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Influence of Hypertension, Lipometabolism Disorders,Obesity and Other Lifestyles on SpontaneousIntracerebral Hemorrhage

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Biomedical and Environmental Sciences 2003年第3期16卷 295-303页

作者： JUN-FUZHOU JI-yuewang YAN-ERLUO HUAI-HONGCHEN SecondAffiliatedHospitalofCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina AffiliatedChildren‘sHospital MedicalCollegeZhejiangUniversity57ZhuganLaneHangzhou310003ZhejiangChina FuyangMunicipalHospitalofTraditionalChineseMedicine 4BeimenRoadFuyang311400ZhejiangChina BrainMedicineResearchInstituteofZhejiangUniversity 88JiefangRoadHangzhou310009ZhejiangChina

Objective To investigate whether hypertension, abnormal lipometabolism, obesity, cigarette smoking and alcohol drinking affect the intracerebral hemorrhagic volumes (IHV) in patients with spontaneous intracerebral hemorrhage (SIHP), and to explore the roles of these factors in spontaneous intracerebral hemorrhage (SIH). Methods Five hundred patients with acute SIH and 200 healthy adult volunteers (HAV) were enrolled in a study of independently randomized controlled design, in which the levels of systolic pressure (SP) and diastolic pressure (DP), and total cholesterol (TCH), triacylglycerols (triglycerides, TG), high density lipoprotein cholesterol (HDL-CH), low density lipoprotein cholesterol (LDL-CH) in serum as well as the level of erythrocytic membrane cholesterol (EM-CH) were measured, and the body mass index (BMI), daily cigarette smoking consumption (DCSC) and daily pure alcohol consumption (DPAC) were calculated. Results Compared with the average parameters in the HAV group, those of SP, DP, TG, LDL-CH and BMI in the SIHP group were significantly increased (P<0.0001), while those of HDL-CH and EM-CH were significantly decreased (P<0.0001). The linear regression and correlation analysis showed that with increased SP, DP, LDL-CH, BMI, DCSC, DPAC and aging as well as decreased HDL-CH and EM-CH, the IHV levels in SIHP were increased gradually (P<0.0001-0.01). The linear stepwise regression analysis suggested that there existed a close correlation among the values of SP, DP, TCH, TG, HDL-CH, LDL-CH, EM-CH, BMI, DCSC, DPAC, age and fflV of the SIH patients, and that Y = - 12.4583 + 0.1127SP -1.1977EM-CH + 0.9788LDL-CH + 0.2477BMI + 0.0382DCSC + 0.0248DP,P<0.0001-0.05. Conclusions The findings in the present study suggest that significantly increased systolic and diastolic pressure, low density lipoprotein cholesterol, body mass index and daily cigarette smoking consumption, and significantly decreased erythrocytic membrane cholesterol may be likely the main factor

关键词： Blood pressure Lipids Cigarette smoking Alcohol drinking Body mass index Spontaneous intracerebral hemorrhage Intracerebral hemorrhagic volume

May Chronic Childhood Constipation Cause Oxidative Stress and Potential Free Radical Damage to Children?

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Biomedical and Environmental Sciences 2004年第3期17卷 266-272页

作者： JI-yuewang YE-LINGWANG SHENG-LIZHOU JUN-FUZHOU SecondAffiliatedHospitalCollegeofMedicine ZhejiangUniversity88JiefangRoadHangzhou310009ZhejiangChina AffiliatedChildren＇sHospital CollegeofMedicineZhejiangUniversity57ZhuganLaneHangzhou310003ZhejiangChina

Objective To investigate whether chronic childhood constipation (CCC) may cause oxidative stress and potential free radical damage to children, and to explore the mechanisms by which CCC may cause oxidative stress and potential free radical damage to chronic constipation patients (CCPs). Methods Sixty CCPs and sixty healthy child volunteers (HCVs) whose ages, gender and others were matched for the CCPs were enrolled in a randomized controlled study, in which levels of vitamin C (VC) and vitamin E (VE) in plasma as well as activities of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes were determined by spectrophotometric analytical methods. Results Compared with average values of the above biochemical parameters in the HCVs group, the average values of VC and VE in plasma as well as those of SOD and CAT in erythrocytes in the CCPs group were significantly decreased (P<0.0001). Linear regression and bivariate correlation analysis showed that with prolonged course of the CCPs, the levels of VC and VE in plasma as well as the activities of SOD and CAT in erythrocytes in the CCPs were decreased gradually (P<0.0001). Conclusion The findings in the present study suggest that chronic childhood constipation causes oxidative stress and potential free radical damage to children with chronic constipation.

关键词： Chronic childhood constipation Oxidative stress Free radicals Free radical damage Antioxidant Antioxidase

Structural evolution of layered oxide cathodes for spent Li-ion batteries:Degradation mechanism and repair strategy

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SusMat 2023年第3期3卷 362-378页

作者： Shan Jin Jianquan Liang Deying Mu Tianning Lin Yuyang Tian Jian Zhang yuewang Meng Chen Qingmo Shi Changsong Dai MIIT Key Laboratory of CriticalMaterials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinChina State Grid Heilongjiang Electric Power Co. Ltd.Electric Power Research InstituteHarbinChina Dongying Cospower Technology Co. Ltd.DongyingChina

Sustainable development has long been recognized as one of the most critical issues in today’s energy and environment-conscious *** has never been more urgent to recycle and reuse the end-of-life cathode ***,this work systematically investigates the structure-critical degradation mechanism of polycrystalline LiNi_(x)Co_(y)Mn_(1−x−y)O_(2)(NCM),combining experimental characterization and DFT *** the key degradation factors,a synergistic repair strategy based on deep mechanochemical activation and heat treatment was successfully proposed to direct regenerate the *** indicate the induction and promotion of synergistic repair technique on the reconstruction of particlemorphology,the recovery of the chemical composition and crystal structure,and the favorable transformation of the impurities phase in the failed *** particular,the synergistic repair process induces a gradient distribution of LiF and further enables partial fluorine doping into the NCM surface,forming abundant oxygen vacancies and increasing the content of highly reactive Ni2+.Benefiting from the comprehensive treatment for the multi-scale and multi-form degradation behaviors,the repaired material exhibits a capacity of 176.8 mA h g^(-1)at 0.1 C,which is comparable to the corresponding commercial material(172.8 mA h g^(-1)).The satisfactory capacity of the recovered cathode proves that it is an effective direct renovating strategy.

关键词： cathode material degradation mechanism impurity phase transformation spent lithium-ion batteries synergistic repair strategy

Potential oxidative stress in children with chronic constipation

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World Journal of Gastroenterology 2005年第3期11卷 368-371页

作者： Jun-FuZhou Jian-GuoLou Sheng-LiZhou Ji-yuewang SecondHospital CollegeofMedicineZhejiangUniversityHangzhou310009ZhejiangProvinceChina Children'sHospital CollegeofMedicineZhejiangUniversityHangzhou310003ZhejiangProvinceChina

AIM: To investigate the potential oxidative stress in children with -chronic constipation and to explore its ***: Seventy children with chronic constipation and 70 age- and sex-matched healthy children were enrolled in a randomized controlled study. Plasma levels of vitamins C and E, activities of superoxide dismutase and catalase and lipoperoxide level in erythrocytes were determined by ***: Compared with healthy children whose vitamin C,vitamin E, superoxide dismutase, catalase and lipoperoxide were 58.35±14.42 μmol/L, 27.15±6.55 μmol/L, 2 206±171U/(g· Hb), 327.3±82.2 K/(g·Hb) and 19.18±4.27 nmol/(g·Hb)respectively, the levels of vitamin C, vitamin E, the activity of superoxide dismutase, and catalase in the children with chronic constipation significantly decreased [46.59±11.51 μmol/L,20.65±4.80 μmol/L, 1943±147 U/(g·Hb) and 269.3±67.8 K/(g·Hb),respectively P＜0.01], while the lipoperoxide significantly increased [25.22±5.01 nmol/(g·Hb), P＜0.01]. With a prolonged course of disease, the levels of vitamin C, vitamin E, the activity of superoxide dismutase and catalase in the children with chronic constipation gradually decreased,while the level of lipoperoxide gradually ***: Chronic constipation can cause potential oxidative stress in children.

关键词： Chronic constipation Potential oxidative stress Spectrophotometry

Recurrent Viral Infections Complicated with Cold Agglutinin Disease after Splenectomy for Thrombocytopenia

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Chinese Medical Journal 2018年第2期131卷 249-250页

作者： Hui-Ping Shi Zhao-yuewang Department of Hematology MOH Key Lab of Thrombosis and Hemostasis Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou Jianqsu 215006 China Collaborative Innovation Center of Hematology Soochow University Suzhou Jiangsu 215006 China

To the Editor： Childhood splenectomy exposes patients to increased risk of bacterial infections. Appropriate vaccination and education have helped combat these; however, insufficient attention is paid to viral infections atter splenectomy. Herein, we report a case of cold agglutinin disease （CAD） caused by recurrent viral infections after splenectomy to treat childhood immune thrombocytopenic purpura （1TP）. Antiviral and immunostimulant therapies were administered, resulting in an improved general condition.

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Dynamic changes in the expression of matrix metalloproteinases and their inhibitors,TIMPs,during hepatic fibrosis induced by alcohol in rats

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World Journal of Gastroenterology 2004年第24期10卷 3621-3627页

作者： Guang-FuXu Peng-TaoLi Xin-yuewang XuJia De-LuTian Liang-DuoJiang Jin-XiangYang DepartmentofinfectiousDiseases 1^stAffiliatedDongzhimenHospitalBeijingUniversityofTraditionalChineseMedicineBeijing100700China DepartmentofDigestiveDiseases 1^stAffiliatedDongzhimenHospitalBeijingUniversityofTraditionalChineseMedicineBeijing100700China BasicMedicineCollegeofBeijingUniversityofTraditionalChineseMedicine Beijing100029China

AIM: To determine the dynamic changes in the expression of matrix metalloproteinases (MMPs) and the endogenous tissue inhibitors of MMPs inhibitors (TIMPs) during hepatic fibrosis induced by ***: Male Sprague-Dawley rats were randomly divided into normal, 4 d, 2 wk, 4 wk, 9 wk and 11 wk groups, and the model rats were fed with a mixture of alcohol by gastric infusion at the designed time, respectively, then decollated and their livers were harvested for the examination of MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1 and TIMP-2 by immunohistochemistry, zymograghy and Western blotting, ***: Normal rats had moderate expression of MMP-2,which was decreased in the model rats except in the 11 wk group, where MMP-2 expression slightly increased. MMP-3 had the similar changing pattern to MMP-2 despite weaker expression. MMP-9 expression decreased in the 4 d and 2 wk groups, rose in the 4 wk group, decreased again in the 9 wk group and returned to normal levels in the 11 wk ***-13 expression decreased in the 4 d and 2 wk groups,and returned to normal levels in the 4 wk, 9 wk and 11 wk groups. TIMP-1 expression decreased in the 4 d and 2 wk groups, but sharply increased in the 4 wk group and sustained at a high level even after modeling was stopped for 2 wk. In normal rats TIMP-2 expression was strong. However, it decreased as soon as modeling began, and then gradually rose, but remained to a level lower than that in normal rats even after modeling was stopped for 2 ***: MMP-2 may not always expresses at a high level during hepatic fibrosis. MMP-13 and MMP-3 are acutely affected by TIMP-1. In this model TIMP-1 is the most powerful factor imposed on capillarization and peri-sinusoidal fibrosis. TIMP-2 is the most effective regulator on the metabolism of type Ⅳ collagen located in the basement of sinus.

关键词：动力变化基因表达矩阵金属蛋白抑制剂 TIMPs 肝纤维化诱导作用酒精老鼠消化系统

Dynamic changes of capillarization and peri-sinusoid fibrosis in alcoholic liver diseases

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World Journal of Gastroenterology 2004年第2期10卷 238-243页

作者： Guang-FuXu Xin-yuewang Gui-LingGe Peng-TaoLi XuJia De-LuTian Liang-DuoJiang Jin-XiangYang DigestiveDepartmentoftheAffiliatedDongzhimenHospital BeijingUniversityofTraditionalChineseMedicineBeijing100700China CentralElectronicMicroscopeExaminationStudioofBeijingUniversityofTCM Beijing100029China. BasicMedicalCollegeofBeijingUniversityofTCM Beijing100029China

AIM:To investigate the dynamic changes of capillarization and peri-sinusoid fibrosis in an alcoholic liver disease model induced by a new ***:Male SD rats were randomly divided into 6 groups,namely normal,4d,2w,4w,9w and 11w *** animals were fed with a mixture of alcohol for designated days and then decollated,and their livers were harvested to examine the pathological changes of hepatocytes, hepatic stellate cells,sinusoidal endothelial cells,sinusoid, *** generation of three kinds of extra cellular matrix was also ***:The injury of hepatocytes became severer as modeling going *** electronic microscope,fatty vesicles and swollen mitochondria in hepatocytes,activated hepatic stellate cells with fibrils could been seen near or around *** of sinusoidal endothelial cells were decreased or disappeared,sinusoidal basement was *** light microscopy typical peri-sinusoid fibrosis, griddinglike fibrosis, broaden portal areas, hepatocyte's fatty and balloon denaturation,iron sediment,dot necrosis,congregated lymphatic cells and leukocytes were *** I collagen showed an increasing trend as modeling going on,slightly recovered when modeling stopped for 2 weeks. Meanwhile,type IV collagen decreased rapidly when modeling began and recovered after modeling stopped for 2 *** increased as soon as modeling began and did not recover when modeling stopped for 2 ***:The pathological changes of the model were similar to that of human ALD,but mild in *** had typical peri-sinusoid fibrosis, however,capillarization seemed to be *** may be related with the reduction of type IV collagen in the basement of sinusoid during modeling.

关键词：酒精性肝病肝纤维化肝功能动物模型病理特点超微结构

Research status of persistent vegetative state in recent 20 years:A bibliometric analysis

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Life Research 2022年第4期5卷 48-53页

作者： Lei Yang Xiao Chen Kai-yuewang Zhuang Liang Li-Yun He Shaanxi University of Traditional Chinese Medicine Xian Yang 712000ShaanxiChina Xi'an Traditional Chinese Medicine Encephalopathy Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine Xi'an 710038ShaanxiChina Institute of Clinical Basic Medicine of Traditional Chinese Medicine Chinese Academy of Chinese Medical SciencesBeijing 100700China

We searched PVS-related literature in the Web of Science Core Collection database,extracted and analyzed the data using the Science Citation Index Extended Edition,and included two types of literature:review and *** search terms were subject=persistent vegetative state and publication year(2001-2021)and language=*** analysis of literature overview,countries and regions,institutions,authors,literature source publications,literature research direction,citation frequency,impact factor,H-index and keywords,*** carried *** VOS viewer 1.6.17 software to visually cluster the keywords in the titles and abstracts of the included literature and analyze the research direction and development trend.A total of 772 PVS-related documents published in the core collection database of Web of Science from 2001 to 2021 were *** country with the largest number of publications was the United States(261 papers,33.80%),and the institution with the largest number of publications was the University of Liège,Belgium(40 papers,5.18%).The author with the largest number of published papers is Laureys S of the University of Liège,Belgium(39 papers,5.05%).The research directions of PVS are mainly neuroscience(350 articles,45.33%),rehabilitation(98 articles,12.69%),and internal medicine(9 articles,11.79%).The literature is mainly from Brain *** annual average impact factor of the top 10 journals in 2020 was 4.55,and their publication volume accounted for 17.35%(134/772)of the total *** 772 articles were cited 23,503 times(21,400 self-citations were excluded),with an average of 30.44 citations per *** H-index of the United States,the United Kingdom and Belgium are 48,27 and 27,which are significantly higher than other countries,and the citation frequencies are 8609,3451 and 3270,accounting for 36.60%,14.68%and 13.90%of the total citations,***'s publication volume is in the middle,but only 8th in citation frequency an

关键词： Persistent plant state bibliometrics H index VOS viewer software

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基于核函数的航空瞬变电磁去噪方法研究

基于核函数的航空瞬变电磁去噪方法研究

作者：岳望成都理工大学

学位级别：硕士

航空瞬变电磁法是以飞机为载体、电磁感应为勘探机理的航空物探方法。相比于地面瞬变电磁法,航空瞬变电磁法具有快速、高效、低成本、受地形影响较小等优点,所以航空瞬变电磁法已经广泛应用于沼泽、湖泊、沙漠、山地、海洋和垃圾填埋场... 详细信息

航空瞬变电磁法是以飞机为载体、电磁感应为勘探机理的航空物探方法。相比于地面瞬变电磁法,航空瞬变电磁法具有快速、高效、低成本、受地形影响较小等优点,所以航空瞬变电磁法已经广泛应用于沼泽、湖泊、沙漠、山地、海洋和垃圾填埋场等区域的矿产勘查,以及水文、工程、环境的调查和污染监测,特别适合中西部地区恶劣的地质环境。但是由于航空瞬变电磁信号频带较宽,特别是中晚期信号较弱,极易受到外部噪声的干扰。如果不能对电磁信号中的噪声进行有效的抑制,那么就会严重影响数据的可靠性和质量,进而影响后期数据的反演精度。本文依托于“十三五”国家重点研发计划项目课题“直升机航空电磁探测数据处理解释软件系统研发”对航空瞬变电磁数据去噪方法进行研究。首先对航空瞬变电磁数据及噪声进行正演模拟,然后研究线性主成分去噪方法和核主成分去噪方法,同时通过模拟含噪电磁数据编程实现来验证其有效性,最后通过实测数据验证所研究去噪方法的适用性。具体来说,本文主要研究内容如下:(1)基于线性主成分分析的航空瞬变电磁去噪方法。主成分分析法主要利用数据的一阶、二阶统计特性,通过坐标变换获得不相关或近似不相关的各个分量,从而实现信噪分离。本文首先读入含噪数据,然后对该数据归一化并求出零均值的协方差矩阵,再对该协方差矩阵进行特征值分解,获得数据的所有分量,最后通过各分量的能量分析提取信号主成分并进行重构并获得滤波后数据。为了测试线性主成分去噪方法的性能,在实验中使用不同信噪比的电磁数据。实验结果分析说明线性主成分去噪方法的适用范围。(2)基于核主成分分析的航空瞬变电磁去噪方法。由于线性主成分去噪方法只利用了一阶和二阶统计特性,使得该方法不能描述非高斯信号,为此本文推荐使用核主成分分析方法。核主成分分析方法是一种非线性主成分分析方法,其核心是通过非线性变换函数把原始数据映射到核空间,使得原来在原始数据空间中只能用非线性主成分分析的数据转换为在核空间中可以用线性主成分分析的数据。因此,作为一种非线性主成分分析方法,核主成分分析可以利用高阶统计特性,从而能较好地描述非高斯信号。本文首先读入含噪数据,然后对该数据归一化并通过核函数计算出核空间中的数据分量,根据对核空间中的各分量分析,最后通过逼近方法获得主分量在原始数据空间中的源像并重构,实现信噪分离。为了测试核主成分去噪方法的性能,在实验中使用和线性主主成分去噪方法相同的含噪电磁数据。实验结果分析显示核主成分去噪方法比线性主成分去噪方法具有更好的去噪效果。(3)为了验证不同核主成分去噪方法对实测数据的适用性,本文使用上述方法对新疆哈密某探区的野外航空飞行实测数据进行去噪处理,并对其去噪性能进行评价。

关键词：航空瞬变电磁法去噪核主成分分析多项式核高斯径向基核