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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He Jinlin Song Min Hu yuehua liu Yan liu Jie Guo Fang Jin Yang Cao lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang li Rui Zou Yulou Tian li Gao Rui Shu Jianwei Chen Renkai liu Shujuan Zou Xiaobing li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

Heritable Targeted Inactivation of Myostatin Gene in Yellow Catfish(Pelteobagrus fulvidraco) Using Engineered Zinc Finger Nucleases

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Heritable Targeted Inactivation of Myostatin Gene in Yellow ...

SEI/dead li-turning capacity loss for high-performance anode-free solid-state lithium batteries

第十届中国实验动物科学年会

作者： Zhangji Dong Jiachun Ge Kui li Zhiqiang Xu Dong liang Jingyun li Junbo li Wenshuang Jia yuehua li Xiaohua Dong Shasha Cao Xiaoxiao Wang Jianlin Pan Qingshun Zhao Model Animal Research Center MOE Key Laboratory of Model Animal for Disease StudyNanjing University Freshwater Fisheries Research Institute of Jiangsu Province NanjingChina College of life Sciences Nanjing Normal University Freshwater Fisheries Research Institute of Jiangsu Province

Yellow catfish(Pelteobagrus fulvidraco) is one of the most important freshwater aquaculture species in ***,its small size and lower meat yield limit its edible ***(MSTN) is a negative regulator of mammalian muscle ***,the function of Mstn in fish remains *** explore roles of mstn gene in fish growth and create a strain of yellow catfish with high amount of muscle mass,we performed targeted disruption of mstn in yellow catfish using engineered zinc-finger nucleases (ZFNs).Employing zebrafish embryos as a screening system to identify ZFN activity,we obtained one pair of ZFNs that can edit mstn in yellow catfish *** the ZFNs,we successfully obtained two founders(Founder July29-7 and Founder July29-8) carrying mutated mstn gene in their germ *** mutated mstn allele inherited from Founder July29-7 was a null allele (mstn) containing a 4 bp insertion,predicted to encode function null *** mutated mstn inherited from Founder July29- 8 was a complex type of mutation(mstn),predicted to encode a protein lacking two amino acids in the N-terminal secretory signal of ***,we obtained 6 mstn and 14 mstn yellow *** our best knowledge,this is the first endogenous gene knockout in aquaculture *** result will help in understanding the roles of mstn gene in fish.

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu li Hongzhang Zhang Guiming Zhong Xiaofei Yang Xianfeng li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical liPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead li

淀粉品种对淀粉与PVA混合浆相分离行为的影响

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棉纺织技术 2000年第9期28卷 24-27页

作者：祝志峰李跃华武汉大学湖北省纺织服装工业学校

以初显分离时间和沉降率为量化指标 ,选择木薯、玉米及小麦三种原淀粉 ,定量研究了淀粉品种对淀粉与PVA 1 799及PVA 1 788混合浆的相分离行为的影响。实验结果表明 :淀粉品种和混合比例对混合浆液的相分离行为有显著影响 ,而PVA醇解度... 详细信息

以初显分离时间和沉降率为量化指标 ,选择木薯、玉米及小麦三种原淀粉 ,定量研究了淀粉品种对淀粉与PVA 1 799及PVA 1 788混合浆的相分离行为的影响。实验结果表明 :淀粉品种和混合比例对混合浆液的相分离行为有显著影响 ,而PVA醇解度的影响则相对较小 ;按小麦淀粉、玉米淀粉、木薯淀粉的顺序 ,混合浆相分离速度逐渐降低 ;随着混合浆中淀粉含量的改变 ,其相分离速度呈“U”形变化特性 ,变化趋势随小麦淀粉、玉米淀粉、木薯淀粉这一顺序加强。

关键词：淀粉浆料聚乙烯醇相分离相分离速度

Theoretical Design of Defects as a Driving Force for Ion Transport in li3OBr Solid Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 147-157页

作者： Xingyun Luo Yanlu li Xian Zhao State Key Lab of Crystal Materials and Institute of Crystal Materials Shandong University Center for Optics Research and Engineering Shandong University

Due to ever-increasing concerns about safety issues in using li ionic batteries,solid electrolytes have extensively *** li-rich antiperovskite li3OBr has been considered as a promising solid electrolyte candidate,but it still suffers challenges to achieve a high ionic conductivity owing to the high intrinsic symmetry of the crystal ***,we presented a design strategy that introduces various point defects and grain boundaries to break the high lattice symmetry of li3OBr crystal,and their effect and microscopic mechanism of promoting the migration of li-ion were explored *** has been found that liiare the dominant defects responsible for the fast li-ion diffusion in bulk li3OBr and its surface,but they are easily trapped by the grain boundaries,leading to the annihilating of the Frenkel defect pair V'li+li,and thus limits the V'lidiffusion at the grain *** VBrdefect near the grain boundaries can effectively drive V'liacross the grain boundary,thereby converting the carrier of li+migration from li,in the bulk and surface to V'liat the grain boundary,and thus improving the ionic conductivity in the whole li3OBr *** work provides a comprehensive insight into the li+transport and conduction mechanism in the li3OBr *** opens a new way of improving the conductivity for all-solid-state li electrolyte material through the defect design.

关键词： defects density functional theory ionic migration solid electrolyte

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肥大细胞在神经纤维瘤中的作用及机制

中华整形外科杂志 2023年第4期39卷 446-450页

作者：李悦华李青峰王智超上海交通大学医学院附属第九人民医院整复外科上海200011

Ⅰ型神经纤维瘤病是因NF1基因突变,其编码的神经纤维蛋白功能失活,过度激活下游RAS通路而使神经嵴细胞发育异常导致的多系统损害性疾病,主要临床表现包含牛奶咖啡斑和多发性和(或)持续增长性神经纤维瘤。随着对神经纤维瘤的深入研究,肥... 详细信息

Ⅰ型神经纤维瘤病是因NF1基因突变,其编码的神经纤维蛋白功能失活,过度激活下游RAS通路而使神经嵴细胞发育异常导致的多系统损害性疾病,主要临床表现包含牛奶咖啡斑和多发性和(或)持续增长性神经纤维瘤。随着对神经纤维瘤的深入研究,肥大细胞在肿瘤微环境中的作用越来越受到关注。该文就肥大细胞在神经纤维瘤中的作用及机制做了总结阐述,期待有助于进一步寻找到临床上治疗神经纤维瘤的有效靶点。

关键词：神经纤维瘤肥大细胞作用机制信号通路

不同pH条件下三氯乙烯及其脱氯产物对苯或甲苯厌氧生物降解的影响

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环境科学学报 2016年第8期36卷 2917-2923页

作者：陈亮刘玉龙李月华刘菲天津大学水利工程仿真与安全国家重点实验室建筑工程学院天津300072 中国石油集团安全环保技术研究院北京102206 天津大学环境科学与工程学院天津300072 中国地质大学(北京)水资源与环境工程北京市重点实验室北京100083

将零价铁渗透反应格栅和生物降解格栅联用,先利用氯代烃易还原脱氯的性质通过零价铁渗透反应格栅去除氯代烃,后利用BTEX易生物降解的性质通过生物降解格栅去除BTEX,可以有效去除地下水中由氯代烃和BTEX这两种性质迥异的污染物形成的混... 详细信息

将零价铁渗透反应格栅和生物降解格栅联用,先利用氯代烃易还原脱氯的性质通过零价铁渗透反应格栅去除氯代烃,后利用BTEX易生物降解的性质通过生物降解格栅去除BTEX,可以有效去除地下水中由氯代烃和BTEX这两种性质迥异的污染物形成的混合污染羽.但在联合格栅技术中,零价铁渗透反应格栅后的强碱性环境(pH>9)、氯代烃脱氯还原中间产物(cis-1,2-DCE)的积累和可能出现的TCE穿透均可对生物降解格栅中BTEX的生物降解产生影响.针对上述问题,本文研究了不同pH条件下TCE和cis-1,2-DCE对苯或甲苯厌氧生物降解的影响.结果发现,碱性pH条件有利于苯或甲苯的生物降解,但不同pH条件下TCE或cis-1,2-DCE的加入对苯或甲苯的生物降解均产生抑制(除pH=7.9,cis-1,2-DCE=100μg·L-1时的甲苯),且TCE对苯和甲苯生物降解的抑制要明显强于cis-1,2-DCE;不同pH条件下,TCE 100和500μg·L-1对苯生物降解的抑制作用没有明显差异,但对甲苯生物降解的抑制却随着TCE浓度的增加而增加;pH=7.9时,cis-1,2-DCE的加入有利于甲苯的生物降解,之后随着pH的增加又转变为抑制.另外,在苯或甲苯厌氧生物降解过程中,可能存在cis-1,2-DCE与苯或甲苯的共代谢生物降解,且甲苯更有利于cis-1,2-DCE的共代谢降解.

关键词：生物降解苯系物氯代烃 pH 地下水

氮掺杂石墨烯负载八面体氧化亚铜复合材料的制备及其电催化性能

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化工进展 2017年第9期36卷 3316-3322页

作者：李月华张蓉姜孟秀王文洋太原理工大学化学化工学院山西太原030024

采用改良的Hummers方法制备出氧化石墨烯(GO),接着利用氮气流通过浓氨水将氨气载入管式炉中,与氧化石墨烯混合。在此过程中,氧化石墨烯表面的含氧官能团发生分解、脱离形成活性中心,与浓氨水发生相互作用,从而实现氮的掺杂,同时氧化石... 详细信息

采用改良的Hummers方法制备出氧化石墨烯(GO),接着利用氮气流通过浓氨水将氨气载入管式炉中,与氧化石墨烯混合。在此过程中,氧化石墨烯表面的含氧官能团发生分解、脱离形成活性中心,与浓氨水发生相互作用,从而实现氮的掺杂,同时氧化石墨烯在高温下被还原成石墨烯,最终形成氮掺杂石墨烯N-rGO。采用化学沉淀法将N-rGO与硫酸铜溶液混合,在还原剂水合肼的作用下八面体氧化亚铜被负载到氮掺杂石墨烯上形成复合材料Cu_2O-N-rGO。通过XRD、SEM和XPS手段对其进行表征分析,结果表明氮原子在石墨烯骨架上以吡咯氮、吡啶氮和石墨氮的形式存在,形成的八面体氧化亚铜被均匀地负载到N-rGO表面。采用循环伏安法和计时电流法对该复合材料Cu_2O-N-rGO的催化性能进行测试,实验结果表明,合成的复合材料Cu_2O-N-rGO对葡萄糖和过氧化氢有良好的催化性能。

关键词：电化学催化纳米粒子氮掺杂石墨烯八面体氧化亚铜葡萄糖过氧化氢

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食管癌患者术后乳糜胸发生情况及其影响因素

河南医学研究 2024年第4期33卷 582-585页

作者：李悦华贾佳吴倩邹其云刘宝兴河南省肿瘤医院胸外二病区河南郑州450000

目的探寻可能影响食管癌患者术后发生乳糜胸的因素,旨在降低临床食管癌患者术后乳糜胸发生风险。方法纳入医院2019年1月至2021年12月收治的830例食管癌患者,依据患者术后有无发生乳糜胸进行分组。对比发生组与未发生组基线资料,探寻食... 详细信息

目的探寻可能影响食管癌患者术后发生乳糜胸的因素,旨在降低临床食管癌患者术后乳糜胸发生风险。方法纳入医院2019年1月至2021年12月收治的830例食管癌患者,依据患者术后有无发生乳糜胸进行分组。对比发生组与未发生组基线资料,探寻食管癌患者术后发生乳糜胸的影响因素。结果830例食管癌患者中,术后发生乳糜胸30例,占比3.61%(30/830),将其纳入发生组;术后未发生乳糜胸800例,占比96.39%(800/830),将其纳入未发生组;发生组肿瘤直径(≥5 cm)、肿瘤病灶位置(中上段)、纵膈淋巴结肿大(是)、肿瘤分期(≥Ⅲ期)占比均高于未发生组(P1,P<0.05)。结论肿瘤直径≥5 cm、肿瘤病灶位置处于中上段、纵膈淋巴结肿大及肿瘤分期≥Ⅲ期均是影响食管癌患者术后乳糜胸发生的因素,针对合并上述危险因素患者,临床可制定针对性干预手段,以降低食管癌患者术后乳糜胸发生风险。

关键词：食管癌乳糜胸影响因素