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A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

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Nano-Micro Letters 2024年第2期16卷 1-14页

作者： Yijian Gao Ying Liu Xiliang Li Hui Wang yuliang yang Yu Luo Yingpeng Wan Chun‑sing Lee Shengliang Li Xiao‑Hong Zhang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Center of Super‑Diamond and Advanced Films(COSDAF)&Department of Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关键词： NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy

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云南省佛教寺院空间分异特征及影响因素

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热带地理 2024年第2期44卷 315-325页

作者：彭文杨宇亮黄雅飞邹开泽段开龙沈洋冬云南师范大学地理学部昆明650500 云南师范大学国际汉语教育学院昆明650500 曲靖市第一中学云南曲靖655000 大理市文物保护管理所云南大理671000

从佛教地理学视角出发,运用GIS的空间分析方法与田野调查相结合,对云南省佛教寺院空间分异特征及影响因素进行研究。结果表明:1)全省佛教寺院空间分布呈现“三核”特征,汉传佛教寺院呈倒“U”型带状分布,藏传佛教寺院呈“一核多中心”分... 详细信息

从佛教地理学视角出发,运用GIS的空间分析方法与田野调查相结合,对云南省佛教寺院空间分异特征及影响因素进行研究。结果表明:1)全省佛教寺院空间分布呈现“三核”特征,汉传佛教寺院呈倒“U”型带状分布,藏传佛教寺院呈“一核多中心”分布,南传佛教寺院呈“两头密、中间疏”分布。2)水平上主要分布于金沙江、澜沧江和珠江流域,垂直上具有“三级阶梯”分布特征。3)云南的复杂人文地理环境是造就佛教寺院分异的关键因素,地理结构是奠定佛教寺院的空间分异特征的基础力量,文化结构促进各部派寺院在交流中形成多元共存格局,制度结构影响的治理方式加剧各部派寺院在不同历史时期的分布范围变化。

关键词：佛教寺院人文地理环境空间分异佛教地理云南省

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Visual experimental study of nanofluids application to promote CO_(2) absorption in a bubble column

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Chinese Journal of Chemical Engineering 2024年第3期67卷 228-237页

作者： Shangyuan Cheng Guisheng Qi yuliang Li Yixuan yang Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of ChinaTaiyuan 030051China

The addition of dispersed-phase nanoparticles in the liquid phase can enhance the gas-liquid transfer process as the suspended nanoparticles affect the transfer process inside the fluid through microdisturbance or micro-convection *** this article,a high-speed digital camera was used to visualize the bubble behavior of CO_(2) in pure water and nanofluids to examine the effects of CO_(2) gas flow rate,nanoparticle solid content and type on the bubble behavior in the *** CO_(2) absorption performance in three water-based nanofluids were compared in a *** the mass transfer characteristics during CO_(2) bubble absorption and the reasons for the enhanced gas-liquid mass transfer effect of nanoparticles were *** results showed that the presence of nanoparticles affected the formation process of bubbles in the fluid,shortened the bubble detachment time,reduced the detachment diameter,effectively increased the gas-liquid contact area,and improved the bubbles detachment *** system with MCM-41 corresponded to a higher overall mass transfer *** MCM-41 contained surfactant that enhanced foaming behavior in *** prevented the transfer of CO_(2) to some extent,and the CO_(2) absorption by uncalined MCM-41/H_(2)O was 5.34%higher than that by pure *** with SiO_(2) nanoparticles with the same particle size and the same composition,MCM-41 had a higher adsorption capacity and better hydrophilicity due to its larger specific surface area and rich porous structure,which was more favorable to accelerate the collision between nanoparticles and CO_(2) bubbles to cause *** the condition of 0.1%(mass)solid content,the enhancement of CO_(2) absorption process by MCM-41 nanoparticles was more significant and improved by 16.9%compared with pure water.

关键词： Nanofluids CO_(2) absorption Mass transfer MCM-41 Bubble column

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基于知识图谱和深度学习的学术论文推荐算法研究

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长江信息通信 2024年第1期37卷 26-28页

作者：杨宇亮石嘉豪陶秀杰林杰南方电网科学研究院有限责任公司广东广州510000

目的:文章针对当前学术论文推荐中存在的不足,提出将知识图谱与深度学习相结合的研究思路,研究一种学术论文推荐算法。方法:搜集文献资料,建立相关知识图谱。对用户的行为喜好及检索要求进行了分析。方法:通过构造查询矢量,度量相似度,... 详细信息

目的:文章针对当前学术论文推荐中存在的不足,提出将知识图谱与深度学习相结合的研究思路,研究一种学术论文推荐算法。方法:搜集文献资料,建立相关知识图谱。对用户的行为喜好及检索要求进行了分析。方法:通过构造查询矢量,度量相似度,生成资源推荐表,完成学术论文推荐。结论:通过与传统算法的比较,本文提出的算法可以使用户的搜索准确率提高4.53%,并且能够显著地提高用户的搜索准确率。

关键词：知识图谱深度学习学术论文

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Advances of graphdiyne-supported metal catalysts in thermocatalytic reactions

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Nano Research 2024年第4期17卷 2223-2233页

作者： Jia Yu Yida yang yuliang Li Changyan Cao Weiguo Song Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesLaboratory of Molecular Nanostructures and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesLaboratory of organic solidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

Supported metal catalysts are widely used in the modern chemical *** electronic interaction between supports and active components is of great significance for heterogeneous ***(GDY),a new type of carbon allotrope with sp-hybridized carbon atoms,πconjugate structure,and electron transmission capability,is a promising candidate as catalyst *** years have witnessed the rapid progress of GDY-supported metal catalysts for different catalysis *** that most processes in the current chemical industry are thermocatalytic reactions,we herein give an overview about the advances and particular characteristics of GDY-supported catalysts in these *** geometric structure and electronic properties of GDY are first ***,the synthesis methods for GDY-supported metal catalysts and their applications in thermocatalytic reactions are discussed,in which the effect of electronic interaction on catalytic performance is ***,the current challenges and future directions of GDY-supported metal catalysts for thermocatalysis are *** is expected that this review will enrich our understanding of the advances of GDY as a superior support for metal catalysts in thermocatalytic reactions.

关键词： graphdiyne metal catalysts thermocatalytic reactions heterogeneous catalysis

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基于大数据技术的创新知识服务与支持平台分析

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电子技术（上海） 2024年第3期53卷 210-211页

作者：杨宇亮林正平陶秀杰石嘉豪南方电网科学研究院有限责任公司广东510700

阐述一种基于大数据技术的创新知识服务与支持平台设计方案。该平台结合大数据分析和人工智能技术,在数据挖掘和知识推荐方面具有较好的应用效果。分析平台的主要功能,提出实现方案。

关键词：大数据技术创新知识数据挖掘知识推荐

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基于智能技术的企业知识管理系统分析

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电子技术（上海） 2024年第3期53卷 206-207页

作者：林正平王庆红杨宇亮石嘉豪南方电网科学研究院有限责任公司广东510700

阐述人工智能在企业知识管理中的应用,包括智能化搜索、智能化分类、智能化推荐。探讨基于人工智能的企业知识管理系统设计与实现,分析系统总体设计、模块设计、实现与运行效果。

关键词：知识管理系统模块设计智能化推荐

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Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice

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Food Science and Human Wellness 2023年第5期12卷 1637-1645页

作者： Zitao Guo Dalong Yi Bo Hu Lingyu Zhu Ji Zhang yuliang yang Chunyu Liu Yi Shi Zhenghua Gu Yu Xin Huaigao Liu Liang Zhang National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing Jiangnan UniversityWuxi 214122China Jiangsu Provincial Research Center for Bioactive Product Processing Technology Jiangnan UniversityWuxi 214122China Anhui Guotai Biotechnology Co. LtdXuancheng 242100China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation.

关键词： Yak bone collagen hydrolysate Peptides Gut microbiota Short-chain fatty acid Lachnospiraceae

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关于科学普及与中国未来发展的思考

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中国科学院院刊 2023年第5期38卷 719-725页

作者：杨玉良中国科学院学部科学普及与教育工作委员会北京100190

科学是人类追求真理的伟大事业,科学普及(以下简称“科普”)是实现创新发展的重要基础性工作。纵观科学发展历程,人类通过科普实现知识体系的开放与共享、生产技术的应用与推广、科学文化的传承与发展、文明理性的启蒙与教育。文章分析... 详细信息

科学是人类追求真理的伟大事业,科学普及(以下简称“科普”)是实现创新发展的重要基础性工作。纵观科学发展历程,人类通过科普实现知识体系的开放与共享、生产技术的应用与推广、科学文化的传承与发展、文明理性的启蒙与教育。文章分析了科普的作用和价值,指出科普有利于促进科学技术与社会的良性互动、提升科技治理水平效能,有利于提升公民科学素养、保障公民行使科学文化权力,有利于加强创新系统和创新文化建设。进而立足中国式现代化建设大背景,指出科普在人才培养、创新发展、社会治理、对外开放等方面大有作为。最后,从坚持科技为民的科普理念、筑牢科普传播阵地、立足科技向善的价值导向、推动开放科学的大力发展、促进科普国际交流与协作等方面指明了科技工作者的科普责任与使命担当。

关键词：科学普及科普的价值中国式现代化

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An Ion-Pumping Interphase on Graphdiyne/Graphite Heterojunction for Fast-Charging Lithium-Ion Batteries

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CCS Chemistry 2024年第1期6卷 110-124页

作者： Juan An Fan Wang Jia-Yue yang Guoxing Li yuliang Li Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy ConversionSchool of Chemistry and Chemical EngineeringInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237 Optics&Thermal Radiation Research Center Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237 Institute of Chemistry The Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

The sluggish lithium-ion(Li-ion)transport kinetics in graphite anode hinders its application in fast-charging Li-ion batteries(LIBs).Here,we develop an ionpumping interphase(IPI)on graphdiyne(GDY)/graphite heterojunction anodes to boost the ionic transport kinetics and enable high-performance,fast-charging *** IPI changed the ion solvation/desolvation environment by covalent/non-covalent interactions with Li ions or solvents to optimize solid-electrolyte interphase(SEI)and regulate Li-ion transport *** studied the in situ growth of few-layer GDY on graphite surface(GDY/graphite)as the IPI and found that the strong interaction between GDY and Li ions enabled surface-induced modification of the ion solvation behavior and surface-assisted desolvation effect to accelerate the Li-ion desolvation process.A functional anion-derived SEI layer with improved Li-ion conductivity was *** with the generated built-in electric field at GDY/graphite hetero-interface self-pumping Li ions to intercalate into the graphite,the Li-ion transport kinetics was significantly enhanced to effectively eliminate Li plating and large voltage polarization of the graphite anodes.A fast Li intercalation in GDY/graphite without Li oversaturation at the edge of the graphite was directly *** superior performance with high capacity(139.2 mA h g^(-1))and long lifespan(1650 cycles)under extremely fast-charging conditions(20 C,1 C=372 mA g^(-1))was achieved on GDY/graphite *** at low temperatures(-20℃),a specific capacity of 128.4 mA h g^(-1) was achieved with a capacity retention of 80%after 500 cycles at a 2 C rate.

关键词： extreme fast-charging lithium-ion batteries lithium-ion transport kinetics ion-pumping interphase graphdiyne/graphite heterojunction

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