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Megsin基因E1-5’UTR区A267G与免疫球蛋白A型肾病阴虚证的相关性

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中西医结合学报 2008年第5期6卷 463-467页

作者：钟逸斐陈以平邓跃毅陈楠王朝晖上海中医药大学龙华医院肾内科上海200032 上海交通大学医学院瑞金医院肾内科上海200025

目的:观察增生为主的原发性免疫球蛋白A型肾病(immunoglobulin Anephropathy,IgAN)患者阴虚证(气阴两虚证、肝肾阴虚证)与megsin基因E1-5’UTR区A267G的相关性,寻找原发性IgAN中医证型微观辨证可能的物质基础。方法:筛选符合标准的原发... 详细信息

目的:观察增生为主的原发性免疫球蛋白A型肾病(immunoglobulin Anephropathy,IgAN)患者阴虚证(气阴两虚证、肝肾阴虚证)与megsin基因E1-5’UTR区A267G的相关性,寻找原发性IgAN中医证型微观辨证可能的物质基础。方法:筛选符合标准的原发性IgAN患者120例,进行megsin基因E1-5’UTR区A267G的单核苷酸多态性(single nucleotide polymorphism,SNP)测序,观察中医证型与SNP的相关性。结果:120例患者中GG型83例,GA型34例,AA型3例。肝肾阴虚证在AA与GA型IgAN患者中所占比例较高,气阴两虚在GG型中所占比例较高(P<0.01);GG型与GA型+AA型比数比(odds ratio,OR)为9.800,95%可信区间(confidence interval,CI)为3.969～24.199。这样的差异同样存在于不同性别和不同年龄之间。结论:Megsin基因E1-5’UTR区A267G可能是区分原发性IgAN肝肾阴虚证和气阴两虚证的物质基础之一。

关键词：免疫球蛋白A型肾病多态性单核苷酸基因 megsin

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi Ji Chaoyi Yang Xuerui Pang yibing Yan yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-yue Shan Jun-Ya Cheng Duan-Rui Qiao yi-ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

Chebyshev spectral variational integrator and applications

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Applied Mathematics and Mechanics(English Edition) 2020年第5期41卷 753-768页

作者： Zhonggui yi Baozeng yue Mingle deng School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China China Academy of Space Technology Beijing 100094China

The Chebyshev spectral variational integrator(CSVI) is presented in this paper. Spectral methods have aroused great interest in approximating numerically a smooth problem for their attractive geometric convergence rates. The geometric numerical methods are praised for their excellent long-time geometric structure-preserving *** to the generalized Galerkin framework, we combine two methods together to construct a variational integrator, which captures the merits of both methods. Since the interpolating points of the variational integrator are chosen as the Chebyshev points,the integration of Lagrangian can be approximated by the Clenshaw-Curtis quadrature rule, and the barycentric Lagrange interpolation is presented to substitute for the classic Lagrange interpolation in the approximation of configuration variables and the corresponding derivatives. The numerical float errors of the first-order spectral differentiation matrix can be alleviated by using a trigonometric identity especially when the number of Chebyshev points is large. Furthermore, the spectral variational integrator(SVI) constructed by the Gauss-Legendre quadrature rule and the multi-interval spectral method are carried out to compare with the CSVI, and the interesting kink phenomena for the Clenshaw-Curtis quadrature rule are discovered. The numerical results reveal that the CSVI has an advantage on the computing time over the whole progress and a higher accuracy than the SVI before the kink position. The effectiveness of the proposed method is demonstrated and verified perfectly through the numerical simulations for several classical mechanics examples and the orbital propagation for the planet systems and the Solar system.

关键词： geometric numerical method spectral method variational integrator Clenshaw-Curtis quadrature rule barycentric Lagrange interpolation orbital propagation

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Hamilton–Pontryagin spectral-collocation methods for the orbit propagation

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Acta Mechanica Sinica 2021年第11期37卷 1696-1713,I0003页

作者： Zhonggui yi Baozeng yue Mingle deng School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081China China Academy of Space Technology Beijing100094China

According to the discrete Hamilton–Pontryagin variational principle,we construct a class of variational integrators in the real vector spaces and extend to the Lie groups for the left-trivialized Lagrangian mechanical systems by employing the spectral-collocation method to discretize the corresponding Lagrangian and kinematic *** constructed framework can be transformed easily to the well-known symplectic partitioned Runge–Kutta methods and the higher order symplectic partitioned Lie Group methods by choosing same interpolation nodes and quadrature *** numerical experiments about the orbit propagation of Kepler two-body system and the rigid-body flow propagation of a free rigid body are conducted,*** simulating results reveal that the constructed update schemes can possess simultaneously the excellent exponent convergence rates of spectral methods and the attractive long-term structure-preserving properties of geometric numerical algorithms.

关键词： Hamilton-Pontryagin principle Spectral-collocation method Lie groups Variational integrator Orbit propagation

健脾补肾通络颗粒联合糖皮质激素治疗脾肾阳虚型重症IgA肾病随机、双盲、对照的多中心研究

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中华肾病研究电子杂志 2013年第5期2卷 35-40页

作者：陈万佳邓跃毅倪兆慧汪年松王怡邓伟上海中医药大学附属龙华医院肾病科 200032 上海交通大学医学院附属仁济医院肾内科上海交通大学医学院附属第六人民医院肾内科上海中医药大学附属岳阳中西医结合医院肾病科复旦大学公共卫生学院

目的探讨健脾补肾通络颗粒配合糖皮质激素治疗脾。肾阳虚型LeeⅢ级及以上IgA肾病患者的有效性及安全性。方法采用多中心、随机、双盲、对照的研究方法。入选病例来自2011年1月至2012年2月在上海4个中心就诊的120例病理表现为LeeⅢ级及... 详细信息

目的探讨健脾补肾通络颗粒配合糖皮质激素治疗脾。肾阳虚型LeeⅢ级及以上IgA肾病患者的有效性及安全性。方法采用多中心、随机、双盲、对照的研究方法。入选病例来自2011年1月至2012年2月在上海4个中心就诊的120例病理表现为LeeⅢ级及以上、中医辨证为脾肾阳虚证的IgA肾病患者。随机分为试验组和对照组，试验组用健脾补肾通络颗粒联合泼尼松；对照组用中药安慰剂颗粒联合泼尼松；两者病例数为1：1。根据患者体重、肾功能状况，口服泼尼松的起始剂量为40～60mg／d，共服用8—12周；其后每两周减5mg，减至30mg／d；再改为每月减5mg，约治疗9个月停服。健脾补肾通络颗粒由黄芪、制黄精、杜仲、夏枯草、炒蒺藜、仙灵脾、茯苓、炒僵蚕、丹参等成分组成，疗程共48周。分别在0．4、12、24、36、48周进行随访，主要观察指标为估算的肾小球滤过率（eGFR），次要观察指标为中医证候变化、血肌酐、24h尿蛋白定量。同时观察不良事件的发生情况。运用混合模型进行重复测量资料分析方法比较各疗效指标变化趋势的差别，P值〈0．05被认为差异有统计学意义。结果最终完成病例数103例，试验组55例，对照组48例。48周时，主要疗效指标：eGFR试验组及对照组较基线均呈升高趋势（t=4．84，2．37；P〈0．05），治疗至24周时试验组eGFR即大于对照组，至48周时eGFR较基线升高差值，试验组明显高于对照组，差异有统计学意义（F=14．39，P〈0．05）。次要疗效指标，中医证候积分、24h尿蛋白量，试验组及对照组均较基线水平下降（t=一12．1，一8．6；P〈0．05）；中医证候积分较基线水平下降差值，试验组高于对照组，差异有统计学意义（F=106．76，P〈0．05）；24h尿蛋白量较基线水平下降差值，对照组高于试验组，差异有统计学意义（F=46．24，P〈0．05）。试验组血清肌酐水平较基线明显下降，差异有统计学意义（t=一4．34，P〈0．05），对照组血清肌酐较基线下降幅度较小，差异无统计学意义（t=一1．12，P〉0．05）。中医证候治疗总有效率试验组为83．33％（50／60），对照组为63．33％（38／60），差异有统计学意义（z2=17．85，P〈0．05）。共出现不良事件14例，试验组5例（5／60，8．3％），对照组9例（9／60，15％），两组比较差异无统计学意义（，=1．294，P=0．255）。结论对脾肾阳虚型LeellI级及以上IgA肾病患者，健脾补肾通络颗粒联合糖皮质激素治疗在改善肾功能及减轻临床症状方面较单独使用糖皮质激素治疗疗效更佳，且有更好的安全性。

关键词： IgA肾病中西医结合治疗脾肾阳虚证健脾补肾通络颗粒

Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients： A Multicenter Study in China

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Chinese Medical Journal 2017年第8期130卷 885-891页

作者： Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang yue-yi deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinica Research Center for Kidney Diseases Beijing 100853 China Department of Nephrology The Second Hospital of Jilin University Changchun Jilin 130041 China Department of Nephrology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai Peritoneal Dialysis Research Center Shanghai 200127 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Nephrology Third Hospital of Hebei Medical University Kidney Disease Research Center of Hebei Province Shijiazhuang Hebei 050081 China Department of Nephrology Institute of Surgery Research Daping Hospital Third Military Medical University Chongqing 400042 China Department of Nephrology Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Shanghai 200233 China Department of Nephrology First Affiliated Hospital of Baotou Medical College Baotou Inner Mongolia 014040 China Department of Nephrology Peking University Third Hospital Beijing 100191 China Department of Nephrology General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Nephrology The First Affiliated Hospital of Shihezi University School of Medicine Shihezi Xinjiang 832008 China Department of Nephrology Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China Department of Nephrology Henan Provincial People's Hospital Zhengzhou Henan 450003 China Department of Nephrology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Nephrology First Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China

Background： Patients on hemodialysis have a high-mortality risk. Tiffs study analyzed factors associated with death in patients on maintenance hemodialysis （MHD）. While some studies used baseline data of MHD patients, this study used the most recent data obtained from patients just prior to either a primary endpoint or the end of the study period to iliad the characteristics of patients preceding ***： Participants were selected from 16 blood purification centers in China from January 2012 to December 2014, Patients＇ data were collected retrospectively. Based on survival status, the participants were divided into two groups： survival group and the death group. Logistic regression analysis was performed to determine/＇actors associated with all-cause mortality.

关键词： Hemodialysis Mortality: Risk Factors

Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao Yang yue-yi deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li ying Li Hao Zhang ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein *** with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine *** a superiority threshold of 15%,neither was statistically ***,serum creatinine and serum albumin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy