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Nano Research 2016年第10期9卷 3099-3115页

作者： Daowei Gao Xin Zhang Xiaoping dai yuchen Qin Aijun Duan Yanbing Yu Hongying Zhuo Hairui Zhao Pengfang Zhang Yan Jiang Jianmei Li Zhen Zhao State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China College of Science China University of Petroleum Beijing 102249 China

A series of novel catalysts consisting of nanosized Au particles confined in micro-mesoporous ZSM-5/SBA-15 （ZSBA） materials with platelet （PL）, rod （RD）, and hexagonal-prism （HP） morphologies have been synthesized in situ. These catalysts possess both SBA-15 and ZSM-5 structures and exhibit excellent stability of their active sites by confinement of the Au nanoparticles （NPs） within ZSBA. The catalysts have been characterized in depth to understand their structure-property relationships. The gold NP dimensions and the pore structure of the catalysts, which were found to be sensitive to calcination temperature and synthetic conditions, are shown to play vital roles in the reduction of 4-nitrophenol. Au/ZSBA-PL, with short mesochannels （210 nm） and a large pore diameter （6.7 nm）, exhibits high catalytic performance in the reduction of 4-nitrophenol, whereas Au/ZSBA-HP and Au/ZSBA-RD, with long mesochannels and relatively smaller pore sizes, show poor catalytic activities. In the case of catalysts with different gold NP sizes, Au/ZSBA-PL-350 with an Au NP diameter of 4.0 nm exhibits the highest reaction rate constant （0.14 min-1） and turnover frequency （0.0341 s-1）. In addition, the effect of the reaction parameters on the reduction of 4-nitrophenol has been systematically investigated. A possible mechanism for 4-nitrophenol reduction over the Au/ZSBA catalysts is proposed.

关键词： gold catalysis porous material environmental pollution 4-nitrophenol

BnlR:A multi-omics database with various tools for Brassica napus research and breeding

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Molecular Plant 2023年第4期16卷 775-789页

作者： Zhiquan Yang Shengbo Wang Lulu Wei Yiming Huang Dongxu Liu Yupeng Jia Chengfang Luo yuchen Lin Congyuan Liang Yue Hu Cheng dai Liang Guo Yongming Zhou Qing-Yong Yang National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan 430070China Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510405China

In the post-genome-wide association study era,multi-omics techniques have shown great power and poten-tial for candidate gene mining and functional genomics ***,due to the lack of effective data integration and multi-omics analysis platforms,such techniques have not still been applied widely in rape-seed,an important oil crop ***,we report a rapeseed multi-omics database(BnlR;http:/l ***/BnlR),which provides datasets of six omics including genomics,transcriptomics,variomics,epigenetics,phenomics,and metabolomics,as well as numerous"variation-gene expression-phenotype"associations by using multiple statistical *** addition,a series of multi-omics search and analysis tools are integrated to facilitate the browsing and application of these *** is the most comprehensive multi-omics database for rapeseed so far,and two case studies demonstrated its power to mine candidate genes associated with specific traits and analyze their potential regulatory mechanisms.

关键词： Brassica napus multi-omics database candidate gene mining functional genomics

Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 292页

作者： Liu, Ran Luo, Zixuan dai, Chong Wei, yuchen Yan, Shuqing Kuang, Xinwen Qi, Kuan Fu, Aisi Li, Yinxin Fu, Shuai Ma, Zhengning dai, Wen Xiao, Xiao Wu, Qing Zhou, Haokui Rao, Yan Yuan, Jingping Shi, Ting Deng, Zixin Chen, Chuang Liu, Tiangang Wuhan Univ Renmin Hosp Wuhan 430071 Peoples R China Shanghai Jiao Tong Univ State Key Lab Microbial Metab Joint Int Res Lab Metab & Dev Sci Shanghai Peoples R China Shanghai Jiao Tong Univ Sch Life Sci & Biotechnol Shanghai 200240 Peoples R China Chinese Acad Sci Shenzhen Inst Synthet Biol Shenzhen Inst Adv Technol CAS Key Lab Quantitat Engn Biol Shenzhen 518055 Peoples R China Wuhan Univ Key Lab Combinatorial Biosynth & Drug Discovery Minist Educ Wuhan 430072 Peoples R China Wuhan Univ Sch Pharmaceut Sci Wuhan 430072 Peoples R China Chinese Univ Hong Kong Dept Microbiol Hong Kong Peoples R China Wuhan Univ Zhongnan Hosp Wuhan 430071 Peoples R China Dgensee Co Ltd Wuhan 430073 Peoples R China Hesheng Tech Co Ltd Wuhan 430073 Peoples R China Wuhan Univ Sch Med Ctr Anim Expt Anim Biosafety Level Lab 3 Wuhan 430071 Peoples R China Wuhan Univ Taikang Ctr Life & Med Sci Wuhan 430072 Peoples R China

Granulomatous lobular mastitis (GLM) is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence, the incidence rate has gradually increased, and has become a serious breast disease that should not be ignored. GLM is highly suspected relative to microbial infections, especially those of Corynebacterium species;however, the mechanisms involved are unclear, and prevention and treatment are difficult. In this study, we demonstrated the pathogenicity of Corynebacterium parakroppenstedtii in GLM using Koch's postulates. Based on the drug sensitization results of C. parakroppenstedtii, and utilizing a retrospective study in conjunction with a comprehensive literature review, we suggested an efficacious, targeted antibiotic treatment strategy for GLM. Subsequently, we identified the pathogenic factor as a new type of glycolipid (named corynekropbactins) secreted by C. parakroppenstedtii. Corynekropbactins may chelate iron, cause the death of mammary cells and other mammary -gland-colonizing bacteria, and increase the levels of inflammatory cytokines. We further analyzed the prevalence of C. parakroppenstedtii infection in patients with GLM. Finally, we suggested that the lipophilicity of C. parakroppenstedtii may be associated with its infection route and proposed a possible model for the development of GLM. This research holds significant implications for the clinical diagnosis and therapeutic management of GLM, offering new insights into targeted treatment approaches.

关键词： prevention diagnosis treatment

Artificial Intelligence for Metaverse:A Framework

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CAAI Artificial Intelligence Research 2022年第1期1卷 54-67页

作者： yuchen Guo Tao Yu Jiamin Wu Yuwang Wang Sen Wan Jiyuan Zheng Lu Fang Qionghai dai Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Department of Automation Tsinghua UniversityBeijing 100084China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

The metaverse is attracting considerable attention *** aims to build a virtual environment that people can interact with the world and cooperate with each *** this survey paper,we re-introduce metaverse in a new framework based on a broad range of technologies,including perception which enables us to precisely capture the characteristics of the real world,computation which supports the large computation requirement over large-scale data,reconstruction which builds the virtual world from the real one,cooperation which facilitates long-distance communication and teamwork between users,and interaction which bridges users and the virtual *** its popularity,the fundamental techniques in this framework are still *** new techniques to facilitate the applications of metaverse is *** recent years,artificial intelligence(AI),especially deep learning,has shown promising results for empowering various areas,from science to *** is reasonable to imagine how we can combine AI with the framework in order to promote the development of *** this survey,we present the recent achievement by AI for metaverse in the proposed framework,including perception,computation,reconstruction,cooperation,and *** also discuss some future works that AI can contribute to metaverse.

关键词： artificial intelligence metaverse perception computation reconstruction cooperation interaction

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu Ying Chi Ting Sun yuchen Gao Xueqing Dou Zhibo Han Feng Xue Huiyuan Li Wei Liu Xiaofan Liu Huan Dong Rongfeng Fu Mankai Ju Xinyue dai Wentian Wang Yueshen Ma Zhen Song Jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research Centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing *** cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune *** prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory *** research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion *** events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up ***,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,*** patients(13/18,72.2%)experienced one or more treatment emergent adverse *** adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion *** overall response rate was 44.4%(8/18)among all enrolled *** sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(*** ID:NCT04014166).

关键词： doses immunity treatment

Na_(2)CO_(3)-responsive Photosynthetic and ROS Scavenging Mechanisms in Chloroplasts of Alkaligrass Revealed by Phosphoproteomics

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Genomics, Proteomics & Bioinformatics 2020年第3期18卷 271-288页

作者： Jinwei Suo Heng Zhang Qi Zhao Nan Zhang Yongxue Zhang Ying Li Baohua Song Juanjuan Yu Jianguo Cao Tai Wang Ji Luo Lihai Guo Jun Ma Xumin Zhang Yimin She Lianwei Peng Weimin Ma Siyi Guo yuchen Miao Sixue Chen Zhi Qin Shaojun dai Development Center of Plant Germplasm Resources College of Life and Environmental SciencesShanghai Normal UniversityShanghai 200234China Alkali Soil Natural Environmental Science Center Northeast Forestry UniversityKey Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil FieldMinistry of EducationHarbin 150040China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Institute of Botany Chinese Academy of SciencesBeijing 100093China AB Sciex Asia Pacific Application Support Center Shanghai 200233China Shanghai Center for Plant Stress Biology Chinese Academy of SciencesShanghai 201602China School of Life Sciences Fudan UniversityShanghai 200433China Institute of Plant Stress Biology State Key Laboratory of Cotton BiologyDepartment of BiologyHenan UniversityKaifeng 475004China Department of Biology Genetics InstitutePlant Molecular and Cellular Biology ProgramInterdisciplinary Center for Biotechnology ResearchUniversity of FloridaGainesvilleFL 32610USA

Alkali-salinity exerts severe osmotic,ionic,and high-p H stresses to *** understand the alkali-salinity responsive mechanisms underlying photosynthetic modulation and reactive oxygen species(ROS)homeostasis,physiological and diverse quantitative proteomics analyses of alkaligrass(Puccinellia tenuiflora)under Na_(2)CO_(3)stress were *** addition,Western blot,real-time PCR,and transgenic techniques were applied to validate the proteomic results and test the functions of the Na_(2)CO_(3)-responsive proteins.A total of 104 and 102 Na_(2)CO_(3)-responsive proteins were identified in leaves and chloroplasts,*** addition,84 Na_(2)CO_(3)-responsive phosphoproteins were identified,including 56 new phosphorylation sites in 56 phosphoproteins from chloroplasts,which are crucial for the regulation of photosynthesis,ion transport,signal transduction,and energy homeostasis.A full-length Pt FBA encoding an alkaligrass chloroplastic fructosebisphosphate aldolase(FBA)was overexpressed in wild-type cells of cyanobacterium Synechocystis *** PCC 6803,leading to enhanced Na_(2)CO_(3)*** these results indicate that thermal dissipation,state transition,cyclic electron transport,photorespiration,repair of photosystem(PS)Ⅱ,PSI activity,and ROS homeostasis were altered in response to Na_(2)CO_(3)stress,which help to improve our understanding of the Na_(2)CO_(3)-responsive mechanisms in halophytes.

关键词： Chloroplasts Na_(2)CO_(3)stress ROS scavenging Phosphoproteomics Puccinellia tenuiflora

预测动车组牵引系统故障率的TSOBP-ARIMA-Prophet组合模型

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中国铁道科学 2024年第4期45卷 147-157页

作者：张雨晨戴贤春刘敬辉李秋芬代成烨中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司铁道科学技术研究发展中心北京100081 中国国家铁路集团有限公司铁路安全研究中心北京100081

针对单一模型预测故障率时的适用性差异问题,在考虑动车组牵引系统故障率数据特点的基础上,提出TSOBP-ARIMA-Prophet组合模型。首先,针对动车组牵引系统故障率的复杂非线性,引入金枪鱼群算法(TSO)优化BP模型,训练出TSOBP预测模型;其次,... 详细信息

针对单一模型预测故障率时的适用性差异问题,在考虑动车组牵引系统故障率数据特点的基础上,提出TSOBP-ARIMA-Prophet组合模型。首先,针对动车组牵引系统故障率的复杂非线性,引入金枪鱼群算法(TSO)优化BP模型,训练出TSOBP预测模型;其次,针对故障率的非平稳波动性,选取ARIMA预测模型;然后,针对故障率的季节周期性,选取Prophet预测模型;最后,运用方差倒数法对3个模型的预测结果赋权,得到TSOBP-ARIMA-Prophet组合模型的预测结果。以某动车组牵引系统为例,采用该组合模型预测故障率,并与3个单一模型及TSOBP-ARIMA组合模型对比验证其预测能力。结果表明:该组合模型预测时均方误差为0.0752,较TSOBP,ARIMA和Prophet模型单独预测时分别降低了45.83%,61.65%和53.42%,预测精度显著提高,且较TSOBP-ARIMA组合模型对数据趋势的感知力更优,可有效提升对动车组牵引系统故障率的预测能力。

关键词：动车组牵引系统故障率预测组合模型 BP模型金枪鱼群算法 ARIMA模型 Prophet模型

结合全局与局部多样性特征的色纺纱色度学指标测试与评价

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纺织学报 2018年第2期39卷 157-164页

作者：袁理代乔民付顺林鄢煜尘武汉纺织大学电子与电气工程学院湖北武汉430200 武汉纺织大学湖北省纺织新材料与先进加工技术省部共建国家重点实验室培育基地湖北武汉430200 武汉纺织大学纺织科学与工程学院湖北武汉430200 武汉大学电子信息学院湖北武汉430072

为建立科学、有效的色纺纱色度学指标测试评价标准,以纺织品数码测色理论为基础,设计并实现色纺纱大幅面微距图像采集系统,克服传统微距图像采集视野范围受限的问题,为色度学指标特征的提取与分析提供保障。重点针对大色差色纺纱特有的... 详细信息

为建立科学、有效的色纺纱色度学指标测试评价标准,以纺织品数码测色理论为基础,设计并实现色纺纱大幅面微距图像采集系统,克服传统微距图像采集视野范围受限的问题,为色度学指标特征的提取与分析提供保障。重点针对大色差色纺纱特有的呈色机制与过程,建立了结合全局颜色特征与局部纹理特征的色度学指标表征模型,提取的三阶颜色矩特征和彩色局部方向模式特征,不仅利用全局与局部特征间的互补性,而且还能结合不同颜色空间的多样性。实验结果表明:对于色纺纱色度学指标的细微改变,提取的多样性特征均能准确、稳定地进行表征,验证了融合算法的有效性和鲁棒性;同时,相较于传统的分光光度法,更具有理想的适应性和实用性。

关键词：色纺纱纱色度学指标大幅面微距图像色矩彩色局部方向模式特征结合