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Relationship between onset of peptic ulcer and meteorological factors

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World Journal of Gastroenterology 2006年第9期12卷 1463-1467页

作者： Da-Yun Liu An-Ning Gao Guo-Du tang Wang-yue yang Jiang Qin Xin-Guo wu Dong-cai Zhu Gui-Ning Wang Jin-Jiang Liu Zhong-hui Liang Department of Gastroenterology Nanning First People's Hospital Nannig 530022 Guangxi Zhuang Autonomous Region China Meteorological Observation Station Nannig 530022 Guangxi Zhuang Autonomous Region China Department of Gastroenterology First Affiliated Hospital Guangxi Medical University Nannig 530012 Guangxi Zhuang Autonomous Region China Department Of Gastroenterology Hospital of Guangxi Zhuang Autonomous Region Nannig 530022 Guangxi Zhuang Autonomous Region China Department of Gastroenterology 303 Hospital of Chinese PLA Nannig 530022 Guangxi Zhuang Autonomous Region China

AIM： To discuss the relationship between onset of peptic ulcer （PU） and meteorological factors （MFs）. METHODS： A total of 24 252 patients were found with active PU in 104 121 samples of gastroscoic examination from 17 hospitals in Nanning from 1992 to 1997. The detectable rate of PU （DRPU） was calculated every month, every ten days and every five days. An analysis of DRPU and MFs was made in the same period of the year. A forecast model based on MFs of the previous month was established. The real and forecast values were tested and verified. RESULTS： During the 6 years, the DRPU from November to April was 24.4 -28.8%. The peak value （28.8%） was in January. The DRPU from May to October was 20.0 -22.6%, with its low peak （20.0%） in June. The DRPU decreased from winter and spring to summer and autumn （P 〈 0.005）. The correlated coefficient between DRPU and average temperature value was -0.8704, -0.6624, -0.5384 for one month, ten days, five days respectively （P 〈 0.01）. The correlated coefficient between DRPU and average highest temperature value was -0.8000, -0.6470,-0.5167 respectively （P 〈0.01）. The correlated coefficient between DRPU and average lowest temperature value was -0.8091, -0.6617, -0.5384 respectively （P 〈0.01）. The correlated coefficient between DRPU and average dew point temperature was -0.7812, -0.6246, -0.4936 respectively （P 〈0.01）. The correlated coefficient between DRPU and average air pressure value was 0.7320, 0.5777, 0.4579 respectively （P 〈0.01）. The average temperature, average highest and lowest temperature, average air pressure and average dew point temperature value of the previous month, ten days and five days could forecast the onset of PU, with its real and forecast values corresponding to 71.8%, 67.9% and 66.6% respectively. CONCLUSION： DRPU is closely related with the average temperature, average highest and lowest temperature, average air pressure and average dew point temperature of each month, every ten days and every five da

关键词： Peptic ulcer Meteorological factors Temperature

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两相区热处理工艺对9Ni钢性能的影响

材料热处理学报 2009年第3期30卷 92-95页

作者：杨跃辉蔡庆伍武会宾王华北京科技大学冶金工程研究院北京100083

利用X射线衍射和扫描电子显微镜研究了不同热处理后9Ni钢中回转奥氏体的含量及其分布,并测定了两相区热处理(QLT)各阶段钢中的回转奥氏体含量,讨论了此过程中9Ni钢组织的演变,进而分析了该工艺对9Ni钢力学性能的影响规律及其机理。结果... 详细信息

利用X射线衍射和扫描电子显微镜研究了不同热处理后9Ni钢中回转奥氏体的含量及其分布,并测定了两相区热处理(QLT)各阶段钢中的回转奥氏体含量,讨论了此过程中9Ni钢组织的演变,进而分析了该工艺对9Ni钢力学性能的影响规律及其机理。结果表明:经两相区热处理后,回转奥氏体的分布状态及稳定性对9Ni钢力学性能的影响更加显著。

关键词： 9Ni钢两相区热处理(QLT) 回转奥氏体

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9Ni钢中回转奥氏体的形成规律及其稳定性

材料热处理学报 2010年第3期31卷 73-77页

作者：杨跃辉武会宾蔡庆伍程莉北京科技大学冶金工程研究院北京100083

采用XRD法测定了不同温度回火后9Ni钢中的回转奥氏体含量,并结合显微组织的变化,研究了回转奥氏体的形成规律及其对性能的影响。同时,采用多种方法研究了所形成的回转奥氏体的稳定性。结果显示:540℃回火时,回转奥氏体的生成比较困难;57... 详细信息

采用XRD法测定了不同温度回火后9Ni钢中的回转奥氏体含量,并结合显微组织的变化,研究了回转奥氏体的形成规律及其对性能的影响。同时,采用多种方法研究了所形成的回转奥氏体的稳定性。结果显示:540℃回火时,回转奥氏体的生成比较困难;570℃回火后其含量达到4.47%,且稳定性较高;570～600℃之间回火,测得的回转奥氏体缓慢增加,稳定性则逐步降低;600℃以上回火,回转奥氏体快速增加,并在630℃左右达到峰值,但稳定性显著降低;回火温度超过630℃,保温期间生成的奥氏体更多,但稳定性更低,其中很大一部分在水冷过程中又发生相变,使最终测得的回转奥氏体含量又快速降低。结果也表明,通过分析回转奥氏体和基体点阵常数的变化趋势能够更加准确地确定回转奥氏体的稳定性。

关键词： 9Ni钢回火温度回转奥氏体稳定性

Sesquiterpenoids from the Whole Plants of Chloranthus holostegius and Their Anti-inflammatory Activities

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Chinese Journal of Chemistry 2021年第5期39卷 1168-1174页

作者： Zhao-Chun Zhan Zhong-Nan wu qing tang Can-Jie Li Wen-Zhi Wang Ji-hui Zhang Xue-Fang Zhuo Yu-Bo Zhang Guo-cai Wang Yao-Lan Li Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollege of PharmacyJinan UniversityGuangzhouGuangdong 510632China The First Affiliated Hospital Jinan UniversityGuangzhouGuangdong 510632China Guangdong Clinical Translational Center for Targeted Drug Deportment of PharmacologySchool of MedicineJinon UniversityGuangzhouGuangdong 510632China

Five new sesquiterpenoids(1-5),chloranholides A-E,along with three known compounds(6-8),were isolated from the whole plants of Chloranthus *** structures were elucidated using the spectroscopic methods(IR,UV,HR-ESI-MS,ID and 2D NMR),and their absolute configurations were determined by the X-ray crystallography and ECD *** 1-8 were evaluated for their anti-inflammatory effects on LPS-induced RAW 264.7 macrophage ***,compound 4 exhibited the most significant anti-inflammatory activity with the secretion levels of TNF-α and IL-6 at 15.52%and 5.98%,respectively,better than that of dexamethasone.

关键词： Chloranthus holostegius Sesquiterpenoids NMR spectroscopy X-ray diffraction Inflammation

Sophaloseedlines A-G: diverse Matrine-Based Alkaloids from Sophora alopecuroides with Potential Anti-Hepatitis B Virus Activities

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Chinese Journal of Chemistry 2021年第9期39卷 2555-2562页

作者： ding Luo Zhong-Nan wu Ji-hui Zhang Qiang Lin Neng-Hua Chen Si Chen qing tang Zhao-Chun Zhan Chun-Lin Fan Yao-Lan Li Guo-cai Wang Yu-Bo Zhang Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollege of PharmacyJinan UniversityGuangzhouGuangdong 510632China Guangdong Clinical Translational Center for Targeted Drug Department of PharmacologySchool of MedicineJinan UniversityGuangzhouGuangdong 510632China

Sophaloseedlines A-G(1-7),seven new matrine-based alkaloids along with two known analogues,were isolated from the seeds of Sophora *** new structures were determined based on extensive spectroscopic data,electronic circular dichroism calculations,and X-ray ***,sophaloseedline A(1)represents a novel rearranged 6(5→17)-abeo-matrine alkaloid featuring unprecedented highly constructed 7/6/5/6 tetracyclic fused ring *** hypothetical biosynthetic pathways for sophaloseedli nes A-F were proposed based on co-existing ***,all the isolated alkaloids were screened for their antiviral activities against hepatitis B virus,and new alkaloids 1 and 2 displayed more potent activities than those of matrine(a parent alkaloid of title plant)and positive control(lamivudine).

关键词： Sophora alopecuroides Matrine-based alkaloid Structure elucidation Anti-HBV activity Biological activity

热装温度对X80管线钢内碳氮化物析出行为的影响

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金属热处理 2008年第3期33卷 9-12页

作者：武会宾余伟蔡庆伍唐荻北京科技大学高效轧制国家工程研究中心北京100083

运用SEM、TEM、EDX及析出物定量分析等方法，通过实验室模拟热送热装工艺，研究了X80管线钢坯分别在750℃和1100℃热装轧制时微合金元素的固溶和析出情况。结果表明，1100℃热装的钢板轧前钢坯中Nb、V、Ti等微合金元素固溶量较高，在轧... 详细信息

运用SEM、TEM、EDX及析出物定量分析等方法，通过实验室模拟热送热装工艺，研究了X80管线钢坯分别在750℃和1100℃热装轧制时微合金元素的固溶和析出情况。结果表明，1100℃热装的钢板轧前钢坯中Nb、V、Ti等微合金元素固溶量较高，在轧制和卷取过程中析出充分，且10nm以下析出颗粒所占比例较高，而750℃热装的钢坯中微合金元素固溶量明显低于1100℃热装的钢坯，其轧后钢板中18～36nm析出颗粒所占比例较高。因此，1100℃热装可以充分发挥微合金元素的析出强化作用。

关键词： X80管线热送热装析出行为

Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study

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World Journal of Gastroenterology 2020年第6期26卷 645-656页

作者： Zhu-Jun Cao Yu-Han Liu Chuan-wu Zhu Shan Yin Wei-Jing Wang Wei-Liang tang Gang-De Zhao Yu-Min Xu Lu Chen Tian-hui Zhou Ming-Hao cai hui Wang Wei cai Shi-San Bao Hai Li qing Xie Department of Infectious diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Infectious diseases The Affiliated Infectious Diseases Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious diseases Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghai 201801China discipline of Pathology School of Medical Sciences and Bosch InstituteUniversity of SydneySydneyNSW 2006Australia

BACKGROUND Reports on bacterial infection(BI)in decompensated cirrhosis(DC)is mainly from alcoholic *** role of BI as a trigger or complication of acute-onchronic liver failure(ACLF)in patients with hepatitis B virus decompensated cirrhosis(HBV-DC)remains to be *** To investigate the impact of BI on the outcomes of the patients with HBV-DC admitted into the hospital with or without *** This retrospective study included patients with HBV-DC admitted to two tertiary centers in ***-hospital overall survival,90-d transplant-free survival,5-year post-discharge survival,and cumulative incidence of ACLF were *** factors for death were analyzed considering liver transplantation as a competing *** A total of 1281 hospitalized HBV-DC patients were included;284 had ACLF at *** overall prevalence of BI was 28.1%.The patients with BI had a significantly lower in-hospital survival and transplant-free 90-d survival than those without,in both the patients admitted with and without *** presence of BI significantly increased the risk of developing ACLF[subdistribution hazard ratio(sHR)=2.52,95%CI:1.75-3.61,Pdischarged alive,those who had an episode of BI had a significantly lower 5-year transplant-free *** was an independent risk factor for death in the patients admitted without ACLF(sHR=3.28,95%CI:1.93-5.57),while in ACLF admissions,the presence of pneumonia,but not other type of BI,independently increased the risk of death(sHR=1.87,95%CI:1.24-2.82).CONCLUSION BI triggers ACLF in patients with HBV-DC and significantly impairs short-term ***-DC patients should be monitored carefully for the development of BI,especially pneumonia,to avoid an adverse outcome.

关键词： Hepatitis B virus Cirrhosis Decompensation Bacterial infection Acute-onchronic liver failure Survival

The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1

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Chinese Journal of Natural Medicines 2019年第3期17卷 198-208页

作者： SUN Meng-Yao WANG Dan-Dan SUN Jian ZHAO Xiao-Hua cai Si wu Qiu-Xue JIE Tao NI Zhen-Hua SUN Jian-yue tang qing-Feng Department of Clinical Laboratory and Central Laboratory Putuo Hospital Shanghai University of Traditional Chinese Medicine Institute of Interdisciplinary Medical Sciences Shanghai University of Traditional Chinese Medicine Department of Clinical Laboratory Shuguang Hospital Shanghai University of Traditional Chinese Medicine Department of Pediatrics Putuo Hospital Shanghai University of Traditional Chinese Medicine

Resistance to cisplatin(DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer(GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula(ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still difficult highly recapitulate the important molecular events in vivo, primary GC cells model derived from clinical patient was constructed in the present study to further evaluate the effect of ZJW and the underlying molecular mechanism. Immunofluorescent staining was used to indentify primary cultured human GC cells. Western blotting was carried out to detect the protein expression. Cell Counting Kit-8(CCK-8) was used to evaluate cell proliferation. Flow cytometry analysis was performed to assess cell apoptosis. ZJW inhibited proliferation and induced apoptosis in primary DDP-resistant GC cells. Notably, the apoptosis in GC cells was mediated by inducing cofilin-1 mitochondrial translocation, down-regulating Bcl-2 and up-regulating Bax expression. Surprisingly, the level of p-AKT protein was higher in DDP-resistant GC cells than that of the DDP-sensitive GC cells, and the activation of AKT could attenuate ZJW-induced sensitivity to DDP. These data revealed that ZJW can increase the chemosensitivity in DDP-resistant primary GC cells by inducing mitochondrial apoptosis and AKT inactivation. The combining chemotherapy with ZJW may be an effective therapeutic strategy for GC chemoresistance patients.

关键词： Primary GC cells ZJW AKT Chemoresistance

Oxaliplatin plus hydroxycamptothecine versus oxaliplatin plus 5-fluorouracil and leucovorin in treatment of advanced colorectal cancer

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Chinese Medical Journal 2006年第21期119卷 1829-1833页

作者： YAO yang SUN Yuan-jue ZHAO hui GUO yue-wu LIN Feng cai Xun tang Xiao-chun tang Li-na ZHANG Wei Department of Oncology Shanghai Sixth People＇s Hospital of Shanghai Jiaotong University Shanghai 200233 China Department of Epidemiology Cancer Research Institute of Shanghai Jiaotong University Shanghai 200032 China

5-fluarouracil-based chemotherapy has become a standard regimen for the treatment of advanced colorectal cancer （ACRC）.^1 Defined as the second line therapy for ACRC with 5-fluarouracil （5-Fu） plus leucovorin （LV） combined with oxaliplatin （OXA）, the response rate （RR）, progression-free survival （PFS） and overall survival （OS） were 21.2%, at 4.7 and 11.5 months, whereas RR, PFS and OS with 5-Fu plus LV combined with irinotecan （CPT-11） were 11.4%, at 3.2 and 12.2 months. There were no statistical difference between the two protocals.^2,3 Those results may well suggest that some of these patients were resistant to 5-Fu. Therefore it is necessary to find a more effective regimen without 5-Fu to treat recurrent ACRC patients that were initially treated with 5-Fu. Our previous study showed that OXA can enhance the function of hydroxycamptothecine （HCPT） in inducing the apoptosis of a human colorectal cell line in vivo.^4 So we chose OXA plus HCPT （OH） regimen to treat 28 patients with ACRC and compared RR, one-year survival rate, PFS, OS and main toxicities with a 5-Fu plus LV combined with OXA （OFL） regimen.

关键词： colorectal cancer hydroxycamptothecine oxaliplatin