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Optical Properties of Ca_(0.25)Ba_(0.75)Nb_2O_6 Thin Films Prepared by Spinning Coating

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Journal of Materials Science & Technology 2011年第9期27卷 821-825页

作者： yuehua Wang Min zhang Xinyin Zhao Na Zhao Department of Physics China University of Mining and Technology Xuzhou 221116 China

Ca0.25Ba0.75Nb2O6 （CBN25） thin film was prepared on quartz substrate by spinning coating and the optical properties were investigated by a Hitachi U-3410 spectrophotometer and a Metricon 2010 prism coupler. The optical band gap, thickness and refractive index at 632.8 nm of the CBN25 thin film were determined to be 3.65 eV, 529 nm and 2.2258, respectively. The dispersion of the refractive index fitted to Sellmeier relation well and optical waves could be guided into the thin film, which implied that CBN25 thin films were promising for integrated optics and optically active devices.

关键词： Ca0.25Ba0.75Nb2O6 Optical property Spinning coating

All-in-one functional supramolecular nanoparticles based on pillar[5]arene for controlled generation,storage and release of singlet oxygen

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Frontiers of Chemical Science and Engineering 2023年第3期17卷 307-313页

作者： Bing Lu Zhecheng zhang Meiyu Qi yuehua zhang Hualing Yang Jin Wang Yue Ding Yang Wang Yong Yao College of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China

The storage and controlled release of singlet oxygen(^(1)O_(2))have attracted increasing attention due to the wide application and microsecond lifetime of^(1)O_(2)in *** we provide an integrated nanoplatform consisting of a diphenylanthracene derivative,a water-soluble pillar[5]arene and a photosensitizer tetrakis(4-hydroxyphenyl)porphyrin(TPP),that may provide the controlled generation,storage and release of singlet *** design a new diphenylanthracene derivative with two trimethylammonium bromide groups on both ends that can be well recognized by the pillar[5]*** formed nanocarriers can be used to load TPP through their supramolecular *** resulting nanoparticles show good water-solubility and uniform spherical *** laser irradiation(660 nm),the nanoparticles exhibit excellent ability for the generation and storage of^(1)O_(2).When the irradiated nanoparticles are heated above 80°C,^(1)O_(2)can be released from the ***,in this paper we pioneer the use of noncovalent interaction to integrate the diphenylanthracene derivatives and photosensitizers into one functional system,which provides a new strategy for the controlled generation,storage and release of singlet *** believe this groundbreaking strategy will have a great potential in providing necessary amounts of^(1)O_(2)for the photodynamic therapy of tumors in dark.

关键词： storage and controlled release of singlet oxygen supramolecular nanoparticles noncovalent interactions pillararenes diphenylanthracene photosensitizers

Long noncoding RNA LINC01124 activates hepatocellular carcinoma cell proliferation, migration, and invasion by absorbing microRNA-1247-5p and overexpressing FOXO3

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Oncology Research 2021年第3期29卷 175-187页

作者： LEI SUN YUE zhang YUQIN YAO HONGLIN DU yuehua zhang AIPING FANG Department of Geriatric Medicine West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu610041China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China Department of Hepatobiliary and Pancreas Surgery Second Clinical Medical College of Jinan University(Shenzhen People’s Hospital)ShenzhenChina Respiratory Disease Research Center West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu610041China

Long intergenic non-protein coding RNA 1124(LINC01124)has been identified as an important regulator of non-small-cell lung ***,the expression and detailed role of LINC01124 in hepatocellular carcinoma(HCC)remain unestablished to ***,this study aimed to elucidate the role of LINC01124 in the aggressiveness of HCC cells and identify the underlying regulatory *** reverse transcriptase-polymerase chain reaction was performed to measure the expression of LINC01124 in *** Counting Kit-8 assay,Transwell cell migration and invasion assays,and a xenograft tumor model were used to investigate the function of LINC01124 in HCC cells,and bioinformatics analysis,RNA immunoprecipitation,luciferase reporter assay,and rescue experiments were used to elucidate the underlying ***,LINC01124 overexpression was confirmed in HCC tissues as well as cell ***,the downregulation of LINC01124 decreased HCC cell proliferation,migration,and invasion in vitro,whereas the upregulation of LINC01124 triggered the opposite ***,LINC01124 ablation impaired tumor growth in *** analyses revealed that LINC01124 functions as a competing endogenous RNA to sponge microRNA-1247-5p(miR-1247-5p)in HCC ***,forkhead box O3(FOXO3)was identified as a direct target of ***3 was positively regulated by LINC01124 in HCC cells through the sequestration of ***,rescue assays revealed that the inhibition of miR-1247-5p or overexpression of FOXO3 reversed the effects of LINC01124 silencing on the HCC cell malignant *** summary,LINC01124 plays a tumor-promoting role in HCC by regulating the miR-1247-5p-FOXO3 *** LINC01124-miR-1247-5p-FOXO3 pathway may provide a foundation for the identification of alternative therapies for HCC.

关键词： HCC Competing endogenous RNA theory Anticancer treatments

Icing on the cake: combining a dual PEG-functionalized pillararene and an A-D-A small molecule photosensitizer for multimodal phototherapy

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Science China Chemistry 2022年第6期65卷 1134-1141页

作者： Bing Lu Zhecheng zhang Yangchaowei Ji Shide Zhou Boyu Jia yuehua zhang Jin Wang Yue Ding Yang Wang Yong Yao Xiaowei Zhan College of Chemistry and Chemical Engineering Nantong UniversityNantong226019China School of Materials Science and Engineering Peking UniversityBeijing100871China

The design of photosensitizers with multimodal antitumor activity and the construction of nanocarriers with specific targeting are two magic weapons to achieve highly efficient tumor phototherapy. Here we developed an A-D-A fused-ring conjugated small molecule photosensitizer DPIC and proposed a new strategy of constructing phototherapy agents, namely using supramolecular vesicles constructed by the self-assembly of a novel dual PEG-functionalized pillararene WP5-2 PEG to load DPIC. These new nanocarriers had excellent water solubility and drug encapsulation rates. The prepared DPIC NPs had a better water solubility compared with DPIC molecules and had a uniform hollow spherical morphology, which is beneficial for cell endocytosis. Under laser irradiation(808 nm), the DPIC NPs had a photothermal conversion efficiency(PTCE) of 55% and a PTCE of 49% under980-nm laser irradiation. The DPIC NPs also displayed dual type I and type II photodynamic activity. DPIC NPs had superior biocompatibility and stability and can also inhibit tumor growth in vitro and in vivo, demonstrating their potential for highly efficient cancer phototherapy.

关键词： A-D-A small molecule photosensitizer amphiphilic pillararene supramolecular vesicle photothermal therapy photodynamic therapy

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Structural diversity and reactivity of d^(10) metal-(4-pyridylthio)acetate system

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Chinese Science Bulletin 2009年第23期54卷 4277-4284页

作者： zhang yuehua WANG Jing ZHENG LingLing HU Sheng LIN ZhuoJia TONG MingLiang Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education State Key Laboratory of Optoelectronic Materialsand Technologies School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China

The hydrothermal synthesis and crystal structures of four coordination polymers, namely, 2D [Zn(μ3-ta)(pytaH)]n (1), 2D [Zn(μ3-pyta)Cl]n (2), 1D [Cd(μ-pyta)2(H2O)]n (3), and 3D [Cd(μ3-pyta)(μ-Cl)]n (4) (pyta = (4-pyridylthio)acetate, ta = thioglycolate), are reported. They are based on (4-pyridylthio)acetate and its derived ligand. The ta2ligand present in 1 was generated from an in situ C(sp2)-S bond cleavage of the pyta ligand. In these compounds, versatile intermolecular interactions, such as close S…S interactions and strong (O―H…O/N/S) or weak (C―H…O/S, C―H…Cl) hydrogen bonding interactions, play an important role in the formation of three-dimensional supramolecular networks in the solid state.

关键词：晶体结构醋酸多样性氢键相互作用反应金属系统水热合成

Effective treatment of NR2F1-related epilepsy with perampanel

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Acta Epileptologica 2023年第4期6卷 238-255页

作者： Xiao Li Kai Gao Yutang Li yuehua zhang Han zhang Yuwu Jiang Department of Pediatrics Peking University First HospitalBeijing100034China Beijing Key Laboratory of Molecular Diagnosis and Study On Pediatric Genetic Diseases Beijing100034China Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijing100034China Institute for Brain Disorders Beijing100034China Rehabilitation Department Women and Children’sHealth Care Hospital of Yantai ZhifuYantai264000China

Background NR2F1 mutations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome(BBSOAS).Although~46.7%of BBSOAS patients present with epilepsy,which is always drug-resistant and associated with higher rates of behavioral and cognitive problems,the treatment and outcomes of NR2F1-related epilepsy have rarely been ***,we present new cases of BBSOAS-related epilepsy and summarize all previously reported cases to explore the effective treatment for this type of *** We identified six new Chinese cases of BBSOAS with *** different de novo heterozygous NR2F1 mutations were identified in these cases,including two novel mutations c.365G>T,***122Phe and c.449G>T,*** combining the six cases and 14 previously reported cases,we analyzed the characteristics and treatment outcomes of NR2F1-related *** Twelve of the 20 patients(60%)had infantile epileptic spasms,while the other patients had generalized tonic/tonic-clonic,focal,myoclonic,absence,or unclassified *** anti-seizure medications,steroids,and a ketogenic diet were administered in these ***,seizures were controlled in only 50%of previously reported cases,while all of the six new cases became seizure-free after perampanel as an add-on *** average time from the addition of perampanel to seizure control was 7.33±4.59 months(range,1–12 months).The median time to seizure freedom was 14 months(1–32 months,>19 months in 3 cases).The average dosage of perampanel needed for epilepsy control was 0.22±0.17 mg/kg per *** In this paper,we comprehensively summarized the clinical characteristics,treatments and outcomes of NR2F1-related epilepsy for the first *** exhibits dramatic efficacy for NR2F1-related *** will help optimize the treatment of this type of epilepsy and provide clues for its pathogenic *** two novel mutations expand the genotype spectrum of this disease.

关键词： NR2F1 Epilepsy Bosch-Boonstra-Schaaf optic atrophy syndrome Perampanel Infantile spasm

RHOBTB2 gene associated epilepsy and paroxysmal movement disorder:two cases report and literature review

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Acta Epileptologica 2021年第1期3卷 126-133页

作者： Xueyang Niu Yan Sun Ying Yang Miaomiao Cheng Quanzhen Tan Jie zhang yuehua zhang Department of Pediatrics Peking University First HospitalBeijing 100034China Department of Neurology Pediatric Patients’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001China

Background:RHOBTB2 gene is associated with developmental and epileptic encephalopathy-64(DEE-64),which is characterized by epilepsy,developmental delay,microcephaly,unspecific facial dysmorphism,and paroxysmal movement *** previous studies showed that the phenotypes of RHOBTB2 gene include developmental and epileptic encephalopathy(DEE)and DEE with paroxysmal movement *** one study showed that patient with RHOBTB2 variant had paroxysmal movement disorders with no *** presentations:Two cases with RHOBTB2 variants are presented here:Case one was diagnosed as DEE,he had recurrent afebrile focal status epilepticus and paroxysmal extrapyramidal symptoms in *** electroencephalogram(EEG)showed focal *** magnetic resonance imaging(MRI)showed cortical *** of case one was ***,case two only showed paroxysmal movement disorders alone in *** EEG showed focal discharges during an interictal dystonic episode and he brain MRI was ***:The phenotypes of RHOBTB2 gene include DEE,paroxysmal movement disorders,and DEE with paroxysmal movement ***2 can be one of the pathogenic genes of paroxysmal movement disorders.

关键词： RHOBTB2 Gene Epilepsy Paroxysmal movement disorders

Discovery of spirooxindole-ferrocene hybrids as novel MDM2 inhibitors

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Chinese Chemical Letters 2021年第6期32卷 1897-1901页

作者： Jun Mu Xin Xie Shanshan Xiong yuehua zhang Yuting Wang Qian Zhao Hongping Zhu Wei Huang Gu He State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese MedicineSchool of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

A series of spirooxindole-ferrocene hybrids bearing five or four contiguous chiral centers were designed and synthesized via *** vitro protein binding and cellular proliferation assays suggested that compound 5 d was the most potent mouse double minute 2 homolog(MDM2)*** addition,mechanistic studies indicated that compound 5 d suppressed MDM2-mediated p53 degradation,induced apoptosis and promoted oxidative *** docking studies have suggested that 5 d binds to MDM2 by mimicking the Trp23 and Leu26 residues of *** work can provide a basis for the development of novel multifunctional MDM2 *** further exploration of more derivatives from this library and additional investigation of organocatalysis application in the development of new molecules may generate new potential lead compounds for cancer-targeted therapy.

关键词： Spirooxindole Ferrocene MDM2 Apoptosis Breast cancer

Study　on　Sythesis　of　Crosslinked　Chitosan　Prolymer　and　Its　Use　in　the　Removal　of　Urea

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Chinese Journal of Reactive Polymers 1994年第1期3卷 47-53页

作者： zhang yuehua zhang Yan He Binglin Institute of Polymer Chemistry Nankai University Tianjin 300071P.R. China

A novel bead form of ploymer of high sorption capacity for urea were obtained by the reaction of glutaric dialdehyde wigh chitosan dispersed in acetic acid solution. The sorption capacity reached ￣ 82.0 mg / g sorbent at 37℃ and pH 7.4 The concentration of urea in the buffer solution was 1300 mg/ L. The sorption of urea was related to the degree of crosslinking of the sorbent, concentration ofurea, ionic strength and temperature.

关键词： Novel sobent, Chitosan Removal of urea.