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Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment

Nano Research 2022年第3期15卷 2288-2299页

作者： Yan Du Di Liu Mingchen Sun Gaofeng Shu Jing Qi yuchan you Yiting Xu Kai Fan Xiaoling Xu Feiyang Jin Jun Wang Qiying Shen Luwen Zhu Xiaoying Ying Jiansong Ji Liming Wu Daren Liu Yongzhong Du Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Lishui Hospital of Zhejiang UniversityZhejiang University School of MedicineLishui 323000China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of General Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Hepatocellular carcinoma(HCC)is a life-threatening disease for which there is no effective treatment *** theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer ***,we develop the sialic acid(SA)modified polymeric micelles at an upper critical solution temperature(UCST)of 43℃(sialic acid-poly(ethylene glycol)-poly(acrylamide-co-acrylonitrile),SA-PEG-p(AAm-co-AN)),which further encapsulated with doxorubicin(DOX)and Gd-CuS nanoparticles(Gd-CuS NPs)for chemo-photothermal treatment of HCC guided by magnetic resonance(MR)/photoacoustic(PA)dual-mode *** resultant SA-PEG-p(AAm-co-AN)/DOX/Gd-CuS(SPDG)had an excellent photothermal conversion efficiency,enabling SPDG with an instantaneous release behavior of DOX under near-infrared(NIR)*** study also revealed that SPDG could actively target to HCC,which was due to that SA had a high affinity with E-selectin overexpressed at the tumor ***,benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX,SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal ***,our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics.

关键词： hepatocellular carcinoma upper critical solution temperature(UCST) Gd-CuS nanoparticles chemo-photothermal therapy magnetic resonance(MR)/photoacoustic(PA)dual-mode imaging

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Micro/nanoelectrode-based electrochemical methodology for single cell and organelle analysis

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Nano Research 2024年第1期17卷 196-206页

作者： Chuchu Xu De Yang yuchan Wang Ruolin Liu Fan Wang Zhongqun Tian Keke Hu Department of Chemistry College of Chemistry&Chemical EngineeringXiamen UniversityXiamen 361005China

Cells are the basic unit of *** analysis of single cells/organelles is essential for uncovering the molecular mechanisms of physiological and pathological processes that are difficult to elucidate on a larger *** paper provides an overview of the commonly used fabrication methods for micro/nanoelectrodes applied in the investigations of single cells/organelles as well as the corresponding electrochemical measurements over the last four years including extracellular measurement,combination of extra and intracellular measurement,intracellular reactive oxygen species and reactive nitrogen species(ROS/RNS)measurement,and isolated organelles measurement.

关键词： single cell/organelle micro/nanoelectrode electrochemical measurement chemical transmitters

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Sparse Reconstructive Evidential Clustering for Multi-View Data

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 459-473页

作者： Chaoyu Gong Yang you School of Computing National University of SingaporeSingapore

Although many multi-view clustering(MVC) algorithms with acceptable performances have been presented, to the best of our knowledge, nearly all of them need to be fed with the correct number of clusters. In addition, these existing algorithms create only the hard and fuzzy partitions for multi-view objects,which are often located in highly-overlapping areas of multi-view feature space. The adoption of hard and fuzzy partition ignores the ambiguity and uncertainty in the assignment of objects, likely leading to performance degradation. To address these issues, we propose a novel sparse reconstructive multi-view evidential clustering algorithm(SRMVEC). Based on a sparse reconstructive procedure, SRMVEC learns a shared affinity matrix across views, and maps multi-view objects to a 2-dimensional humanreadable chart by calculating 2 newly defined mathematical metrics for each object. From this chart, users can detect the number of clusters and select several objects existing in the dataset as cluster centers. Then, SRMVEC derives a credal partition under the framework of evidence theory, improving the fault tolerance of clustering. Ablation studies show the benefits of adopting the sparse reconstructive procedure and evidence theory. Besides,SRMVEC delivers effectiveness on benchmark datasets by outperforming some state-of-the-art methods.

关键词： Evidence theory multi-view clustering(MVC) optimization sparse reconstruction

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Non-Deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： Dan you Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)

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Shaping the Spatial Coherence of Quantum Source

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Chinese Physics Letters 2024年第9期41卷 38-39页

作者： Chenglong you Quantum Photonics Laboratory Department of Physics and AstronomyLouisiana State UniversityBaton RougeLouisiana 70803USA

There has been immense research interest in quantum entanglement due to its ability to generate stronger-thanclassical nonlocal correlations.^([1,2])These strong,nonlocal correlations form the backbone of various quantum information *** of the core principles of quantum entanglement is quantum coherence,which provides deep insights into the statistical correlations among quantum particles.^([3–5])Quantum coherence reflects the wavelike properties of quantum particles,enabling them to exhibit interference and unique quantum behaviors.

关键词： particles. quantum backbone

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Theoretical study on the synergistic mechanism of Fe-Mn in sodium-ion batteries

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PARTICUOLOGY 2024年第10期93卷 284-290页

作者： you, Yang Yuan, Mingliang Cent South Univ Sch Mineral Proc & Bioengn Changsha 410083 Peoples R China

This article conducts first-principles calculations to initially explore the construction of two configurations, NaFeO2 2 (NFO) and NaMnO2 2 (NMO), and studies the mixing enthalpies under different Fe-Mn ratios. The results indicate that NaFe3/8Mn5/8O2 3/8 Mn 5/8 O 2 (NFMO) exhibits the most thermodynamically stable structure. Subsequent calculations on the mixing enthalpies and volume changes during the sodium extraction process for NFO, NMO, and NFMO configurations are presented, along with the partial density of states (PDOS) and Bader charges of transition metals (TM) and oxygen. These calculations reveal the synergistic mechanism of Fe and Mn. Fe and Mn can engage in more complex electron exchanges during sodium extraction, optimizing the internal electron density distribution and overall charge balance, thereby stabilizing the crystal structure and reducing the migration of Fe3 & thorn; 3 & thorn; to the sodium layers during deep sodium extraction. The interaction between Fe's 3d electrons and Mn's 3d electrons through the shared oxygen atoms' 2p orbitals occurs in the Fe-Mn-O network. This interaction can lead to a rebalancing of the electron density around Mn3+ 3 + atoms, mitigating the asymmetric electron density distribution caused by the d 4 configuration of the lone Mn3+ 3 + and suppressing the Jahn-Teller effect of Mn3 & thorn;. 3 & thorn; . Moreover, the synergistic effects between Fe and Mn can provide a more balanced charge distribution, reducing extreme changes to the charge state of oxygen atoms and decreasing the irreversible oxygen release caused by anionic redox reactions during deep sodium extraction, thereby enhancing the material's stability. This in-depth study of the interaction mechanism at the microscopic level when co- doping Fe and Mn offers valuable insights for the rational design and development of high-performance cathode materials. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sci

关键词： First-principles calculations Sodium-ion batteries Layered oxides NaFe 3/8 Mn 5/8 TOTAL-ENERGY CALCULATIONS CATHODE PERFORMANCE LI

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A new 3D plastoelastohydrodynamic lubrication model for rough surfaces

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Friction 2024年第6期12卷 1176-1193页

作者： Shengyu you Jinyuan TANG Qiang WANG State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China

Plastoelastohydrodynamic lubrication of rough surfaces(R-PEHL)is a cutting-edge area of research in interface fluid-structure coupling *** existing R-PEHL model calculates the elastic-plastic deformation of rough surface by the Love equation in a semi-infinite space smooth surface,which deviates from the actual ***,it is an innovative work to study the exact solution of elastic-plastic deformation of rough surface and its influence on the solution results of R-PEHL *** this paper,a new contact calculation model of plastoelastohydrodynamic lubrication(PEHL)with three-dimensional(3D)rough surface is proposed by integrating numerical method of EHL and finite element *** new model eliminates an original error introduced by the assumption of semi-infinite space in contact calculation,providing wide applicability and high *** the given rough surfaces and working conditions,the study reveals that:(1)the oil film pressure calculated by the new model is lower than that of the smooth surface in semi-infinite space by 200–800 MPa;(2)the Mises stress of the new model is 2.5%–26.6%higher than that of the smooth surface in semi-infinite space;(3)compared with the semi-infinite space assumption,the rough surface plastic deformation of the new model is increased by 71%–173%,and the local plastic deformation singularity may appear under the semi-infinite space assumption;(4)the plastic deformation caused by the first contact cycle on the rough surface of the new model accounts for 66.7%–92.9%of the total plastic deformation,and the plastic deformation of the semi-infinite space accounts for 50%–83.3%.This study resolves the contradiction between the smooth surface assumption and the rough surface in the existing R-PEHL model,establishing a solid logic foundation for the accurate solution of R-PEHL model.

关键词： rough surface plastoelastohydrodynamic lubrication(PEHL) asperity plastic deformation semi-infinite space

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Data-Driven Control of Linear Systems via Quantized Feedback

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Journal of Systems Science & Complexity 2024年第1期37卷 152-168页

作者： LI Xingchen ZHAO Feiran you Keyou Department of Automation and BNRist Tsinghua UniversityBeijing 100084China

Quantized feedback control is fundamental to system synthesis with limited communication *** sharp contrast to the existing literature on quantized control which requires an explicit dynamical model,the authors study the quadratic stabilization and performance control problems with logarithmically quantized feedback in a direct data-driven framework,where the system state matrix is not exactly known and instead,belongs to an ambiguity set that is directly constructed from a finite number of noisy system *** this end,the authors firstly establish sufficient and necessary conditions via linear matrix inequalities for the existence of a common quantized controller that achieves our control objectives over the ambiguity ***,the authors provide necessary conditions on the data for the solvability of the LMIs,and determine the coarsest quantization density via semi-definite *** theoretical results are validated through numerical examples.

关键词： Data-driven control linear matrix inequalities linear systems quantized control.

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Spin Resolved Zero-Line Modes in Minimally Twisted Bilayer Graphene from Exchange Field and Gate Voltage

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Chinese Physics Letters 2024年第7期41卷 111-116页

作者： Sanyi you Jiaqi An Zhenhua Qiao International Centre for Quantum Design of Functional Materials CAS Key Laboratory of Strongly Coupled Quantum Matter Physicsand Department of PhysicsUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

The reliance on spin-orbit coupling or strong magnetic fields has always posed significant challenges for the mass production and even laboratory realization of most topological materials. Valley-based topological zero-line modes have attracted widespread attention due to their substantial advantage of being initially realizable with just an external electric field. However, the uncontrollable nature of electrode alignment and precise fabrication has greatly hindered the advancement in this field. By utilizing minimally twisted bilayer graphene and introducing exchange fields from magnetic substrates, we successfully realize a spin-resolved, electrode-free topological zeroline mode. Further integration of electrodes that do not require alignment considerations significantly enhances the tunability of the system's band structure. Our approach offers a promising new support for the dazzling potential of topological zero-line mode in the realm of low-energy-consumption electronics.

关键词： structure field topological

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Jackknife Model Averaging for Composite Quantile Regression

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Journal of Systems Science & Complexity 2024年第4期37卷 1604-1637页

作者： you Kang WANG Miaomiao ZOU Guohua School of Mathematical Sciences Capital Normal UniversityBeijing 100089China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100105China

In this paper,the authors propose a frequentist model averaging method for composite quantile regression with diverging number of *** from the traditional model averaging for quantile regression which considers only a single quantile,the proposed model averaging estimator is based on multiple *** well-known delete-one cross-validation or jackknife approach is applied to estimate the model *** resultant jackknife model averaging estimator is shown to be asymptotically optimal in terms of minimizing the out-of-sample composite final prediction *** studies are conducted to demonstrate the finite sample performance of the new model averaging *** proposed method is also applied to the analysis of the stock returns data and the wage data.

关键词： Asymptotic optimality composite quantile regression cross-validation model averaging

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