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Food Science and Human Wellness 2024年

作者： Xiaoben Liang yuhong chen Zhijie Zheng Yonghui Zheng Haichong Wu Longyan University & Fujian Provincial Key Laboratory for Prevention and Control of Animal Infectious Diseases and Biotechnology College of Animal Sciences and Veterinary Medicine， Guangxi University Department of Veterinary Medicine， College of Animal Sciences， Zhejiang University

Mastitis often occurs during women’s lactation period， causing great psychological and physical pain to women. Fucoidan， a sulfated polysaccharide obtained from brown algae， has much broader biological properties. However， the roles of fucoidan in lipopolysaccharides (LPS)-induced mastitis are still undiscovered. The present study was aimed to evaluate the influences of fucoidan on LPS-induced mouse mastitis and investigate its possible mechanisms. The expression profiles of fucoidan acting on mastitis were analyzed by Network pharmacology. Additionally， mechanism experiments verified the mechanism of fucoidan on mastitis. The results of in vivo study displayed that the treatment of fucoidan to LPS-stimulated mouse mastitis decreased the inflammatory damage， proinflammatory cytokines level and repaired the completeness of blood-milk barrier. In the study of mouse mammary epithelial cells， fucoidan suppressed the secretion of reactive oxygen species (ROS)and enhanced the activity of antioxidant enzymes. Molecular experiments suggested that fucoidan promoted Nrf2 nuclear import and autophagy via activating the AMPK signaling pathway. The above results indicated that in mastitis， fucoidan promoted Nrf2 nuclear import and autophagy via activating the AMPK signaling pathway， thereby suppressing oxidative stress and inflammatory injury to the mammary glands and protecting the blood-milk barrier.

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Comparison of clinical features of nephrotic syndrome after haploidentical and matched donor hematopoietic stem cell transplantation

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Chinese Medical Journal 2024年第4期137卷 478-480页

作者： Wei Sun Yuanyuan Zhang yuhong chen Yuqian Sun Yifei cheng Fengrong Wang Huan chen Yao chen chenhua Yan Xiaodong Mo Wei Han Lanping Xu Yu Wang Xiaohui Zhang Kaiyan Liu Xiaojun Huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationPeking UniversityBeijing 10004China

To the Editor:Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is one of the most effective options for hematological ***,allo-HSCT treatment can cause serious ***-transplant kidney damage is an important *** this study,we retrospectively analyzed the frequency of nephrotic syndrome(NS)after allo-HSCT and compared the frequency and clinical characteristics of NS between haploidentical donor(HID)and matched donor(MD)HSCT(including matched sibling donors[MSD]and unrelated donors[URD]).

关键词： hematopoietic clinical matched

“国教”重建:论蔡元培“以美育代宗教”的审美国家设想

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文艺研究 2024年第7期 28-40页

作者：陈雨泓首都师范大学文学院

蔡元培“以美育代宗教”视审美教化为不统而统的国家意识形态及新文化的整体方向,试图以此批判传统政教、建立现代教育乃至社会伦理的政教转型。该倡导来自社会政治诉求,却呈现为“纯粹之美育”,是一种去政治的文化政治。蔡元培的问题... 详细信息

蔡元培“以美育代宗教”视审美教化为不统而统的国家意识形态及新文化的整体方向,试图以此批判传统政教、建立现代教育乃至社会伦理的政教转型。该倡导来自社会政治诉求,却呈现为“纯粹之美育”,是一种去政治的文化政治。蔡元培的问题意识来自对中国社会革命及思想的体验和批判,并受欧游中的社会观察所影响。美育能促成良性、自由且殊途同归的现代社群关系,其实践及理论参与建构了欧洲民族国家认同,蔡元培认为中国也能由此重建社会伦理。20世纪20年代前后,“以美育代宗教”的“审美国家”设想在国内讨论中得到广泛回应,代表一种时代关注、选择及未来可能性。

关键词：国家意识形态蔡元培社会伦理社群关系民族国家认同以美育代宗教政治诉求审美教化

美育及其理想:晚清民初政治小说潮流中的《石头记索隐》

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红楼梦学刊 2024年第4期 194-215页

作者：陈雨泓首都师范大学文学院 100048

《石头记索隐》的构思受晚清民初政治小说潮流的影响,该著“牵强附会”的恶评与解读《红楼梦》为政治小说所呈现的表述张力有关,也是著作自圆其说、实现社会价值两种诉求博弈的结果。通过阐释《红楼梦》为以“香草美人”影射康熙朝文人... 详细信息

《石头记索隐》的构思受晚清民初政治小说潮流的影响,该著“牵强附会”的恶评与解读《红楼梦》为政治小说所呈现的表述张力有关,也是著作自圆其说、实现社会价值两种诉求博弈的结果。通过阐释《红楼梦》为以“香草美人”影射康熙朝文人本事的“离骚式小说”,蔡元培建构政治小说,以文人悲剧召唤民族国家认同及社会责任感,以此实现小说的社会教化功能,完成了有创见、自成体系的美育实践。

关键词：蔡元培石头记索隐美育政治小说离骚

Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

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Frontiers of Medicine 2024年第1期18卷 192-203页

作者： Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang Yufang Bi Meng Dai yuhong chen Jieli Lu Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关键词： famine obesity body mass index waist-to-hip ratio low-energy fracture

血糖变异系数对急诊脓毒症患者脓毒症相关性脑病的预测价值

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中国急救医学 2024年第9期44卷 815-821页

作者：陈伟沈琦陈虞红绍兴市上虞人民医院急诊科EICU 浙江绍兴312300

目的分析血糖变异系数(GLUcv)对急诊脓毒症患者脓毒症相关性脑病(SAE)的预测价值。方法采用前瞻性队列研究方法,入选2022年3月至2024年2月在绍兴市上虞人民医院急诊重症监护病房(EICU)诊治的脓毒症患者,检测患者入院24 h内末梢血糖,并计... 详细信息

目的分析血糖变异系数(GLUcv)对急诊脓毒症患者脓毒症相关性脑病(SAE)的预测价值。方法采用前瞻性队列研究方法,入选2022年3月至2024年2月在绍兴市上虞人民医院急诊重症监护病房(EICU)诊治的脓毒症患者,检测患者入院24 h内末梢血糖,并计算GLUcv。以脓毒症确诊28 d内SAE事件为研究终点,将28 d内并发SAE的患者纳入SAE组,未并发SAE患者纳入N-SAE组。比较分组后组间主要资料与指标水平的差异,通过构建Logistic回归模型,分析脓毒症并发SAE与GLUcv及其他主要指标的关系。采用限制性立方样条法,分析GLUcv与脓毒症并发SAE风险的剂量反应关系。绘制受试者工作特征(ROC)曲线与临床决策曲线,分析GLUcv对脓毒症并发SAE的预测价值。结果最终有135例患者完成研究,患者入院24 h内GLUcv结果为12.59~33.60,根据GLUcv四分位数由低到高将135例患者分为Q_(1)~Q_(4)组,Q_(4)组SAE发生率高于Q_(1)~Q_(3)组,Q_(3)和Q_(4)组急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、血清淀粉样蛋白A(SAA)、白细胞介素(IL)-6及神经元特异性烯醇化酶(NSE)水平高于Q_(1)和Q_(2)组,24 h乳酸清除率低于Q_(1)和Q_(2)组(P<0.05)。患者确诊后28 d内并发SAE 57例,发生率约42.22%。SAE组入院时APACHEⅡ评分、GLUcv、IL-6及NSE水平高于N-SAE组,24 h乳酸清除率低于N-SAE组(P<0.05)。构建Logistic回归模型结果显示,脓毒症并发SAE可能与入院时APACHEⅡ评分、24 h乳酸清除率、GLUcv、IL-6、NSE及SAA有关(P<0.05)。绘制ROC曲线,GLUcv预测脓毒症患者并发SAE曲线下面积(AUC)为0.797,最佳截断值为23.24。采用限制性立方样条法分析,脓毒症患者入院24 h内GLUcv与入院28 d内SAE发生风险呈线性剂量反应关系(P<0.05),当GLUcv阈值达到23.24时,SAE风险随着GLUcv升高而增加。绘制临床决策曲线,GLUcv预测脓毒症并发SAE临床净收益情况理想,且联合其他指标能提高整体决策获益。结论脓毒症患者并发SAE与GLUcv的升高有关,SAE风险随GLUcv升高而增加,脓毒症患者入院24 h内GLUcv可预测SAE高风险人群,且联合其他指标能提高整体风险预测的净收益率。

关键词：脓毒症脓毒症相关性脑病血糖变异系数预测临床决策曲线

从“事件性”到“去事件性”:论帕慕克小说创作的转型

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外语研究 2024年第1期41卷 106-111页

作者：陈玉洪彭叶兰州大学外国语学院甘肃兰州730000

帕慕克较早作品具有“事件性”,而晚近作品具有“去事件性”,这种反差反映了帕慕克对待民族传统智慧和西方现代知识态度的变化。这位曾经拥抱西方的知识分子在晚近作品中向传统之根回归,通过塑造“不合时宜”的人物形象,揭示被世俗化、... 详细信息

帕慕克较早作品具有“事件性”,而晚近作品具有“去事件性”,这种反差反映了帕慕克对待民族传统智慧和西方现代知识态度的变化。这位曾经拥抱西方的知识分子在晚近作品中向传统之根回归,通过塑造“不合时宜”的人物形象,揭示被世俗化、现代化话语所压抑的历史记忆和文化符号,赋予其超越时空的生命力。较早作品中的人物忠于事件,回到实在界的空无,向他者敞开并与之融合,从而创造新的文化符号,改写传统文化体系。相反,晚近小说中的主人公拒绝事件,停留在东方古老智慧的先验框架中,是作者文化立场和创作心态转变在文本上的征兆。事件性讽喻了土耳其人在东方与西方、传统与现代间不断自我革命、自我扬弃的历史进程。

关键词：奥尔罕·帕慕克事件性去事件性

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng Lulu chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu yuhong chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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天然气自动疏水阀阀芯固定结构的改进

化工设计通讯 2024年第2期50卷 58-60页

作者：陈宇红四川德阳联益石油天然气勘探开发有限公司四川德阳618000

天然气自动疏水阀是一种用于固定式气液分离器(压力容器)的自动排液装置,因其设计和制造上的缺陷,阀芯总成固定支座或其排水口在损坏时,由于受到生产现场安全条件的限制,无法进行就地快速维修,给生产的连续性和生产安全造成严重影响。... 详细信息

天然气自动疏水阀是一种用于固定式气液分离器(压力容器)的自动排液装置,因其设计和制造上的缺陷,阀芯总成固定支座或其排水口在损坏时,由于受到生产现场安全条件的限制,无法进行就地快速维修,给生产的连续性和生产安全造成严重影响。针对该设备存在的问题,对其阀芯总成固定结构进行改进,以实现就地安全快修和降低设备停待对生产的影响。

关键词：压力容器自动疏水阀设备维修结构改进

硅外延生长反应腔内外延反应过程的数值仿真建模及实验研究

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机械工程学报 2024年第5期60卷 209-218页

作者：邓世伟沈文杰陈宇宏白天梅德庆汪延成浙江大学流体动力基础件与机电系统全国重点实验室杭州310058 浙江大学浙江省先进制造技术重点实验室杭州310058 浙江晶盛机电股份有限公司绍兴310023

硅外延片是大规模集成电路、半导体器件等的基础功能材料,是通过外延反应在单晶硅片上生长均匀的外延薄层。外延层的厚度和电阻率的均匀性控制是硅外延生长的关键技术难题,其生长质量受反应腔室的结构与热流场设计影响较大。基于单片式... 详细信息

硅外延片是大规模集成电路、半导体器件等的基础功能材料,是通过外延反应在单晶硅片上生长均匀的外延薄层。外延层的厚度和电阻率的均匀性控制是硅外延生长的关键技术难题,其生长质量受反应腔室的结构与热流场设计影响较大。基于单片式硅外延生长反应腔室的结构,建立了反应腔内气体输运与外延反应的多物理场仿真模型,分析了腔室结构对热场分布均匀性的影响规律。随后通过数值仿真,研究了载气流量、进气梯度、基座转速等工艺参数对硅外延生长反应过程的影响。随后,开展了反应腔内多测点温度的测试实验,结果表明不同工艺条件下数值仿真预测的温度与实测的温度分布及变化规律相较一致,最大温度预测偏差<1.2%。基于仿真分析,获得了优化的外延生长工艺参数组合,并开展了200 mm硅外延生长反应实验,测试结果表明硅外延层的厚度不均匀性<0.76%,电阻率不均匀性<1.58%,满足集成电路硅片制造所需的外延层高品质生长要求。

关键词：硅外延层外延生长化学气相沉积热流场反应腔室