Alkaloid Dimers Isolated from Thalictrum baicalense Have Antitumor Activities

作     者：Jingjing Xue Yuetong Wang Fangshen Liu Hangao Yang Bin Lin Zhanlin Li Yongkui Jing Dahong Li Huiming Hua Jingjing Xue;Yuetong Wang;Fangshen Liu;Hangao Yang;Bin Lin;Zhanlin Li;Yongkui Jing;Dahong Li;Huiming Hua

作者机构：Key Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangLiaoning 110016China School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyangLiaoning 110016China Wuya College of InnovationShenyang Pharmaceutical UniversityShenyangLiaoning 110016China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2022年第40卷第15期

页      面：1831-1841页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundationof China(No.82173715) 

主　　题：Thalictrum baicalense Heterodimeric isoquinoline alkaloid Thalifaberine-type ABI alkaloids Antitumor activity Apoptosis 

摘      要：Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense *** *** structures were determined by extensive spectroscopic methods and ECD *** A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at *** biosynthetic routes of 1 are proposed.