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A Graded Speed Control Method for Cyborg Rats Based on Electrical Stimulation of the Cuneiform Nucleus

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Journal of Bionic Engineering 2024年第3期21卷 1334-1346页

作者： Hanyi ling Le Han Nenggan Zheng Qiushi Academy for Advanced Studies(QAAS) Zhejiang UniversityHangzhou310007China The State Key Lab of Brain-Machine Intelligence Zhejiang UniversityHangzhou310007China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310007China College of Computer Science and Technology Zhejiang UniversityHangzhou310007China CCAI by MOE and Zhejiang Provincial Government(ZJU) Hangzhou310007China

The precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg ***,the current stimulation techniques cannot realize the graded control of the *** this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(CnF)of the Mesencephalic Locomotor Region(MLR).Detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration *** concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg *** the amplitude of stimulation was found to affect the response time exhibited by the cyborg *** study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.

关键词： Cyborg rats Cuneiform nucleus Graded control Speed regulation

Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements

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Zoological Research 2024年第1期45卷 138-151页

作者： tao Jiang Zhi-Min Zhou Zi-Qi ling Qing Zhang Zhong-Zi Wu Jia-Wen Yang Si-Yu Yang Bin Yang Lu-Sheng Huang National Key Laboratory of Pig Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely *** serve as an excellent animal model for studying genomic sequence biology due to the extensive diversity among their wild and domesticated ***,we conducted an integrated analysis using H3K27ac ChIP-seq,H3K4me3 ChIP-seq,and RNA-seq data from 10 different tissues of seven fetuses and eight closely related adult *** aimed to annotate the regulatory elements and TEs to elucidate their associations with histone modifications and mRNA expression across different tissues and developmental *** on correlation analysis between mRNA expression and H3K27ac and H3K4me3 peak activity,results indicated that H3K27ac exhibited stronger associations with gene expression than ***,1.45%of TEs overlapped with either the H3K27ac or H3K4me3 peaks,with the majority displaying tissue-specific ***,a TE subfamily(LTR4C_SS),containing binding motifs for SIX1 and SIX4,showed specific enrichment in the H3K27ac peaks of the adult and fetal ***-seq analysis also revealed widespread expression of TEs in the exons or promoters of genes,including 4688 TE-containing transcripts with distinct development stage-specific and tissue-specific *** note,1967 TE-containing transcripts were enriched in the *** identified a long terminal repeat(LTR),MLT1F1,acting as a testis-specific alternative promoter in SRPK2(a cell cycle-related protein kinase)in our pig *** element was also conserved in humans and mice,suggesting either an ancient integration of TEs in genes specifically expressed in the testes or parallel evolutionary ***,our findings demonstrate that TEs are deeply embedded in the genome and exhibit important tissue-specific biological functions,particularly in the reproductive

关键词： Transposable elements Porcine Histone modification Alternative promoter TE-containing transcript

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Improved RF power performance via electrostatic shielding effect using AlGaN/GaN/graded-AlGaN/GaN double-channel structure

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Science China(Information Sciences) 2024年第4期67卷 341-342页

作者： Chunzhou SHI ling YANG Meng ZHANG Hao LU Mei WU Bin HOU Xuerui NIU Qian YU Wenliang LIU Wenze GAO Xiaohua MA yue HAO School of Advanced Materials and Nanotechnology Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology Xidian University

GaN-based high-electric-mobility transistors(HEMTs) have been investigated thoroughly because of their promising applications in high-frequency,-voltage, and-power applications. However, the theoretical material limit prevents conventional single-heterostructure GaN HEMTs from achieving high performance despite numerous efforts [1–3].

关键词： Drain current

Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing ling PANG Shu tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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Unveiling quality of clinical trial in China:from concern to confirmation

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Cancer Communications 2024年第5期44卷 576-579页

作者： Huiyao Huang Yiru Hou Hong Fang ling Xu yue Yu Huifang Zhang Jing Zhang Yu Tang Gongtao Lan Wenbao Zhang Ning Li Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsuP.R.China Department of Quality Medicine Boehringer Ingelheim(China)Investment Co LtdShanghaiP.R.China Department of Clinical Development Quality Pfizer Research and Development(China)BeijingP.R.China Department of Drug Registration National Medical Products AdministrationBeijingP.R.China Bureau of Medical Administration National Health CommissionBeijingP.R.China

The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality *** China has made significant progress over the past 20 years in terms of the clinical trial quantity[1],quality and participation in multiregional trials[2],there still remain concerns regarding the trial quality,which could be associated with the self-inspection initiative in 2015[3].

关键词： clinical corners confirmation

Synergy of metal-support interaction and positive Pd species promoting efficient C-CI bond activation on Pd-based Ce-MOF-derived catalysts

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Rare Metals 2024年第11期 5835-5847页

作者： Xiao-Jie Hu Yu-Han Sun ling-yue Liu Dan-Jun Mao Shou-Rong Zheng State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing University Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University

Monochloroacetic acid（MCAA） is identified as a highly carcinogenic disinfection by-product in chlorinated drinking *** this study,a series of CeO2-supported Pd catalysts（Pd/MCeO2） were synthesized through one-step calcination of Pd-loaded Ce-UiO-66-BDC（CeMOF）,and the liquid-phase catalytic hydrodechlorination of MCA A was explored using these *** comparison,Pd/CeO2catalysts were additionally synthesized using the conventional impregnation *** characterization results reveal that the catalysts exhibit strong metal-support interaction,leading to high Pd dispersion and Pdn+***,the calcination temperature significantly influences catalytic performance,with the catalyst calcined at 500℃（Pd/MCeO2-500） demonstrating the highest catalytic activity and achieving complete dechlorination of MCA A within 50 ***,it is found that the catalytic MCAA hydrodechlorination using the catalysts adheres to the Langmuir-Hinshelwood ***,low reaction pH is favorable for the catalytic hydrodechlorination of MCAA,enhancing MCAA adsorption on the catalyst surface due to the electrostatic interaction between MCAA and the catalyst *** results suggest that the presence of Pdn+efficiently facilitates MCAA adsorption and C-Cl cleavage,thus significantly enhancing the liquid-phase catalytic hydrodechlorination.

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小儿急性腹泻布拉氏酵母菌散联合磷酸铝凝胶治疗效果及对T淋巴细胞水平影响

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社区医学杂志 2018年第18期16卷 1423-1426页

作者：陶月玲刘青平顶山市湛河区妇幼保健院儿科河南平顶山467000 平顶山市湛河区妇幼保健院妇保科河南平顶山467000

目的给予急性腹泻患儿临床常规补液、抗生素和保护胃肠黏膜等对症治疗不足以快速纠正胃肠道菌群紊乱,布拉氏酵母菌散可快速纠正肠道微生态失衡,提高免疫力、改善腹泻体征症状,本研究旨在探讨布拉氏酵母菌散联合硫酸铝凝胶治疗急性腹泻... 详细信息

目的给予急性腹泻患儿临床常规补液、抗生素和保护胃肠黏膜等对症治疗不足以快速纠正胃肠道菌群紊乱,布拉氏酵母菌散可快速纠正肠道微生态失衡,提高免疫力、改善腹泻体征症状,本研究旨在探讨布拉氏酵母菌散联合硫酸铝凝胶治疗急性腹泻患儿疗效及对T淋巴细胞水平的影响。方法选取2012-09-01-2017-08-31平顶山市湛河区妇幼保健院收治的急性腹泻患儿134例,根据治疗方式的不同分为联合组和对照组,各67例,均给予常规对症治疗,对照组行磷酸铝凝胶治疗,联合组在此基础上给予布拉氏酵母菌散治疗,观察两组疗效、炎症指标及对T淋巴细胞水平的影响。结果联合组呕吐、腹痛、腹泻及大便常规异常的症状消失时间均短于对照组,大便频率及大便性状评分低于对照组(均P<0.001)。联合组血清白介素-10(Interleukin-10,IL-10)水平治疗后为(7.36±1.52)ng/mL低于治疗前的(47.66±8.25)ng/mL,F时间=30.645,且低于同期对照组的(14.66±5.25)ng/mL,F组间=7.153,均P<0.001。联合组血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平治疗后为(2.22±0.53)mg/L低于治疗前的(4.66±1.08)mg/L,F时间=24.351,且低于同期对照组的(3.97±0.86)mg/L,F组间=5.584,均P<0.001。联合组治疗后CD3^+、CD4^+水平升高,CD8^+水平下降,CD4^+/CD8^+升高,且优于对照组(均P<0.001)。联合组和对照组不良反应总发生率分别为2.99%和5.97%,差异无统计学意义,连续矫正_χ~2=0.175,P=0.676。结论急性腹泻患儿给予布拉氏酵母菌散联合磷酸铝凝胶治疗,可快速改善患者急性腹泻的体征症状及肠道炎症反应,提高其免疫功能。

关键词：布拉氏酵母菌散硫酸铝凝胶急性腹泻患儿 T淋巴细胞水平

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Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： ling-ling Chen Ren-Fei Cao Hua Ke Zhi-Min Chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China Engineering Technology Research Center for Environmental Protection Materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

Predictive value of angiopoietin-like protein 8 in metabolic dysfunction-associated fatty liver disease and its progression:A case-control study

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World Journal of Diabetes 2024年第3期15卷 418-428页

作者： Lu-Lu Gan Can Xia Xuan Zhu yue Gao Wen-Chang Wu Qi Li ling Li Zhe Dai Yi-Min Yan Medical College Wuhan University of Science and TechnologyWuhan 430071Hubei ProvinceChina Department of Endocrinology Xiaogan Hospital Affiliated with Wuhan University of Science and TechnologyThe Central Hospital of XiaoganXiaogan 432000Hubei ProvinceChina Department of Endocrinology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND The prevalence of metabolic dysfunction-associated fatty liver disease(MAFLD)is rapidly increasing,currently affecting approximately 25%of the global *** fibrosis represents a crucial stage in the development of MAFLD,with advanced liver fibrosis elevating the risks of cirrhosis and hepatocellular *** serum markers are less effective in diagnosing liver fibrosis compared to more complex ***,imaging techniques like transient elastography face limitations in clinical application due to equipment and technical ***,it is imperative to identify a straightforward yet effective method for assessing MAFLD-associated liver *** To investigate the predictive value of angiopoietin-like protein 8(ANGPTL8)in MAFLD and its *** We analyzed 160 patients who underwent abdominal ultrasonography in the Endocrinology Department,Xiaogan Central Hospital affiliated to Wuhan University of Science and Technology,during September 2021-July *** abdominal ultrasonography and MAFLD diagnostic criteria,among the 160 patients,80 patients(50%)were diagnosed with *** MAFLD group was divided into the liver fibrosis group(n=23)and non-liver fibrosis group(n=57)by using a cut-off fibrosis-4 index≥*** regression was used to analyze the risk of MAFLD and the risk factors for its *** operating characteristic curves were used to evaluate the predictive value of serum ANGPTL8 in MAFLD and its *** Compared with non-MAFLD patients,MAFLD patients had higher serum ANGPTL8 and triglyceride-glucose(TyG)index(both P<0.05).Serum ANGPTL8(r=0.576,P<0.001)and TyG index(r=0.473,P<0.001)were positively correlated with *** ANGPTL8 was a risk factor for MAFLD[odds ratio(OR):1.123,95%confidence interval(CI):1.066-1.184,P<0.001).Serum ANGPTL8 and ANGPTL8+TyG index predicted MAFLD[area under the curve(AUC):0.832 and 0.886,respectively;both P<0.05].Compared with MAFL

关键词： Angiopoietin-like protein 8 Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index Liver fibrosis