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黄芩素可缓解蛛网膜下腔出血后神经元的铁死亡

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中国组织工程研究 2025年第1期29卷 52-57页

作者：朱婷岳婷婷崔悦鲁悦李伟杭春华南京中医药大学鼓楼临床医学院江苏省南京市210008 南京大学医学院附属鼓楼医院神经外科江苏省南京市210008

背景:铁死亡是一种区别于凋亡、坏死等新型细胞程序性死亡的方式,主要由累积的脂质过氧化引起,已被证实参与蛛网膜下腔出血后的病理过程。黄芩素是一种铁螯合剂,能够抑制脂质过氧化反应,但其在蛛网膜下腔出血后早期脑损伤中缓解神经元... 详细信息

背景:铁死亡是一种区别于凋亡、坏死等新型细胞程序性死亡的方式,主要由累积的脂质过氧化引起,已被证实参与蛛网膜下腔出血后的病理过程。黄芩素是一种铁螯合剂,能够抑制脂质过氧化反应,但其在蛛网膜下腔出血后早期脑损伤中缓解神经元铁死亡的作用仍未明确。目的:探讨黄芩素治疗蛛网膜下腔出血后对神经元铁死亡的影响及机制。方法:提取孕16-17 d C57BL/6L胎鼠大脑皮质神经元细胞,运用血红蛋白刺激原代神经元模拟体外蛛网膜下腔出血模型。采用CCK-8法检测5,15,25,50,100μmol/L黄芩素作用24 h后原代神经元细胞的活力,确定黄芩素的最适浓度。然后将原代神经元细胞分为对照组、血红蛋白组、血红蛋白+黄芩素组,利用试剂盒检测细胞内活性氧和丙二醛水平,RT-PCR检测铁死亡相关标记物PTGS2、SLC7A11、谷胱甘肽过氧化物酶4的mRNA表达;进一步将原代神经元细胞分为对照组、SLC7A11抑制剂Erastin组、血红蛋白组、血红蛋白+黄芩素组、血红蛋白+黄芩素+Erastin组,Western blot检测铁死亡相关标记物SLC7A11和谷胱甘肽过氧化物酶4的蛋白表达。结果与结论:(1)选取25μmol/L黄芩素作为后续实验浓度;(2)与血红蛋白组相比,血红蛋白+黄芩素组丙二醛和活性氧水平显著下降(P <0.05);(3)与血红蛋白组相比,血红蛋白+黄芩素组PTGS2的m RNA表达显著下降,SLC7A11和谷胱甘肽过氧化物酶4的m RNA表达显著升高(P <0.000 1);(4)SLC7A11抑制剂Erastin能在一定程度上逆转黄芩素改善的铁死亡作用(P <0.05);(5)结果表明,黄芩素可通过SLC7A11/GPX4通路缓解蛛网膜下腔出血后神经元细胞的铁死亡。

关键词：蛛网膜下腔出血黄芩素铁死亡神经元 Erastin 小鼠

Irreducible Weight Modules with a Finite-Dimensional Weight Space over the Twisted N z 1 SchrSdinger-Neveu- Schwarz Algebra

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Algebra Colloquium 2017年第4期24卷 697-704页

作者： Huanxia Fa jianzhi Han Junbo Li School of Mathematics and Statistics Qingdao University Qingdao Shandong 266071 China School of Mathematics and Statistics Changshu Institute of Technology Changshu Jiangsu 215500 China School of Mathematical Sciences Tongji University Shanghai 200092 China School of Mathematics and Statistics Qingdao University Qingdao Shandong 266071 China

It is shown that there are no simple mixed modules over the twisted N = 1 Schrodinger-Neveu-Schwarz algebra, which implies that every irreducible weight module over it with a non-trivial finite-dimensional weight spac... 详细信息

关键词： twisted N = 1 Schrodinger-Neveu-Schwarz algebra weight module irre-ducible module

Nanogels as Contrast Agents for Molecular Imaging

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Chinese Journal of Chemistry 2016年第6期34卷 547-557页

作者： jianzhi Zhu Wenjie Sun Xiangyang Shi College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Shanghai 201620 China

Nanogels （NGs） as soft nanosized materials have gained a variety of interests in biomedical fields. The versatile NG scaffolds with 3-dimensional spherical shape, high loading efficiency, tunable surface functionalization, and excellent biocompatibility afford their uses as carrier to load mono- or multi-mode molecular imaging contrast agents （CAs）. This review summarizes the synthesis routes and applications of NGs as CAs for molecular imaging applications including magnetic resonance （MR）, computed tomography （CT）, radionuclide, optical, and dual/mul- ti-modality imaging.

关键词： nanogels contrast agents MR imaging CT imaging radionuclide imaging optical imaging dual/multi-modality imaging

Land-use changes in the small watershed of the Loess Plateau,hilly-gully region, China

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Journal of Forestry Research 2015年第1期26卷 91-99页

作者： Yini Han jianzhi Niu Feizhou Wu Key Laboratory of Soil and Water Conservation & Desertification Combating Beijing Forestry University

As more and more farmland is converted to forestry, the need for effective decision support regarding the use of land in the fragile ecological environment of the Loess Plateau hilly-gully area. The Luoyugou watershed was chosen as the study area to calculate the single dynamic degree, integrated dynamic degree, and change indexes of land use, as well as the land-use type transition matrix. This was done by interpreting the TM and SPOT images of the Luoyugou watershed in 1986, 1995, and2004 and making statistical analysis. The results of ou statistical analysis show that the conversion of slope farm land to terrace and forest land plays a dominant role in land-use changes in the Luoyugou watershed from 1986 to2004. The land-use changes are mainly driven by popula tion growth, socio-economic development, consume spending, and investment in forest ecology.

关键词： Loess Plateau hilly-gully region Luoyugou watershed Land use and cover changes Driving force

The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat

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Science China(Life Sciences) 2004年第3期47卷 251-257页

作者： LIAO Xiaomei ZHANG Yingchun WANG Yipeng WANG jianzhi Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

In Alzheimer抯 disease (AD), hyperphosphorylation of tau may be the underlying mechanism for the cytoskeletal abnormalities and neuronal death. It was reported that cy-clin-dependent kinase5 (cdk-5) could phosphorylate tau at most AD-related epitopes in vitro. In this study, we investigated the effect of cdk-5 overexpression on tau phosphorylation and spatial memory in rat. We demonstrated that 24 h after transfection into rat hippocampus, cdk-5 was overexpressed and induced a reduced staining with antibody tau-1 and an enhanced staining with antibodies 12e8 and PHF-1, suggesting hyperphosphorylation of tau at Ser199/202, Ser262/356 and Ser396/404 sites. Additionally, the cdk-5 transfected rats showed long latency to find the hidden platform in Morris water maze compared to the control rat. 48 h after transfection, the level of cdk-5 was decreased significantly, and the latency of rats to find the hidden platform was prolonged. It implies that in vivo overexpression of cdk-5 leads to impairment of spatial memory in rat and tau hyperphosphorylation may be the underlying mechanism.

关键词： cyclin-dependent kinase5 (cdk-5) tau spatial memory Alzheimer抯 disease.

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Highly sensitive simultaneous electrochemical determination of myricetin and rutin via solid phase extraction on a ternary Pt@r-GO@MWCNTs nanocomposite

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Journal of Pharmaceutical Analysis 2019年第5期9卷 358-366页

作者： Satar Tursynbolat Yrysgul Bakytkarim jianzhi Huang Lishi Wang School of Chemistry and Chemical Engineering South China University of Technology

The simultaneous electrochemical determination of myricetin and rutin remains a challenge due to their indistinguishable *** solve this problem,we constructed a ternary platinum nanoparticle,reduced graphene oxide,multi-walled carbon nanotubes (Pt@r-GO@MWCNTs) nanocomposite via a facile one-pot synthetic *** the optimized conditions,the ternary Pt@r-GO@MWCNTs nanocomposite exhibited good electrocatalytic activity toward myricetin and rutin via solid phase extraction and excellent performance for the simultaneous determination of myricetin and *** oxidation peak current of myricetin was proportional to its concentrations in the range of 0.05-50μM with a detection limit of 0.01μM (S/N=3).The linear range for rutin was 0.05-50μM with a detection limit of 0.005μM(S/N=3).The ternary nanocomposite sensor also exhibited good reproducibility and stability,and was successfully used for the simultaneous determination of myricetin and rutin in real orange juice samples with recoveries ranging between 100.57% and 108.46%.

关键词： Ternary nanocomposite Simultaneous determination Electrochemical sensor Myricetin Rutin

Ultrasensitive electrochemical determination of metronidazole based on polydopamine/carboxylic multi-walled carbon nanotubes nanocomposites modified GCE

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Journal of Pharmaceutical Analysis 2018年第2期8卷 124-130页

作者： Satar Tursynbolat Yrysgul Bakytkarim jianzhi Huang Lishi Wang School of Chemistry and Chemical Engineering South China University of Technology

An ultrasensitive electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nanotubes(MWCNTs à COOH) nanocomposites modified glassy carbon electrode(GCE) was presented in this work, which has been developed for highly selective and highly sensitive determination of an antimicrobial drug, metronidazole. The preparation of polydopamine/MWCNTs–COOH nanocomposites/GCE sensor is simple and possesses high reproducible, where polydopamine can be coated on the surface of MWCNTs–COOH via a simple electropolymerization process. Under optimized conditions, the proposed sensor showed ultrasensitive determination for metronidazole with a wide linear detection range from5 to 5000 mmol/dm^3 and a low detection limit of 0.25 mmol/dm^3(S/N=3). Moreover, the proposed sensor has been successfully applied for the quantitative determination of metronidazole in real drug samples. This work may provide a novel and effective analytical platform for determination of metronidazole in application of real pharmaceutical and biological samples analysis.

关键词： Metronidazole Polydopamine Carboxylic multi-walled carbon nanotubes Nanocomposites Electrochemical determination Electrochemical sensor