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Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

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Chinese Journal of Chemical Engineering 2024年第4期68卷 65-75页

作者： Xuwei Liu Wei Chen yufei Xia Guanghui Ma Reiji Noda Wei ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering ***,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly *** gap in knowledge holds significant potential for enhancing vaccine *** study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell *** transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case *** factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion *** simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport ***,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single *** study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering *** insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug ***,the desired transport efficiency varies depending on the specific *** instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词： Pickering emulsion Skeletal muscular cells Transport phenomena Dissipative particle dynamics Drug delivery

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大腔体压机腔体压强28 GPa的标定方法

高压物理学报 2024年第3期38卷 121-128页

作者：葛雨非由存王星淋连敏赵鑫宇丰丙涛马孝慈陶强胡阔刘兆东周强朱品文吉林大学物理学院超硬材料国家重点实验室综合极端条件高压科学中心吉林长春130012

在大腔体压机中,一般利用压标物质相变时的电阻变化进行腔体压强标定,但目前仍缺少在22.5~34.5 GPa区间的相变压标物质。地球深部矿物50%MgSiO_(3)-_(50)%Al_(2)O_(3)(En_(50)Cor_(50))在高温高压下转变为钙钛矿结构,且在27 GPa以上钙... 详细信息

在大腔体压机中,一般利用压标物质相变时的电阻变化进行腔体压强标定,但目前仍缺少在22.5~34.5 GPa区间的相变压标物质。地球深部矿物50%MgSiO_(3)-_(50)%Al_(2)O_(3)(En_(50)Cor_(50))在高温高压下转变为钙钛矿结构,且在27 GPa以上钙钛矿结构MgSiO_(3)中溶解的Al_(2)O_(3)含量随压力升高而增加。为此,选取En_(50)Cor_(50)作为大腔体压机中28 GPa的压标物质进行高压腔体压强的间接标定。首先,利用常用压标物质的相变进行腔体压强标定,得到低压区系统油压-腔体压强的校正曲线(6.0~22.5 GPa);随后,根据低压区校正曲线及前人对En_(50)Cor_(50)的研究结果,估算28 GPa腔体压强对应的系统油压;将En_(50)Cor_(50)在预估油压、2000 K温度条件下保温3~7 h;最后,利用X射线衍射、拉曼光谱、电子探针等手段对En_(50)Cor_(50)进行测试分析。结果表明:在该条件下成功合成了布里奇曼石,且Al2O_(3)的溶解度大于13.7%,对照前人的研究结果,确定样品腔体压强约为29 GPa。该方法成功标定了大腔体压机在28 GPa附近的腔体压强,填补了大腔体压机在该压强范围的标定空白。

关键词：大腔体压机压力标定 28 GPa 高温高压

Green synthesis of ZSM-5 using silica fume and catalytic co-cracking of lignin and plastics for production of monocyclic aromatics

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Chinese Journal of Chemical Engineering 2024年第1期65卷 92-105页

作者： Hongbing Fu yufei Gu Tianhua Gao Fuwei Li Hengshuo Gu Hucheng ge Yuke Liu Zhixia Li Hongfei Lin Jiangfei Cao School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Guangxi Bossco Environmental Protection Technology Co. Ltd.Nanning 530007China School of Environmental and Chemical Engineering Zhaoqing UniversityZhaoqing 526000China

ZSM-5 with hierarchical pore structure was synthesized by a simple two-step hydrothermal crystallization from silica fume without using any organic ammonium *** synthesized ZSM-5 were oval shaped particles with a particle size about 2.0 μm and weak acid-dominated with proper Brønsted(B)and Lewis(L)acid *** ZSM-5 was used for catalytic co-cracking of n-octane and guaiacol,lowdensity polyethylene(LDPE)and alkali lignin(AL)to enhance the production of benzene,toluene,ethylbenzene and xylene(BTEX).The most significant synergistic effect occurred at n-octane/guaiacol at 1:1 and LDPE/AL at 1:3,under the condition,the achieved BTEX selectivity were 24%and 33%(mass)higher than the calculated values(weighted average).The highest BTEX selectivity reached 88.5%,which was 3.7%and 54.2%higher than those from individual cracking LDPE and *** synthesized ZSM-5 exhibited superior catalytic performance compared to the commercial ZSM-5,indicating potential application prospect.

关键词： Silica fume ZSM-5 Catalytic co-cracking Plastics Lignin

Regulation of different light conditions for efficient biomass production and protein accumulation of Spirulina platensis

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Journal of Oceanology and Limnology 2024年第1期42卷 174-186页

作者： yufei ZHANG Xianjun LI Yuhui LI Shiqi LIU Yanrui CHEN Miao JIA Xin WANG Lu ZHANG Qiping GAO Liang ZHANG Daoyong YU Baosheng ge State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology China University of Petroleum(East China)Qingdao 266580China Tongwei Co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610093China

Light plays an important role in the photosynthesis and metabolic process of ***,how different light conditions regulate the biomass production and protein accumulation of microalgae is mostly *** this study,the influence of different light conditions,including light colors,densities,and light:dark cycles on the cell growth and biochemical composition of Spirulina platensis was symmetrically *** different colored lights,*** all shows an increase trend within the increased light intensity ranges;however,each showing different optimal light *** the same light intensity,different colored lights show different growth rate of *** following the sequence of red>white>green>yellow>*** maximum growth rate and protein accumulation were determined as 21.88 and 5.10 mg/(L·d)when illuminated under red *** energy efficiency of different light sources was calculated and ranked as red>white>blue≈green>*** analysis suggests that red light can promote cell growth and protein accumulation by upregulating genes related to photosynthesis,carbon fixation,and C-N metabolism *** study provides a conducive and efficient way to promote biomass production and protein accumulation of *** by regulating light conditions.

关键词： microalgae light emitting diode protein accumulation biomass production transcriptomic analysis

Comparison of luteinizing hormone and androgen on the development of rat immature Leydig cells

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Comparison of luteinizing hormone and androgen on the develo...

农村地区智障学生家庭教育问题根源探析——基于某农村地区特殊教育学校的质性研究

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Qiqi Zhu Xiaoheng Li Zhijian Su yufei ge Yiyan Wang Guimin Wang Jingjing Guo Connie Zhao Hong-Shan ge Ren-Shan ge The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Institutes of Life and Health Engineering of Jinan University Population Council & Rockefeller University

The transition of immature into adult Leydig cells is the last step of ***,the regulation of this process is still *** objective of the present study was to determine whether luteinizing hormone(LH)or androgen contributes to this *** Leydig cells were purified from thirty-five-day-old male Sprague Dawley rats and cultured with either LH(1ng/ml)or androgen(7α-methyl-19-nortestosterone,MENT,100 nM)for 2 *** or MENT treatment

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少年儿童研究 2022年第2期 44-54页

作者：葛玉飞湖北省钟祥市特殊教育学校

从家庭环境的视角出发,深度访谈ZX市特殊教育学校的13名智障学生家长和5名班主任教师,发现造成智力障碍学生家庭教育问题的根源包括:家庭环境条件限制、家长的思想观念和教育态度错误、家长采用的教育方式方法不当等因素。

关键词：智力障碍学生家庭教育家庭环境抚养模式

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EPC总承包模式在改扩建工程项目中的实践

建筑施工 2018年第6期40卷 1045-1047页

作者：戈玉飞上海现代建筑设计集团工程建设咨询有限公司上海200041

EPC总承包模式是近年来国家在房建领域大力推行的一种新的工程建设模式。结合上海市南湖职校改扩建工程,阐述了EPC项目管理团队如何针对工程特点、重点和难点所采取的一系列管理措施和方法,总结了一些经验或教训,可供类似项目借鉴。

关键词： EPC总承包改扩建工程项目管理分包合同运维模式

自体浓缩生长因子膜在口腔黏膜组织缺损中的应用

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中华整形外科杂志 2018年第9期34卷 724-728页

作者：葛宇飞乔光伟葛长艺孙小娟康佳楠宁夏医科大学口腔医学院银川750001 宁夏医科大学总医院口腔颌面外科烟台市福山区人民医院口腔科

目的评价自体浓缩生长因子膜应用于口腔黏膜组织缺损修复的临床疗效.方法选择因手术切除造成口腔黏膜组织缺损的患者39例,随机分为试验组和对照组,试验组19例应用自体浓缩生长因子膜修复创面,对照组20例不覆盖膜.术后1、2、3周及1、2... 详细信息

目的评价自体浓缩生长因子膜应用于口腔黏膜组织缺损修复的临床疗效.方法选择因手术切除造成口腔黏膜组织缺损的患者39例,随机分为试验组和对照组,试验组19例应用自体浓缩生长因子膜修复创面,对照组20例不覆盖膜.术后1、2、3周及1、2、3个月定期复查,比较2组创面愈合情况.结果试验组19例患者CGF膜均成活,未发生感染.试验组术后2、3周及1个月时创面愈合率均高于对照组（P〈0.05）;术后1、2、3周及1个月时VAS评分均低于对照组（P〈0.05）;术后3个月时VSS评分的平均分低于对照组（P〈0.05）.结论应用CGF膜修复口腔黏膜组织缺损,可缩短创面愈合时间、减轻术后不适感、减少术后瘢痕形成,安全有效.

关键词：口腔黏膜自体浓缩生长因子膜缺损修复

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基于树突细胞算法与对支持向量机的入侵检测

计算机应用 2015年第11期35卷 3087-3091页

作者：梁鸿葛宇飞陈林王雯娇中国石油大学计算机与通信工程学院山东青岛266580

针对入侵检测技术在处理大规模数据时存在的高误报率、低训练速度和低实时性的问题,提出了一种基于树突细胞算法与对支持向量机的入侵检测策略(DCTWSVM)。利用树突细胞算法(DCA)对威胁数据进行初始检测,在此基础上利用对支持向量机(TWS... 详细信息

针对入侵检测技术在处理大规模数据时存在的高误报率、低训练速度和低实时性的问题,提出了一种基于树突细胞算法与对支持向量机的入侵检测策略(DCTWSVM)。利用树突细胞算法(DCA)对威胁数据进行初始检测,在此基础上利用对支持向量机(TWSVM)进行检测结果的优化处理。为了验证策略的有效性,设计性能对比实验,实验结果表明,相较于DCA、支持向量机(SVM)、反向传播(BP)神经网络,DCTWSVM策略的检测精度提高了2.02%、2.30%、5.44%,误报率分别降低了0.26%、0.46%、0.90%,训练速度相较于SVM提高了两倍且只需耗费极少的训练时间,可以更好地适用于大规模数据下的实时入侵检测环境。

关键词：树突细胞算法对支持向量机入侵检测大数据