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Comparison of Efficacy and Safety between First and Second Generation Drug-eluting Stents in Patients with Stable Coronary Artery Disease： A Single-center Retrospective Study

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Chinese Medical Journal 2017年第14期130卷 1654-1661页

作者： Ru Liu Fei Xiong Yuan Wen Yuan-Liang Ma Yi Yao Zhan Gao Bo Xu yue-jin yang Shu-Bin Qiao Run-Lin Gao jin-Qing Yuan Department of Cardiology Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of Physiology Colleges of Pharmacy and Medicine University of Kentucky Lexington KY 40536 USA

Background：Lots of trials demonstrate that second-generation drug-eluting stents （G2-DES）,with their improved properties,offer significantly superior efficacy and safety profiles compared to first generation DES （Gl-DES） for patients with coronary artery disease （CAD） receiving percutaneous coronary intervention （PCI）.This study aimed to verify the advantage of G2-DES over G1-DES in Chinese patients with stable CAD （SCAD）.Methods：For this retrospective observational analysis,2709 SCAD patients with either G1-DES （n =863） or G2-DES （n =1846） were enrolled consecutively throughout *** score matching （PSM） was applied to control differing baseline ***-year outcomes,including major adverse coronary events as well as individual events,including target vessel-related myocardial infarction,target lesion revascularization （TLR）,target vessel revascularization,and cardiogenic death were ***：The incidence of revascularization between G1-and G2-DES showed a trend of significant difference with a threshold P-value （8.6% vs.6.7%,x2 =2.995,P =0.084）.G2-DES significantly improved TLR-free survival compared to G1-DES （96.6% vs.97.9%,P =0.049） and revascularization-free survival curve showed a trend of improvement of G2-DES （92.0% vs.93.8%,P =0.082）.These difterences diminished after *** Cox proportional hazard regression analysis showed a trend for G 1-associated increase in revascularization （hazard ratio：1.28,95% confidence interval：0.95-1.72,P =0.099） while no significance was found after *** endpoints showed no significant differences after multivariate adjustment regardless of ***：G1-DES showed the same safety as G2-DES in this large Chinese cohort of real-world ***,G2-DES improved TLR-ffee survival of SCAD patients 2 years after *** advantage was influenced by baseline clinical ***-DES was associated with a trend of increase in revascularization risk and was not an independent predictor o

关键词： Drug-etuting Stents Percutaneous Coronary Intervention Stable Coronary Artery Disease

Analyses on an electronic voltage transformer's failure by its resonance with very fast transient overvoltage and suppression

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High Voltage 2024年第1期9卷 150-162页

作者： Ruoyu Han Houda Zhu Qing Chen Hongbin Li yue Tong Linshan Han yang Jiao School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhanChina China Electric Power Research Institute WuhanChina School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhanChina

As voltage measuring devices are widely used in the high voltage power system with a primary-secondary-fusion structure,electronic voltage transformers are directly connected to the primary conductor and would face much more serious electromagnetic environments than general secondary *** a result,they would still experience failures even when general protection measures are adopted to suppress overvoltages'*** address this issue,an innovative method is proposed after analyses are conducted on the resonance between a transformer and an *** this method,an air-cored coil is installed in a transformer to artificially shift its natural frequency and to dodge the high-frequency dominant component of a transient overvoltage,avoiding the aforementioned resonance and suppressing the secondary *** addition,simulations and laboratory tests are conducted to prove this method's validity.

关键词： transient resonance mentioned

Advances in targeted therapy for human epidermal growth factor receptor 2 positive in advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2318-2334页

作者： Ya-Kun Jiang Wei Li Ying-yang Qiu Meng yue Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Health Management Center Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Yong Loo Lin School of Medicine National University of SingaporeSingapore 119077Singapore

Emerging therapeutic methods represented by targeted therapy are effective supplements to traditional first-line chemoradiotherapy *** epidermal growth factor receptor 2(HER2)is one of the most important targets in targeted therapy for gastric *** combined with chemotherapy has been used as the first-line treatment for advanced gastric *** safety and efficacy of pertuzumab and margetuximab in the treatment of gastric cancer have been ***,monoclonal antibodies,due to their large molecular weight,inability to penetrate the blood-brain barrier,and drug resistance,lead to decreased therapeutic efficacy,so it is necessary to explore the efficacy of other HER2-targeting therapies in gastric ***-molecule tyrosine kinase inhibitors,such as lapatinib and pyrrotinib,have the advantages of small molecular weight,penetrating the blood-brain barrier and high oral bioavailability,and are expected to become the drugs of choice for perioperative treatment and neoadjuvant therapy of gastric cancer after validation by large-scale clinical trials in the ***-drug conjugate,such as T-DM1 and T-DXd,can overcome the resistance of monoclonal antibodies despite their different mechanisms of tumor killing,and are a supplement for the treatment of patients who have failed the treatment of monoclonal antibodies such as ***,after more detailed stratification of gastric cancer patients,various gastric cancer drugs targeting HER2 are expected to play a more significant role.

关键词： Human epidermal growth factor receptor 2 Gastric cancer Targeted therapy Review

Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy

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World Journal of Psychiatry 2024年第7期14卷 1017-1026页

作者： Xiu-Qiao Hao Xiang-Dan yang yue Qi Department of Hematology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a rapidly growing malignant tumor,and chemotherapy is one of the treatments used to combat *** advancements of science and technology have resulted in more and more patients being able to receive effective treatment,they still face side effects such as fatigue and *** is important to thoroughly investigate the factors that contribute to cancer-related fatigue(CRF)during *** To explore the factors related to CRF,anxiety,depression,and mindfulness levels in patients with DLBCL during *** General information was collected from the electronic medical records of eligible *** quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short *** Piper Fatigue Scale was used to evaluate the CRF *** Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression *** analysis and multivariate regression analysis were used to investigate the factors related to *** The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74±*** 25 patients,the highest rate of mild fatigue was in the cognitive dimension(40.32%),and in 35 patients the highest moderate fatigue rate in the behavioral dimension(56.45%).In the emotional dimension,severe fatigue had the highest rate of occurrence,34 cases or 29.03%.The CRF score was positively correlated with cancer experience(all P<0.01)and negatively correlated with cancer treatment efficacy(all P<0.01).Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level were related to CRF in patients with DLBCL during *** There was a significant correlation between CRF and perceptual control level in *** staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level

关键词： Diffuse large B-cell lymphoma Chemotherapy Cancer-related fatigue Anxiety Depression Mindfulness

Lath-like phases formed at an extremely high temperature in a Mg-RE(RE=rare earth)-Al alloy

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Rare Metals 2024年第8期43卷 3937-3945页

作者： Bo Deng Shu-Hui Lv Qiang yang Dong-yue Zhao Jun-Yuan Fan Xin Qiu School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Chongqing Research Institute Changchun University of Science and TechnologyChongqing 401135China

Thermal stable intermetallic particles are important for the heat resistance of magnesium(Mg)*** this work,many lath-like particles formed in α-Mg grains of a Mg-8Gd-3Sm-0.7Al casting alloy when heat-treated at 873 ***-resolution high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM) characterizations indicate that most of them are Mg-containing Al_(2)(Gd,Sm),with the atomic ratio of Mg:Al:(Gd,Sm) being ~1:1:1;a small part of them with relatively wider thickness are long-period stacking ordered(LPSO) phases simultaneously containing both 14H and 18R *** followed common orientation relationships with Mg matrix as those reported in previous *** addition,many Mg laths were observed in the primary blocky Al_(2)(Gd,Sm) phase at grain boundaries,where the atomic ratio of Al:(Gd,Sm) in the Al_(2)(Gd,Sm) matrix was 2:***,density functional theory(DFT) calculations illustrated the detail structure of the re-constructed Mg/Al_(2)RE interface and simultaneously deduced the underlying reason for the re-dissolution of the newly formed Mg-containing Al_(2)(Gd,Sm) plates in α-Mg matrix.

关键词： Magnesium alloy HAADF-STEM Microstructures Intermetallic particles Orientation relationships Interfaces

Demand and key technology for a LEO constellation as augmentation of satellite navigation systems

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Satellite Navigation 2024年第1期5卷 1-9页

作者： Yuanxi yang yue Mao Xia Ren Xiaolin Jia Bjiao Sun Xi’an Research Institute of Surveying and Mapping Xi’an710054ShaanxiChina State National Key Laboratory of Geo-Information Engineering Xi’an710054ShaanxiChina

A Low Earth Orbit(LEO)constellation augmenting satellite navigation is important in the future development of Global Navigation Satellite System(GNSS).GNSS augmented by LEO constellations can improve not only the accuracy of Positioning,Navigation,and Timing(PNT),but also the consistency and reliability of secure PNT *** paper mainly analyzes the diverse demands of different PNT users for LEO augmented GNSS,including the precision demand in real-time,the availability demand in special areas,the navigation signal enhancement demand in complex electromagnetic environments,and the integrity demand with high ***,the possible contributions of LEO constellations to PNT performance are analyzed from multiple aspects.A particular attention is paid to the special PNT user requirements that cannot be fulfilled with existing GNSS,such as the PNT service demand in the polar regions and the onboard GNSS orbit determination demand of some LEO *** key technologies to be considered in the constellation design,function realization,and payload development of the LEO-augmented navigation system are summarized.

关键词： Low earth orbit navigation constellation Accuracy augmentation Orbit determination Integrity

Comprehensive Evaluation of Distributed PV Grid-Connected Based on Combined Weighting Weights and TOPSIS-RSR Method

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Energy Engineering 2024年第3期121卷 703-728页

作者： yue yang Jiarui Zheng Long Cheng Yongnan Zhu Hao Wu Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin132012China Siping Suburban Power Supply Company State Grid Jilin Electric Power Co.Ltd.Siping136000China

To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and objective combination of assignment and technique for order preference by similarity to an ideal solution(TOPSIS)—rank sum ratio(RSR)(TOPSIS-RSR)*** on the traditional distribution network evaluation system,a comprehensive evaluation system has been *** fully considers the new development requirements of distributed PV access on the environmental friendliness and absorptive capacity of the distribution grid and comprehensively reflects the impact of distributed PV grid *** analytic hierarchy process(AHP)was used to determine the subjective weights of the primary indicators,and the Spearman consistency test was combined to determine the weights of the secondary indicators based on three objective assignment *** subjective and objective combination weights of each assessment indicator were calculated through the principle of minimum *** the distance between the indicators to be evaluated and the positive and negative ideal solutions,the relative closeness ranking,and qualitative binning by TOPSIS-RSR method to obtain the comprehensive evaluation results of different *** setting up different PV grid-connected scenarios and utilizing the IEEE33 node simulation algorithm,the correctness and effectiveness of the proposed subject-object combination assignment and integrated assessment method are verified.

关键词： Distributed PV grid-connected comprehensive evaluation evaluation indicator system combined subjective and objective empowerment TOPSIS-RSR method

Microseismic source location using deep learning:A coal mine case study in China

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3407-3418页

作者： yue Song Enyuan Wang Hengze yang Chengfei Liu Baolin Li Dong Chen School of Safety Engineering China University of Mining and TechnologyXuzhou221116China State Key Laboratory of Coal Mine Disaster Prevention and Control China University of Mining and TechnologyXuzhou221116China School of Environment and Safety Engineering North University of ChinaTaiyuan030051China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining TechnologyXuzhou221116China

Microseismic source location is crucial for the early warning of rockburst ***,the conventional methods face challenges in terms of the microseismic wave velocity and arrival time *** techniques,such as the full convolutional neural network(FCNN),can capture spatial information but struggle with complex microseismic *** the FCNN with the long shortterm memory(LSTM)network enables better time-series signal classification by integrating multiscale information and is therefore suitable for waveform *** LSTM-FCNN model does not require extensive data preprocessing and it simplifies the microseismic source location through feature *** this study,we utilized the LSTM-FCNN as a regression learning model to locate the seismic ***,the method of short-time-average/long-time-average(STA/LTA)arrival time picking was employed to augment spatiotemporal ***,oversampling the on-site data was performed to address the issue of data imbalance,and finally,the performance of LSTM-FCNN was ***,we compared the LSTM-FCNN model with previous deep-learning *** results demonstrated remarkable location capabilities with a mean absolute error(MAE)of only 7.16 *** model can realize swift training and high accuracy,thereby significantly improving risk warning of rockbursts.

关键词： Microseismic source location Rockburst Deep learning Intelligent early warning

COMPARISON OF SHORT- AND LONG-TERM OUTCOMES BETWEEN CYPHER AND TAXUS DRUG-ELUTING STENTS FOR IN-STENT RESTENOSIS

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Chinese Medical Sciences Journal 2007年第1期22卷 5-8页

作者： Ji-lin Chen yue-jin yang Shu-bin Qiao Min Yao Xue-wen Qin Bo Xu Hai-bo Liu Yong-jian Wu jin-qing Yuan Jue Chen Shi-jie You Jun Dai Jian-jun Li Run-lin Gao Center for Diagnosis ＆ Treatment of Coronary Heart Disease Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037

Objective To compare the short- and long-term clinical outcomes between sirolimus-eluting stent （ Cypher stent） and paclitaxel-eluting stent （TAXUS stent） in patients with in-stent restenosis （ISR） lesions of the coronary arteries. Methods From December 2002 to March 2005, 253 patients with ISR lesions of the coronary arteries were selected and divided into two groups. Cypher group （152 cases） was treated with Cypher or Cypher Select stents, and TAXUS group （101 cases） with TAXUS stents. A total of 262 ISR lesions in these patients were treated with 308 drog-eluring stents （DESs）, including 176 Cypher or Cypher Select stents and 132 TAXUS stents. All patients were followed up for 10 months. Procedure success rates of DES implantation in both groups were observed. Major adverse cardiac events （MACE） rates in hospital and at 10 months follow-up, as well as in-DES restenosis observed using coronary angiography at follow-up were compared between two groups. Results Success rate of DES implantation was 100% in both groups. No significant difference in MACE rate during hospitalization was found between the two groups. However, at 10 months follow-up, MACE rate was higher in TAXUS group than in Cypher group （ 16.00% vs. 6.67%, P =0. 031 ）. As for coronary angiography at 10 months follow-up, we observed an increasing tendency of in-DES restenosis rate in TAXUS group compared with Cypher group （29.41% vs. 14.04%, P=0.075）. Conclusions Cypher and TAXUS DESs both have good short- and long-term outcomes in treating ISR. Cypher DES proved better long-term clinical outcome than TAXUS DES.

关键词： in-stent restenosis drug-eluting stent outcome