性及急性期重度疼痛患者早期给予抗病毒及抗病理神经痛可有效预防疱疹后神经痛。

关键词：带状疱疹神经痛危险因素