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基于CMADS和流域相似理论的无资料地区水文模拟——以元江-红河流域为例

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南水北调与水利科技（中英文） 2024年第3期22卷 534-544页

作者：王洁陈裕迪梁峰铭葛慧刘淼陈家栋王丽荣南京信息工程大学水文与水资源工程学院南京210044 广德市农业农村局安徽广德242200 江苏省水文水资源勘测局南京210029 江苏省水文水资源勘测局南京分局南京210007 河北省气象灾害防御和环境气象中心石家庄050021

无水文资料地区,水文模型的参数难以确定。基于此,提出一套无资料地区水文模拟的方法体系,首先利用开源再分析数据驱动水文模型,然后基于流域相似性理论进行模型参数移植,完成无资料地区水文模拟。以元江-红河多国跨界流域为例,将流域... 详细信息

无水文资料地区,水文模型的参数难以确定。基于此,提出一套无资料地区水文模拟的方法体系,首先利用开源再分析数据驱动水文模型,然后基于流域相似性理论进行模型参数移植,完成无资料地区水文模拟。以元江-红河多国跨界流域为例,将流域划分成123个子流域,基于根据高程、坡度、形状系数、森林覆盖率、降水与蒸散发等指标,利用主成分分析和流域相似度计算对123个子流域进行相似性分析;再基于水文资料和相似性结果,将7个有流量资料的子流域划分出4组相似流域;对有资料流域进行参数率定和验证,模拟结果良好,经过参数移植后,无资料流域的模拟结果均得到了提高。基于流域相似性的参数区域化和开源再分析数据的无资料地区水文模拟方法,可以为无资料地区的水文模拟与水资源管理带来更多可能。

关键词：无资料 CMADS SWAT模型流域相似性参数移植

肥大细胞在特应性皮炎发病中的作用及相关治疗进展

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中华临床免疫和变态反应杂志 2024年第2期18卷 174-180页

作者：陈玉迪刘琬杨敏常建民北京医院皮肤科国家老年医学中心中国医学科学院老年医学研究院北京100730

特应性皮炎(atopic dermatitis,AD)发病机制复杂,多种细胞参与其发病过程。肥大细胞主要分布于皮肤和黏膜,是多种变态反应性疾病的重要效应细胞,但肥大细胞在AD发病机制中的作用尚不完全明确。研究表明,肥大细胞主要通过“IgE-FcεRI-... 详细信息

特应性皮炎(atopic dermatitis,AD)发病机制复杂,多种细胞参与其发病过程。肥大细胞主要分布于皮肤和黏膜,是多种变态反应性疾病的重要效应细胞,但肥大细胞在AD发病机制中的作用尚不完全明确。研究表明,肥大细胞主要通过“IgE-FcεRI-组胺”途径和“MrgprB2/X2-类胰蛋白酶”途径在AD的发病中发挥作用,同时肥大细胞还释放多种2型炎症相关细胞因子进一步促进AD的免疫失衡。本文主要回顾近年来肥大细胞在AD发病机制中的研究及相关治疗进展,以期为AD的治疗与管理提供新思路。

关键词：肥大细胞特应性皮炎高亲和力IgE受体 mas相关G蛋白偶联受体

Comments on“Anatomically distinct fibroblast subsets determine skin autoimmune patterns”

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Chinese Medical Journal 2022年第14期135卷 1695-1696页

作者： yudi chen Jianmin Chang Department of Dermatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Vitiligo is an autoimmune skin disorder characterized by white patches of the skin losing functional epidermal *** depigmentation of the skin impairs patients’quality of life *** than 80%of patients with vitiligo have bilateral symmetric patterns of depigmentation,which is classified as nonsegmental ***,few research revealed the cellular and molecular mechanisms that orchestrate the patterned activities of cutaneous immune cells in vitiligo *** what orchestrates the activities of cutaneous immune cells is essential for determining the therapeutic targets of the disease.

关键词： autoimmune patients Vit

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基于非分散红外的动态减少抖动反演方法

激光与光电子学进展 2024年第15期61卷 174-179页

作者：陈雨迪李琪詹韬刘路王玉伟廖娟张玉钧高彦伟唐七星安徽农业大学工学院安徽合肥230036 中国科学院合肥物质科学研究院安徽光学精密机械研究所中国科学院环境光学与技术重点实验室安徽合肥230031

利用非分散红外技术测量气体体积分数时,不可避免地受到快速抖动、毛刺、振动等带来的影响,影响测量的准确性。提出一种基于非分散红外的动态减少抖动反演方法,通过倾斜度的判断,提取复位信号,进而进行基线拟合与校正,减少基线漂移。随... 详细信息

利用非分散红外技术测量气体体积分数时,不可避免地受到快速抖动、毛刺、振动等带来的影响,影响测量的准确性。提出一种基于非分散红外的动态减少抖动反演方法,通过倾斜度的判断,提取复位信号,进而进行基线拟合与校正,减少基线漂移。随后通过自动迭代拟合,获取积分面积,实现体积分数反演,从而解决信号的抖动问题。在实验系统里进行了车载实验,结果表明,车速变化时,所提方法最大波动值幅度为58.84%,差分检测方法最大波动值幅度为62.12%,两种方法的相关系数是95.263,可以有效地解决信号抖动问题。车速恒定时,所提方法气体体积分数的平均值为10.01%,差分检测方法体积分数的平均值为9.98%,所提方法的标准差为0.0374,差分检测方法的标准差为0.191。证明了所提方法反演体积分数的准确性,该方法提高了测量稳定性。

关键词：非分散红外动态抖动反演方法

A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： yudi cheng Xiao Wang Jiao chen Zihan Zhang Jiadong Ou Mengyao She Fulin chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2)S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/Hcy and H_(2)S with different fluorescent signals(green-red for Cys/Hcy,red for H_(2)S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H_(2)S in various living cancer cells(HeLa,A549,and HepG2)and in *** not only visualized the transformation pathway of several thiols in HepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys/Hcy and H_(2)S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury

Preparation and properties of poly(ethylene glycol)-bpoly( 3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 395-410页

作者： Yichuan HONG Haojie YU Li WANG Xiang chen Di SHEN Yu WANG Shuning REN yudi HUANG Jian YANG State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose *** designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of ***(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer ***-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic *** patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the *** insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good *** results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.

关键词： Diabetes Hyaluronic acid Phenylboronic acid(PBA) Glucose responsive hydrogel Microneedles

Comprehensive,Continuous,and Vertical Measurements of Seawater Constituents with Triple-Field-of-View High-Spectral-Resolution Lidar

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Research 2024年第2期2023卷 191-201页

作者： Kai Zhang Yatong chen Hongkai Zhao Zhongping Lee Emmanuel Boss Iwona Stachlewska Davide Dionisi Cedric Jamet Paolo D.Girolamo Aleksey Malinka chengchong Jiang Hongda Wu Lingyun Wu Feitong chen Xiaolei Zhu Nanchao Wang Chuxiao chen Qun Liu Lan Wu yudi Zhou Weibiao chen Dong Liu Ningbo Research Institute State Key Laboratory of Modern Optical InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological lnnovation Center Zhejang UniversityHangzhou 311200China Donghai Laboratory.Zhoushan 316021 China State Key Lab of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China School of Marine Sciences University of MaineOronoME 04469-5741USA Faculty of Physics University of WarsawWarsaw 02093Poland institute of Marine Sciences Italian National Research CouncilRome 00133Italy Universitédu Littoral Cote d'Opale CNRSUniv.LilleIRDUMR 8187-LOG-Laboratoire d'Oceanologie et de GéosciencesWimereux F-6293 Francen Institute Scuola di Ingegneria Universita della BasilicataPotenza 85100Italy Institute of Physics National Academy of Sciences of BelarusMinsk 220072Belarus Key Laboratory of Space Laser Communication and Detection Technology Shanghai lnstitute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Inteligent Optics&Photonics Research Center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Jiaxing 314000China

Measuring the characteristics of seawater constituent is in great demand for studies of marine ecosystems and ***,existing techniques based on remote sensing or in situ samplings present various tradeoffs with regard to the diversity,synchronism,temporal-spatial resolution,and depth-resolved capacity of their data ***,we demonstrate a novel oceanic triple-field-of-view(FOV)high-spectral-resolution lidar(HSRL)with an iterative retrieval *** technique provides,for the first time,comprehensive,continuous,and vertical measurements of seawater absorption coefficient,scattering coefficient,and slope of particle size distribution,which are validated by simulations and field ***,it depicts valuable application potentials in the accuracy improvement of seawater classification and the continuous estimation of depth-resolved particulate organic carbon *** triple-FOV HSRL with high performance could greatly increase the knowledge of seawater constituents and promote the understanding of marine ecosystems and biogeochemistry.

关键词： lidar Vertical seawater

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从学科属性入手的短期行为管理探索

科学学与科学技术管理 2007年第9期28卷 20-26页

作者：陈玉娣古继宝梁樑中国科学技术大学管理学院合肥230027

通过对被SCI收录的25个国家19个学科领域论文的统计数据分析,验证学科间短期倾向差异的存在。以这种存在性为前提,将学科推广到包括工科、人文社会科学在内的我国学术界。剖析导致这种差异的学科属性根源,并探讨了基于学科属性的短期行... 详细信息

通过对被SCI收录的25个国家19个学科领域论文的统计数据分析,验证学科间短期倾向差异的存在。以这种存在性为前提,将学科推广到包括工科、人文社会科学在内的我国学术界。剖析导致这种差异的学科属性根源,并探讨了基于学科属性的短期行为管理办法。

关键词：短期倾向科技论文引频率学科属性制度建议

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蔓生和矮生长豇豆氮磷钾吸收特性

中国蔬菜 2000年第5期 12-15页

作者：关佩聪刘厚诚陈玉娣华南农业大学园艺系广州五山510642

研究了蔓生和矮生长豇豆的氮磷钾吸收特性。结果表明 ,两类长豇豆对氮磷钾的吸收 ,均以氮最多 ,钾次之 ,磷最少。蔓生类型的吸收比例为 2 .75～ 2 .92∶1∶2 .15～ 2 .75,矮生类型为4 .4 9∶1∶4 .2 1。蔓生类型比矮生类型的吸收量大 ,... 详细信息

研究了蔓生和矮生长豇豆的氮磷钾吸收特性。结果表明 ,两类长豇豆对氮磷钾的吸收 ,均以氮最多 ,钾次之 ,磷最少。蔓生类型的吸收比例为 2 .75～ 2 .92∶1∶2 .15～ 2 .75,矮生类型为4 .4 9∶1∶4 .2 1。蔓生类型比矮生类型的吸收量大 ,蔓生类型中白豆角比青豆角稍大。蔓生长豇豆营养生长期的吸收量微少 ,生殖生长期约占总吸收量的 98%。豆荚利用的氮磷钾逐渐增加 ,至结荚后期利用了氮磷的 6 5%～ 70 % ,钾的近 4 0 %。矮生长豇豆在营养生长期的吸收量约占 2 0 % ,生殖生长期约占 80 % ,豆荚只利用氮磷的 35%～ 4 0 %和钾的 30 %左右。

关键词：蔓生矮生长豇豆氮磷钾养分吸收特性施肥