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An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 51-57页

作者： Jiang, Ming-De zheng, Shu-mei xu, Hui Zeng, Wei-zheng Zhang, Yong Sun, Hao-Ping Wang, yun-Xia Qin, Jian-Ping wu, Xiao-Ling Gen Hosp Chenghu Milt Command Dept Gastroenterol Chengdu 610083 Peoples R China

BACKGROUND: The pathogenesis of hepatic fibrosis and cirrhosis is still not fully understood. The extracellular signal-regulated kinase (ERK) pathway is involved in the regulation of cell proliferation and differentiation. The aim of this study was to investigate the effects of PD98059, a specific inhibitor of ERK, on the cell cycle, cell proliferation, secretion of type I collagen and expression of cyclin D1 mRNA, CDK4 mRNA and transforming growth factor-beta 1 (TGF-beta 1) mRNA in rat hepatic stellate cells (HSCs) stimulated by acetaldehyde. METHODS: Rat HSCs stimulated by acetaldehyde were incubated with PD98059 at different concentrations. The cell cycle was analysed by flow cytometry. Cell proliferation was assessed by the methyl thiazolyl tetrazolium colorimetric assay. The mRNA expression of cyclin D1, CDK4 and TGF-beta 1 was examined using the reverse transcriptase-polymerase chain reaction. Type I collagen in the culture medium was detected by enzyme-linked immunosorbent assay. RESULTS: 20, 50 and 100 mu mol/L PD98059 significantly inhibited the proliferation and provoked a G0/G1-phase arrest of acetaldehyde-induced HSCs in a dose-dependent manner. The secretion of type I collagen and the expression of cyclin D1, CDK4 and TGF-beta 1 mRNA in acetaldehyde-induced HSCs were markedly inhibited by 50 and 100 mu mol/L PD98059, respectively. CONCLUSIONS: The ERK pathway regulates the cell proliferation, secretion of type I collagen and the expression of TGF-beta 1 mRNA in rat HSCs stimulated by acetaldehyde, which is likely related to its regulative effect on the cell cycle.

关键词： extracellular signal-regulated kinase hepatic stellate cell hepatic fibrosis

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Radiotherapy of unicentric mediastinal Castleman's disease

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Chinese Journal of Cancer 2011年第5期30卷 351-356页

作者： yue-Min Li Peng-Hui Liu Yu-Hai Zhang Huo-Sheng Xia Liang-Liang Li Yi-mei Qu Yong wu Shou-yun Han Guo-Qing Liao Yong-Dong Pu Cancer Center PLA 309 Hospital Beijing 100091 P.R. China Cancer Center The General Hospital of PLA Beijing 100853P. R. China

Castleman's disease is a slowly progressive and rare lymphoproliferative ***,we report a 55-year-old woman with superior mediastinal Castleman's disease being misdiagnosed for a long *** found a 4.3 cm mass localized in the superior mediastinum accompanied with severe clinical *** patient underwent an exploratory laparotomy,but the mass failed to be totally *** examination revealed a mediastinal mass of Castleman's *** radiotherapy of 30 Gy by 15 fractions,the patient no longer presented previous *** 3 months after radiotherapy of 60 Gy by 30 fractions,Computed tomography of the chest showed significantly smaller mass,indicating partial *** a 10-month follow-up,the patient was alive and free of symptoms.

关键词：放射治疗临床症状淋巴组织病理检查增生性本地化放疗剖腹

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2019—2020年160例儿童肺炎链球菌脑膜炎临床流行病学多中心研究

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中国当代儿科杂志 2024年第2期26卷 131-138页

作者：王彩云许红梅刘钢刘静俞蕙陈必全郑帼舒敏杜丽君徐志伟黄丽素李海波汪东白松婷单庆文朱春晖田健美郝建华林爱伟林道炯吴谨准张新华曹清陶仲宾陈源朱国龙薛萍汤正珍苏学文曲政海赵仕勇庞琳邓慧玲舒赛男陈英虎浙江大学医学院附属儿童医院感染科浙江杭州310052 重庆医科大学附属儿童医院感染科重庆400014 首都医科大学附属北京儿童医院感染科北京100045 湖南省儿童医院感染科湖南长沙410007 复旦大学附属儿科医院感染科上海201102 安徽省儿童医院感染科安徽合肥230022 南京医科大学附属儿童医院神经科江苏南京210008 四川大学华西第二医院儿科四川成都610044 山西省儿童医院神经内科山西太原030006 温州医科大学附属第二医院/育英儿童医院普儿科浙江温州325027 上海交通大学医学院附属新华医院感染科上海200092 吉林大学第一医院儿科门诊吉林长春130061 西安交通大学附属儿童医院陕西西安710002 郑州大学第一附属医院儿科河南郑州450052 广西医科大学第一附属医院儿科广西南宁530021 江西省儿童医院感染科江西南昌330006 苏州大学附属儿童医院感染科江苏苏州215002 河南开封市儿童医院感染科河南开封475000 山东大学儿童院感染科山东济南250022 海南省妇幼保健院感染科海南海口571103 厦门大学附属妇女儿童医院儿科福建厦门361003 山西省儿童医院新生儿科山西太原030006 上海交通大学医学院附属上海儿童医学中心感染科上海200127 兰州大学第一医院儿科甘肃兰州730013 河北医科大学第二医院儿科河北石家庄050004 青海省妇女儿童医院感染消化科青海西宁810007 太原市妇幼保健院儿内科山西太原030012 遵义市第一人民医院儿科贵州遵义563099 内蒙古自治区人民医院儿科内蒙古呼和浩特750306 青岛大学附属医院儿科山东青岛266003 杭州市儿童医院感染科浙江杭州310005 首都医科大学附属北京地坛医院儿科北京100102 西安市中心医院儿科陕西西安710004 华中科技大学同济医学院附属同济医院儿科湖北武汉430030

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿... 详细信息

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿的临床信息、实验室资料和微生物学资料。结果160例PM患儿中,男103例,女57例;年龄15 d至15岁,其中3月龄至<3岁109例(68.1%)。脑脊液培养分离SP菌株95例(59.4%),血培养分离SP菌株57例(35.6%)。脑脊液宏基因组二代测序和脑脊液SP抗原检测阳性率分别为40%(35/87)、27%(21/78)。55例(34.4%)患儿存在1个或多个化脓性脑膜炎高危因素;113例(70.6%)患儿有1个或多个颅外感染病灶;18例(11.3%)有明确基础疾病。临床症状以发热最常见(147例,91.9%),其次是精神萎靡(98例,61.3%)、呕吐(61例,38.1%)等。69例(43.1%)患儿住院期间发生颅内并发症,常见并发症为硬膜下积液和/或积脓(43例,26.9%)、脑积水(24例,15.0%)、脑脓肿(23例,14.4%)、脑出血(8例,5.0%)。硬膜下积液和/或积脓和脑积水主要发生在<1岁患儿,分别为91%(39/43)、83%(20/24)。SP菌株对万古霉素(100%,75/75)、利奈唑胺(100%,56/56)、厄他培南(100%,6/6)完全敏感;对左氧氟沙星(81%,22/27)、莫西沙星(82%,14/17)、利福平(96%,25/26)和氯霉素(91%,21/23)敏感率高;对青霉素(16%,11/68)、克林霉素(6%,1/17)敏感率低;对红霉素完全耐药(100%,31/31)。痊愈和好转出院率分别为22.5%(36/160)、66.2%(106/160);18例(11.3%)出现不良结局。结论儿童PM多见于3月龄至<3岁婴幼儿,颅内并发症多发生在<1岁患儿,发热是PM患儿最常见的临床表现,硬膜下积液和/或积脓、脑积水是最常见的并发症。脑脊液非培养检测方法有助于提高病原菌检出率。超过10%PM患儿出现不良结局。SP菌株对万古霉素、利奈唑胺、厄他培南、左氧氟沙星、莫西沙星、利福平、氯霉素敏感率高。

关键词：肺炎链球菌脑膜炎流行病学多中心研究儿童

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核桃花中绿原酸、新绿原酸和隐绿原酸的提取工艺优化及其抗氧化活性研究

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食品安全质量检测学报 2024年第11期15卷 284-293页

作者：李倩张洁雷凤梅张卢峰王佳音宋莲军乔明武邝运起沈玥河南农业大学食品科学技术学院郑州450002 河南省食品加工与流通安全控制工程技术研究中心郑州450002 原荣农业有限公司三门峡472200

目的探讨干燥核桃花中绿原酸、隐绿原酸和新绿原酸的最佳提取工艺及其抗氧化活性。方法采用超声波辅助乙醇法提取核桃花中的绿原酸、新绿原酸和隐绿原酸,以提取温度、乙醇体积分数、提取时间和料液比为自变量,以得率的总评归一值(overal... 详细信息

目的探讨干燥核桃花中绿原酸、隐绿原酸和新绿原酸的最佳提取工艺及其抗氧化活性。方法采用超声波辅助乙醇法提取核桃花中的绿原酸、新绿原酸和隐绿原酸,以提取温度、乙醇体积分数、提取时间和料液比为自变量,以得率的总评归一值(overall desirability,OD)为因变量,应用响应面对提取工艺进行优化,并通过体外实验评价了其抗氧化活性。结果最佳提取工艺为:温度77℃、乙醇体积分数67%、提取时间28 min,料液比1:23(g/mL)。此时,绿原酸、新绿原酸和隐绿原酸的总提取率最佳,OD值可达0.91,对1,1-二苯基-2-三硝基苯肼(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基、2,2’-联氮-二(3-乙基-苯并噻唑啉-6-磺酸)二铵盐[2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)ammonium salt,ABTS]阳离子自由基和羟自由基的半数抑制浓度(half-maximal Inhibitory concentrations,IC50)值分别为41.63、41.68和34.43μg/mL。结论优选出的工艺稳定可行,且提取液具有较好的体外抗氧化活性,为核桃花中绿原酸类成分的进一步开发利用提供了理论基础。

关键词：核桃花绿原酸新绿原酸隐绿原酸抗氧化活性提取工艺响应面法

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Predictive value of serum uric acid on cardiovascular disease and all-cause mortality in urban Chinese patients

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Chinese Medical Journal 2010年第11期123卷 1387-1391页

作者： wu Yong-quan LI Jue xu Yuan-xi WANG Yong-liang LUO Ying-yi HU Da-yi LIU Wei-jing yang Ming PI Lin WANG Ming-sheng WANG Ji-yun ZHAO Shu-mei LI mei-jing Department of Cardiology Beijing Friendship Hospital affiliated toCapital Medical University Beijing 100050 China Heart Lung and Blood Vessel Centre Medical School of TongjiUniversity Shanghai 200065 China Department of Cardiology Tongji Hospital of Tongji UniversityShanghai 200065 China Department of Cardiology Shanghai 10th Hospital Shanghai200072 China Department of Cardiology Beijing Fuxing Hospital affiliated toCapital Medical University Beijing 100038 China Department of Cardiology - B-eijing Chuiyangliu HospitalBeijing100022 China Department of cardiology Beijing Shijingshan HospitalBeijing100043 China Department of Cardiology Beijing Tongren Hospital Affiliated toCapital Medical University Beijing 100005 China Department of Cardiology Shanghai Oriental Hospital Shanghai200120 China

Background The association between increased serum uric acid （SUA） levels and cardiovascular risk has been debated for decades. Several large studies have provided conflicting results regarding the clinical significance of elevated SUA levels in cardiovascular disease （CVD） or cerebrovascular disease. The aim of this study was to investigate the relationship between SUA and CVD and all-cause mortality and their potential diagnostic value. Methods A total of 3570 in-patients ranging in age from 56 to 95 years （mean （67.36_＋11.36） years） were selected from 20 hospitals in Beijing and Shanghai. A carefully designed questionnaire was used to gather baseline data of each patient All patients were divided into two main groups according to their SUA levels： high SUA and normal SUA groups. Serum indices and other important parameters were measured. Results Compared with normal SUA group, high SUA group had significant difference in systolic blood pressure （SBP）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, body mass index （BMI）, and age （P 〈0.05 or P 〈0.01）. High SUA prevailed in female and patients with history of essential hypertension, while history of smoking and diabetes showed no significant difference between two groups. All-cause and CVD mortality occurred more frequently in high SUA group than in normal SUA group. In the accumulative survival analysis, high SUA group had lower survival rate than normal SUA group both in CVD and all-cause mortality. COX regression analysis indicated that the history of smoking, age and high SUA were independent risk factors for the development of CVD. Conclusions These preliminary observations suggest that patients with high SUA levels would face higher risk of mortality. SUA measurement may be applied as a routine predictor for clinical assessment.

关键词： serum uric acid, cardiovascular disease mortality

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Adsorption of octanohydroxamic acid at fluorite surface in presence of calcite species

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Transactions of Nonferrous Metals Society of China 2021年第12期31卷 3891-3904页

作者： zhou-jie WANG Long-hua xu Hou-qin wu Huan zhou Jin-ping MENG Xiao-mei HUO Ling-yun HUANG Key Laboratory of Solid Waste Treatment and Resource Recycle Ministry of EducationSouthwest University of Science and TechnologyMianyang 621010China State Key Laboratory for Environment-friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China

The surface properties of fluorite are often affected by dissolved gangue species(e.g.,calcite)during the flotation *** testing with and without the addition of calcite supernatant was conducted using octanohydroxamic acid(OHA)as the *** results revealed that dissolved calcite species significantly affected the flotation behavior of *** transform infrared spectra confirmed that the decrease in flotation recovery was linked to lower OHA *** chemistry analysis indicated that CaCO_(3) and Ca^(2+)from the calcite supernatant were the most favorably adsorbed species,and X-ray photoelectron spectroscopy analysis confirmed the surface adsorption of calcite *** functional theory simulations provided a detailed analysis of the multidentate adsorption configuration of OHA,which was the most favorable for adsorption on the fluorite *** adsorption energy calculation showed that the calcite dissolved species were more stably adsorbed on the fluorite surface than *** pre-adsorption of calcite dissolved species hindered the adsorption of OHA due to electrostatic repulsion.

关键词： fluorite calcite flotation dissolved species DFT calculation

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Early Research on COVID-19: A Bibliometric Analysis

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The Innovation 2020年第2期1卷 37-46,36页

作者： yue Gong Ting-can Ma yang-yang xu Rui yang Lan-jun Gao Si-hua wu jing Li Ming-liang yue Hui-gang Liang Xiao He Tao yun National Science Library Chinese Academy of SciencesBeijing 100190China wuhan Library Chinese Academy of ScienceWuhan 430071China Department of Library Information and Archives ManagementUniversity of Chinese Academy of SciencesBeijing 100190China China Center for Information Industry Development Beijing 100036China Key Laboratory of Plant Resources and Beijing Botanical Garden Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China Clinical Medical College Yangzhou UniversityYangzhou225001China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China China Science and Technology Exchange Center Beijing 100045China These authors contributed equally

In December 2019,an outbreak of pneumonia,which was named COVID-2019,emerged as a global health *** worldwide are engaged in attempts to elucidate the transmission and pathogenic mechanisms of the causative ***-19 was declared a pandemic by the World Health Organization in March 2020,making it critical to track and review the state of research on COVID-19 to provide guidance for further ***,bibliometric and knowledge mapping analyses of studies on COVID-19 were performed,including more than 1,500 papers on COVID-19 available in the PubMed and China National Knowledge Infrastructure databases from January 1,2020 to March 8,*** this review,we found that because of the rapid response of researchers worldwide,the number of COVID-19-related publications showed a high growth trend in the first 10 days of February;among these,the largest number of studies originated in China,the country most affected by pandemic in its early *** findings revealed that the epidemic situation and data accessibility of different research teams have caused obvious difference in emphases of the pub***,there was an unprecedented level of close cooperation and information sharing within the global scientific community relative to previous coronavirus *** combed and drew the knowledge map of the SARS-CoV-2 literature,explored early status of research on etiology,pathology,epidemiology,treatment,prevention,and control,and discussed knowledge gaps that remain to be urgently *** perspectives on treatment,prevention,and control are also presented to provide fundamental references for current and future coronavirus research.

关键词： COVID-19 SARS-COV-2 BIBLIOMETRIC ANALYSIS RESEARCH STATUS KNOWLEDGE SCAPE KNOWLEDGE MAP

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Venovenous extra-corporeal membrane oxygenation for severe acute respiratory distress syndrome: a matched cohort study

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Chinese Medical Journal 2019年第18期132卷 2192-2198页

作者： Song-Qiao Liu Ying-Zi Huang Chun Pan Lan-Qi Guo Xiao-Ting Wang wen-Kui Yu yun-Fu wu Jie Yan Hong-Sheng Zhao Ling Liu Feng-mei Guo jing-Yuan xu Yi yang Hai-Bo Qiu Department of Critical Care Medicine Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu 210009 China Department of Critical Care Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100010 China Department of General Surgery Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu 210002 China Department of Critical Care Medicine Suzhou Hospital Affiliated to Nanjing Medical University Suzhou Jiangsu 215001 China Department of Critical Care Medicine Wuxi People’s Hospital Nanjing Medical University Wuxi Jiangsu 214023 China Department of Critical Care Medicine Hospital of Nantong University Nantong Jiangsu 226001 China

Background:Although the use of extra-corporeal membrane oxygenation (ECMO) has been rapidly increasing,the benefit of ECMO in patients with acute respiratory distress syndrome (ARDS) remains *** objective was to investigate the effect of venovenous ECMO (VV-ECMO) on adult patients with severe ***:We conducted a multi-center,retrospective,cohort study in the intensive care units (ICUs) of six teaching hospitals between January 2013 and December *** with severe ARDS who received W-ECMO support were *** detailed demographic data and physiologic data were used to match ARDS patients without *** primary endpoint was the 28-day ***:Ninety-nine patients with severe ARDS supported by VV-ECMO and 72 patients without ECMO were included in this *** acute physiology and chronic health evaluation Ⅱ score was 23.1 ± 6.3 in the ECMO group and 24.8 ± 8.5 in the control group (P =0.1195).The sequential organ failure assessment score was 12.8 ± 3.4 in the ECMO group and 13.7 ± 3.5 in the control group (P =0.0848).The 28-day mortality of patients with ECMO support was 39.4%,and that of the control group was 55.6%.The survival analysis curve showed that the 28-day mortality in the ECMO group was significantly lower than that in the control group (P =0.0097).Multivariate Cox regression analysis showed that the independent predictors of the 28-day mortality were the requirement of vasopressors before ECMO (hazard ratio [HR]:1.006;95% confidence interval [CI]:1.001-1.013;P =0.030) and duration of mechanical ventilation before ECMO (HR:3.299;95% CI:1.264-8.609;P =0.034).Conclusions:This study showed that ECMO improved the survival of patients with severe *** duration of mechanical ventilation and the requirement of vasopressors before ECMO might be associated with an increased risk of death.

关键词： Acute respiratory distress syndrome Extra-corporeal membrane oxygenation Mortality Multi-center Mechanical ventilation

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Key determinants of misdiagnosis of tracheobronchial tuberculosis among senile patients in contemporary clinical practice:A retrospective analysis

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World Journal of Clinical Cases 2021年第25期9卷 7330-7339页

作者： Fei Tang Lian-Jun Lin Shu-Liang Guo Wei Ye Xian-Kui Zha Yu Cheng Ying-Feng wu yue-Ming Wang Xiao-mei Lyu Xiao-yun Fan Li-Ping Lyu Department of Geriatric Respiratory and Critical Care The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Interventional Pulmonology and Endoscopic Diagnosis and Treatment Center Anhui Chest HospitalHefei 230022Anhui ProvinceChina Department of Respiratory and Critical Care Medicine Peking University First HospitalBeijing 100034China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Tracheobronchial tuberculosis(TBTB)is a common subtype of pulmonary *** diseases often obscure the diagnosis of senile *** To characterize senile patients with TBTB and to identify the potential causes of *** One hundred twenty patients with senile TBTB who were admitted to the Anhui Chest hospital between May 2017 and May 2019 were retrospectively *** were classified as diagnosed group(n=58)and misdiagnosed group(n=62).Clinical manifestations,laboratory results,radiographic data,and endoscopic findings were compared between the two *** Patients in the misdiagnosed group were most commonly diagnosed as pulmonary tuberculosis(non-TBTB,29/62,46.8%),general pneumonia(9/62,14.5%),chronic obstructive pulmonary disease(8/62,12.9%),and tracheobronchial carcinoma(7/62,11.3%).The time elapsed between disease onset and confirmation of diagnosis was significantly longer in the misdiagnosed group[median(first quartile,third quartile):6.32(4.94,16.02)mo vs 3.73(2.37,8.52)mo].The misdiagnosed group had lower proportion of patients who underwent bronchoscopy[33.87%(21/62)vs 87.93%(51/58)],chest computed tomography(CT)scan[69.35%(43/62)vs 98.28%(57/58)],and those who showed CT signs of tuberculosis[27.91%(12/62)vs 50%(29/58)]as compared to that in the diagnosed group(P0.05).CONCLUSION Insufficient or inaccurate radiographic or bronchoscopic assessment was the predominant cause of delayed diagnosis of *** implementation and better interpretation of CT scan and early implementation of bronchoscopy can help reduce misdiagnosis of senile TBTB.

关键词： Senile tracheobronchial tuberculosis Misdiagnosis Clinical characteristics Pulmonary tuberculosis Tuberculosis

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双清合剂治疗卫气同病证流行性感冒有效性和安全性多中心随机对照非劣效性试验

引用

中国中西医结合杂志 2024年第9期44卷 1036-1043页

作者：林江涛孙增涛封继宏吴建华陆光兵郭瑞斌麻晓李月荣申云红王光恩马晓斌黄滔郭安张常喜赵小兵孙绪武江柏华甄会陈红平丁俊平中日友好医院呼吸与危重症医学科北京100029 天津中医药大学热病与呼吸疾病研究所天津300250 天津中医药大学第二附属医院呼吸与危重症医学科天津300250 山西省汾阳医院呼吸与危重症医学科山西032200 眉山市中医医院呼吸与危重症医学科四川620000 阳煤集团总医院呼吸与危重症医学科四川620000 漯河市中医院急诊科河南462000 济南市章丘区人民医院感染性疾病科济南250200 长治市第二人民医院感染疾病科山西046000 邯郸市中医院呼吸科河北056001 山东省立医院呼吸与危重症医学科济南250000 眉山市人民医院发热门诊四川620000 天津中医药大学研究生院天津300250 宁夏回族自治区中医医院肺病科银川750000 枣庄妇幼保健院呼吸科山东277000 牡丹江市中医医院呼吸科黑龙江157000 黑龙江省中医医院肺病科哈尔滨150036 中国中药协会呼吸病药物研究专业委员会北京100061 北京药海宁康医药科技有限公司北京100101 哈尔滨康赛思医药科技开发有限公司哈尔滨150001

目的观察双清合剂治疗卫气同病证流行性感冒的有效性及安全性。方法采用多中心、随机、双盲、双模拟平行对照、非劣效性试验设计,将240例卫气同病证流行性感冒患者采用分层区组随机化方法,使用SAS软件按1:1随机分为试验组和对照组,每组... 详细信息

目的观察双清合剂治疗卫气同病证流行性感冒的有效性及安全性。方法采用多中心、随机、双盲、双模拟平行对照、非劣效性试验设计,将240例卫气同病证流行性感冒患者采用分层区组随机化方法,使用SAS软件按1:1随机分为试验组和对照组,每组120例。试验组服用双清合剂和磷酸奥司他韦胶囊模拟剂,对照组服用磷酸奥司他韦胶囊和双清合剂模拟剂,两组疗程均为5日。分别于治疗前、治疗3日、治疗5日时进行访视,评价其主要临床症状缓解时间、完全退热时间、退热起效时间、对乙酰氨基酚使用量、中医证候积分、中医证候疗效、重要临床症状缓解时间、重症/危重流感发生率及安全性。结果试验期间,共脱落/剔除16例(试验组8例、对照组8例),最终纳入符合方案集224例,其中试验组112例,对照组112例。与对照组比较,试验组可缩短头痛缓解时间[28.00(17.75,42.99)h vs.41.00(18.75,59.00)h]、减少肌肉或关节酸痛缓解时间[37.83(12.88,52.77)h vs.38.07(13.50,69.25)h](P0.05)。两组患者不良反应发生率,试验组为4.17%和对照组为1.67%,差异无统计学意义(χ^(2)=1.36,P>0.05)。结论双清合剂可有效缓解卫气同病证流行性感冒的头痛、肌肉或关节酸痛症状,效果优于磷酸奥司他韦胶囊;在改善发热、咳嗽、汗出、面赤、咳黄痰临床症状,减少对乙酰氨基酚使用量,降低中医证候积分方面与磷酸奥司他韦胶囊疗效相当;安全性与磷酸奥司他韦胶囊相当。(中国临床试验注册中心注册***2400087831)。

关键词：流行性感冒卫气同病双清合剂随机对照试验中西医结合

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