Dynamic changes of capillarization and peri-sinusoid fibrosis in alcoholic liver diseases
Dynamic changes of capillarization and peri-sinusoid fibrosis in alcoholic liver diseases作者机构：DigestiveDepartmentoftheAffiliatedDongzhimenHospitalBeijingUniversityofTraditionalChineseMedicineBeijing100700China CentralElectronicMicroscopeExaminationStudioofBeijingUniversityofTCMBeijing100029China. BasicMedicalCollegeofBeijingUniversityofTCMBeijing100029China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2004年第10卷第2期
页 面：238-243页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：酒精性肝病 肝纤维化 肝功能 动物模型 病理特点 超微结构
摘 要：AIM:To investigate the dynamic changes of capillarization and peri-sinusoid fibrosis in an alcoholic liver disease model induced by a new ***:Male SD rats were randomly divided into 6 groups,namely normal,4d,2w,4w,9w and 11w *** animals were fed with a mixture of alcohol for designated days and then decollated,and their livers were harvested to examine the pathological changes of hepatocytes, hepatic stellate cells,sinusoidal endothelial cells,sinusoid, *** generation of three kinds of extra cellular matrix was also ***:The injury of hepatocytes became severer as modeling going *** electronic microscope,fatty vesicles and swollen mitochondria in hepatocytes,activated hepatic stellate cells with fibrils could been seen near or around *** of sinusoidal endothelial cells were decreased or disappeared,sinusoidal basement was *** light microscopy typical peri-sinusoid fibrosis, griddinglike fibrosis, broaden portal areas, hepatocyte s fatty and balloon denaturation,iron sediment,dot necrosis,congregated lymphatic cells and leukocytes were *** I collagen showed an increasing trend as modeling going on,slightly recovered when modeling stopped for 2 weeks. Meanwhile,type IV collagen decreased rapidly when modeling began and recovered after modeling stopped for 2 *** increased as soon as modeling began and did not recover when modeling stopped for 2 ***:The pathological changes of the model were similar to that of human ALD,but mild in *** had typical peri-sinusoid fibrosis, however,capillarization seemed to be *** may be related with the reduction of type IV collagen in the basement of sinusoid during modeling.
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