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痰热清注射液对慢性阻塞性肺疾病急性加重期患者肺功能与血清炎症细胞因子的影响

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中国中医急症 2019年第6期28卷 1050-1053页

作者：陈红邓正旭杜月君宋磊林家晨张士放付道芳徐治波四川省成都市第二人民医院

目的观察痰热清注射液联合布地奈德对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能与血清炎症细胞因子的影响。方法患者158例随机分为两组,对照组给予常规治疗,同时雾化吸入布地奈德混悬液,观察组在此基础上静脉滴注痰热清注射液,两... 详细信息

目的观察痰热清注射液联合布地奈德对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能与血清炎症细胞因子的影响。方法患者158例随机分为两组,对照组给予常规治疗,同时雾化吸入布地奈德混悬液,观察组在此基础上静脉滴注痰热清注射液,两组疗程均为14d。观察两组临床疗效,对比两组治疗前后第1秒用力呼气量占预计值的百分比(FEV1%)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)等肺功能指标与白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)等血清炎症细胞因子水平。结果治疗后观察组总有效率为94.94%,明显高于对照组的84.81%(P<0.05);治疗后两组肺功能指标、各项血清炎症细胞因子水平均有改善(P<0.05),且观察组各项指标改善情况均显著优于对照组(P<0.05)。结论痰热清注射液联合布地奈德治疗AECOPD患者临床疗效显著,可有效改善患者肺功能,降低患者炎症反应。

关键词：慢性阻塞性肺疾病痰热清注射液布地奈德肺功能炎症细胞因子

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去带盲升结肠可控膀胱术后贮尿囊结石

临床泌尿外科杂志 2008年第1期23卷 46-48页

作者：杜跃军谭万龙郑少斌黄崇学张辉见娄艳南方医科大学南方医院泌尿外科广州510515

目的：探讨去带盲升结肠可控膀胱术后贮尿囊结石的发生原因与对应措施。方法：对去带盲升结肠可控膀胱术后患者105例随访14-94个月，平均43．5个月，对相关临床资料进行回顾性分析。结果：贮尿囊结石发生率6．7％（7／105），6例手术治... 详细信息

目的：探讨去带盲升结肠可控膀胱术后贮尿囊结石的发生原因与对应措施。方法：对去带盲升结肠可控膀胱术后患者105例随访14-94个月，平均43．5个月，对相关临床资料进行回顾性分析。结果：贮尿囊结石发生率6．7％（7／105），6例手术治愈，其中2例行经皮穿刺膀胱镜下气压导弹道碎石，4例行贮尿囊切开取石，术后随访未见复发。结论：去带盲升结肠可控膀胱术后贮尿囊结石的发生多与症状性泌尿系感染相关，规律、充分的贮尿囊冲洗及定时清洁导尿对于预防贮尿囊结石有重要作用；选择性地采取经皮穿刺膀胱镜下碎石术或贮尿囊切开取石术，均可取得理想治疗效果。

关键词：可控膀胱术结肠结石

3种预警评分预测慢性阻塞性肺疾病急性加重期患者预后价值比较

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现代仪器与医疗 2019年第2期25卷 70-73+77页

作者：付道芳徐治波陈红曾嘉涛杜月君杨春梅成都市第二人民医院呼吸内科

目的:比较3种预警评分预测慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的价值。方法:选取193例AECPOD患者,于入院时分别使用英国国家早期预警评分(NEWS)、CURB-65评分、急性生理与慢性健康(APACHE-Ⅱ)评分评价患者病情,并按照患者预后... 详细信息

目的:比较3种预警评分预测慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的价值。方法:选取193例AECPOD患者,于入院时分别使用英国国家早期预警评分(NEWS)、CURB-65评分、急性生理与慢性健康(APACHE-Ⅱ)评分评价患者病情,并按照患者预后,将其分别纳入死亡组和存活组、入住ICU组和未入住ICU组、机械通气组和非机械通气组、有创机械通气组和非有创机械通气组,比较各组患者NEWS、CURB-65、APACHE-Ⅱ评分的差异,并运用受试者工作特征曲线(ROC)及曲线下面积(AUC),分析3种预警评分预测AECOPD患者预后的参考价值。结果:193例患者预后转归为死亡8例(4.42%),存活185例(95.85%);入住ICU 22例(11.40%);行机械通气50例(25.91%),其中8例行有创机械通气(16.00%)。死亡组、入住ICU组、机械通气组、有创机械通气组入院时NEWS、CURB-65、APACHE-Ⅱ评分均分别高于存活组、未入住ICU组、非机械通气组、非有创机械通气组,差异有统计学意义(P <0.05)。APACHE-Ⅱ评分预测AECOPD患者死亡、入住ICU、机械通气、有创机械通气的AUC均高于NEWS评分、CURB-65评分,NEWS评分预测AECOPD患者预后的AUC均高于CURB-65评分。CURB-65评分预测AECOPD患者预后的AUC均在0.7以上。结论:NEWS、CURB-65、APACHE-Ⅱ评分均可为AECOPD患者预后的预测提供可靠参考,NEWS、CURB-65评分简便易行,而APACHE-Ⅱ评分则更为全面、客观,可根据临床实际情况合理选择。

关键词：预警评分慢性阻塞性肺疾病急性加重期预后预测

An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development

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Neuroscience Bulletin 2021年第8期37卷 1091-1106页

作者： Ran Zhang Hui He Bo Yuan Ziyan Wu Xiuzhen Wang Yasong du yuejun Chen Zilong Qiu Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China University of the Chinese Academy of Sciences Beijing100049China Shanghai Mental Health Center School of MedicineShanghai Jiao Tong UniversityShanghai200030China

Genetic composition plays critical roles in the pathogenesis of autism spectrum disorder(ASD).Especially,inherited and de novo intronic variants are often seen in patients with ***,the biological significance of intronic variants is difficult to ***,among a Chinese ASD cohort,we identified a recurrent inherited intronic variant in the CHD7 gene,which is specifically enriched in East Asian ***7 has been implicated in numerous developmental disorders including CHARGE syndrome and *** investigate whether the ASD-associated CHD7 intronic variant affects neural development,we established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to *** differentiation towards the forebrain neuronal lineage,we found that neural cells carrying the CHD7 intronic variant exhibited developmental delay and maturity ***,we found that TBR1,a gene also implicated in ASD,was significantly increased in neurons carrying the CHD7 intronic variant,suggesting the intrinsic relevance among ASD ***,the morphological defects found in neurons carrying CHD7 intronic mutations were rescued by knocking down TBR1,indicating that TBR1 may be responsible for the defects in CHD7-related ***,the CHD7 intronic variant generated three abnormal forms of transcripts through alternative splicing,which all exhibited loss-of-function in functional *** study provides crucial evidence supporting the notion that the intronic variant of CHD7 is potentially an autism susceptibility site,shedding new light on identifying the functions of intronic variants in genetic studies of autism.

关键词： Autism CHD7 Intronic variant Inherited variant TBR1

Convergence of Compressible Euler-Maxwell Equations to Compressible Euler-Poisson Equations

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Chinese Annals of Mathematics,Series B 2007年第5期28卷 583-602页

作者： yuejun PENG Shu WANG Laboratoire de Mathematiques CNRS UMR 6620Universite Blaise Pascal（Clermont-Ferrand 2）63177 Aubiere cedexFrance.） College of Applied Sciences Beijing University of Technology Beijing 100022China.

In this paper, the convergence compressible Euler-Poisson equations in a of time-dependent Euler-Maxwell equations to torus via the non-relativistic limit is studied. The local existence of smooth solutions to both systems is proved by using energy estimates for first order symmetrizable hyperbolic systems. For well prepared initial data the convergence of solutions is rigorously justified by an analysis of asymptotic expansions up to any order. The authors perform also an initial layer analysis for general initial data and prove the convergence of asymptotic expansions up to first order.

关键词： Euler-Maxwell equations Compressible Euler-Poisson equations Non-relativistic limit Asymptotic expansion and convergence

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白血病导致的阴茎异常勃起11例诊治

现代泌尿外科杂志 2008年第6期13卷 458-460页

作者：杜跃军谭万龙郑少斌熊林吴芃张辉见陈鹏亮南方医科大学南方医院泌尿外科广东广州510515 解放军187中心医院外一科海南海口571159

目的探讨白血病相关阴茎异常勃起的诊疗特点及预后。方法回顾性分析1992年2月至2005年1月我院11例白血病相关阴茎异常勃起患者的临床资料及随访记录。结果本组11例均为慢性粒细胞白血病(CML)。年龄18~56岁,平均23岁。阴茎异常勃起均为... 详细信息

目的探讨白血病相关阴茎异常勃起的诊疗特点及预后。方法回顾性分析1992年2月至2005年1月我院11例白血病相关阴茎异常勃起患者的临床资料及随访记录。结果本组11例均为慢性粒细胞白血病(CML)。年龄18~56岁,平均23岁。阴茎异常勃起均为低流量型,持续勃起时间8~72 h,平均25.3 h。11例经治疗后异常勃起均获缓解,其中非手术治疗4例,手术治疗7例,术后阴茎完全恢复疲软时间0~5 d,平均2.8 d。8例随访时间3~20个月,平均14.7个月,3例失随访。6例于术后7 d^5月恢复勃起功能,平均26 d,其中2例持续勃起≤12 h,3例为13~24 h,1例为25~48 h。2例术后出现勃起功能障碍,其中1例持续勃起25~48 h,1例>48 h。结论白血病导致的阴茎异常勃起以血液动力学分类主要为缺血型,为了避免阴茎缺血坏死及继发阴茎勃起障碍,应该尽可能地在24 h内采取包括外科处理、化疗及血细胞分离等有效手段解除病理性勃起状态。

关键词：阴茎异常勃起白血病

The microRNA pathway activation in insect cell model upon Autographa californica multiple nucleopolyhedrovirus infection

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BIOCELL 2023年第3期47卷 627-645页

作者： QIAOJIN JIA yuejun FU Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of BiotechnologyShanxi UniversityTaiyuan030006China Department of Medical Laboratory Science Fenyang CollegeShanxi Medical UniversityFenyang032200China

Background:The immune system of insects exerts fundamentally different antiviral mechanisms than ***(miRNAs)play vital roles in developing insect antiviral *** expression profiles of insects changed significantly during baculovirus ***:Differential expression profiles of miRNAs in Spodoptera frugiperda were monitored by next-generation sequencing(NGS)and RT-qPCR during Autographa californica multiple nucleopolyhedrovirus(AcMNPV)*** transcription levels of genes were detected by *** 50%tissue culture infective dose(TCID_(50))endpoint dilution assay was used to determine the proliferation of progeny ***:NGS revealed that 49 miRNAs were differentially expressed in Sf9 cells,and 10 of them were significantly up-or *** RT-qPCR analysis,we observed the similar trends for the expression patterns of significantly differentially expressed miRNAs from ***,the transcription levels of core genes,Exportin5,Dicer1,and Argonaute1,in miRNA biogenesis pathways were significantly increased after AcMNPV *** five selected miRNAs,miR-34-5p could regulate the proliferation of baculovirus progeny virus and energy ***:The miRNAs biogenesis pathway in Sf9 cells plays an important role and may be stimulated to resist AcMNPV *** work provides evidence for the molecular mechanism of baculovirus-insect interaction and offers novel ideas and directions for green pest control technology.

关键词： microRNAs Spodoptera frugiperda Autographa californica multiple nucleopolyhedrovirus Host-virus interaction

缺血型阴茎异常勃起的处理与预后(附14例报告)

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临床泌尿外科杂志 2008年第6期23卷 415-417,420页

作者：杜跃军谭万龙毛向明郑少斌吴芃张辉见陈鹏亮熊林南方医科大学南方医院泌尿外科广州510515 解放军第187中心医院外一科

目的：探讨缺血型阴茎异常勃起的临床特点。方法：回顾性分析14例缺血型阴茎异常勃起患者的临床资料，持续勃起时间6-168h。平均32h。非手术治疗5例。手术治疗9例。结果：术后阴茎完全恢复疲软时间0-9天，平均3．5天。11例随访3-38个月... 详细信息

目的：探讨缺血型阴茎异常勃起的临床特点。方法：回顾性分析14例缺血型阴茎异常勃起患者的临床资料，持续勃起时间6-168h。平均32h。非手术治疗5例。手术治疗9例。结果：术后阴茎完全恢复疲软时间0-9天，平均3．5天。11例随访3-38个月，7例于术后7天-5个月恢复正常勃起功能，其中3例持续勃起时间≤12h。3例为13-24h。1例为48h；4例术后仍出现勃起功能障碍，其中1例持续勃起时间为12-24h，2例为24-48h。1例〉48h。3例失访。结论：持续缺氧及酸中毒是导致缺血型阴茎异常勃起预后不良的主要原因。对于勃起时间≤24h患者，采取有效手段解除病理性勃起，可以有效避免继发不可逆转的阴茎勃起障碍；对于勃起时间〉24h患者，为避免进一步延误治疗时机，可直接选择手术治疗。

关键词：阴茎异常勃起缺血治疗预后

(Full) Leakage resilience of Fiat-Shamir signatures over lattices

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Frontiers of Computer Science 2022年第5期16卷 181-191页

作者： yuejun LIU Yongbin ZHOU Rui ZHANG Yang TAO State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijing 100093China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China

Fiat-Shamir is a mainstream construction paradigm of lattice-based signature *** its theoretical security is well-studied,its implementation security in the presence of leakage is a relatively under-explored ***,even some side-channel attacks on lattice-based Fiat-Shamir signature(FS-Sig)schemes have been proposed since 2016,little work on the leakage resilience of these schemes *** still,the proof idea of the leakage resilience of FS-Sig schemes based on traditional number-theoretic assumptions does not apply to most lattice-based FS-Sig *** this,we propose a framework to construct fully leakage resilient lattice-based FS-Sig schemes in the bounded memory leakage(BML)*** framework consists of two *** first part shows how to construct leakage resilient FS-Sig schemes in BML model from leakage resilient versions of nonlossy or lossy identification schemes,which can be instantiated based on lattice *** second part shows how to construct fully leakage resilient FS-Sig schemes based on leakage resilient ones together with a new property called state *** show almost all lattice-based FS-Sig schemes have this *** a concrete application of our fundamental framework,we apply it to existing lattice-based FS-Sig schemes and provide analysis results of their security in the leakage setting.

关键词： leakage resilience lattice-based signatures FiatShamir paradigm side-channel attacks post-quantum cryptography