Non-coding RNA in drug resistance of gastric cancer

作     者：Ya-Jun Luo Qing-Mei Huang Yan Ren Zi-Lin Liu Cheng-Fei Xu Hao Wang Jiang-Wei Xiao 

作者机构：Department of Gastrointestinal SurgeryThe First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of Gastrointestinal SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of OncologyThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第11期

页      面：957-970页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China(NSFC)Grant,No.81070378,and No.81270561 Sichuan Outstanding Youth Fund Project Grant,No.2015JQ0060 

主　　题：Non-coding RNAs Long non-coding RNAs MicroRNAs Drug resistance Multidrug resistance Gastric cancer 

摘      要：Gastric cancer(GC)is the third leading cause of cancer-related mortality *** poorly prognosis and survival of GC are due to diagnose in an advanced,non-curable stage and with a limited response to *** acquisition of drug resistance accounts for the majority of therapy failure of chemotherapy in GC *** the mechanisms of anticancer drug resistance have been broadly studied,the regulation of these mechanisms has not been completely *** evidence has recently highlighted the role of non-coding RNAs(ncRNAs),including long non-coding RNAs and microRNAs,in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of *** review the literature on ncRNAs in drug resistance of *** review summarizes the current knowledge about the ncRNAs’characteristics,their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant GC.