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Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang Li‑Yong Zhang Jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑yue Li Jian‑Guo Wang Long Zhang Fu‑Qiang Cao zhi‑Cheng Zhang Xin‑zhi Jiang Luo‑Huan Wang Zi‑Ming Li Lu‑Yang Song Liang‑Ting Sun Qi Wu Jia‑Qing Li Bao‑Qun Cui Li‑Hua Chen Rui‑Gang Ma Er‑Tao Li Gang Lian Yao‑De Sheng zhi‑Hong Li Bing Guo Wei‑Ping Liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

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Corrigendum to“3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation”[Virol Sin 38(2023)387–397]

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Virologica Sinica 2024年第2期39卷 351-354页

作者： Xiangju Wu Lei Chen Chao Sui yue Hu Dandan Jiang Fan Yang Laura C.Miller Juntong Li Xiaoyan Cong Nataliia Hrabchenko Changhee lee Yijun Du Jing Qi Shandong Key Laboratory of Animal Disease Control and Breeding Key Laboratory of Livestock and Poultry Multi-omics of MARAInstitute of Animal Science and Veterinary MedicineInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan250100China College of Life Science Shandong Normal UniversityJinan250358China State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference LaboratoryKey Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730050China Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS66506USA College of Veterinary Medicine and Virus Vaccine Research Center Gyeongsang National UniversityJinju52828Republic of Korea

Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several *** Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly *** has been m... 详细信息

关键词： STAT1 FMDV bands

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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-lee yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Flexible one-dimensional photonic crystal films composed of chalcogenide glass and water-soluble polymer for curvature sensing

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Chinese Optics Letters 2024年第2期22卷 135-140页

作者：陈新宇黎张成赵若兰何钰何月梁治陶光明侯冲 School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Vascular Aging Ministry of EducationTongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518063China

Curvature sensing plays an important role in structural health monitoring,damage detection,real-time shape control,modification,*** curvature sensors with large measurement ranges,high sensitivity,and linearity remains a major *** this study,a curvature sensor based on flexible one-dimensional photonic crystal(1D-PC)films was *** flexible 1D-PC films composed of dense chalcogenide glass and water-soluble polymer materials were fabricated by solution *** flexible 1D-PC film curvature sensor has a wide measurement range of 33-133 m-1and a maximum sensitivity of0.26 nm/m^(-1).The shift of the transmission peak varies approximately linearly with the curvature in the entire measurement *** kind of 1D-PC film curvature sensor provides a new idea for curvature sensing and measurement.

关键词： curvature sensor one-dimensional photonic crystals solution processing chalcogenide glass flexible film

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毛泽东思想在法语世界的深远影响——由《论持久战》法文版广泛传播谈起

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毛泽东邓小平理论研究 2024年第4期 99-107,F0003页

作者：龙治铭岳颖清华大学马克思主义学院

以《论持久战》为代表的毛泽东军事著作是中国人民克敌制胜的法宝,在世界范围内都受到特别关注。20世纪风起云涌的民族解放运动迫切需要科学理论指导,《论持久战》法文译本为法语世界的解放斗争提供了强大的理论武器,产生了重大回应与影... 详细信息

以《论持久战》为代表的毛泽东军事著作是中国人民克敌制胜的法宝,在世界范围内都受到特别关注。20世纪风起云涌的民族解放运动迫切需要科学理论指导,《论持久战》法文译本为法语世界的解放斗争提供了强大的理论武器,产生了重大回应与影响:29个国家和地区先后获得独立,法兰西第四共和国殖民体系瓦解,法兰西第五共和国成立并成为第一个与新中国友好建交的西方国家。中国共产党成功的革命道路、革命经验和革命智慧为全世界所有被压迫民族和被压迫人民带来新希望,极大推动了全世界的民族独立和人民解放运动,体现了中国化的马克思主义为世界社会主义运动和民族解放斗争作出的独特贡献。

关键词：《论持久战》毛泽东思想法语世界民族解放运动

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Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai Yan-Yan Xue Weigang Ge Liang yue Xiao-Yan Li Rong-Rong Lin Guo-Ping Peng Wenhao Jiang Sainan Li Kun-Mu Zheng Bin Jiang Jian-Ping Jia Tiannan Guo zhi-Ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic *** ADspecific early diagnostic and disease staging biomarkers are *** this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 *** biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 *** quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,*** the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,*** 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,*** 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative ***,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD *** findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

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PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： yue-Hong Kong Mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

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海啸作用下跨海桥梁上部结构流-固耦合数值研究

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工程力学 2024年第9期41卷 111-122页

作者：杨志莹祝兵黄博张跃志殷瑞涛西南交通大学土木工程学院成都610031 重庆交通大学土木工程学院重庆400074

海啸是威胁跨海桥梁安全的主要灾害之一,深入研究海啸与桥梁上部结构耦合作用过程,明确桥梁上部结构波浪力以及桥梁支座受力状态对跨海桥梁安全具有重要意义。该文采用开源软件OpenFOAM建立二维数值水槽,以溃坝波模拟海啸,通过求解RANS... 详细信息

海啸是威胁跨海桥梁安全的主要灾害之一,深入研究海啸与桥梁上部结构耦合作用过程,明确桥梁上部结构波浪力以及桥梁支座受力状态对跨海桥梁安全具有重要意义。该文采用开源软件OpenFOAM建立二维数值水槽,以溃坝波模拟海啸,通过求解RANS方程来获取流体运动,并采用k-ε湍流模型解决RANS方程的封闭性问题,以弹簧-质量-阻尼体系模拟桥梁上部结构运动体系,通过流体与质量-弹簧-阻尼体系间实时数据传递,模拟海啸与桥梁上部结构之间的耦合效应。并利用溃坝波解析解及已有的试验数据验证了数值模型的可靠性。在此基础上,通过对比在水平方向采用刚性约束或不同刚度的弹性约束时上部结构的波浪力,研究了流-固耦合效应以及约束刚度对桥梁上部结构波浪力的影响,同时分析了在海啸作用过程中桥梁各支座的受力状态。结果表明:该文建立的数值模型能够准确地模拟海啸波浪与结构耦合作用过程;考虑流固耦合效应后,上部结构受到的最大波浪力明显减小,水平力最大值减小16.8%~21.0%,竖向力最大值减小15.5%~19.5%;相比于上部结构水平波浪力,支座承受的水平力波动更明显且其最大值达到上部结构水平力的1.25倍;迎浪侧支座在不同时刻存在拉和压两种不同工作状态,其最大拉力达到上部结构竖向波浪力最大值的90%以上;背浪侧支座仅承受压力,其最大压力约为迎浪侧支座最大压力的1.11倍~1.55倍。

关键词：跨海桥梁流固耦合数值模拟波浪力支座力

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Screening and immune infiltration analysis of ferroptosis-related genes in pancreatic cancer with predictions for traditional Chinese medicine treatments

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Natural Therapy Advances 2024年第3期7卷 1-13页

作者： Meng-Ru Yang Ying Zhang Jing-Bai Li Xin-Ru Shen Zi-yue Pi zhi-Dong Liu School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Tianjin University of Traditional Chinese MedicineTianjin 301617China

Background:This study aims to explore the involvement of ferroptosis-related genes and pathogenesis in pancreatic cancer and predict potential therapeutic interventions using Traditional Chinese Medicine(TCM).Methods:We utilized gene expression datasets,ferroptosis upregulated genes and applied machine learning algorithms,including LASSO and SVM-RFE,to identify key ferroptosis-related genes in pancreatic *** Gene Ontology,Kyoto Encyclopedia of Genes and Genomes,and Disease Ontology enrichment analysis,immune infiltration analysis and correlation analysis between immune infiltrating cells and characteristic genes on differentially expressed genes using the R software *** potential traditional Chinese medicine for targeted ferroptosis gene therapy for pancreatic cancer through Coremine and Herb ***:Seventeen feature genes were identified,with significant implications for immune cell infiltration in pancreatic *** results of immune cell infiltration analysis showed that B cells naive,B cells memory,T cells regulatory,and M0 macrophages were significantly upregulated in pancreatic cancer patients;Mast cells resting were significantly *** herbal medicines such as ginkgo,turmeric,ginseng,Codonopsis pilosula,Zedoary turmeric,deer tendons,senna leaves,Guanmu Tong,Huangqi,and Banzhilian are potential drugs for targeted ferroptosis gene therapy for pancreatic ***:TIMP1 emerged as a key gene,with several TCM herbs predicted to modulate its expression,offering new avenues for treatment.

关键词： pancreatic cancer ferroptosis immune infiltration bioinformatics traditional Chinese medicine prediction

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Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

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Photonics Research 2024年第6期12卷 1274-1282页

作者： TING ZENG QI SHEN YUAN CAO JIAN-YU GUAN MENG-ZHE LIAN JIN-JIAN HAN LEI HOU JIAN LU XIN-XIN PENG MIN LI WEI-yue LIU JIN-CAI WU YONG WANG JUAN YIN JI-GANG REN HAI-FENG JIANG QIANG ZHANG CHENG-zhi PENG JIAN-WEI PAN Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

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