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A phase Ⅰ study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 46-54页

作者： Pin zhang Lin Wang yueying Zhen Zhihong Wang Hesheng zhang Richard Jones Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Hemay Pharmaceutical Co. LTDTianjin 300308China

Objective: Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor with the target of epidermal growth factor receptor(EGFR)/human epidermal growth factor receptor 2(HER2), which demonstrated anti-tumor activity in preclinical studies. This first-in-human study evaluated the safety, pharmacokinetics,tolerability and preliminary anti-tumor activity of Hemay022 in HER2-positive advanced breast cancer patients.Methods: Heavily pretreated patients with HER2-positive advanced breast cancer were assigned to eight dose cohorts in a 3+3 dose-escalation pattern at doses of 50-600 mg QD and 300 mg BID. Eligible patients were given a single dose of Hemay022 on d 1 in week 0, followed by once daily continuous doses for four weeks in 28-day cycles.Pharmacokinetic samples were obtained on d 1 and d 28. Clinical responses were assessed every eight weeks.Results: Twenty-eight patients with advanced breast cancer were treated with Hemay022. The most frequently reported drug-related adverse events were diarrhoea(85.7%), vomiting(28.6%), nausea(25.0%) and decreased appetite(17.9%). No grade 4 drug-related adverse events were reported. At 50-600 mg doses, steady state areas under the concentration-time curve and peak concentrations increased with doses. One patient achieved complete response(CR), and three achieved partial response(PR). The objective response rate(ORR) and disease control rate(DCR) were 14.3% and 46.4% in 28 patients, respectively. The median progression-free survival(PFS) was3.98 months.Conclusions: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase Ⅲ trial(No. NCT05122494).

关键词： Advanced breast cancer HER2-positive Hemay022 first-in-human trial

Genetic architecture of leaf morphology revealed by integrated trait module in Catalpa bungei

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Horticulture Research 2023年第4期10卷 161-173页

作者： Miaomiao zhang Bingyang Liu Yue Fei Xiaowei Yang Linjiao Zhao Chaozhong Shi Yueying Zhang Nan Lu Chuangye Wu Wenjun Ma Junhui Wang State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China Academy of Forest and Grassland Inventory and Planning National Forestry and Grassland AdministrationBeijing 100714China Wenxian Forestry Science Research Institute Jiaozuo 454850China

Leaves are crucial for maintaining plant growth and development via photosynthesis,and their function is simultaneously regulated by a suite of phenotypic traits.Although much is known about the genetic architecture of individual leaf traits,unraveling the genetic basis of complex leafmorphology remains a challenge.Based on the functional correlation and coordination ofmulti-traits,we divided 15 leaf morphological traits into three modules,comprising size(area,length,width,and perimeter),shape(leaf lobes,aspect ratio,circularity,rectangularity,and the relevant ratios),and color(red,green,and blue)for an ornamental tree species,Catalpa bungei.A total of 189 significant single-nucleotide polymorphisms were identified in the leaves of C.bungei:35,82,and 76 in the size,shape,and color modules,respectively.Four quantitative trait loci were common between the size and shape modules,which were closely related according to phenotype correlation,genetic mapping,and mRNA analysis.The color module was independent of them.Synergistic changes in the aspect ratio,leaf lobe,and circularity suggest that these traits could be the core indicators of the leaf shape module.The LAS and SRK genes,associated with leaf lobe and circularity,were found to function in plant defense mechanisms and the growth of leaves.The associations between the SRK and CRK2 genes and the leaf lobe and circularity traits were further verified by RT-qPCR.Our findings demonstrate the importance of integrating multi-trait modules to characterize leaf morphology and facilitate a holistic understanding of the genetic architecture of intraspecific leaf morphology diversity.

关键词： circular integrating finding

A review of anodic catalysts and their application in(non-)Kolbe electrocatalytic decarboxylation of carboxylic acids

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Carbon Resources Conversion 2023年第4期6卷 287-297页

作者： Shichun Wang Dezhang Ren yueying Du Mengjie zhang Nahui zhang Yaguang Sun Zhibao Huo College of Marine Ecology and Environment Shanghai Ocean University999 Huchenghuan RoadShanghai 201306China The Key Laboratory of Inorganic Molecule-Based Chemistry of Liaoning Province Shenyang University of Chemical TechnologyShenyang110142China Shanghai Engineering Research Center of River and Lake Biochain Construction and Resource Utilization Shanghai201702China

Biomass,as the exclusive and abundant organic resources,is considered to be the promising renewable resource.Carboxylic acids are one of the many compounds that can be obtained from raw biomass.Decarboxylation of carboxylic acids into fuels and chemicals via electrochemical method at mild reaction condition has been studied for many years.The(non-)Kolbe reaction,one of the oldest organic electrochemical reactions,is the decarboxylation of carboxylic acids to produce alkanes,alcohols,esters,etc.And electrode materials influence the production of electrocatalytic decarboxylation products from carboxylic acids.Therefore,this work mainly reviews the recent advances in applications of anodic materials for(non-)Kolbe electrocatalytic decarboxylation of carboxylic acids.It discusses the reaction mechanism of(non-)Kolbe electrolytic reaction,and the electrocatalytic oxidation of carboxylic acid using different electrodes and electrolytic systems to synthesize fuels and chemicals.Also,various types of electrode catalysts,such as Pt-based catalysts,C-based catalysts,and other catalysts,are introduced in detail.Finally,the challenges and future trends of the(non-)Kolbe reaction of carboxylic acids are presented.This review found that platinum-based electrocatalysts proved to be the most promising catalysts at present.And in recent years,a variety of synthesis methods have been developed to synthesize small size and high-performance noble metal based amorphous catalysts.Another approach is to study catalysts without platinum electricity,such as Ru,Ir,Ti and carbon materials.The review is helpful in understanding and know the anodic materials and their application in(non-)Kolbe electrocatalytic decarboxylation of carboxylic acids for the readers.

关键词： Electrocatalytic decarboxylation Carboxylic acid (non-)Kolbe reaction Anode material Catalysis

A Natural Polymer Captor for Immobilizing Polysulfide/Polyselenide in Working Li-SeS_(2) Batteries

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Nano-Micro Letters 2021年第7期13卷 55-73页

作者： Yin zhang Menglei Wang Yi Guo Lingzhi Huang Boya Wang Yunhong Wei Peng Jing Yueying Zhang Yun zhang Qian Wang Jingyu Sun Hao Wu Engineering Research Center of Alternative Energy Materials and Devices of Ministry of Education College of Materials Science and EngineeringSichuan UniversityChengdu 610064People’s Republic of China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province College of EnergySoochow Institute for Energy and Materials Innovations(SIEMIS)Soochow UniversitySuzhou 215006People’s Republic of China

SeS_(2) has become a promising cathode material owing to its enhanced electrical conductivity over sulfur and higher theoretical specific capacity than selenium;however,the working Li-SeS_(2) batteries have to face the practical challenges from the severe shuttling of soluble dual intermediates of polysulfide and polyselenide,especially in high-SeS_(2)-loading cathodes.Herein,a natural organic polymer,Nicandra physaloides pectin(NPP),is proposed to serve as an effective polysulfide/polyselenide captor to address the shuttling issues.Informed by theoretical calculations,NPP is competent to provide a Lewis base-based strong binding interaction with polysulfides/polyselenides via forming lithium bonds,and it can be homogeneously deposited onto a three-dimensional double-carbon conductive scaffold to finally constitute a polysulfide/polyselenide-immobilizing interlayer.Operando spectroscopy analysis validates the enhanced polysulfide/polyselenide trapping and high conversion efficiency on the constructed interlayer,hence bestowing the Li-SeS_(2) cells with ultrahigh rate capability(448 mAh g^(−1)at 10 A g^(−1)),durable cycling lifespan(≈0.037%capacity attenuation rate per cycle),and high areal capacity(>6.5 mAh cm^(−2))at high SeS_(2) loading of 15.4 mg cm^(−2).Importantly,pouch cells assembled with this interlayer exhibit excellent flexibility,decent rate capability with relatively low electrolyte-to-capacity ratio,and stable cycling life even under a low electrolyte condition,promising a low-cost,viable design protocol toward practical Li-SeS_(2) batteries.

关键词： Li-SeS_(2)batteries Nicandra physaloides pectin Interlayer Shuttle effect Pouch cells

Self-Assembly 3D Porous Crumpled MXene Spheres as Efficient Gas and Pressure Sensing Material for Transient All-MXene Sensors

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Nano-Micro Letters 2022年第4期14卷 1-14页

作者： Zijie Yang Siyuan Lv Yueying Zhang Jing Wang Li Jiang Xiaoteng Jia Chenguang Wang Xu Yan Peng Sun Yu Duan Fangmeng Liu Geyu Lu State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012People’s Republic of China School of Electronic and Information Engineering Changchun University of Science and TechnologyChangchun 130022People’s Republic of China

Environmentally friendly degradable sensors with both hazardous gases and pressure efficient sensing capabilities are highly desired for various promising applications,including environmental pollution monitoring/prevention,wisdom medical,wearable smart devices,and artificial intelligence.However,the transient gas and pressure sensors based on only identical sensing material that concurrently meets the above detection needs have not been reported.Here,we present transient all-MXene NO_(2) and pressure sensors employing three-dimensional porous crumpled MXene spheres prepared by ultrasonic spray pyrolysis technology as the sensing layer,accompanied with water-soluble polyvinyl alcohol substrates embedded with patterned MXene electrodes.The gas sensor achieves a ppb-level of highly selective NO_(2) sensing,with a response of up to 12.11%at 5 ppm NO_(2) and a detection range of 50 ppb-5 ppm,while the pressure sensor has an extremely wide linear pressure detection range of 0.14-22.22 kPa and fast response time of 34 ms.In parallel,all-MXene NO_(2) and pressure sensors can be rapidly degraded in medical H_(2)O_(2) within 6 h.This work provides a new avenue toward environmental monitoring,human physiological signal monitoring,and recyclable transient electronics.

关键词： All-MXene 3D porous crumpled MXene sphere Transient NO2 and pressure sensor

Mid-infrared plasmonic silicon quantum dot/HgCdTe photodetector with ultrahigh specific detectivity

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Science China(Information Sciences) 2023年第4期66卷 286-292页

作者： yueying CUI Zhouyu TONG Xinlei zhang Wenhui WANG Weiwei ZHAO Yuanfang YU Xiaodong PI Jialin zhang Zhenhua NI School of Physics and Key Laboratory of MEMS of Ministry of Education Southeast University State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University

Highly sensitive photodetectors operating at mid-infrared(MIR) wavelengths are urgently required for the applications of astronomy, optical communication, security monitoring, and so forth. However,further promoting the sensitivity in conventional MIR devices for a higher detectivity is challenging. Among the potential strategies, integrating localized surface plasmon resonance with MIR semiconductors is a promising approach to developing high-performance optoelectronics. Here we demonstrate a high-sensitivity boron(B)-doped silicon quantum dot(Si-QD)/HgCdTe(MCT) MIR photodetector. Because of plasmon-induced hot-hole tunneling and enhanced light absorption, the hybrid photodetector exhibits a high specific detectivity of ～1.6×109cm·Hz1/2·W-1(Jones) and a high-speed response(～224 ns for the rise time and ～580 ns for the fall time) at room temperature. Furthermore, the device achieves high-performance spectral blackbody detection with a peak detectivity of up to 1.6×1011Jones at ～5.8 μm under a cryogenic environment of 77 K, higher than that of bare MCT. This prominent enhancement can be attributed to the further suppression of hot-hole cooling due to a reduced phonon population at low temperatures, which facilitates more efficient hot-carrier extraction and contributes to ultrahigh sensitivity. The plasmonic material-integrated MCT architecture can pave the way for developing high-performance MIR photodetection.

关键词： doped silicon quantum dots HgCdTe localized surface plasmon resonance hot-hole tunneling mid-infrared photodetector

Towards consistent machine translation of abbreviated terms in scientific literature

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High Technology Letters 2021年第3期27卷 282-293页

作者：何彦青 Sun yueying Wu Zhenfeng Pan You zhang Junsheng Research Center for Information Science Theory and Methodology Institute of Scientific and Technical Information of ChinaBeijing 100038P.R.China

Scientific literature often contains abbreviated terms in English for brief.Machine translation(MT)systems can help to share knowledge in different languages among researchers.Current MT systems may translate the same abbreviated term in different sentences into different target terms.MT systems translate the abbreviated term in two ways:one is to use translation of the full name,the other is to use the abbreviated term directly.Abbreviated terms may be ambiguous and polysemous,and MT systems do not have an explicit strategy to decide which way to use without context information.To get the consistent translation for abbreviated terms in scientific literature,this paper proposes a translation model for abbreviated terms that integrates context information to get consistent translation of abbreviated terms.The context information includes the positions of abbreviated term and domain attributes of scientific literature.The first abbreviated term is translated in full name while the latter ones of the same abbreviated term will show the abbreviated form in the translation text.Experiments of translation from Chinese to English show the effectiveness of the proposed translation model.

关键词： abbreviated term context information domain information machine translation(MT)

Self-templating thermolysis synthesis of Cu2-xS@ M （M = C, TiO2, MoS2） hollow spheres and their application in rechargeable lithium batteries

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Nano Research 2018年第2期11卷 831-844页

作者： Yunhui Wang He Li Yiyong zhang yueying Peng Peng zhang Jinbao Zhao State Key Lab of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Xiamen China Collaborative Innovation Center of Chemistry for Energy Materials College of Chemistry and Chemical Engineering Xiamen University Xiamen China State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle Xiamen University Xiamen China College of Energy Xiamen University Xiamen China

Owing to their unique structural stability and impressive long-term cycling performance, coated hollow structures are highly attractive for energy storage systems, especially batteries. Many efforts have been devoted and various strategies have been proposed to prepare such materials. In the present work, we propose a self-templating thermolysis strateg different from traditional wet processing methods, to fabricate cuprous sulfide hollow spheres coated with different shells, by exploiting the thermal decomposition properties of the core （CuS） and the protection provided by the shell. To demonstrate the generality of this synthetic approach, three different coating materials （carbon, TiO2, MoS2） have been chosen to prepare Cu2_S@C, Cu2_S@TiO2 and Cu2_xS@MoS2 hollow spheres. All synthesized composite materials were then assembled as electrodes and tested in lithium batteries, showing excellent cycling stability. In particular, the electro- chemical properties of Cu2_xS@C were thoroughly investigated. The results of this work provide an alternative route to prepare coated metal sulfide hollow soheres for enerL^v storage aoDlications.

关键词： self-templatingthermolysis,sulfide,hollow spheres,lithium batteries

The application of nanostructured transition metal sulfides as anodes for lithium ion batteries

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Journal of Energy Chemistry 2018年第6期27卷 1536-1554页

作者： Jinbao Zhao Yiyong zhang Yunhui Wang He Li yueying Peng State Key Laboratory of Physical Chemistry of Solid Surfaces State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle Collaborative Innovation Center of Chemistry for Energy Materials College of Chemistry and Chemical Engineering Xiamen University Xiamen361005 Fujian China

With wide application of electric vehicles and large-scale in energy storage systems, the requirement ofsecondary batteries with higher power density and better safety gets urgent. Owing to the merits of hightheoretical capacity, relatively low cost and suitable discharge voltage, much attention has been paid tothe transition metal sulfides. Recently, a large amount of research papers have reported about the appli-cation of transition metal sulfides in lithium ion batteries. However, the practical application of transitionmetal sulfides is still impeded by their fast capacity fading and poor rate performance. More well-focusedresearches should be operated towards the commercialization of transition metal sulfides in lithium ionbatteries. In this review, recent development of using transition metal sulfides such as copper sulfides,molybdenum sulfides, cobalt sulfides, and iron sulfides as electrode materials for lithium ion batteriesis presented. In addition, the electrochemical reaction mechanisms and synthetic strategy of transitionmetal sulfides are briefly summarized. The critical issues, challenges, and perspectives providing a fur-ther understanding of the associated electrochemical processes are also discussed.

关键词： Transition metal sulfides Lithium ion batter Anode