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骨质疏松症易感基因多态性在广西壮族人群中的研究进展

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中国医学科学院学报 2024年第1期46卷 82-87页

作者：黄思雨叶广彬何钰佳宾晓芸周敏黄秀峰右江民族医学院基础医学院广西百色533000 右江民族医学院公共卫生与管理学院广西百色533000

本文旨在对广西壮族群体中骨质疏松症(OP)易感基因多态性的研究进行系统总结和阐述,包括维生素D受体、雌激素受体、降钙素受体、脂联素基因及其他与OP相关的基因多态性。在壮族与其他不同种族或民族间,对基因型和等位基因分布频率进行... 详细信息

本文旨在对广西壮族群体中骨质疏松症(OP)易感基因多态性的研究进行系统总结和阐述,包括维生素D受体、雌激素受体、降钙素受体、脂联素基因及其他与OP相关的基因多态性。在壮族与其他不同种族或民族间,对基因型和等位基因分布频率进行差异性比较分析,以此厘清壮族现有的可能与OP相关的基因,以及与壮族OP相关的基因多态性,为少数民族OP易感基因的研究提供一个代表性的解决方案。

关键词：少数民族骨质疏松症基因多态性

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手机信令支撑下的城镇体系结构测度——从流空间视角

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西安建筑科技大学学报（自然科学版） 2024年第1期56卷 131-140页

作者：俞艳樊建高昕欣何宇嘉徐雅馨武汉理工大学资源与环境工程学院湖北武汉430070 中国人民解放军陆军边海防学院陕西西安710108

城镇体系结构是城镇协同与制约关系的空间呈现.通过立足城镇体系的“三结构”,运用手机信令数据,从流空间的视角构建多尺度的城镇体系结构测度框架,对城镇等级规模结构和地域空间结构进行整合.测度过程中通过耦合联系流量和联系流向改... 详细信息

城镇体系结构是城镇协同与制约关系的空间呈现.通过立足城镇体系的“三结构”,运用手机信令数据,从流空间的视角构建多尺度的城镇体系结构测度框架,对城镇等级规模结构和地域空间结构进行整合.测度过程中通过耦合联系流量和联系流向改进了城镇等级规模测度模型;同时从城镇分布、联系及组合状态三个方面测度城镇地域空间结构.最后,以宁波市乡镇为对象展开测度,结果表明该市呈现“一主四副,五轴四区”的空间格局,据此完成了宁波市城市总体规划实施评估,继而验证了该框架的可行性与科学性并提出了市域空间格局的优化建议.

关键词：城镇体系结构手机信令乡镇

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交通规划导向的科技赋能交通小区划分方法

现代城市研究 2024年第6期39卷 100-106页

作者：俞艳何宇嘉高昕欣张宸赫阎程武汉理工大学资源与环境工程学院武汉理工大学

文章以手机信令、路网大数据为基础,提出了针对交通规划的科技赋能交通小区划分方法,以路网数据划分聚类单元,利用手机信令数据准确识别聚类单元内居民出行时空分布特征,基于改进耦合空间聚类算法进行聚类,借助现状路网对聚类结果进行... 详细信息

文章以手机信令、路网大数据为基础,提出了针对交通规划的科技赋能交通小区划分方法,以路网数据划分聚类单元,利用手机信令数据准确识别聚类单元内居民出行时空分布特征,基于改进耦合空间聚类算法进行聚类,借助现状路网对聚类结果进行修正得到交通小区划分结果。宁波市实例研究表明,科技赋能交通小区划分方法能兼顾居民出行时空特征和城市路网匹配,并能较好保证交通小区的整体连续性,该方法适用性强,可为交通规划的科学制定提供借鉴。

关键词：交通小区划分手机信令出行特征耦合空间聚类算法

Governing the gold rush into emerging markets: a case study of Indonesia’s regulatory responses to the expansion of Chinese-backed online P2P lending

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Financial Innovation 2020年第1期6卷 842-865页

作者： Angela Tritto yujia he Victoria Amanda Junaedi Institute for Emerging Market Studies The Hong Kong University of Science and TechnologyLo Ka Chung BuildingClear Water BayKowloonHong Kong SARChina Patterson School of Diplomacy and International Commerce University of KentuckyLexingtonKY 40506USA Business School The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina

Peer-to-peer(P2P)lending has the potential to boost financial inclusion in emerging *** paper contributes to the literature on fintech governance in emerging Asian *** examines the case of the Indonesian government’s approach in regulating the P2P lending sector using both primary interviews and secondary firmlevel *** by regulation tightening in China and regulatory gaps in Indonesia,Chinese investments became the largest in this sector contributing,however,to growing risks from illegal business *** Indonesian government responded by creating new regulations and institutions,mitigating risks without stifling the potential for financial *** conclude a proactive approach towards monitoring and regulating emerging high-tech industries should be sought by strengthening links with industry and civil society,and through international cooperation for policy and knowledge sharing.

关键词： Fintech P2P Internet finance Governance Emerging market

TGF-βsignaling in health,disease,and therapeutics

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1466-1505页

作者： Ziqin Deng Tao Fan Chu Xiao he Tian yujia Zheng Chunxiang Li Jie he Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

ransforming growth factor(TGF)-βis a multifunctional cytokine expressed by almost every tissue and cell *** signal transduction of TGF-βcan stimulate diverse cellular responses and is particularly critical to embryonic development,wound healing,tissue homeostasis,and immune homeostasis in *** dysfunction of TGF-βcan play key roles in many diseases,and numerous targeted therapies have been developed to rectify its pathogenic *** the past decades,a large number of studies on TGF-βsignaling have been carried out,covering a broad spectrum of topics in health,disease,and ***,a comprehensive overview of TGF-βsignaling is required for a general picture of the studies in this *** this review,we retrace the research history of TGF-βand introduce the molecular mechanisms regarding its biosynthesis,activation,and signal *** also provide deep insights into the functions of TGF-βsignaling in physiological conditions as well as in pathological ***-β-targeting therapies which have brought fresh hope to the treatment of relevant diseases are *** the summary of previous knowledge and recent updates,this review aims to provide a systematic understanding of TGF-βsignaling and to attract more attention and interest to this research area.

关键词： homeostasis healing wound

基于手机信令数据的宁波市医疗资源均等性评估

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地理空间信息 2024年第7期22卷 1-4,11页

作者：俞艳闫奇奇阎程张宸赫何宇嘉高昕欣武汉理工大学湖北武汉430070

目前对医疗资源均等性的评估大多基于传统数据,仅从供或需单一方面开展,其结果不够全面。鉴于此,采用POI数据和手机信令等多源大数据,从供给和需求双向出发,对宁波市医疗资源的均等性进行综合评估。结果表明,宁波市医疗资源整体均等性较... 详细信息

目前对医疗资源均等性的评估大多基于传统数据,仅从供或需单一方面开展,其结果不够全面。鉴于此,采用POI数据和手机信令等多源大数据,从供给和需求双向出发,对宁波市医疗资源的均等性进行综合评估。结果表明,宁波市医疗资源整体均等性较好,但局部地区仍存在不均等现象,需要针对各地区的具体情况制定合适的政策,以发展各区医疗资源。

关键词：手机信令医疗资源均等性可达性 POI

Piperazine-derived ionizable lipids for enhanced mRNA delivery and cancer immunotherapy

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Nano Research 2024年第8期17卷 7357-7364页

作者： Kai Xu yujia Xu Jin Sun Xinwei Cheng Chenxi Lu Wenzhong Chen Bingfang he Tianyue Jiang School of Pharmaceutical Sciences Nanjing Tech UniversityNanjing 211816China Department of Nano Formulation Nanjing GeneLeap BiotechnologyNanjing 210061China

Messenger ribonucleic acid(mRNA)-based therapeutics hold great prospects in disease treatment and lipid nanoparticles(LNPs)are the most extensively applied non-viral platform for RNA delivery in *** the clinical success of LNPs as vehicles have been achieved,developing LNPs with enhanced mRNA transmembrane delivery and transfection efficiency in a non-toxic manner is highly desirable and *** this study,we designed a series of new ionizable amino lipids with piperazinederived headgroups and constructed a group of LNPs to promote the transfection activity of mRNA *** them,LNP formulated with lipid 10(L10-LNP)can efficiently package mRNA and perform superior transfection efficiency both in vitro and in vivo,which is mainly attributed to the improved intracellular uptake and effective endosomal *** verified that a single administration of L10-LNP packaging interleukin(IL)-12 mRNA induced tumor shrink and even regression by robust activation of immune effector CD8^(+)T cells and stimulating the generation of IFN-γwithout causing systemic toxicity,which provides a promising platform for clinical cancer immunotherapy.

关键词： ionizable lipid lipid nanoparticle piperazine-derived lipid mRNA therapeutics cancer immunotherapy

Role of Exosomal Modulation of Macrophages in Liver Fibrosis

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Journal of Clinical and Translational hepatology 2024年第2期12卷 201-209页

作者： Bin Fan he Xie Qi Tan Qingyuan Li Tao Gong Baoren he yujia Li Limin Chen Institute of Blood Transfusion(IBT) Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College(PUMC)ChengduSichuanChina The Hospital of Xidian Group Xi’anShaanxiChina Department of Clinical Medicine North Sichuan Medical CollegeNanchongSichuanChina The Joint Laboratory of Transfusion-Transmitted Diseases(TTDs)between Institute of Blood Transfusion(IBT) Chinese Academy of Medical Sciences(CAMS)and Nanning Blood CenterNanningGuangxiChina

Exosomes are 60–120 nm diameter double-membrane lipid organelles discharged by *** studies have shown that exosomes exert multiple functions in both physical and diseased processes,such as intercellular information exchange,immune response,and disease *** chronic injury to the liver often leads to inflammation and liver fibrosis(LF),a disorder that,if unchecked,may progress to cirrhosis,liver failure,portal hypertension,and even hepatocellular *** an essential component of host innate immunity against pathogen invasion,macrophages play an important role in modulating inflammation homeostasis by finely tuning the polarization process of macrophages into either M1 or M2 subtypes in response to different *** a critical contributor to the inflammation process,macrophages also play a complex and instrumental function in the progression of *** review focuses on recent advancements in the role of macrophage-associated exosomes implicated in LF,including macrophage-released exosomes and macrophage-targeted *** addition,the progress made in exosomebased antifibrotic therapy by in vivo and in vitro studies is also highlighted.

关键词： Exosome Macrophage Liver fibrosis hepatocyte Mesenchymal stem cell hepatic stellate cell

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie Liu Xuqiang Liu Kaiyue he Yongping Jian yujia Li Jinrong Guo Jingyu Yang Zhixiang Xu Wenyi Kang School of Life Sciences Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China Shenzhen Research Institute of henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK hepatocellular carcinoma