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Science China Chemistry 2025年

作者： Shiguo Fu Xiaofeng Zhang Kaixuan Wang Linfeng Chen Fan Xia Yong cui Yan Liu School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Faculty of Materials Science and Chemistry China University of Geosciences

Enantioselective separations of racemates using porous materials are highly attractive and significant in both fundamental research and technological applications. However, achieving controlled chiral pore surfaces to create the necessary driving force for enantiomer discrimination poses a fundamental challenge. Herein, we demonstrate that chiral covalent organic frameworks(COFs) possess the essential characteristics for effective enantioseparations through synthetic control over pore surfaces. We synthesized three 3D chiral COFs (CCOFs) featuring abundant chiral recognition sites on the pore walls via the condensation of enantiopure dialdehyde of 2,2′-dihydroxy-1,1′-binaphthyl and tetraamine. All CCOFs with high stability exhibit an 11-fold interpenetrated framework with tubular open channels, decorated with dihydroxyl or diethoxyl groups. The CCOFs with dihydroxyl groups serve as solid adsorbents for the adsorptive separation and solid-phase extraction of various chiral 1-phenylethanol-derived enantiomers, particularly racemic drugs, achieving up to 98%enantiomeric excess. In contrast, the CCOF with diethoxy groups is unable to resolve the racemates. These CCOF materials can be recycled and reused without any apparent loss of performance. Density functional theory (DFT) calculations reveal that the enantiospecific recognition arises from the well-organized chiral inner sphere and multiple chiral host-guest interactions.

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

复方曲肽注射液联合依达拉奉治疗老年急性脑梗死的疗效评价及其机制研究

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中国医学前沿杂志（电子版） 2021年第10期13卷 144-149页

作者：崔玉环杜丹蒋静刘玮刘占矿颜娟董利平河北北方学院附属第一医院老年科河北张家口075000 河北北方学院附属第一医院检验科河北张家口075000 河北北方学院附属第一医院药学部河北张家口075000

目的探究复方曲肽注射液联合依达拉奉治疗老年急性脑梗死的临床疗效及其作用机制。方法选取2019年3月至2020年8月于河北北方学院附属第一医院治疗的老年急性脑梗死患者125例,研究中脱落5例,最终纳入统计的患者共120例,依据随机数字表法... 详细信息

目的探究复方曲肽注射液联合依达拉奉治疗老年急性脑梗死的临床疗效及其作用机制。方法选取2019年3月至2020年8月于河北北方学院附属第一医院治疗的老年急性脑梗死患者125例,研究中脱落5例,最终纳入统计的患者共120例,依据随机数字表法将入选患者分为治疗组和对照组,每组各60例。两组患者均接受抗血小板、控制血压、营养支持、改善微循环等常规治疗,在此基础上,治疗组患者给予复方曲肽注射液联合依达拉奉治疗,对照组患者仅给予依达拉奉治疗,均持续治疗14 d。观察两组患者临床疗效和不良反应发生情况,比较两组患者治疗前后美国国家卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)、改良Rankin量表(modified Rankin scale,mRS)评分、内皮损伤指标[可溶性血栓调节蛋白(soluble thrombomodulin,sTM)、D-二聚体(D-dimer,D-D)、内皮素1(endothelin 1,ET-1)、可溶性髓样细胞触发受体样转录因子-1(soluble triggering receptor expressed on myeloid cells-like transcript 1,sTLT-1)]、Kelch样环氧氯丙烷相关蛋白-1(Kelch-like epichlorohydrin-associated protein 1,Keap1)-核转录因子红系2相关因子2(nuclear factor-erythroid 2-related factor 2,Nrf2)-抗氧化响应元件(antioxidant response element,ARE)信号通路相关蛋白[血红素加氧酶1(heme oxygenase-1,HO1)、醌氧化还原酶(quinone oxidoreductase 1,NQO1)、Keap1、Nrf2、ARE]水平的差异。结果治疗后两组患者sTM、D-D、ET-1、sTLT-1、Keap1水平和NIHSS、mRS评分均显著低于本组治疗前(均P0.05)。结论复方曲肽注射液联合依达拉奉治疗能够显著改善老年急性脑梗死患者的神经功能,疗效确切,其作用机制可能与减轻内皮损伤、抑制Keap1-Nrf2-ARE信号通路活化等密切相关。

关键词：复方曲肽注射液依达拉奉急性脑梗死老年患者临床疗效作用机制

赣江上游太平江流域景观格局演变及驱动因素分析

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江西理工大学学报 2019年第1期40卷 54-61页

作者：边晓辉刘友存王杰崔玉环刘燕丁倩倩江西理工大学建筑与测绘工程学院江西赣州341000 江西理工大学资源与环境工程学院江西赣州341000 安徽大学资源与环境工程学院合肥230601 安徽农业大学理学院合肥230036

基于GIS和RS,以赣江上游太平江流域1995年、2005年和2015年的三期遥感影像为基础进行解译.利用景观类型变化率、开发度,以及景观格局动态度分析了近20年来太平江流域景观格局时空变化和驱动因素.得出的结果是:(1) 1995—2015年,太平江... 详细信息

基于GIS和RS,以赣江上游太平江流域1995年、2005年和2015年的三期遥感影像为基础进行解译.利用景观类型变化率、开发度,以及景观格局动态度分析了近20年来太平江流域景观格局时空变化和驱动因素.得出的结果是:(1) 1995—2015年,太平江流域主要的景观类型为林地,2015年已经占流域总面积的67%.草地面积一直缩减,水域和其它用地占地面积小,变化率较大,开发度相对稳定.建设用地在2005—2015年的动态度和开发度高达80%,变化显著.(2)景观类型中,草地和建设用地的斑块数量逐步增长,林地和其它用地的斑块数量急剧下降.只有局部区域景观格局呈现多样性和丰富性,主要表现在建设用地、耕地和草地相连接的区域.景观水平中,斑块数量和斑块密度增加,香浓多样性指数和香浓均匀度指数均呈现下降趋势,分别从1.33和0.67下降到1.22和0.63.(3)经济因素是太平江流域景观格局变化的主要影响因子.

关键词： RS GIS 景观格局变化动态度赣江上游

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei cui Yiyao Pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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牡荆苷对脑缺血再灌注损伤小鼠抗氧化酶的影响

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中国医药导报 2016年第33期13卷 12-15,20页

作者：颜娟郑茂东崔玉环赵虹琇赵秀花班旭霞河北北方学院附属第一医院药学部河北张家口075000 河北北方学院附属第一医院老年科河北张家口075000

目的研究牡荆苷对脑缺血再灌注损伤小鼠抗氧化酶的作用及机制。方法雄性昆明种小鼠70只,按随机数字表法分为正常对照组、假手术组、模型组、牡荆苷组(10、20、40 mg/kg)、尼莫地平组(0.6 mg/kg),采用线栓法制备脑缺血再灌注模型,牡荆苷... 详细信息

目的研究牡荆苷对脑缺血再灌注损伤小鼠抗氧化酶的作用及机制。方法雄性昆明种小鼠70只,按随机数字表法分为正常对照组、假手术组、模型组、牡荆苷组(10、20、40 mg/kg)、尼莫地平组(0.6 mg/kg),采用线栓法制备脑缺血再灌注模型,牡荆苷组在缺血再灌注前连续腹腔给予牡荆苷3 d,缺血再灌注后,每天给药1次,连续给药7 d,检测小鼠神经功能损伤评分,采用试剂盒法检测脑组织、血清中丙二醛(MDA)含量、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、髓过氧化物酶(MPO)的活性。结果与假手术组比较,模型组神经功能损伤评分显著升高(P0.05)。结论牡荆苷对小鼠脑缺血再灌注损伤的保护作用可能通过抗氧化作用来实现。

关键词：牡荆苷脑缺血再灌注抗氧化酶

m^(6)A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 371-383页

作者： yuhuan Li Qingyang Zhang Guanshen cui Fang Zhao Xin Tian Bao-Fa Sun Ying Yang Wei Li State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

N6-methyladenosine(m^(6)A)is one of the most abundant modifications on m RNAs and plays important roles in various biological *** formation of m^(6)A is catalyzed by a methyltransferase complex(MTC)containing a key factor methyltransferase-like 3(Mettl3).However,the functions of Mettl3 and m^(6)A modification in hepatic lipid and glucose metabolism remain ***,we showed that both Mettl3 expression and m^(6)A level increased in the livers of mice with high fat diet(HFD)-induced metabolic *** of Mettl3 aggravated HFDinduced liver metabolic disorders and insulin *** contrast,hepatocyte-specific knockout of Mettl3 significantly alleviated HFD-induced metabolic disorders by slowing weight gain,reducing lipid accumulation,and improving insulin ***,Mettl3 depletion-mediated m^(6)A loss caused extended RNA half-lives of metabolism-related genes,which consequently protected mice against HFD-induced metabolic *** findings reveal a critical role of Mettl3-mediated m^(6)A in HFD-induced metabolic disorders and hepatogenous diabetes.

关键词： Mettl3 RNA methylation High fat diet Insulin resistance Lpin1

“五位一体”涉外法治人才培养的实践育人路径探索

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武汉大学学报（哲学社会科学版） 2025年第1期78卷 43-53页

作者：崔晓静武汉大学法学院湖北武汉430072

加强以实践为导向的育人机制建设,不仅是联系法学理论教学与实务的桥梁,也是涉外法治人才培养的重点和提升法律人才培养质量的关键。当前我国涉外法治人才实践教育存在课堂教学的理念与模式陈旧、实务课程缺乏系统性与针对性、实习实训... 详细信息

加强以实践为导向的育人机制建设,不仅是联系法学理论教学与实务的桥梁,也是涉外法治人才培养的重点和提升法律人才培养质量的关键。当前我国涉外法治人才实践教育存在课堂教学的理念与模式陈旧、实务课程缺乏系统性与针对性、实习实训资源开发不足以及国际实习机会稀缺等方面的问题,它们表现在实践教学的各个环节。要解决这些问题,高校在涉外法治人才培养中应当坚持“五位一体”的涉外法治人才培养实践育人路径,从引导课堂实练、设计实务课程、强化校内实训、组织校外实践、拓展国际实习网络五方面进行一体化针对性改革,整体提升涉外法治人才实践能力培育的实效。

关键词：实践育人涉外法治人才培养教学改革法学教育习近平法治思想

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高压泡沫涨裂破岩特性试验研究

岩土工程学报 2025年第1期47卷 125-134页

作者：刘送永崔松顾聪聪中国矿业大学机电工程学院江苏徐州221116 中国矿业大学智能采矿装备技术全国重点实验室江苏徐州221116 安徽理工大学机电工程学院安徽淮南232001

针对钻爆法和机械法在岩石破碎工程中的弊端,基于泡沫的高黏性和可压缩性,提出了高压泡沫涨裂破岩技术。首先设计高压泡沫涨裂破岩装置,理论分析高压泡沫瞬间释放冲击岩石涨裂孔过程,搭建高压泡沫涨裂力测试装置并开展涨裂力影响试验,... 详细信息

针对钻爆法和机械法在岩石破碎工程中的弊端,基于泡沫的高黏性和可压缩性,提出了高压泡沫涨裂破岩技术。首先设计高压泡沫涨裂破岩装置,理论分析高压泡沫瞬间释放冲击岩石涨裂孔过程,搭建高压泡沫涨裂力测试装置并开展涨裂力影响试验,建立高压泡沫涨裂破岩试验系统,探讨不同空气体积分数时的泡沫涨裂特性,揭示高压泡沫涨裂破岩机理。研究表明:高压泡沫释放时,能够在涨裂孔内产生比泡沫初始压力更高的涨裂力,但涨裂力随泡沫空气体积分数增加而先增大后减小,高压泡沫涨裂破岩经历了裂纹初生、裂纹扩展、涨裂抛掷、涨裂结束4个阶段,破岩重量随泡沫空气体积分数的增加而先增大后减小,当空气体积分数为60%时,由高压泡沫冲击涨裂孔产生的压应力波在岩石上表面反射形成的拉应力造成岩石破坏形式为涨裂坑,空气体积分数为70%~90%时,泡沫涨裂形式为大块岩石分离,这主要是由孔底直角处应力集中效应造成。

关键词：高压泡沫涨裂破岩裂纹扩展涨裂力

Polarization-encoded neural networks with simplified grating patch

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Science China Technological Sciences 2025年

作者： Chengyan ZHONG Xiang WANG Lingfei LI Yuanchi cui Lei XIAO Dawei SONG Junxiong GUO Wen HUANG Yufeng GUO Yu LIU College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Nanjing Mumusili Technology Co. LTD School of Integrated Circuits Tsinghua University Institute of Advanced Study School of Electronic Information and Electrical Engineering Chengdu University State Key Laboratory of Electronic Thin Films and Integrated Devices School of Integrated Circuit Science and EngineeringUniversity of Electronic Science and Technology of China

Optical neural networks (ONNs) offer a promising solution for high-performance, energy-efficient artificial intelligence hardware by leveraging the parallelism and speed of light. However, the large-scale implementation of ONNs remains challenging due to the bulky footprint and complex control of optical synapses. In this work, we propose and simulate a plasmonic polarized synaptic architecture that overcomes the diffraction limit and enables ultra-compact ONNs. By tuning the polarization state of incident light, the optical transmittance through each plasmonic unit can be dynamically adjusted to represent a synaptic weight. Our plasmonic structures, with features as small as 40 nm, operate well below this limit in the visible spectrum (400–750 nm). Compared with diffraction and interference-based circuit designs, our proposed method achieves a substantial reduction in synaptic density by factors of 150000-fold and 1500-fold, respectively. Furthermore, we successfully demonstrate a proof-of-concept plasmonic ONN applied to the Canadian Institute for Advanced Research—10classes (CIFAR-10) dataset using a Visual Geometry Group network with 16 layers (VGG16) model. After training for 80epochs, the network achieves an accuracy of 93%. The polarization-tunable plasmonics paves the way towards scalable ONNs for next-generation artificial intelligence (AI) accelerators and smart sensors.

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