Sophaloseedlines A-G: Diverse Matrine-Based Alkaloids from Sophora alopecuroides with Potential Anti-Hepatitis B Virus Activities

作     者：Ding Luo Zhong-Nan Wu Ji-Hui Zhang Qiang Lin Neng-Hua Chen Si Chen Qing Tang Zhao-Chun Zhan Chun-Lin Fan Yao-Lan Li Guo-Cai Wang Yu-Bo Zhang Ding Luo;Zhong-Nan Wu;Ji-Hui Zhang;Qiang Lin;Neng-Hua Chen;Si Chen;Qing Tang;Zhao-Chun Zhan;Chun-Lin Fan;Yao-Lan Li;Guo-Cai Wang;Yu-Bo Zhang

作者机构：Institute of Traditional Chinese Medicine&Natural ProductsGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollege of PharmacyJinan UniversityGuangzhouGuangdong 510632China Guangdong Clinical Translational Center for Targeted DrugDepartment of PharmacologySchool of MedicineJinan UniversityGuangzhouGuangdong 510632China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第9期

页      面：2555-2562页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81803376,82074116,81973190) the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515020033) the Natural Science Foundation of Guangdong Province(No.2018B030311020) the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036) the Guangdong Basic and Applied Basic Research Foundation-Regional Joint Fund(Youth Fund Project,No.2020A1515110415) the high performance public computing service platform of Ji nan Un iversity 

主　　题：Sophora alopecuroides Matrine-based alkaloid Structure elucidation Anti-HBV activity Biological activity 

摘      要：Sophaloseedlines A-G(1-7),seven new matrine-based alkaloids along with two known analogues,were isolated from the seeds of Sophora *** new structures were determined based on extensive spectroscopic data,electronic circular dichroism calculations,and X-ray ***,sophaloseedline A(1)represents a novel rearranged 6(5→17)-abeo-matrine alkaloid featuring unprecedented highly constructed 7/6/5/6 tetracyclic fused ring *** hypothetical biosynthetic pathways for sophaloseedli nes A-F were proposed based on co-existing ***,all the isolated alkaloids were screened for their antiviral activities against hepatitis B virus,and new alkaloids 1 and 2 displayed more potent activities than those of matrine(a parent alkaloid of title plant)and positive control(lamivudine).