Icing on the cake: combining a dual PEG-functionalized pillararene and an A-D-A small molecule photosensitizer for multimodal phototherapy

作     者：Bing Lu Zhecheng Zhang Yangchaowei Ji Shide Zhou Boyu Jia Yuehua Zhang Jin Wang Yue Ding Yang Wang Yong Yao Xiaowei Zhan Bing Lu;Zhecheng Zhang;Yangchaowei Ji;Shide Zhou;Boyu Jia;Yuehua Zhang;Jin Wang;Yue Ding;Yang Wang;Yong Yao;Xiaowei Zhan

作者机构：College of Chemistry and Chemical EngineeringNantong UniversityNantong226019China School of Materials Science and EngineeringPeking UniversityBeijing100871China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2022年第65卷第6期

页      面：1134-1141页

核心收录：

学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (21801139, 21871227) the Innovation and Entrepreneurship Program of Jiangsu Province (JSSCBS20211106) 

主　　题：A-D-A small molecule photosensitizer amphiphilic pillararene supramolecular vesicle photothermal therapy photodynamic therapy 

摘      要：The design of photosensitizers with multimodal antitumor activity and the construction of nanocarriers with specific targeting are two magic weapons to achieve highly efficient tumor phototherapy. Here we developed an A-D-A fused-ring conjugated small molecule photosensitizer DPIC and proposed a new strategy of constructing phototherapy agents, namely using supramolecular vesicles constructed by the self-assembly of a novel dual PEG-functionalized pillararene WP5-2 PEG to load DPIC. These new nanocarriers had excellent water solubility and drug encapsulation rates. The prepared DPIC NPs had a better water solubility compared with DPIC molecules and had a uniform hollow spherical morphology, which is beneficial for cell endocytosis. Under laser irradiation(808 nm), the DPIC NPs had a photothermal conversion efficiency(PTCE) of 55% and a PTCE of 49% under980-nm laser irradiation. The DPIC NPs also displayed dual type I and type II photodynamic activity. DPIC NPs had superior biocompatibility and stability and can also inhibit tumor growth in vitro and in vivo, demonstrating their potential for highly efficient cancer phototherapy.