Multidisciplinary team for the diagnosis and treatment of 2cases of primary intestinal yolk sac tumor

作     者：Qiujuan Huang Changxu Liu Ruijun Tang Jie Li Wei Li Lei Zhu Yuhong Guo Lin Zhang Tongyuan Qu Lingyi Yang Lingmei Li Yalei Wang Baocun Sun Bin Meng Jie Yan Wengui Xu Huilai Zhang Dengfeng Cao Wenfeng Cao 

作者机构：Department of PathologyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of PathologyGuilin TCM Hospital of ChinaGuilin 541002China Department of Pediatric OncologyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of LymphomaTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Molecular Image and Nuclear MedicineTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of PathologyTianjin Central Hospital of Gynecology ObstetricsTianjin 300110China The Lauren V Ackerman Laboratory of Surgical PathologyDivision of Anatomic and Molecular PathologyDepartment of Pathology and ImmunologyWashington University School of MedicineSaint LouisMO 63110USA 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2018年第15卷第4期

页      面：461-467页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by Tianjin Municipal Health Bureau Science and Technology Foundation(Grant No.16KG125) National Clinical Research Center for Cancer 

主　　题：Yolk sac tumor intestine extragonadal immunohistochemistry multidisciplinary team (MDT) 

摘      要：Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein(AFP) level(≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically,tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin(AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology,immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.