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数字电离层建设的必要性

科技导报 2017年第19期35卷 62-66页

作者：乐新安万卫星中国科学院地质与地球物理研究所中国科学院地球与行星物理重点实验室北京100029 中国科学院大学地球科学学院北京100049

实际应用中,针对不同的电离层电波传播效应,对不同的电离层参量特性,需采用不同手段的观测或不同参量模式的预测预报,解决不同的应用需求。这种"各自为阵"的方式不仅浪费资源,应用效果也较差。为此,本文提出了数字电离层概念,即综合利... 详细信息

实际应用中,针对不同的电离层电波传播效应,对不同的电离层参量特性,需采用不同手段的观测或不同参量模式的预测预报,解决不同的应用需求。这种"各自为阵"的方式不仅浪费资源,应用效果也较差。为此,本文提出了数字电离层概念,即综合利用中国已有及已经立项的空地多源立体探测体系,在电离层模式化研究的基础上,通过数据融合和数据同化,用数字化方式描述电离层状态参量过去、现在和未来的状况,高效统筹解决各类工程应用中对不同电离层参量的需求。介绍了数字电离层建设的必要性和国内外现状,重点说明了其主要内容和面临的技术瓶颈。

关键词：电离层数据同化高频通信北斗卫星导航系统

TavWA1 is critical for wheat growth by modulating cell morphology and arrangement

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Journal of Integrative Plant Biology 2025年第1期67卷 71-86页

作者： Guowei Chang yue Li Lei Peng Chuncai Shen Yipeng Lu wan Teng Yangyang Liu Yingchun wang Weiqi Zhu Cuimin Liu Xue He Yiping Tong Xueqiang Zhao Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Zhaoxian Experiment Station Shijiazhuang Academy of Agricultural and Forestry SciencesZhaoxian 515300China

Plant growth is determined by the production of cells and initiation of new *** genes that control cell number and cell size is of great significance for understanding plant growth *** this study,we characterized two wheat mutants,ah and dl,with abnormal *** ah mutant is a naturally occurring variant characterized by severe dwarfism,increased tiller number,and reduced grain length,while the dl mutant is derived from an ethyl methane sulfonate(EMS)-mutagenized population and exhibits smaller grain size and slightly reduced plant *** analyses revealed abnormal cell number,cell morphology and arrangement in the stems and leaves of the ah mutant,along with reduced cell length in the grains of the dl ***-based cloning identified that both mutants carry mutations in the same gene TavWA1-7D,which encodes a protein with a von Willebrand factor A(vWA)*** ah mutant harbors a 174-bp insertion in the 1,402-bp coding sequence(CDS)of TavWA1-7D,causing premature termination of protein translation,while the dl mutant contains a Glu420Lys *** the TavWA1-7D ahthrough clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease 9-mediated genome editing leads to a severe dwarfism *** C-terminus of the protein is crucial for its correct subcellular localization and interaction,supporting its critical role for TavWA1-7D *** analysis showed that the dwarf phenotype of the ah mutant is associated with impaired photosynthesis,ribosome function,and nucleosome ***,TavWA1-7D interacts with an E3 ligase,Ta VIP1-3B,the expression levels of which are elevated in both *** and knockout studies of TaVIP1-3B demonstrated its negative regulatory role in cell length and grain ***,our findings suggest that TavWA1-7D plays a vital role in regulating wheat growth and yield-related traits,with the dl mutant's short grain phen

关键词： grain size severe dwarf TaVIP1 TavWA1 wheat

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei wan Xiuqin Rao yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Pharmacological role of Herba Patriniae and Coix seed in colorectal cancer

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 1-8页

作者： Yu-xin Zhang Hui wan Guan-yue Shan Jun-Ya Cheng Yi-Ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

Colorectal cancer(CRC)is the most prevalent cancer globally,and its traditional treatment modalities commonly encompass radiation therapy,chemotherapy,surgery and the administration of cytotoxic ***,novel chemotherapy drugs that combine traditional Chinese medicine(TCM)with herbal extracts exhibit superior comprehensive ***,we delved into an article authored by wang et al,focusing specifically on the pharmacological effects of"Herba Patriniae and Coix seed(HC)"and their targeted mechanisms in combating *** the perspective of TCM philosophy,damp-heat stagnation and toxicity are the cardinal pathogenic factors underlying ***,renowned for their abilities to antipyretic and enhance diuresis,have demonstrated promising efficacy in preliminary studies for the treatment of *** findings offer potential insights in favor of fostering anti-cancer medications.

关键词： Colorectal cancer Herba Patriniae Coix seed Antitumor Chinese medicine

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui wan Yu-xin Zhang Guan-yue Shan Jun-Ya Cheng Duan-Rui Qiao Yi-Ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

发酵类中药的特点、微生物组成及真菌毒素污染概况

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中国中药杂志 2025年第1期50卷 48-57页

作者：张会茹郭梦月吕建欣朱婉暄王闯康馨心骆骄阳杨美华中国医学科学院北京协和医学院药用植物研究所中草药物质基础与资源利用教育部重点实验室北京100193

发酵类中药具有悠久的药用历史,包括淡豆豉、胆南星、半夏曲、红曲、建曲等。发酵技术在最早的中药专著《神农本草经》中便有记载,微生物是发酵过程中必不可少的关键组成部分。然而,由发酵过程不规范导致的发酵类中药中产毒真菌和真菌... 详细信息

发酵类中药具有悠久的药用历史,包括淡豆豉、胆南星、半夏曲、红曲、建曲等。发酵技术在最早的中药专著《神农本草经》中便有记载,微生物是发酵过程中必不可少的关键组成部分。然而,由发酵过程不规范导致的发酵类中药中产毒真菌和真菌毒素污染问题严重影响药材质量,对消费者生命健康安全造成威胁。该文对发酵类中药的特点、微生物组成及真菌毒素污染概况进行系统阐述,为其质量安全控制提供理论依据。

关键词：发酵类中药发酵技术微生物真菌毒素质量控制

Partial intestinal obstruction secondary to multiple lipomas within jejunal duplication cyst: A case report

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World Journal of Gastroenterology 2010年第17期16卷 2190-2192页

作者： wan, xin-yue Deng, Tao Luo, He-Sheng Wuhan Univ Dept Gastroenterol Renmin Hosp Wuhan 430060 Hubei Province Peoples R China

Lipoma within jejunal duplication presenting as abdominal bloating and partial intestinal obstruction is an exceptional clinical *** report a case of 68-year-old man complaining of abdominal bloating for 10 d due to multiple lipomas arising from jejunal duplication *** a few cases of a single lipoma within a Meckel’s diverticulum giving rise to this clinical scenario have been reported in the English language ***,no case of multiple lipomas within jejunal duplication cysts has been *** present a case in which doubleballoon endoscopy revealed a small intestinal structure changed into Meckel’s diverticulum-like cavities containing several *** case highlights intestinal lipoma as an uncommon cause of adult intussusceptions,which should be included in the differential diagnosis of small intestinal obstruction and appropriate examinations should be chosen.

关键词： Duplication cyst Lipoma Double-balloon endoscopy Jejunum Intestinal obstruction

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苦瓜第一雌花节位的遗传研究

江西农业大学学报 2017年第1期39卷 50-54页

作者：张景云黄月琴万新建关峰涂建辉缪南生江西省农业科学院蔬菜花卉研究所江西南昌330200 福建丰圣蔬菜有限公司福建南平354100

为探明苦瓜熟性机理,本试验应用植物数量性状主基因+多基因混合遗传模型方法对强雌系苦瓜‘Q11-2’与强雄系BK0604杂交组合多个世代群体的第一雌花节位进行了联合分析,结果表明,‘Q11-2’与BK0604第一雌花节位遗传符合两对主基因+多基... 详细信息

为探明苦瓜熟性机理,本试验应用植物数量性状主基因+多基因混合遗传模型方法对强雌系苦瓜‘Q11-2’与强雄系BK0604杂交组合多个世代群体的第一雌花节位进行了联合分析,结果表明,‘Q11-2’与BK0604第一雌花节位遗传符合两对主基因+多基因遗传模型。该杂交组合的B1、B2、F2群体主基因遗传率分别为85.09%、46.29%和85.12%,多基因遗传率分别为0、48.77%、9.39%。这将有助于在今后育种中早期进行选择。

关键词：苦瓜第一雌花节位遗传

基于埋底界面修饰策略制备正式钙钛矿太阳电池

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物理学报 2025年第2期74卷 245-255页

作者：商文丽王立坤张晓春岳鑫李一锋万政慧杨华翼李婷王辉辽宁师范大学物理与电子技术学院大连116029 西安电子科技大学微电子学院西安710071 中国科学院大连化学物理研究所大连116023 大连科技学院实验实训中心大连116025

二氧化锡是正式钙钛矿太阳电池理想的电子传输层材料.二氧化锡与钙钛矿之间的界面缺陷是制约钙钛矿太阳电池转换效率提高的关键因素.因此,本文提出了一种基于埋底界面修饰策略制备正式钙钛矿太阳电池的方法.通过在二氧化锡中掺杂甲基溴... 详细信息

二氧化锡是正式钙钛矿太阳电池理想的电子传输层材料.二氧化锡与钙钛矿之间的界面缺陷是制约钙钛矿太阳电池转换效率提高的关键因素.因此,本文提出了一种基于埋底界面修饰策略制备正式钙钛矿太阳电池的方法.通过在二氧化锡中掺杂甲基溴化胺,形成埋底界面,减少了二氧化锡与钙钛矿之间的界面缺陷,提升了二氧化锡的电子迁移率,并促进高质量钙钛矿材料的生长,制备的正式钙钛矿太阳电池转换效率达23.12%,为制备高效正式钙钛矿太阳能电池提供了一种有效策略.

关键词：正式钙钛矿太阳电池埋底界面甲基溴化胺

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