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Synthetic and Systems Biotechnology 2023年第4期8卷 647-653页

作者： Yuzhou wang Jinyi Qian Fang Yan yuetong wang Tianqiong Shi Zhidong Zhang Chao Ye He Huang School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing210023China Institute of Microbiology Xinjiang Academy of Agricultural SciencesUrumqi830091China

Special environmental microorganisms are considered to be of great industrial application value because of their special genotypes,physiological functions and *** research and development of special environmental microorganisms will certainly bring about some innovations in biotechnology processes and change the face of *** Special Environmental Microbial Database(DSEMR)is a comprehensive database that provides information on special environmental microbial resources and correlates them with synthetic biological *** aggregates information on specific environmental microbial genomes,physiological properties,culture media,biological parts,and metabolic pathways,and provides online tool analysis data,including 5268 strains from 620 genera,31 media,and 42,126 biological *** short,DSEMR will become an important resource for the study of microorganisms in special environments and actively promote the development of synthetic biology.

关键词： Special environment microorganism Physiological functions Synthetic biological parts

Alkaloid Dimers Isolated from Thalictrum baicalense Have Antitumor Activities

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Chinese Journal of Chemistry 2022年第15期40卷 1831-1841页

作者： Jingjing Xue yuetong wang Fangshen Liu Hangao Yang Bin Lin Zhanlin Li Yongkui Jing Dahong Li Huiming Hua Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense *** *** structures were determined by extensive spectroscopic methods and ECD *** A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at *** biosynthetic routes of 1 are proposed.

关键词： Thalictrum baicalense Heterodimeric isoquinoline alkaloid Thalifaberine-type ABI alkaloids Antitumor activity Apoptosis

中成药治疗中风的临床研究及评价(2021—2022年)

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世界中医药 2024年第8期19卷 1108-1113,1128页

作者：宋雯婷冯超男季昭臣胡海殷王玥彤张雅姿金鑫瑶杨丰文天津中医药大学循证医学中心天津301617 中国中医科学院广安门医院保定医院保定071000 现代中医药海河实验室天津301617

目的:通过对2021年度发表的中成药治疗中风的临床随机对照试验(RCTs)进行系统的收集、整理、分析和评价,对中成药治疗中风临床证据进行阶段性总结,为后续研究的开展及证据转化应用提供参考。方法:基于中医药循证研究证据库系统(EVDS)中... 详细信息

目的:通过对2021年度发表的中成药治疗中风的临床随机对照试验(RCTs)进行系统的收集、整理、分析和评价,对中成药治疗中风临床证据进行阶段性总结,为后续研究的开展及证据转化应用提供参考。方法:基于中医药循证研究证据库系统(EVDS)中的中成药临床证据数据库收录的文献,补充检索国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)、Cochrane Library、PubMed、EMbase数据库,获取2021年度发表的中成药治疗中风RCTs并进行统计分析。结果:检索得到符合要求的RCTs 147篇,其中样本量≥100例的RCTs 67篇(45.58%);涉及中成药51种,其中口服中成药25种,中药注射剂26种;涉及干预/对照措施16种,其中“中成药+西药+常规治疗”与“西药+常规治疗”比较最多(91篇,61.90%);纳入的147篇RCTs中,仅1篇未报告疗程,63.95%的研究疗程为14 d;研究总体方法学质量仍存在一些问题,尤其是分配隐藏、盲法及其他偏倚等条目低风险率不足5%,此外研究注册和样本量估算等鲜有报告。结论:2021年度发表的中成药治疗中风RCTs在随机方法、分配隐藏、实施偏倚(盲法应用)、其他偏倚4个方面的报告存在明显不足。

关键词：中成药中风随机对照试验循证医学中医证据报告年度报告

Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway

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Life Metabolism 2023年第5期2卷 25-37页

作者： Na wang Tiange Yao Chenfei Luo Ling Sun yuetong wang Steven X.Hou Department of Cell and Developmental Biology at School of Life Sciences State Key Laboratory of Genetic EngineeringInstitute of Metabolism and Integrative BiologyHuman Phenome InstituteFudan UniversityShanghai 200438China

Tumor immunotherapy has achieved breakthroughs in a variety of tumors. However, the systemic absence of T cells in tumors and immunosuppressive tumor microenvironment so far limits the efficacy of immunotherapy to a small population of patients. Therefore, novel agents to increase T-cell tumor infiltration are urgently needed in the clinic. We recently found that inhibition of the ADP-ribosylation factor 1 (Arf1)-mediated lipid metabolism not only kills cancer stem cells (CSCs) but also elicits an anti-tumor immune response. In this study, we revealed a mechanism that targeting Arf1 promotes the infiltration of cytotoxic T lymphocytes (CTLs) into tumors through the C-C chemokine ligand 5 (CCL5)- C-C chemokine receptor type 5 (CCR5) pathway. We found that blockage of Arf1 induces the production of the unsaturated fatty acid (PE 18:1) that binds and sequestrates peroxisome proliferator- activated receptor-γ (PPARγ) from the PPARγ-nuclear factor-κB (NF-κB) cytoplasmic complex. The released NF-κB was then phospho-rylated and translocated into the nucleus to regulate the transcription of chemokine CCL5. CCL5 promoted infiltration of CTLs for tumor regression. Furthermore, the combination of the Arf1 inhibitor and programmed cell death protein 1 (PD-1) blockade induced an even stronger anti-tumor immunity. Therefore, targeting Arf1 represents a novel anti-tumor immune approach by provoking T-cell tumor infiltration and may provide a new strategy for tumor immunotherapy.

关键词： immune checkpoint blockade cancer stem cells cytotoxic T cells PPARγ CCL5-CCR5 pathway Arf1

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肾炎康复片治疗紫癜性肾炎的系统评价

天津中医药 2024年第8期41卷 998-1004页

作者：胡智庞稳泰金鑫瑶张雅姿宋雯婷王玥彤杨丰文天津中医药大学天津301617

[目的]系统评价肾炎康复片治疗紫癜性肾炎的疗效及安全性。[方法]计算机检索中国知网(CNKI)、维普(VIP)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library、Web of Science,检索时间为建库至2023年6月20日... 详细信息

[目的]系统评价肾炎康复片治疗紫癜性肾炎的疗效及安全性。[方法]计算机检索中国知网(CNKI)、维普(VIP)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library、Web of Science,检索时间为建库至2023年6月20日,搜集关于肾炎康复片治疗紫癜性肾炎的随机对照试验(RCT)。由两名研究者独立筛选文献、提取数据,采用Cochrane推荐的风险偏倚评估工具ROB2评估文献的偏倚风险,随后交叉核对。应用RevMan 5.4软件进行统计分析,对肾炎康复片治疗紫癜性肾炎的疗效及安全性进行系统评价。[结果]纳入9篇文献,样本量共853例。总体偏倚风险中,2项研究评为高偏倚风险,7项研究评为有一定偏倚风险。Meta分析结果提示,肾炎康复片能够提升治疗紫癜性肾炎患者的临床疗效[RR=1.19,95%CI(1.10,1.30),P<0.0001],降低24 h尿蛋白定量[SMD=-0.78,95%CI(-1.01,-0.56),P<0.00001],改善蛋白尿疗效[RR=2.23,95%CI(1.77,2.83),P<0.00001],降低尿红细胞计数[SMD=-0.70,95%CI(-1.04,-0.37),P<0.0001],改善血尿疗效[RR=1.66,95%CI(1.05,2.60),P=0.03]。肾炎康复片联合西医常规治疗的不良事件较少。[结论]肾炎康复片在紫癜性肾炎患者的治疗中安全有效,受纳入研究数量和质量的限制,该结论尚待更多高质量研究予以验证。

关键词：肾炎康复片紫癜性肾炎临床疗效系统评价 Meta分析

The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1400-1411页

作者： Shuo wang Tian Liu yuetong Huang Chaoying Du Danping wang Xiyan wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Medical Devices Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Binzhou Medical UniversityBinzhou 256600China

The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly *** the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug *** study designed four docetaxel(DTX)prodrugs using disulfide bonds as activation modules and different lengths of branched-chain fatty alcohols as assembly modules(C_(16),C_(18),C_(20),and C_(24)).The lengths of the assembly modules determined the self-assembly ability of prodrugs and affected the activation modules’*** extension of the carbon chains improved the prodrugs’self-assembly ability and pharmacokinetic behavior while reducing the cytotoxicity and increased cumulative *** use of C_(20) can balance efficacy and *** results provide a great reference for the rational design of prodrug nanoassemblies.

关键词： Prodrugs Nanoassemblies Self-assembly Branched-chain fatty alcohols Disulfide bond Docetaxel Efficacy Safety

Microfluidics for Medical Additive Manufacturing

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Engineering 2020年第11期6卷 1244-1257页

作者： Jie wang Changmin Shao yuetong wang Lingyun Sun Yuanjin Zhao Department of Rheumatology and Immunology.Institute of Translational Medicine The Afliated Drum Tower Hospital of Nonjing University Medical SchoolNanjing 210008China College of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Additive manufacturing plays a vital role in the food,mechanical,pharmaceutical,and medical *** these fields,medical additive manufacturing has led to especially obvious improvements in medical instruments,prostheses,implants,and so forth,based on the advantages of cost-effectiveness,customizability,and quick *** the features of precise structural control,high throughput,and good component manipulation,microfluidic techniques present distinctive benefits in medical additive manufacturing and have been applied in the areas of drug discovery,tissue engineering,and organs on ***,a comprehensive review of microfluidic techniques for medical additive manufacturing is useful for scientists with various ***,we review recent progress in the development of microfluidic techniques for medical additive *** evaluate the distinctive benefits associated with microfluidic technologies for medical additive manufacturing with respect to the fabrication of droplet/fiber templates with different *** applications of microfluidic techniques for medical additive manufacturing are emphasized,such as cell guidance,three-dimensional(3D)cell culture,tissue assembly,and cell-based ***,we present challenges in and future perspectives on the development of microfluidics for medical additive manufacturing.

关键词： Microfluidics Biomaterial Additive manufacturing Droplet Fiber

Smart Microneedles for Therapy and Diagnosis

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Research 2020年第1期2020卷 1295-1320页

作者： Xiaoxuan Zhang yuetong wang Junjie Chi Yuanjin Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

Microneedles represent a cutting-edge and idea-inspiring technology in biomedical engineering,which have attracted increasing attention of scientific researchers and medical *** the past decades,numerous great achievements have been *** fabrication process of microneedles has been simplified and becomes more precise,easy-to-operate,and ***,microneedles with various features have been developed and the microneedle materials have greatly *** recent years,efforts have been focused on generating smart microneedles by endowing them with intriguing functions such as adhesion ability,responsiveness,and controllable drug *** improvements enable the microneedles to take an important step in practical applications including household drug delivery devices,wearable biosensors,biomedical assays,cell culture,and microfluidic chip *** this review,the fabrication strategies,distinctive properties,and typical applications of the smart microneedles are *** accomplishments,remaining challenges,and future prospects are also presented.

关键词： smart accomplishment enable

Boston Ivy-Inspired Disc-Like Adhesive Microparticles for Drug Delivery

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Research 2021年第1期2021卷 1604-1614页

作者： Lijun Cai Guopu Chen yuetong wang Cheng Zhao Luoran Shang Yuanjin Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Zhongshan-Xuhui Hospital The Shanghai Key Laboratory of Medical EpigeneticsThe International Co-Laboratory of Medical Epigenetics and MetabolismMinistry of Science and Technologyand Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Department of Rheumatology Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

Microparticles with strong adherence are expected as efficient drug delivery ***,we presented an ingenious hydrogel microparticle recapitulating the adhesion mechanism of Boston ivy tendrils adhesive discs(AD)for durable drug *** particles were achieved by replicating a silica colloidal crystal aggregates assembled in a droplet template after rapid solvent *** to their unique shape,the nanostructure,and the sticky hydrogel component,such novel microparticles exhibited prominent adhesive property to the wet tissue *** was demonstrated that the bioinspired microcarriers loading with dexamethasone had a good therapeutic effect for ulcerative colitis due to the strong adhesion ability for prolonging the maintenance of drug *** virtues make the biomimetic microparticles potentially ideal for many practical clinical applications,such as drug delivery,bioimaging,and biodiagnostics.

关键词： environment Boston template

High-performance wood-based thermoelectric sponges for thermal energy harvesting and smart buildings

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Nano Research 2024年第6期17卷 5349-5357页

作者： Ding Zhang Qi Li Yanjie Fang Peijia Bai Lili Liu Jiaqi Guo Guangfa wang yuetong Zhou Rujun Ma School of Materials Science and Engineering National Institute for Advanced MaterialsSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China

The development of renewable woods for power generation can help improve the energy efficiency of buildings,and promote the concept design and implementation of“smart buildings”.Here,with specific chemical treatment and hydrothermal synthesis,we demonstrated the practical value of natural wood for thermoelectric power generation in smart *** prepared wood-based thermoelectric sponges show high Seebeck coefficients of 320.5 and 436.6μV/K in the vertical and parallel directions of the longitudinal channel of *** 500 cycles of the compressive strain at 20%,the corresponding Seebeck coefficients increase up to 413.4 and 502.1μV/K,respectively,which is attributed to the improved contact and connection between tellurium thermoelectric *** Seebeck coefficients are much larger than those of most reported inorganic thermoelectric ***,the thermoelectric sponges maintain excellent thermoelectric and mechanical *** further modeled the application value of wood-based thermoelectric sponges in smart buildings for power *** high thermoelectric electricity can be obtained,such as in Beijing with over 1.5 million kWh every year,demonstrating the great potential in thermal energy harvest and energy supply.

关键词： wood thermoelectric effect thermal energy harvesting smart buildings energy supply