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DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYDOUN yuji KATO HIROKI KAMO ANNA HÜSCH HAYATO MIZUTA RYOTA KAWAHARA SIRO SIMIZU Department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its ***,the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

Third-line therapies in patients with Kawasaki disease refractory to first-and second-line intravenous immunoglobulin therapy

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World Journal of Pediatrics 2022年第11期18卷 781-785页

作者： Takashi Furuta Hiroki Yasudo Seigo Okada yuji Ohnishi Akiko Kawakami-Miyake Yasuo Suzuki Shouichi Ohga Shunji Hasegawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi755-8505Japan Department of Pediatrics Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan

Kawasaki disease(KD)is an acute febrile ilness characterized by systemic vasculitis affecting the small-and mediumsized arteries in children [1,2].One of the most critical complications of KD is the development of coronary artery lesions(CALs)approximately after 12 days of ilness,which may lead to myocardial infarction[3].High-dose intravenous immunoglobulin(IVIG)and oral administration of aspirin have been established as the first-line therapy for KD[4,5].

关键词： intravenous acute immunoglobulin

Perianal tuberculosis: A case report and review of the literature

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World Journal of Clinical Cases 2015年第9期3卷 848-852页

作者： Sayaka Tago yuji Hirai Yusuke Ainoda Takahiro Fujita Mikio Takamori Ken Kikuchi Department of Infectious Diseases Tokyo Women’s Medical University Department of Pulmonary Medicine Tokyo Metropolitan Tama Medical Center

Tuberculosis(TB) is still a major health problem worldwide. We present a rare case of an immunocompetent patient with perianal TB. A 38-year-old man visited a clinic with pain, swelling, and redness in the perineum. He had been persistently coughing for the past 6 mo. The abscess had formed a fistula to the perianal region, indicating perianal abscess. Mycobacterium tuberculosis was found in sputum and perianal abscess. Surgical drainage was performed, and oral anti-tuberculous drugs were administered for 6 mo. The patient's clinical course was favorable. On review of the literature on 58 cases of perianal TB, we found that the duration of persistent perianal lesion was much longer in patients without active pulmonary TB(APTB) than in those with APTB(66.4 mo vs 8.3 mo; confidence interval, 0.0760-0.9620, P = 0.0380). Thus, in cases of non-healing or recurrent perianal lesions, TB should be considered.

关键词： Tuberculosis Abscess Ulcer Hemorrhoids Fistula

On the Generalization of Hilbert’s 17th Problem and Pythagorean Fields

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Advances in Pure Mathematics 2013年第7期3卷 1-4页

作者： yuji Shimizuike 3-9-7 Fukawa Asakita-ku Hiroshima 739-1751 Japan

The notion of preordering, which is a generalization of the notion of ordering, has been introduced by Serre. On the other hand, the notion of round quadratic forms has been introduced by Witt. Based on these ideas, it is here shown that 1) a field F is formally real n-pythagorean iff the nth radical, RnF is a preordering (Theorem 2), and 2) a field F is n-pythagorean iff for any n-fold Pfister form ρ. There exists an odd integer l(>1) such that l×ρ is a round quadratic form (Theorem 8). By considering upper bounds for the number of squares on Pfister’s interpretation, these results finally lead to the main result (Theorem 10) such that the generalization of pythagorean fields coincides with the generalization of Hilbert’s 17th Problem.

关键词： Hilbert’s 17th Problem Preorderings nth Radical Pythagorean Fields Round Quadratic Forms

In vivo inducing collagen regeneration of biodegradable polymer microspheres

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Regenerative Biomaterials 2021年第5期8卷 95-107页

作者： Yixin Zhang Hanwen Liang Qian Luo Jianlin Chen Nan Zhao Wenxia Gao yuji Pu Bin He Jing Xie School of Smart Health Chongqing College of Electronic EngineeringChongqing 401331China School of Laboratory Medicine Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin FoodChengdu Medical CollegeChengdu 610500China Puliyan(Nanjing)Medical Science&Technology Co.LTD Nanjing 211500China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325027China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Stomatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical *** impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal ***,eight biodegradable polymers with different molecular weights,chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine *** microspheres with 20-100 lmwere *** in vitro degradation study showed that poly(L-lactic-co-glycolic acid)75/25 microspheres degraded the fastest,whereas poly(L-lactic acid)(PLLA)microspheres with intrinsic viscosity of 6.89([g]¼6.89)with the highest molecular weight showed the slowest degradation *** these microspheres were fabricated dermal fillers according to the formula of SculptraVR,they were injected subcutaneously into the back skin of *** vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by *** microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter ***([g]¼3.80)microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine *** properties of size,morphology and degradation behavior would influence the foreign body reaction and collagen regeneration.

关键词： biodegradable polymers microspheres collagen regeneration dermal fillers

Development of Animal Husbandry in Hunchun City of Jilin Province

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Asian Agricultural Research 2017年第9期9卷 11-15页

作者： yuji JIN Agricultural College of Yanbian University

Based on actual situations of the development of animal husbandry in Hunchun City of Jilin Province,this paper analyzed advantages of development of animal husbandry in Hunchun City. Besides,it elaborated current situations of development of animal husbandry in Hunchun City. Finally,it introduced existing problems in animal husbandry of Hunchun City,and came up with recommendations for the development of animal husbandry of Hunchun City.

关键词： Hunchun City Animal husbandry Current development situations Recommendations

A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method

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International Journal of Oral Science 2017年第2期9卷 80-86页

作者： Hiroyuki Yamaguchi yuji Ishida Jun Hosomichi Jun-ichi Suzuki Risa Usumi-Fujita Yasuhiro Shimizu Sawa Kaneko Takashi Ono Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Advanced Clinical Science and Therapeutics Graduate School of MedicineThe University of TokyoTokyoJapan

The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B(NF-κB) decoy oligodeoxynucleotide(ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6J mice by ultrasound radiation at low(LUM-Sc) and high(HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble *** inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation(A-Sc). Then, an NF-κB decoy was transfected into the periodontal tissue using the highintensity ultrasound-microbubble(HUM-NF) technique to examine the anti-inflammatory effects of the decoy ODN. Western blot analysis was performed to investigate the expression of interleukin(IL)-1β, IL-6 and intercellular adhesion molecule-1(ICAM-1)in the gingival tissues in the HUM-Sc, the HUM-NF and control groups. The fluorescence microscopy results showed that the fluorescent intensity in the periodontal tissues in the LUM-Sc and HUM-Sc groups was significantly higher than that in the A-Sc and the control groups. The fluorescent intensity in the HUM-Sc group, especially in the gingival connective tissue,was the highest of all groups. Western blot analysis indicated that the protein expression levels of IL-1β, IL-6 and ICAM-1 in the HUM-NF group were significantly lower than those in the HUM-Sc and the control groups. These findings suggest that the high-intensity ultrasound-microbubble technique is an effective tool for decoy transfection into the periodontal tissue.

关键词： decoy oligodeoxynucleotide gene therapy periodontal tissue ultrasound

Observation of Environmental Stress Cracking in Polymethylmethacrylate by Using the Chemiluminescence Method

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Materials Sciences and Applications 2015年第11期6卷 1084-1088页

作者： yuji Higuchi Energy Technology Laboratories Osaka Gas Co. Ltd. Osaka Japan

Polymethylmethacrylate (PMMA) is highly regarded for its transparency, and is used in such products as cameras and Video Tape Recorders as plastic lenses to take advantage of its excellent optical properties. Also, it is used in numerous other industrial fields like automobile lamp lenses, billboards, and lighting equipment. The phenomenon of environmental stress cracking is known to occur in PMMA due to ethanol, and there are cases when this may become a factor which causes damage of molded products. In the present paper, upon close observation by using the method of chemiluminescence in order to elucidate the mechanism by which this environmental stress cracking occurs, we report that we are able to capture the formation of a radical at the moment of cracking.

关键词： Polymethylmethacrylate Environmental Stress Cracking Chemiluminescence Radical

Development and Application of Laser Peening in Japan

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航空制造技术 2006年第1期49卷 73-77页

作者： yuji Sano Toshiba Corporation Yokohama/Japan

This paper reviews the current status of research and development on laser peening without protective coating(LPPC) in Japan. LPPC is an innovative process since it does not require any surface coating that is formed prior to laser irradiation in conventional laser peening for preventing the surface from melting. Surface residual stress of various metal materials was converted from tensile to compressive by LPPC. High cycle fatigue property was remarkably improved for steels, aluminum alloys and titanium alloys. Accelerating stress corrosion cracking (SCC) tests showed that LPPC completely prevents SCC of sensitized austenitic stainless steels, nickel-based alloys and their weld metals. LPPC has been utilized to combat against SCC in Japanese nuclear power reactors since 1999.

关键词：激光敲击应力疲劳腐蚀裂化金属处理结构力学