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Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

World Journal of Gastroenterology 2017年第8期23卷 1387-1396页

作者： Hadar Goldvaser Noa Katz Shroitman Irit Ben-Aharon Ofer Purim yulia kundel Daniel Shepshelovich Tzippy Shochat Aaron Sulkes Baruch Brenner Institute of Oncology Davidoff Cancer CenterBeilinson HospitalRabin Medical Center Sackler Faculty of Medicine Tel Aviv University Division of Medical Oncology and Hematology Princess Margaret Cancer Centre and the Department of MedicineUniversity of Toronto Department of Medicine A Beilinson HospitalRabin Medical Center Statistical Consulting Unit Beilinson HospitalRabin Medical Center

AIM To characterize colorectal cancer(CRC) in octogenarians as compared with younger *** A single-center, retrospective cohort study which included patients diagnosed with CRC at the age of 80 years or older between 2008-2013. A control group included consecutive patients younger than 80 years diagnosed with CRC during the same period. Clinicopathological characteristics, treatment and outcome were compared between the groups. Fisher's exact test was used for dichotomous variables and χ2 was used for variables with more than two categories. Overall survival was assessed by Kaplan-Meier survival analysis, with the log-rank test. Cancer specific survival(CSS) and disease-free survival were assessed by the Cox proportional hazards model, with the Fine and Gray correction for non-cancer death as a competing *** The study included 350 patients, 175 patients in each group. Median follow-up was 40.2 mo(range 1.8-97.5). Several significant differences were noted. Octogenarians had a higher proportion of Ashkenazi ethnicity(64.8% vs 47.9%, P < 0.001), a higher rate of personal history of other malignancies(22.4% vs 13.7%, P = 0.035) and lower rates of family history of any cancer(36.6% vs 64.6%, P < 0.001) and family history of CRC(14.4% vs 27.3%, P = 0.006). CRC diagnosis by screening was less frequent in octogenarians(5.7% vs 20%, P < 0.001) and presentation with performance status(PS) of 0-1 was less common in octogenarians(71% vs 93.9%, P < 0.001). Octogenarians were more likely to have tumors located in the right colon(45.7% vs 34.3%, P = 0.029) and had a lower prevalence of well differentiated histology(10.4% vs 19.3%, P = 0.025). They received less treatment and treatment was less aggressive, both in patients with metastatic and non-metastatic disease, regardless of PS. Their 5-year CSS was worse(63.4% vs 77.6%, P = 0.009), both for metastatic(21% vs 43%, P = 0.03) and for non-metastatic disease(76% vs 88%, P = 0.028).CONCLUSION Octogenarians pre

关键词：冒号直肠老八十至八十九岁年龄

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Dose-Dense Regimen of Cisplatin and Infusional Fluorouracil in Advanced Gastric Cancer—A Single Institution Experience

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Journal of Cancer Therapy 2013年第2期4卷 529-535页

作者： Ofer Purim yulia kundel Roni Shapira Baruch Brenner Institute of Oncology Chaim Sheba Medical Center Tel Hashomer Israel Institute of Oncology Davidoff Center Rabin Medical Center Petach Tiqwa and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

Chemotherapy with continuous infusion of 5-fluorouracil and cisplatin in a monthly schedule is one of the most common regimens in the treatment of advanced gastric cancer. In this study, we evaluated the efficacy and safety of a dosedense administration of this regimen in this patient population. Sixty-six consecutive patients with previously untreated histologically confirmed unresectable or metastatic gastric adenocarcinoma were treated with a 2-hour infusion of cisplatin 100 mg/m2 followed by continuous infusion of 5-fluorouracil 1000 mg/m2/day for 5 days, every 21 days. The most common grade ≥3 toxicities were fatigue (42%), nausea/vomiting (30%) and leucopenia (12%). Four patients (6%) died from treatment-related toxicity. The response rate was 35%, the median progression-free survival was 4.3 months and the median survival was 5.9 months. In light of these results, the dose-dense approach seems to offer little, if any, benefit compared with the standard regimens.

关键词： Gastric Cancer Dose-Dense Cisplatin Fluorouracil

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MicroRNAs as a potential prognostic factor in gastric cancer

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World Journal of Gastroenterology 2011年第35期17卷 3976-3985页

作者： Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak yulia kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir Institute of Oncology Davidoff CenterRabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978Israel Rosetta Genomics Ltd. Rehovot 76706Israel Clalit Research Institute Clalit Medical ServicesTel Aviv 69978Israel Institute of Oncology Rabin Medical CenterGolda-Hasharon HospitalPetach Tikva 49100Israel Institute of Oncology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Institute of Pathology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Institute of Pathology Rabin Medical CenterGolda-Hasharon HospitalPetach Tikva 49100Israel Cancer Research UK Cambridge Research InstituteCambridge CB2 OREUnited Kingdom Department of Gastroenterology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978 Israel

AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric ***:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was *** RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA *** profiling using miR microarrays was performed to identify potential biomarkers of recurrence after *** expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and *** miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis ***:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric *** these,miR-451 had the strongest prognostic impact.

关键词：小分子RNA 预后胃癌 microRNA 肿瘤患者聚合酶链反应辅助治疗手术切除

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