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Usefulness of continuous suction mouthpiece during esophagogastroduodenoscopy: A single-center, prospective,randomized study

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World Journal of Gastrointestinal Endoscopy 2013年第10期5卷 508-513页

作者： Takao Maekita Jun Kato yukihiko nakatani Shotaro Enomoto Ema Takano Masahiro Tsuji Tsuyoshi Nakaya Kosaku Moribata Yosuke Muraki Naoki Shingaki Toru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Masao Ichinose Department of Gastroen-terology School of Medicine Wakayama Medical UniversityWakayama Department of Internal Medicine Nakaya HospitalWakayama

AIM: To develop a new continuous suction mouthpiece(CSM) and evaluate its usefulness for screening esophagogastroduodenoscopy(EGD).METHODS: A total of 196 patients who were scheduled to undergo screening EGD were assigned to one of two groups: a group using the CSM and a group using a conventional mouthpiece. Extent of salivary flow,frequency of saliva suction, number of choking episodesduring the examination, and incidence of aspiration pneumonia after the examination were evaluated and compared between the two groups. Adverse events during and after EGD were also examined. In addition, the oral cavity was meticulously examined after the EGD.RESULTS: The same number of patients was randomly allocated to each group. There were no significant differences between the two groups in sex, age,biopsy procedure, duration of procedure and depth of sedation. Aspiration pneumonia and other significant adverse events were not observed in either group. The grade of extent of salivary flow was significantly lower in patients with the CSM than in patients with the conventional mouthpiece(P < 0.001). Although there was no significant difference, less frequent suctioning and fewer choking episodes were observed in patients with the CSM than in patients with the conventional mouthpiece(P = 0.082 and P = 0.084, respectively). In addition, there were no patients in the CSM group who required saliva suctioning during the procedure.CONCLUSION: Use of the CSM during screening EGD can reduce the extent of salivary flow. The device is expected to reduce complications and contamination with saliva.

关键词： Mouthpiece Esophagogastroduodenoscopy Aspiration Saliva Suction

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Cell surface protein engineering for high-performance whole-cell catalysts

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Frontiers of Chemical Science and Engineering 2017年第1期11卷 46-57页

作者： Hajime nakatani Katsutoshi Hori Department of Biotechnology Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan

Cell surface protein engineering facilitated by accumulation of information on genome and protein structure involves heterologous production and modifica- tion of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts. In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a cartier protein. The target proteins are fused to the carrier proteins that transport and tether them to the cell surface, as well as to a secretion signal. This paper reviews cell surface display systems for prokaryotic and eukaryotic cells from the perspective of carrier proteins, which determine the number of displayed molecules, and the localization, size, and direction （N- or C-terminal anchoring） of the passengers. We also discuss advanced methods for displaying multiple enzymes and a new method for the immobilization of whole-cell catalysts using adhesive surface proteins.

关键词： cell surface engineering surface display,whole-cell catalysts bioprocess

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Intramolecular proton transfer: a reliable solution to design all-visible-light-activated dithienylethenes

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Science China Chemistry 2020年第4期63卷 421-422页

作者： Keitaro nakatani Juan Xie Universite Paris-Saclay ENS Paris-SaclayCNRSPPSM61 av.du President Wilson94235 CachanFrance

In the fields of materials science and life science,the ability to influence key properties of molecular systems by using light is of great significance.Photochromic compounds play a key role in such systems since they can reversibly photoisomerize between two states[1].Among photochromic series,dithienylethenes(DTEs)can undergo reversible conrotatory 671 photocyclization and cycloreversion have drawn much attention due to the excellent thermal irreversibility and outstanding fatigue resistance[2].

关键词： fatigue resistance visible

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The present and future status of Japanese foundry industry

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China Foundry 2008年第3期5卷 205-208页

作者： Kanetake nakatani Foundry Society Inc.Room 501Kikai Shinko Kaikan 3-5-8Shiba-KoenMinato-ku Tokyo 105-0011Japan

An introduction is given in detail about the current situation of Japanese foundry industry in 2006 from aspects such as the delivery structure of castings,scale and numbers of foundries,current profit of foundry industry as well as the background of lower profitability,etc.The development trend of Japanese foundry industry was also predicted,such as the transition of foundries from family business to modern company business,the improvement of rejection ratio and yield,application of IT to production and management,human resources and the challenge for zero emission and so on.

关键词：日本铸造工业零点发射人力资源

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Aggregation-induced emission and thermally activated delayed fluorescence of 2,6-diaminobenzophenones

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Science China Chemistry 2018年第8期61卷 925-931页

作者： Masaki Shimizu Masaki nakatani Kenta Nishimura Faculty of Molecular Chemistry and Engineering Kyoto Institute of Technology

Exploration of novel organic luminophores that exhibit thermally activated delayed fluorescence(TADF) in the aggregated state is very crucial for advance of delayed luminescence-based applications such as time-gated bio-sensing and temperature sensing.We report herein that synthesis, photophysical properties, molecular and crystal structures, and theoretical calculations of 2,6-bis(diarylamino)benzophenones. Absorption spectra in solution and calculations using density functional theory(DFT) method revealed that the optical excitation took place through intramolecular charge-transfer from one diarylamino moiety to an aroyl group. While the benzophenones did not luminesce in solution, the solids of the benzophenones emitted green light with moderate-to-good quantum yields. Thus, the benzophenones exhibit aggregation-induced emission. Based on the lifetime measurement, the green emission of the solids was found to include TADF. The emergence of the TADF is supported by the small energy gap between the excited singlet and triplet states, which was estimated by time-dependent DFT calculations. Thin films of poly(methyl methacrylate) doped by the benzophenones also showed green prompt and delayed fluorescence whose lifetimes were in the order of microseconds. Linear correlation between logarithm value of TADF lifetime and temperature was observed with the benzophenone in powder, suggesting that the benzophenones can serve as molecular thermometers workable under aqueous conditions.

关键词：排放聚集荧光激活水晶结构时间依赖温度计 poly

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Hazard Mitigation Planning for Debris flow Based on Numerical Simulation Using Kanako Simulator

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Journal of Mountain Science 2012年第4期9卷 529-537页

作者： LIU Jinfeng nakatani Kana MIZUYAMA Takahisa Key Laboratory of Mountain Surface Process and Hazards Institute of Mountain Hazards and EnvironmentChineseAcademy of SciencesChengdu 610041China Department of Erosion Control Engineering Kyoto UniversityKyoto 6068502Japan

Debris flow often causes enormous loss to life and property,especially on alluvial fans.Engineering structures such as retention check dams are essential to reduce the damage.In hazard mitigation evaluation and planning it is of significance to determine the location,size and type of dam and the effects of damage mitigation.We present a numerical simulation method using Kanako simulator for hazard mitigation planning of debris flow disaster in Tanjutani Gully,Kyoto City,Japan.The simulations were carried out for three situations:1) the simulations of erosion,deposition,hydrograph changing and inundation when there were no mitigation measures;2) the simulations of check dams in four locations(470 m,810 m,1,210 m and 1,610 m from the upstream end) to identify the best location;3) the simulations of check dams of three types(closed,slit and grid) to analyze their effects on sediment trapping and discharge reduction.Based on the simulations,it was concluded that two closed check dams(located at 470 m and 1,610 m from the upstream end) in the channel and a drainage channel on the alluvial fan can reduce the risk on the alluvial fan to an acceptable level.

关键词：数值模拟方法泥石流灾害减灾规划模拟器冲积扇工程结构缓解措施水文变化

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Case study of debris flow disaster scenario caused by torrential rain on Kiyomizu-dera, Kyoto, Japan - using Hyper KANAKO system

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Journal of Mountain Science 2016年第2期13卷 193-202页

作者： Kana nakatani Satoshi HAYAMI Yoshifumi SATOFUKA Takahisa MIZUYAMA Department of Erosion Control Engineering Kyoto University Kyoto 606-8502 Japan CTI Engineering Co. Ltd. Osaka 541-0045 Japan Department of Civil Engineering Ritsumeikan University Shiga 606-8502 Japan National Graduate Institute for Policy Studies Tokyo106-8677 Japan

This paper presents debris-flow numerical simulations using the Hyper KANAKO system,developed by the authors.The system uses the debris flow simulator KANAKO 2D equipped with a graphical user interface(GUI);hence,a user can easily produce appropriate landform data for simulations using standard laser profiler data,and visualize the results using a GIS.Hyper KANAKO was applied to the streams around Kiyomizu-dera in Kyoto,Japan.Kiyomizu-dera is a famous temple in Japan which is visited by numerous tourists throughout the year.We simulated a disaster scenario of debris flow caused by torrential rain.We set the hydrograph using rainfall intensity data,and set the landform data using information from the Geospatial Information Authority of Japan(GSI) and a digital elevation model(DEM).We evaluated different mesh sizes and also used a digital surface model(DSM) to consider the building heights.The simulation results showed that with small mesh size,the debris flowmoved through the roads,which seems realistic for a disaster situation.When buildings were considered,the flow direction changed,and a 1-m flow depth,which was deeper than in other cases,appeared in the flow path.This may pose a dangerous situation for evacuations.

关键词：泥石流灾害子系统日本清水暴雨京都图形用户界面地理空间信息

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Influence of Housing and Urban Development on Debris Flow Flooding and Deposition

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Journal of Mountain Science 2013年第2期10卷 273-280页

作者： Kana nakatani Yuki OKUYAMA Yuji HASEGAWA Yoshifumi SATOFUKA Takahisa MIZUYAMA Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto City606-8502Japan National Institute for Land and Infrastructure Management AsahiTsukuba CityIbaraki305-0804Japan Civil Engineering Research Laboratory 904-1 TohigashiTsukuba CityIbaraki300-2633Japan Department of Civil Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsu CityShiga525-8577Japan

Debris flows form deposits when they reach an alluvial fan until they eventually stop.However,houses located in the alluvial fan might affect the debris flow flooding and deposition processes.Few previous studies have considered the effects of houses on debris flow flooding and deposition.This study conducted model experiments and numerical simulations using the Kanako2D debris flow simulator to determine the influence of houses on debris flow flooding and deposition.The model experiments showed that when houses are present,the debris flow spreads widely in the cross direction immediately upstream of the houses,especially when the flow discharge is large or the grain size is small.Houses located in the alluvial fan also influence the deposition area.The presence of houses led to flooding and deposition damage in some places and reduced the damage in others.The simulation also demonstrated the influence of houses.Both the model experiment and the simulation showed that houses change the flooding and deposition areas.

关键词：沉积过程泥石流洪水城市发展住房模型实验冲积扇可能影响

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Groundwater monitoring of an open-pit limestone quarry:Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses

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International Journal of Mining Science and Technology 2018年第6期28卷 849-857页

作者： Khy Eam Eang Toshifumi Igarashi Megumi Kondo Tsurugi nakatani Carlito Baltazar Tabelin Ryota Fujinaga Laboratory of Groundwater and Mass Transport Division of Sustainable Resources EngineeringGraduate School of EngineeringHokkaido UniversitySapporo 060-8628Japan Laboratory of Groundwater and Mass Transport Division of Sustainable Resources EngineeringFaculty of EngineeringHokkaido UniversitySapporo 060-8628Japan Mitsubishi Materials Corporation Tokyo 1008117Japan Ryoko Lime Industry Co. Ltd.Chichibu-gunSaitama 3680072Japan Laboratory of Mineral Processing and Resources Recycling Division of Sustainable Resources EngineeringFaculty of EngineeringHokkaido UniversitySapporo 0608628Japan

Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately watersoluble minerals like calcite. In this study, the hydrogeological and geochemical evolutions of groundwater in a limestone quarry composed of three strata: limestone layer(covering), interbedded layer under the covering layer, and slaty greenstone layer(basement) were investigated. Water-rock interaction in the open-pit limestone quarry was evaluated using PHREEQC, while hierarchical cluster analysis(HCA)and principal component analysis(PCA) were used to classify and identify water sources responsible for possible groundwater mixing within rock layers. In addition, Geochemist's Workbench was applied to estimate the mixing fractions to clarify sensitive zones that may affect rock slope stability. The results showed that the changes in Ca2+and HCO3àconcentrations of several groundwater samples along the interbedded layer could be attributed to mixing groundwater from the limestone layer and that from slaty greenstone layer. Based on the HCA and PCA results, groundwaters were classified into several types depending on their origin:(1) groundwater from the limestone layer(LO),(2) mixed groundwater flowing along the interbedded layer(e.g., groundwater samples L-7, L-11, S-3 and S-4), and(3) groundwater originating from the slaty greenstone layer(SO). The mixing fractions of 41% LO: 59% SO, 64% LO: 36% SO, 43%LO: 57% SOand 25% LO: 75% SOon the normal days corresponded to groundwaters L-7, L-11, S-3 and S-4,respectively, while the mixing fractions of groundwaters L-7 and L-11(61% LO: 39% SOand 93% LO: 7% SO,respectively) on rainy days became the majority of groundwater originating from the limestone layer.These indicate that groundwater along the interbedded layer significantly affected the stability of rock slopes by enlarging multi-breaking zones in the layer through calcite dissolution and inducing high water pressure, te

关键词： Water-rock interaction Groundwater mixing Interbedded layer Geochemist’s workbench Rock slope stability

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Determination of the Dzyaloshinskii-Moriya interaction using pattern recognition and machine learning

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npj Computational Materials 2021年第1期7卷 198-204页

作者： Masashi Kawaguchi Kenji Tanabe Keisuke Yamada Takuya Sawa Shun Hasegawa Masamitsu Hayashi Yoshinobu nakatani Department of Physics The University of TokyoTokyo 113-0033Japan Toyota Technological Institute Nagoya 468-8511Japan Department of Chemistry and Biomolecular Science Faculty of EngineeringGifu UniversityGifu 501-1193Japan University of Electro-Communications Tokyo 182-8585Japan

Machine learning is applied to a large number of modern devices that are essential in building an energy-efficient smart society.Audio and face recognition are among the most well-known technologies that make use of such artificial intelligence.In materials research,machine learning is adapted to predict materials with certain functionalities,an approach often referred to as materials informatics.Here,we show that machine learning can be used to extract material parameters from a single image obtained in experiments.The Dzyaloshinskii–Moriya(DM)interaction and the magnetic anisotropy distribution of thin-film heterostructures,parameters that are critical in developing next-generation storage class magnetic memory technologies,are estimated from a magnetic domain image.Micromagnetic simulation is used to generate thousands of random images for training and model validation.A convolutional neural network system is employed as the learning tool.The DM exchange constant of typical Co-based thin-film heterostructures is studied using the trained system:the estimated values are in good agreement with experiments.Moreover,we show that the system can independently determine the magnetic anisotropy distribution,demonstrating the potential of pattern recognition.This approach can considerably simplify experimental processes and broaden the scope of materials research.

关键词： pattern interaction system

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