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Comprehensive prognostic and immune analysis of sterol Oacyltransferase 1 in patients with hepatocellular carcinoma

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World Journal of Hepatology 2024年第3期16卷 439-451页

作者： Chang-Jiao Gan yue zheng Bin Yang Li-Min Cao Development Research Department National Medical Products Administration Institute of Executive DevelopmentBeijing 100071China School of Medicine Nankai University Affiliated Third Center HospitalTianjin 300070China Tianjin Institute of Hepatobiliary Disease The Third Central Hospital of TianjinTianjin 300170China Department of Science and Technology Tianjin Third Central HospitalTianjin 300170China

BACKGROUND Sterol O-acyltransferase 1(SOAT1)is an important target in the diagnosis and treatment of liver cancer.However,the prognostic value of SOAT1 in patients with hepatocellular carcinoma(HCC)is still not clear.AIM To investigate the correlation of SOAT1 expression with HCC,using RNA-seq and gene expression data of The Cancer Genome Atlas(TCGA)-liver hepatocellular carcinoma(LIHC)and pan-cancer.METHODS The correlation between SOAT1 expression and HCC was analyzed.Cox hazard regression models were conducted to investigate the prognostic value of SOAT1 in HCC.Overall survival and disease-specific survival were explored based on TCGA-LIHC data.Biological processes and functional pathways mediated by SOAT1 were characterized by gene ontology(GO)analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of differentially expressed genes.In addition,the protein-protein interaction network and co-expression analyses of SOAT1 in HCC were performed to better understand the regulatory mechanisms of SOAT1 in this malignancy.RESULTS SOAT1 and SOAT2 were highly expressed in unpaired samples,while only SOAT1 was highly expressed in paired samples.The area under the receiver operating characteristic curve of SOAT1 expression in tumor samples from LIHC patients compared with para-carcinoma tissues was 0.748,while the area under the curve of SOAT1 expression in tumor samples from LIHC patients compared with GTEx was 0.676.Patients with higher SOAT1 expression had lower survival rates.Results from GO/KEGG and gene set enrichment analyses suggested that the PI3K/AKT signaling pathway,the IL-18 signaling pathway,the calcium signaling pathway,secreted factors,the Wnt signaling pathway,the Jak/STAT signaling pathway,the MAPK family signaling pathway,and cell–cell communication were involved in such association.SOAT1 expression was positively associated with the abundance of macrophages,Th2 cells,T helper cells,CD56bright natural killer cells,and Th1 cells,and negatively linked to the abundance of Th17 cells,dendritic

关键词： Sterol O-acyltransferase 1 Hepatocellular carcinoma Prognostic Immune

Optimizing 2D-metal contact in layered Tin-selenide via native oxide modulation

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Nano Research 2024年第4期17卷 3014-3020页

作者： yue zheng Qi You Zhentian Yin Jian Tang Ke Jiang Zihao Xie Henan Li Cheng Han Yumeng Shi International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China

The discovery of two-dimensional(2D)semiconductor has opened up new avenues for the development of short-channel field-effect transistors(FETs)with desired electrical performance.Among them,orthorhombic tin-selenide(SnSe)has garnered increasing attention due to its potential applications in a variety of electronic,optoelectronic,and thermoelectric devices.However,the realization of high-performance SnSe FETs with low contact resistance(Rc)remains a challenge.Herein,we systematically investigate the contact of few-layer SnSe FETs through the modulation of native oxide on SnSe by using different metals.It is found that chromium(Cr)-contacted devices possess the best FET performance,such as electron mobility up to 606 cm^(2)/(V·s)at 78 K,current on/off ratio exceeding 1010,and saturation current of~550μA/μm,where a negligible Schottky barrier(SB)of~30 meV and a low contact resistance of~425Ωμm are achieved.X-ray photoelectron spectroscopy(XPS)and cross-sectional electron dispersive X-ray spectroscopy(EDX)results further reveal that the improved contact arises from the Cr-induced reduction of native oxide(SnOx)to Sn,which thins the tunneling barrier for efficient electron injection.Our findings provide a deep insight into the 2D-metal contact of SnSe and pave the way for its applications in future nanoelectronics.

关键词： few-layer SnSe field-effect transistors(FETs) Cr contact native oxide contact resistance(Rc) Schottky barrier(SB)

Interlayer exciton dynamics of transition metal dichalcogenide heterostructures under electric fields

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Nano Research 2024年第5期17卷 4555-4572页

作者： Jian Tang yue zheng Ke Jiang Qi You Zhentian Yin Zihao Xie Henan Li Cheng Han Xiaoxian Zhang Yumeng Shi International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Luminescence and Optical Information Ministry of EducationInstitute of Optoelectronic TechnologyBeijing Jiaotong UniversityBeijing 100044China

Stacking single layers of atoms on top of each other provides a fundamental way to achieve novel material systems and engineer their physical properties,which offers opportunities for exploring fundamental physics and realizing next-generation optoelectronic devices.Among the two-dimensional(2D)-stacked systems,transition metal dichalcogenide(TMDC)heterostructures are particularly attractive because they host tightly-bonded interlayer excitons which possess various novel and appealing properties.These interlayer excitons have drawn significant research attention and hold high potential for the application in unique optoelectronic devices,such as polarization-and wavelength-tunable single photon emitters,valley Hall transistors,and possible high-temperature superconductors.The development of these devices requires a comprehensive understanding of the fundamental properties of these interlayer excitons and the impact of electric fields on their behaviors.In this review,we summarize the recent advances on the understanding of interlayer exciton dynamics under electric fields in TMDC heterostructures.We put emphasis on the electrical modulation of interlayer excitons’emission,the valley Hall transport of charge carriers after the separation of interlayer excitons by an electric field,and the correlation physics of interlayer excitons and charges under electrical doping and tuning.Challenges and perspectives are finally discussed for the application of TMDC heterostructures in future optoelectronics.

关键词： interlayer exciton transition metal dichalcogenide(TMDC)heterostructures circular polarization valley Hall effect strong coupling

HetNets Under Decoupled Uplink and Downlink Access with UE Random Discontinuous Transmission: Local Delay and Energy Efficiency

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China Communications 2024年第3期21卷 205-216页

作者： Zhang yue zheng Fuchun Luo Jingjing School of Electronic and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Due to the limited uplink capability in heterogeneousnetworks (HetNets), the decoupled uplinkand downlink access (DUDA) mode has recently beenproposed to improve the uplink performance. In thispaper, the random discontinuous transmission (DTX)at user equipment (UE) is adopted to reduce the interferencecorrelation across different time slots. By utilizingstochastic geometry, we analytically derive themean local delay and energy efficiency (EE) of an uplinkHetNet with UE random DTX scheme under theDUDA mode. These expressions are further approximatedas closed forms under reasonable assumptions.Our results reveal that under the DUDA mode, there isan optimal EE with respect to mute probability underthe finite local delay constraint. In addition, with thesame finite mean local delay as under the coupled uplinkand downlink access (CUDA) mode, the HetNetsunder the DUDA mode can achieve a higher EE witha lower mute probability.

关键词： decoupled uplink and downlink access(DUDA) heterogeneous networks(HetNets) random discontinuous transmission(DTX) stochastic geometry

Heterogeneous Image Knowledge Driven Visual Perception

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 255-257页

作者： Lan Yan Wenbo zheng Fei-yue Wang IEEE the College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China the School of Computer Science and Artificial Intelligence Wuhan University of TechnologyWuhan 430070China the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,This letter is concerned with visual perception closely related to heterogeneous images.Facing the huge challenge brought by different image modalities,we propose a visual perception framework based on heterogeneous image knowledge,i.e.,the domain knowledge associated with specific vision tasks,to better address the corresponding visual perception problems.

关键词： Visual visual knowledge

Numerical simulation of transient characteristics in a bulb turbine during the load rejection process

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Journal of Hydrodynamics 2024年第1期36卷 170-183页

作者： yue Lu Yu-quan Zhang Zhong-wei He Yuan zheng College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China College of Energy and Electrical Engineering Hohai UniversityNanjing210098China Huadong Engineering Corporation Ltd. Hangzhou311122China

To evaluate the safety of the bulb tubular turbine,the dynamic hydraulic characteristics of a hydropower station system during the load rejection process are studied through numerical simulations and a prototype test.In the developed model,a dynamic grid technology(DGT)controls the closure of the guide vane and the blade,whilst the moment balance equation and the user-defined function(UDF)provide the runner’s rotation speed.The 3-D transient simulation method can well predict the rotation speed and mass flow curves in the state of load rejection.The simulation outcomes of the system performance are basically consistent with the measurement data of the prototype.As observed,the runner is subjected to the reversely increased torque and axial force,the system is in a braking phase,and the maximum speed peaks at 144.6%of the rated speed.Moreover,the internal flow of the runner is greatly affected by the closure of the guide vane,and the draft tube forms an eccentric spiral vortex rope.It breaks downstream,aggravating the instability of the draft tube.Overall,the transient characteristics span for the first five seconds,demonstrating the importance of establishing an efficient governing controller.The obtained results are useful for designing the turbine’s flow channel with a double regulating function and comprehending the turbine’s transient characteristics.

关键词： Bulb tubular turbine load rejection numerical simulation dynamic grid prototype test

A Novel Scheduling Framework for Multi-Programming Quantum Computing in Cloud Environment

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Computers, Materials & Continua 2024年第5期79卷 1957-1974页

作者： Danyang zheng Jinchen Xv Feng yue Qiming Du ZhihengWang zheng Shan Information Engineering University Zhengzhou450001China

As cloud quantum computing gains broader acceptance,a growing quantity of researchers are directing their focus towards this domain.Nevertheless,the rapid surge in demand for cloud-based quantum computing resources has led to a scarcity,which in turn hampers users from achieving optimal satisfaction.Therefore,cloud quantum computing service providers require a unified analysis and scheduling framework for their quantumresources and user jobs to meet the ever-growing usage demands.This paper introduces a new multi-programming scheduling framework for quantum computing in a cloud environment.The framework addresses the issue of limited quantum computing resources in cloud environments and ensures a satisfactory user experience.It introduces three innovative designs:1)Our framework automatically allocates tasks to different quantum backends while ensuring fairness among users by considering both the cloud-based quantum resources and the user-submitted tasks.2)Multi-programming mechanism is employed across different quantum backends to enhance the overall throughput of the quantum cloud.In comparison to conventional task schedulers,our proposed framework achieves a throughput improvement of more than two-fold in the quantum cloud.3)The framework can balance fidelity and user waiting time by adaptively adjusting scheduling parameters.

关键词： Quantum computing scheduling multi-programming qubit mapping

Analysis and monitoring of drug therapy in a patient with peptic ulcer complicated by infection:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1530-1535页

作者： Yan-Ping Gou yue Huang Li Chen Wei zheng Yun-Hua zheng The Second People’s Hospital of Meishan City&Renshou County People’s Hospital Meishan 620500Sichuan ProvinceChina Quality Evaluation and Medical Record Management The Affiliated Hospital of Southwest Jiaotong University&The Third People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Patriotic Health Campaign Qionglai City Health BureauChengdu 610000Sichuan ProvinceChina

BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.

关键词： Ampicillin-sulbactam Famotidine Lansoprazole Kangfuxin Liquid Chinese pharmacist Case report

Parallel Vision ■ Image Synthesis/Augmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 782-784页

作者： Wenwen Zhang Wenbo zheng Qiang Li Fei-yue Wang the School of Computer Science Shaanxi Normal UniversityXi’an 710119China the School of Computer Science and Technology Wuhan 430070China the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,Scene understanding is an essential task in computer vision.The ultimate objective of scene understanding is to instruct computers to understand and reason about the scenes as humans do.Parallel vision is ... 详细信息

关键词： instru explanation computer