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Journal of Magnesium and Alloys 2023年第9期11卷 3350-3361页

作者： Yi-hao luo wei-li Cheng Hui Yu Hong-xia Wang Xiao-feng Niu Li-fei Wang Hang Li Zhi-yong You Hua Hou School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The creep properties, microstructural characteristics and creep mechanisms of as-cast Mg-5Bi-5Sn(BT55) alloy without and with Mn(BTM550) addition were investigated via creep at 423, 448, and 473 K as well as stresses of 30, 50 and 75 MPa. The results indicate that adding Mn can result in the formation of primary and the dynamic precipitated α-Mn phases. In addition, the morphology of the precipitated Mg_(3)Bi_(2) phase and the orientation relationship between Mg_(2)Sn precipitates and α-Mg can be effectively modified. Tailoring the microstructural characteristics is responsible for the improved creep performance of BTM550 alloy. The dominant creep mechanisms in BT55 and BTM550 alloys are dislocation cross-slip and climb, respectively. Furthermore, twinning and pyramidal slip play an assisting part in both alloys during creep process.

关键词： Mg alloy Microstructural characteristics Creep properties Precipitates Dislocation

Non-coding RNA in drug resistance of gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 957-970页

作者： Ya-Jun luo Qing-Mei Huang Yan Ren Zi-Lin Liu Cheng-Fei Xu hao Wang Jiang-wei Xiao Department of Gastrointestinal Surgery The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Oncology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

Gastric cancer(GC)is the third leading cause of cancer-related mortality *** poorly prognosis and survival of GC are due to diagnose in an advanced,non-curable stage and with a limited response to *** acquisition of drug resistance accounts for the majority of therapy failure of chemotherapy in GC *** the mechanisms of anticancer drug resistance have been broadly studied,the regulation of these mechanisms has not been completely *** evidence has recently highlighted the role of non-coding RNAs(ncRNAs),including long non-coding RNAs and microRNAs,in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of *** review the literature on ncRNAs in drug resistance of *** review summarizes the current knowledge about the ncRNAs’characteristics,their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant GC.

关键词： Non-coding RNAs Long non-coding RNAs MicroRNAs Drug resistance Multidrug resistance Gastric cancer

Long non-coding RNA MEG3 regulates autophagy after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第4期17卷 824-831页

作者： Tian-hao Li Hong-wei Sun Lai-Jun Song Bo Yang Peng Zhang Dong-Ming Yan Xian-Zhi Liu Yu-Ru luo Department of Neurosurgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

Severe cerebral ischemia/reperfusion injury has been shown to induce high-level autophagy and neuronal ***,it is extremely important to search for a target that inhibits autophagy *** non-coding RNA MEG3 participates in ***,it remains unclear whether it can be targeted to regulate cerebral ischemia/reperfusion *** results revealed that in oxygen and glucose deprivation/reoxygenation-treated HT22 cells,MEG3 expression was obviously upregulated,and autophagy was increased,while knockdown of MEG3 expression greatly reduced ***,MEG3 bound mi R-181 c-5 p and inhibited its expression,while mi R-181 c-5 p bound to autophagy-related gene ATG7 and inhibited its *** experiments revealed that mir-181 c-5 p overexpression reversed the effect of MEG3 on autophagy and ATG7 expression in HT22 cells subjected to oxygen and glucose deprivation/*** vivo experiments revealed that MEG3 knockdown suppressed autophagy,infarct volume and behavioral deficits in cerebral ischemia/reperfusion *** findings suggest that MEG3 knockdown inhibited autophagy and alleviated cerebral ischemia/reperfusion injury through the mi R-181 c-5 p/ATG7 signaling ***,MEG3 can be considered as an intervention target for the treatment of cerebral ischemia/reperfusion *** study was approved by the Animal Ethics Committee of the First Affiliated Hospital of Zhengzhou University,China(approval ***20190538)on January 4,2019.

关键词： ATG7 autophagy cerebral infarction cerebral ischemia/reperfusion injury long non-coding RNA miR-181c-5p neuron oxygen and glucose deprivation/reoxygenation

Development of a novel difficulty scoring system for laparoscopic liver resection procedure in patients with intrahepatic duct stones

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3133-3141页

作者： Bo luo Si-Kai Wu Ke Zhang Pei-Hong Wang wei-wei Chen Ning Fu Zhi-Ming Yang Jing-Cheng hao Department of Hepatobiliary and Vascular Surgery The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of General Surgery The Western Theater Command General HospitalChengdu 610500Sichuan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

BACKGROUND For intrahepatic duct(IHD)stones,laparoscopic liver resection(LLR)is currently a reliable ***,the current LLR difficulty scoring system(DSS)is only available for patients with hepatocellular *** To explore the development of a DSS for IHD stone patients with LLR and the validation of its *** We used clinical data from 80 patients who received LLR for IHD ***-six of these patients were used in multiple linear regression to construct a scoring *** 34 patients from different centers were used as external *** completeness of our DSS was then evaluated in patients with varying degrees of surgical difficulty based on documented surgical outcomes in the study group of *** The following five predictors were ultimately included and scored by calculating the weighted contribution of each factor to the prediction of operative time in the training cohort:Location of stones,number of stones≥3,stones located in the bile ducts of several grades,previous biliary surgery less than twice,distal bile duct ***,the data set was validated using a DSS developed from the *** following variables were identified as statistically significant in external validation:Operative time,blood loss,intraoperative transfusion,postoperative alanine aminotransferase,and Clavien-Dindo grading≥*** variables demonstrated statistically significant differences in patients with three or more *** Patients with IHD stones have varying degrees of surgical difficulty,and the newly developed DSS can be validated with external data to effectively predict risks and complications after LLR surgery.

关键词： Intrahepatic duct stones Laparoscopic liver resection Difficulty scoring system Outcome Complication

A novel PCYT2 mutation identified in a Chinese consanguineous family with hereditary spastic paraplegia

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Journal of Genetics and Genomics 2021年第8期48卷 751-754页

作者： Qiao wei Wen-Jiao luo hao Yu Pei-Shan Wang Hai-Lin Dong Hong-Fu Li Zhi-Ying Wu Department of Neurology and Research Center of Neurology in Second Affiliated Hospital Zhejiang University School of MedicineKey Laboratory of Medical Neurobiology of Zhejiang ProvinceHangzhouZhejiang 310009China

Hereditary spastic paraplegia(HSP) is a rare neurodegenerative disease due to a length-dependent distal axonopathy of the corticospinal tract(Fink, 2006). HSP has highly clinical heterogeneity and is classified into p... 详细信息

关键词： clinical hereditary cor

Suppression and Compensation of the Third-Order Dispersion Effect on Polarization Modes in Birefringent Fibres

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Chinese Physics Letters 2001年第9期18卷 1222-1224页

作者： XU Wen-Cheng CHEN wei-Cheng luo Ai-Ping CUI Hu CHEN Yong-Zhu LIU Song-hao Institute of Quantum Electronics South China Normal UniversityGuangzhou 510631

The influence of the third-order dispersion (TOD) on the polarization mode dispersion (PMD) is investigated. It is found that the TOD effect destroys orthogonal polarization modes in optical birefringent fibres. A new method is proposed to compensate for the PMD by means of cascading the fibres with the positive and negative TOD. This has proven to be practicable in long transmissions.

关键词： polarization dispersion Dispersion

Hypersonic flow control of shock wave/turbulent boundary layer interactions using magnetohydrodynamic plasma actuators

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2020年第9期21卷 745-760页

作者： hao JIANG Jun LIU Shi-chao luo Jun-yuan WANG wei HUANG Science and Technology on Scramjet Laboratory National University of Defense TechnologyChangsha 410073China

The effect of magnetohydrodynamic(MHD)plasma actuators on the control of hypersonic shock wave/turbulent boundary layer interactions is investigated here using Reynolds-averaged Navier-Stokes calculations with low magnetic Reynolds number approximation.A Mach 5 oblique shock/turbulent boundary layer interaction was adopted as the basic configuration in this numerical study in order to assess the effects of flow control using different combinations of magnetic field and *** show that just the thermal effect of plasma under experimental actuator parameters has no significant impact on the flow field and can therefore be *** the basis of the relative position of control area and separation point,MHD control can be divided into four types and so effects and mechanisms might be *** these,D-type control leads to the largest reduction in separation length using magnetically-accelerated plasma inside an isobaric dead-air region.A novel parameter for predicting the shock wave/turbulent boundary layer interaction control based on Lorentz force acceleration is then proposed and the controllability of MHD plasma actuators under different MHD interaction parameters is *** results of this study will be insightful for the further design of MHD control in hypersonic vehicle inlets.

关键词： Hypersonic Shock wave/turbulent boundary layer interaction Magnetohydrodynamic(MHD) Flow control

Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1166-1186页

作者： Shanshan Rao Zehui He Zun Wang hao Yin Xiongke Hu Yijuan Tan Tengfei Wan hao Zhu Yi luo Xin Wang Hongming Li Zhenxing Wang Xinyue Hu Chungu Hong Yiyi Wang Mingjie luo wei Du Yuxuan Qian Siyuan Tang Hui Xie Chunyuan Chen Department of Orthopedics Movement System Injury and Repair Research CenterXiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Angmedicine Changsha 410008China Xiangya School of Nursing Central South UniversityChangsha 410013China Department of Pediatric Orthopedics Hunan Children’s HospitalUniversity of South ChinaChangsha 410007China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangsha 410008China School of Nursing Xinjiang Medical UniversityUrumqiXinjiang 830000China Department of Rehabilitation Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Aging increases the risks of various diseases and the vulnerability to *** senescence is a hallmark of aging that contributes greatly to aging and aging-related *** study demonstrates that extracellular vesicles from human urine-derived stem cells(USC-EVs)efficiently inhibit cellular senescence in vitro and in *** intravenous injection of USC-EVs improves cognitive function,increases physical fitness and bone quality,and alleviates aging-related structural changes in different organs of senescence-accelerated mice and natural aging *** anti-aging effects of USC-EVs are not obviously affected by the USC donors’ages,genders,or health *** analysis reveals that USC-EVs are enriched with plasminogen activator urokinase(PLAU)and tissue inhibitor of metalloproteinases 1(TIMP1).These two proteins contribute importantly to the anti-senescent effects of USC-EVs associated with the inhibition of matrix metalloproteinases,cyclin-dependent kinase inhibitor 2A(P16INK4a),and cyclin-dependent kinase inhibitor 1A(P21cip1).These findings suggest a great potential of autologous USC-EVs as a promising anti-aging agent by transferring PLAU and TIMP1 proteins.

关键词： Extracellular vesicles Urine-derived stem cells Cellular senescence Anti-aging PLAU TIMP1 Senescence-accelerated mice Natural aging mice

Temperature inversion enables superior stability for low-temperature Zn-ion batteries

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Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian Yi Rui-Yang Li wei-hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai Wu Zhang Lan Lan-Fang Que Bao-Sheng Liu hao luo Zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

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Journal of Pharmaceutical Analysis 2024年第1期14卷 86-99页

作者： Shengyou Li Xue Gao Yi Zheng Yujie Yang Jianbo Gao Dan Geng Lingli Guo Teng Ma Yiming hao Bin wei Liangliang Huang Yitao wei Bing Xia Zhuojing luo Jinghui Huang Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi'an710032China

A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death distinguished by imbalance in iron and thiol metabolism, leading to lethal lipid peroxidation. However, the molecular mechanisms of ferroptosis in the context of PNI and nerve regeneration remain unclear. Ferroportin (Fpn), the only known mammalian nonheme iron export protein, plays a pivotal part in inhibiting ferroptosis by maintaining intracellular iron homeostasis. Here, we explored in vitro and in vivo the involvement of Fpn in neuronal ferroptosis. We first delineated that reactive oxygen species at the injury site induces neuronal ferroptosis by increasing intracellular iron via accelerated UBA52-driven ubiquitination and degradation of Fpn, and stimulation of lipid peroxidation. Early administration of the potent arterial vasodilator, hydralazine (HYD), decreases the ubiquitination of Fpn after PNI by binding to UBA52, leading to suppression of neuronal cell death and significant acceleration of axon regeneration and motor function recovery. HYD targeting of ferroptosis is a promising strategy for clinical management of PNI.

关键词： Ferroptosis UBA52 Ferroportin Ubiquitination Hydralazine Peripheral nerve injury