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双档案粒子群算法求解柔性作业车间调度问题

计算机工程与应用 2023年第11期59卷 294-301页

作者：张宇嘉宋威江南大学人工智能与计算机学院江苏无锡214122

针对最小化完工时间的柔性作业车间调度问题(FJSP),提出了双档案粒子群算法(DAPSO)。构建精英档案和进步档案分别存储具有较好适应值的精英粒子的个体历史最优位置(Pbest)和进步较快粒子的位置。利用精英档案中的粒子计算解可信度,并根... 详细信息

针对最小化完工时间的柔性作业车间调度问题(FJSP),提出了双档案粒子群算法(DAPSO)。构建精英档案和进步档案分别存储具有较好适应值的精英粒子的个体历史最优位置(Pbest)和进步较快粒子的位置。利用精英档案中的粒子计算解可信度,并根据解可信度来判断当前群体所处的进化状态,粒子根据进化状态调整向两个档案中学习的力度以达到收敛性与多样性的平衡。在Kacem的5个测试问题和MK系列10个测试问题开展了广泛实验,通过与其他算法按照最小完工时间、平均完工时间进行了比较,证明了DAPSO在求解FJSP问题时的有效性。

关键词：粒子群优化算法柔性作业车间调度双档案机制解可信度

Interpulse stimulation Fourier-transform coherent anti-Stokes Raman spectroscopy

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Photonics Research 2023年第2期11卷 357-363页

作者： MINJIAN LU yujia zhang XINYI CHEN YAN LI HAOYUN WEI Department of Precision Instrument State Key Laboratory of Precision Measurement Technology and InstrumentsTsinghua UniversityBeijing 100084China

Exploiting the time-resolving ability of ultrafast pulses, Fourier-transform coherent anti-Stokes Raman scattering(FT-CARS) stands out among the coherent Raman spectroscopic techniques for providing high-speed vibrational spectra with high spectral resolution, high Raman intensity, and immunity to nonresonant background. However,the impulsive stimulation nature of FT-CARS imposes heavy demands on the laser source and makes it inherently difficult to monitor high-frequency vibrations. Here, a novel FT-CARS strategy to our knowledge based on interpulse stimulation is proposed to provide more flexible measuring wavenumber region and lighten the requirement on ultrafast pulses. The mechanism of this technique is analyzed theoretically, and simulation is performed to show an orders-of-magnitude improvement of Raman intensity in the high-wavenumber region by the ***, an ytterbium-doped fiber laser and photonic crystal fiber-based solitons are employed to provide two~100-fs pulses as the pump and Stokes, respectively, and to perform interpulse stimulation FT-CARS without sophisticated dispersion control devices. The high-wavenumber region and upper-part fingerprint region measurements are demonstrated as examples of flexible measurement. Combined with other rapid scanning techniques, such as resonant scanners or a dual-comb scheme, this interpulse stimulation FT-CARS promises to make the fascinating FT-CARS available for any desired wavenumber region, covering many more realistic scenarios for biomedical, pathological, and environmental research.

关键词： coherent resonant vibrational

Field-effect transistor memories based on ferroelectric polymers

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Journal of Semiconductors 2017年第11期38卷 1-14页

作者： yujia zhang Haiyang Wang Lei zhang Xiaomeng Chen Yu Guo Huabin Sun Yun Li School of Electronic Science and Engineering National Laboratory of Solid-State Microstructures Collaborative Innovation Center of Advanced Microstructures Nanjing 210093 China

Field-effect transistors based on ferroelectrics have attracted intensive interests, because of their non-volatile data retention, rewritability, and non-destructive read-out. In particular, polymeric materials that possess ferroelectric properties are promising for the fabrications of memory devices with high performance, low cost, and large-area manufacturing, by virtue of their good solubility, low-temperature processability, and good chemical stability. In this review, we discuss the material characteristics of ferroelectric polymers, providing an update on the current development of ferroelectric field-effect transistors（Fe-FETs） in non-volatile memory applications.

关键词： ferroelectric polymers field-effect transistor memories ferroelectricity

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阶梯型矿灯反光杯的设计及效果研究

煤矿安全 2022年第7期53卷 153-157页

作者：张宇佳中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿安全技术国家重点实验室辽宁抚顺113122

针对矿灯照明角度和照明均匀性难以兼得的行业现状,基于LED光源的发光特性及煤矿井下工况的照明需求,设计了一款阶梯型反光杯;使用TracePro进行仿真模拟,仿真结果表明通过该反光杯二次配光后,光源能量得到重新分配,能够同时获得较远的... 详细信息

针对矿灯照明角度和照明均匀性难以兼得的行业现状,基于LED光源的发光特性及煤矿井下工况的照明需求,设计了一款阶梯型反光杯;使用TracePro进行仿真模拟,仿真结果表明通过该反光杯二次配光后,光源能量得到重新分配,能够同时获得较远的中心射程、较广的照明范围及主要照明区域的均匀性;提出了将图像识别技术应用于照明均匀度的分析的思想,并通过MATLAB编写相关程序对所设计的反光杯进行实际验证。结果表明,采用阶梯型反光杯的矿灯照明均匀度可达82.17%,相比常见的深光杯和浅光杯提升了约10个百分点。

关键词： LED矿灯反光杯照明均匀度图像识别 TracePro

Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy

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Neuroscience Bulletin 2024年第5期40卷 564-576页

作者： yujia Shen Yiwei Gong Xiaoli Da Shajing Gao Shuo zhang Minjuan Sun Yuanzhi Yang Xiaoyun Qiu Menghan Li Yang Zheng Fan Fei Yi Wang Zhong Chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Institute of Pharmacology and Toxicology NHC and CAMS Key Laboratory of Medical NeurobiologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Department of Neurology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310003China

Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary *** is one of the major resultants of pharmacoresistance and failure of surgical outcomes in epilepsy,but still lacks effective ***,we aimed to test the effects of low-frequency stimulation(LFS)at the subiculum for secondary epileptogenesis in a mouse ***,secondary epileptogenesis was simulated at regions both contralateral and ipsilateral to the primary focus by applying successive kindling *** kindled at the right CA3 showed higher seizure susceptibilities at both the contralateral CA3 and the ipsilateral entorhinal cortex and had accelerated kindling processes compared with naive *** at the ipsilateral subiculum during the primary kindling progress at the right CA3 effectively prevented secondary epileptogenesis at both the contralateral CA3 and the ipsilateral entorhinal cortex,characterized by decreased seizure susceptibilities and a retarded kindling process at those secondary *** application along with the primary epileptogenesis was ***,the effects of LFS on secondary epileptogenesis were associated with its inhibitory effect at the secondary focus through interfering with the enhancement of synaptic connections between the primary and secondary *** results imply that LFS at the subiculum is an effective preventive strategy for extensive secondary epileptogenesis in temporal lobe epilepsy and present the subiculum as a target with potential translational importance.

关键词： Secondary epileptogenesis Low-frequency stimulation Subiculum Temporal lobe epilepsy

AtVQ25 promotes salicylic acid-related leaf senescence by fine-tuning the self-repression of AtWRKY53

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Journal of Integrative Plant Biology 2024年第6期66卷 1126-1147页

作者： Qi Tan Mingming Zhao Jingwei Gao Ke Li Mengwei zhang Yunjia Li Zeting Liu yujia Song Xiaoyue Lu Zhengge Zhu Rongcheng Lin Pengcheng Yin Chunjiang Zhou Geng Wang Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Research Center of the Basic Discipline of Cell BiologyHebei Collaboration Innovation Center for Cell Signaling and Environmental AdaptationHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China College of Chemical Engineering Shijiazhuang UniversityShijiazhuang 050035China Institute of Botany Chinese Academy of SciencesBeijing 100093China

Most mechanistic details of chronologically ordered regulation of leaf senescence are *** networks centered on AtWRKY53 are crucial for orchestrating and integrating various senescence-related ***,AtWRKY53binds to its own promoter and represses transcription of AtWRKY53,but the biological significance and mechanism underlying this selfrepression remain *** this study,we identified the VQ motif-containing protein AtVQ25as a cooperator of *** expression level of AtVQ25 peaked at mature stage and was specifically repressed after the onset of leaf ***25-overexpressing plants and atvq25 mutants displayed precocious and delayed leaf senescence,***,we identified AtWRKY53 as an interacting partner of *** determined that interaction between AtVQ25 and AtWRKY53 prevented AtWRKY53from binding to W-box elements on the AtWRKY53promoter and thus counteracted the selfrepression of *** addition,our RNA-sequencing data revealed that the AtVQ25-AtWRKY53 module is related to the salicylic acid(SA)*** leaf senescence and SA-induced leaf senescence in AtVQ25-overexpressing lines were inhibited by an SA pathway mutant,atsid2,and Nah G transgenic plants;AtVQ25-overexpressing/atwrky53 plants were also insensitive to SA-induced leaf ***,we demonstrated that AtVQ25 directly attenuates the self-repression of AtWRKY53 during the onset of leaf senescence,which is substantially helpful for understanding the timing of leaf senescence onset modulated by AtWRKY53.

关键词： AtWRKY53 leaf senescence salicylic acid transcriptional regulation VQ motif-containing proteins

基于提升老年人体力活动水平的寒地城市公园热舒适性研究——主观感知和客观监测

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建筑科学 2023年第4期39卷 81-89,204页

作者：冷红张钰佳袁青哈尔滨工业大学建筑学院哈尔滨150000 自然资源部寒地国土空间规划与生态保护修复重点实验室哈尔滨150000

室外热舒适性的改善可以提升老年人体力活动水平进而促进健康,热舒适性受物理、生理和心理因素影响,考虑心理因素作用的主观热感知在影响老年人活动水平中与基于客观监测的热指标同样重要。本研究以典型寒地城市哈尔滨为例,采用主观感... 详细信息

室外热舒适性的改善可以提升老年人体力活动水平进而促进健康,热舒适性受物理、生理和心理因素影响,考虑心理因素作用的主观热感知在影响老年人活动水平中与基于客观监测的热指标同样重要。本研究以典型寒地城市哈尔滨为例,采用主观感知和客观监测相结合的方式,对寒地城市背景下老年人体力活动水平与热舒适性关联机理进行探讨。研究结果表明:1)社会心理因素对主观热感知有显著影响;2)心理适应是老年人抵抗热不适感进行活动的主要原因;3)不同强度活动主体对热环境需求具有差异,并针对以上研究结果提出热舒适性优化建议以提升老年人体力活动水平。

关键词：体力活动水平热舒适性寒地城市热感知老年人

Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model

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Science China Life Sciences 2024年

作者： Weiwei zhang Linghuan Wang yujia Wang Yan Fang Ruihua Cao Zhiyi Fang Dong Han Xu Huang Zhenghui Gu Yingjie zhang Yan Zhu Yan Ma Feng Cao Department of Cardiology The Second Medical Centre Chinese PLA General Hospital National Clinical Research Center for Geriatric Diseases School of Medicine Nankai University Department of Cardiology Beijing Friendship Hospital Capital Medical University

Atherosclerosis is the pathological cause of atherosclerotic cardiovascular disease （ASCVD）, which rapidly progresses during the cellular senescence. Sodium-glucose cotransporter 2 inhibitors （SGLT2is） reduce major cardiovascular events in patients with ASCVD and have potential antisenescence effects. Here, we investigate the effects of the SGLT2 inhibitor dapagliflozin on cellular senescence in atherosclerotic mice. Compared with ApoE-/-control mice treated with normal saline, those in the ApoE-/-dapagliflozin group, receiving intragastric dapagliflozin （0.1 mg kg-1d-1） for 14 weeks, exhibited the reduction in the total aortic plaque area （48.8%±6.6%vs. 74.6%±8.0%,P<0.05）, the decrease in the lipid core area (（0.019±0.0037） mm2vs.（0.032±0.0062） mm2, P<0.05) and in the percentage of senescent cells within the plaques （16.4%±3.7%vs. 30.7%±2.0%, P<0.01）, while the increase in the thickness of the fibrous cap (（21.6±2.1）μm vs.（14.6±1.5）μm, P<0.01). Transcriptome sequencing of the aortic arch in the mice revealed the involvement of the PPARα and the fatty acid metabolic signaling pathways in dapagliflozin’s mechanism of ameliorating cellular aging and plaque progression. In vitro, dapagliflozin inhibited the expression of PPARα and its downstream signal FABP4, by which the accumulation of senescent cells in human aortic smooth muscle cells （HASMCs） was reduced under high-fat conditions. This effect was accompanied by a reduction in the intracellular lipid content and alleviation of oxidative stress. However, these beneficial effects of dapagliflozin could be reversed by the PPARα *** analysis and molecular docking simulations revealed that dapagliflozin might exert its effects by directly interacting with the RXRA protein, thereby influencing the expression of the PPARα signaling pathway. In conclusion, the cellular senescence of aortic smooth muscle cells is potentially altered by dapagliflozin through the suppression of the RXRA-PPARα-FABP4 s

关键词：

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren Xiaobing Chen Mengmeng Xiao Xi Li Zhe Xi Gen zhang Dongmei Qin Kunrong Yang Zhigang Zheng Quan zhang Xiaogang Xia Peng Li Lingwei Gu Ting Wu Chenghua Luo Shu-Hai Lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism