检索结果-南通市图书馆

Effects of bone morphogenetic protein-4 on spatial memory and cholinergic expression in the dentate gyrus after fornix-fimbria transection in rats

引用

Neural Regeneration Research 2008年第1期3卷 1-4页

作者： lei Liu Yilong Xue Jingkun Pan Yazhuo Hu yuhong Gao Yun Luo Department of Neurosurgery General Hospital of Chinese PLA Beijing 100853 China Laboratory for Cell Biology Institute of Geriatrics General Hospital of Chinese PLA Beijing 100853 China

BACKGROUND： Previous experiments have confirmed bone morphogenetic proteins （BMPs） upregulate cholinergic expression in neurons isolated from the embryonic rat hippocampus and cerebral cortex. Therefore, BMPs could be useful for treating Alzheimer＇s disease and other neurodegenerative diseases. OBJECTIVE： BMP-4 was infused into the hippocampal dentate gyrus of fomix-fimbria transected rats to test the effects of BMP-4 on cholinergic expression in dentate gyrus neurons, and to observe changes in spatial memory behavior. DESIGN： A randomized controlled animal experiment. SETTING： Department of Neurosurgery and Laboratory for Cell Biology, Institute of Geriatrics, General Hospital of Chinese PLA. MATERIALS： Twenty-seven healthy adult male Sprague Dawley （SD） rats, weighing 250-300 g, were provided by the Laboratory Animal Center of the General Hospital of Chinese PLA. Reagents： BMP-4 （B-2680, Sigma Company） and choline acetyl transferase （CHAT） antibody （AB5042, Chemicon Company） were used in this study. Equipments： a rat stereotaxic instrument （type： SN-2N, Narushige Group, Japan） and Image-prog-plus image analysis software （Media Cybernetics company, USA） were used in this study. The protocol was carried out in accordance with ethical guidelines for the use and care of animals. METHODS： This experiment was performed in the Institute of Geriatrics, General Hospital of Chinese PLA between July 2004 and March 2005. Rats were randomly divided into 4 groups： Alzheimer＇s disease group （n = 7）, normal control group （n = 5）, BMP-4-Alzheimer＇s disease group （n = 8）, and model group （n = 7）. In the Alzheimer＇s disease group, the left hippocampal fomix-fimbria of rats was transected to mimic Alzheimer＇s disease symptoms. In the BMP-4-Alzheimer＇s disease group, 1 μt L BMP-4 （10 mg/L） was perfused into the left dentate gyrus with a microinjector at 1 μ L/min. In the model group, 1 μ L saline was perfused into the same position by the same method. Twenty-eight days after injection

关键词： senile dementia bone morphogenetic-protein-4 hippocampus dentate gyrus cholinergicneuron Alzheimer's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats

引用

Journal of Traditional Chinese Medicine 2024年第4期44卷 670-679页

作者： LIU Tongtong ZHANG Xi YANG Hui LIN Xiaoyuan LIU Jian ZHANG Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu lei Chang LONG Hongping LUO Yan XIANG Yun GE Jinwen WANG yuhong MENG Pan Institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China the Second People's Hospital of Hunan Province Changsha 410007China The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410007China Hunan Academy of Chinese Medicine Changsha 410013China

OBJECTIVE:To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons,and to elucidate the mechanism behind the ***:The antidepressant mechanism of luteolin was studied by using CUMS rat model and primary hippocampal neurons in fetal *** vivo,novelty suppressed feeding,open-field and sucrose preference tests as well as Morris water maze were *** content of brain derived neurotrophic factor(BDNF),5-hydroxytryptamine(5-HT),norepinephrine(NE),and dopamine(DA)in serum were detected by enzyme-linked immunosorbent *** mechanisms of luteolin were explored based on neurotrophin and hippocampal neurogenesis,and *** of the septotemporal axis in hippocampus was assayed using the 5-bromo-2-deoxyuridine(BrdU),the expression of BDNF,neurotrophin-3(NT-3),and nerve growth factor(NGF)in hippocampus dentate gyrus region were measured by *** vitro,BDNF,NT-3,tropomyosin receptor kinase B(TrkB),and phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB)were detected through the high content analysis(HCA)to investigate neurotrophin and ***:Induction of CUMS in rats induced depressive symptoms,while luteolin significantly enhanced sucrose consumption,decreased feeding latency,increased locomotor activity,escape latency,distance of target quadrant and regulated the content of depressive-like *** analysis revealed that luteolin increased the abundance of new born neurons that had been labeled with BrdU,BrdU+neuronal nuclear antigen,and BrdU+doublecortin in septo-temporal axis of S2(mid-septal)and T3(mid-temporal).Moreover,expression of BDNF,NT-3,and NGF increased significantly in the septo-temporal axis of S2 and *** showed increased expression of BDNF,NT-3,TrkB and p-CREB in primary hippocampal ***:The results provided direct ev

关键词： fetal rats Survival

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

有界线性算子的a-Browder定理及(R_(1))性质

引用

浙江大学学报（理学版） 2022年第6期49卷 676-681页

作者：车雨红戴磊渭南师范学院数学与统计学院陕西渭南714099

给出了有界线性算子满足a-Browder定理且具有(R_(1))性质的充要条件,研究了算子函数满足a-Browder定理且具有(R_(1))性质的判定方法,应用所得结论,给出了一类重要算子及其函数满足a-Browder定理且具有(R_(1))性质的判别定理。

关键词： a-Browder定理 (R1)性质谱

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Krill oil attenuates obesity-induced skeletal muscle atrophy in mice

引用

Food Science and Human Wellness 2024年

作者： Mengqing Zhou yuhong Yang Yan Zheng Zijian Wu Chen Chen Qijian Liang Yu Yang Hao Wu Xin Guo lei Du School of Public Health， Cheeloo College of Medicine， Shandong University Research Center of Translational Medicine， Jinan Central Hospital， Shandong University School of Food Science and Engineering， Qilu University of Technology (Shandong Academy of Sciences)

Obesity is associated with skeletal muscle mass loss and physical dysfunction. Krill oil (KO) has been shown to be beneficial in human health. However， the effect of KO on obesity-induced skeletal muscle atrophy is still unclear. In this study， the male C57BL/6J mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity， and then were intragastric administration with 400 mg/kg bw KO for an additional 6 weeks. The results showed that KO treatment reduced body weight， fat accumulation and serum pro-inflammatory cytokines in HFD-induced obese mice. Importantly， KO treatment attenuated skeletal muscle atrophy in HFD-fed mice， as evidenced by preserving skeletal muscle mass， average myofiber cross-sectional area and grip strength. KO administration also mitigated obesity-induced ectopic lipid deposition and inflammatory response in skeletal muscle. Additionally， KO treatment inhibited the transcriptional activities of nuclear factor-kappa B (NF-κB) p65 and forkhead box O 3a (FoxO3a)， and then down-regulated muscle atrophy F-box (MAFbx) and muscle-specific RING finger protein 1 (MuRF1) protein levels in skeletal muscle from HFD-fed mice. KO administration also improved obesity-induced impaired muscle protein synthesis via activating PI3K/Akt pathway. Furthermore， KO treatment enhanced muscle mitochondrial biogenesis in HFD-induced obese mice via activating PGC-1α pathway. Collectively， KO might be developed as a potential nutritional supplement for the prevention and treatment of obesity-induced skeletal muscle atrophy.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

微创非手术牙周治疗技术的临床研究进展

引用

国际口腔医学杂志 2024年第2期51卷 227-232页

作者：马瑜鸿赵蕾口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院牙周病科成都610041

牙周炎是造成牙齿脱落的主要原因之一。传统的牙周非手术治疗(NSPT)是规范化牙周序列治疗的第一步,然而该治疗对存在骨内缺陷的中重度牙周炎患者的治疗效果有限,常需要进一步行牙周手术治疗。随着“微创牙科”治疗理念的不断推广,有学... 详细信息

牙周炎是造成牙齿脱落的主要原因之一。传统的牙周非手术治疗(NSPT)是规范化牙周序列治疗的第一步,然而该治疗对存在骨内缺陷的中重度牙周炎患者的治疗效果有限,常需要进一步行牙周手术治疗。随着“微创牙科”治疗理念的不断推广,有学者提出了微创非手术牙周治疗技术(MINST),即以微创操作进行非手术牙周治疗的技术。MINST可在一定条件内替代牙周手术治疗来改善牙周骨内缺损的牙周临床指标,并在减少术后疼痛、提高美观和患者接受度等方面取得较为满意的效果。本文总结了MINST的提出和临床应用进展,分析该技术与传统的NSPT和微创牙周手术治疗的效果,并就该技术联合其他辅助治疗手段(包括局部药物治疗、釉基质衍生物、牙周内镜)的应用进展进行综述。

关键词：牙周炎骨内缺损牙周非手术治疗微创治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

互引系统情报元评价

引用

图书情报工作 2009年第10期53卷 50-53,32页

作者：宋宇红陶蕾浙江纺织服装学院图书馆宁波315211

论述互引系统情报元评价模型研究的主要成果。在引用有向赋权图来表达复杂的互引系统的基础上,综述评价情报元地位的几种模型,指出通常使用的简单统计方法只是上述模型粗略的近似模型,在本原连通条件下给出存在性、唯一性、初值无关性定... 详细信息

论述互引系统情报元评价模型研究的主要成果。在引用有向赋权图来表达复杂的互引系统的基础上,综述评价情报元地位的几种模型,指出通常使用的简单统计方法只是上述模型粗略的近似模型,在本原连通条件下给出存在性、唯一性、初值无关性定理,并用图表及实例进行说明。

关键词：情报元有向赋权图评价模型本原连通

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multidisciplinary team for the diagnosis and treatment of 2cases of primary intestinal yolk sac tumor

引用

Cancer Biology & Medicine 2018年第4期15卷 461-467页

作者： Qiujuan Huang Changxu Liu Ruijun Tang Jie Li Wei Li lei Zhu yuhong Guo Lin Zhang Tongyuan Qu Lingyi Yang Lingmei Li Yalei Wang Baocun Sun Bin Meng Jie Yan Wengui Xu Huilai Zhang Dengfeng Cao Wenfeng Cao Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of Pathology Guilin TCM Hospital of ChinaGuilin 541002China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Lymphoma Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Molecular Image and Nuclear Medicine Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Central Hospital of Gynecology ObstetricsTianjin 300110China The Lauren V Ackerman Laboratory of Surgical Pathology Division of Anatomic and Molecular PathologyDepartment of Pathology and ImmunologyWashington University School of MedicineSaint LouisMO 63110USA

Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein(AFP) level(≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically,tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin(AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology,immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.

关键词： Yolk sac tumor intestine extragonadal immunohistochemistry multidisciplinary team (MDT)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First-principles study on the mechanical properties and thermodynamic properties of Mo-Ta alloys

引用

Plasma Science and Technology 2020年第6期22卷 180-187页

作者： Xin ZHANG Heng LI yuhong XU Qijun LIU Yangyang LIU Zilin CUI Haifeng LIU Xianqu WANG Jie HUANG Hai LIU Jun CHENG Ming LI Shaofei GENG Changjian TANG Guangjiu lei Institute of Fusion Science School of Physical Science and TechnologySouthwest Jiaotong UniversityChengdu 610031People's Republic of China School of Physical Science and Technology Southwest Jiaotong UniversityKey Laboratory of Advanced Technologies of MaterialsMinistry of Education of ChinaChengdu 610031People's Republic of China Southwestern Institute of Physics Chengdu 610041People's Republic of China School of Physical Science and Technology Sichuan UniversityChengdu 610065People's Republic of China

The mechanical properties,thermodynamic properties and electronic structure of Mo1-xTax(Mo-Ta)alloys(x=0,0.0625,0.125,0.25,0.3125,0.5 and 1)were calculated by using *** electronic structure of Mo-Ta alloys was analysed by the projected density of states(PDOS).The low temperature heat capacity was estimated by Fermi energy and Debye *** is shown that the formation enthalpy will decrease with the increase of Ta content,and the cohesive energy will increase with the increase of the Ta *** the other hand,the addition of Ta atoms will reduce the strength and improve the ductility of Mo-Ta alloys,the Debye temperature will decrease and the low temperature heat capacity will be improved with the increase of the Ta *** these results will be useful for the research of new plasma grid(PG)materials,which is mainly used in neutral beam injection(NBI)systems to produce negative hydrogen ions.

关键词： first principles calculations Mo-Ta alloy mechanical properties thermodynamic

来源：

维普期刊数据库

同方期刊数据库评论