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Preparation and characterization of a metered dose transdermal spray for testosterone

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Acta Pharmaceutica Sinica B 2013年第6期3卷 392-399页

作者： Wangding Lu Huafei luo yubo Wu Zhuangzhi Zhu hao Wang National Pharmaceutical Engineering Research Center China State Institute of Pharmaceutical IndustryShanghai 201203China

The objective of the present work was to develop a metered dose transdermal spray(MDTS)formulation for transdermal delivery of testosterone and to characterize its *** release from a series of formulations was assessed in *** from hairless mice was used in permeation experiments with Franz diffusion *** spray pattern,pump seal efficiency,average weight per metered dose and dose uniformity were *** optimized formulation containing 10%(w/v)testosterone,9%(v/v)azone and 91%(v/v)ethanol was based on good skin permeation and acceptable drug concentration and permeation enhancer(PE)content.A skin irritation study indicated that the formulation was non-irritating in a rat *** in vivo pharmacokinetic study indicated that the optimized formulation showed a different plasma concentration-time profile from that of the commercially available product *** Testopatchs product demonstrated a more sustainable drug *** evaluation of the testosterone MDTS indicated that it could deliver reproducible amounts of the formulation per *** results obtained showed that the MDTS is a potential alternative therapeutic system for transdermal testosterone delivery.

关键词： Metered dose transdermal spray Testosterone Transdermal vehicle Azone Permeability Pharmacokinetics Rat

Mechanisms for the link between onset and duration of open water in the Kara Sea

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Acta Oceanologica Sinica 2021年第11期40卷 119-128页

作者： Chunming Dong Hongtao Nie Xiaofan luo hao wei wei Zhao School of Marine Science and Technology Tianjin UniversityTianjin 300072China

The sea ice conditions in the Kara Sea have important impacts on Arctic shipping,oil and gas production,and marine environmental *** this study,sea ice coverage(C_(R))less than 30%is considered as open water,its onset and end dates are defined as T_(open)and T_(close),*** sea ice melt onset(T_(melt))is defined as the date when ice-sea freshwater flux initially changes from ice into the ***-based sea ice concentration(SIC)from 1989 to 2019 shows a negative correlation between T_(open)and T_(close)(r=-0.77,p<0.01)in the Kara *** phenomenon is also obtained through analyzing the hindcast simulation from 1994 to 2015 by a coupled ocean and sea-ice model(NAPA1/4).The model results reveal that thermodynamics dominate the sea ice variations,and ice basal melt is greater than the ice surface *** budget estimation suggests that the heat flux is significant correlated with T_(open)(r=-0.95,p<0.01)during the melt period(the duration of multi-year averaged T_(melt)to T_(open))influenced by the sea ice ***,this heat flux is also suggested to dominate the interannual variation of the heat input during the whole heat absorption process(r=0.81,p<0.01).The more heat input during this process leads to later T_(close)(r=0.77,p<0.01).This is the physical basis of the negative correlation between T_(open)and T_(close).Therefore,the duration of open water can be predicted by T_(open)and thence support earlier planning of marine activities.

关键词： sea ice open water onset duration of open water heat budget Kara Sea

Effect of compressive strength on the performance of the NEMO-LIM model in Arctic Sea ice simulation

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Journal of Oceanology and Limnology 2023年第1期41卷 1-16页

作者： Chunming DONG Xiaofan luo Hongtao NIE wei Zhao hao wei School of Marine Science and Technology Tianjin UniversityTianjin 300072China

Satellite records show that the extent and thickness of sea ice in the Arctic Ocean have significantly decreased since the early *** prediction of sea ice is highly important,but accurate simulation of sea ice variations remains highly *** improving model performance,sensitivity experiments were conducted using the coupled ocean and sea ice model(NEMO-LIM),and the simulation results were compared against satellite ***,the contribution ratios of dynamic and thermodynamic processes to sea ice variations were *** results show that the performance of the model in reconstructing the spatial distribution of Arctic sea ice is highly sensitive to ice strength decay constant(C^(rhg)).By reducing the C^(rhg) constant,the sea ice compressive strength increases,leading to improved simulated sea ice *** contribution of thermodynamic processes to sea ice melting was reduced due to less deformation and fracture of sea ice with increased compressive ***,dynamic processes constrained more sea ice to the central Arctic Ocean and contributed to the increases in ice concentration,reducing the simulation bias in the central Arctic Ocean in *** root mean square error(RMSE)between modeled and the CryoSat-2/SMOS satellite observed ice thickness was reduced in the compressive strength-enhanced model *** ice thickness,especially of multiyear thick ice,was also reduced and matched with the satellite observation better in the freezing *** provide an essential foundation on exploring the response of the marine ecosystem and biogeochemical cycling to sea ice changes.

关键词： sea ice compressive strength sensitivity experiment ocean-sea ice model Arctic Ocean

Design of hexagon microstrip antenna for vehicle-to-vehicle communication

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The Journal of China Universities of Posts and Telecommunications 2016年第4期23卷 69-76页

作者： hao Honggang Li Jiayu Huang Daili luo wei College of Photoelectric Engineering Chongqing University of Posts and Telecommunications

Considering the shortcomings of the existing vehicle-to-vehicle（V2V） communication antennas, this paper proposes a regular hexagon broadband microstrip antenna. By loading shorting pins and etching V-shape slots with different size at each angle of the regular hexagon patch, it realizes impedance matching and obtains better impedance bandwidth. The simulated results show that the relative bandwidth of this antenna reaches 35.55%, covers the frequency band of 4.74 GHz to 6.79 GHz. The antenna acquires an omni-directional radiation pattern in the horizontal plane whose out of roundness is less than 0.5 d B. In addition, the antenna is manufactured and tested, whose tested results are basically consistent with simulated results. Because the height of antenna is 3 mm, it is easy to be hidden on roof of a vehicle for V2 V communication.

关键词： regular hexagon microstrip antenna shorting pins V-shape slots omni-directional radiation pattern V2V communication

Linkage Between Winter Temperatures in the Yellow Sea and Atmospheric Circulation Indices

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Journal of Ocean University of China 2019年第2期18卷 261-270页

作者： YUAN Chengyi wei hao luo Xiaofan KUANG Xiaodi College of Marine and Environmental Sciences Tianjin University of Science and Technology School of Marine Science and Technology Tianjin University National Marine Environmental Forecasting Center

This study investigated the linkage between winter temperature in the Yellow Sea(YS), China, and atmospheric indices and established this linkage through statistical models. The water temperature was obtained through hindcast simulation using a global–regional nested ocean model for the period of 1958–2007. The interannual variations of the simulated temperature were validated using satellite and in-situ observations. In the YS, the winter sea surface temperature(SST) had obvious interannual variations, with the maximum SST exceeding 2℃, and a significant shift from the cold to warm phase during 1988–1989. Based on the mechanism study, statistical models for the variations of water temperature in the YS were established using suitable atmospheric indices as predictors. For the northern YS(NYS) and the coastal region of the southern YS(SYS), statistical models of SST were established using linear regression based on the December–January–February mean Arctic oscillation index(AOI), representing the dominant large-scale atmospheric variability in boreal winter. For the YS warm current(YSWC) region, statistical models were established using both the AOI and the first principal component of the local wind stress curl(PC1-Curl), derived from the empirical orthogonal functions analysis. The PC1-Curl represents the influence of the local wind stress curl on the west-to-east shifts of the YSWC pathway. The applications proved that the models presented in this study have the ability to estimate winter temperatures in the YS within the recent years.

关键词： water temperature statistical model interannual variations atmospheric variability empirical orthogonal function analysis

人脐带间充质干细胞来源外泌体抗小鼠肾缺血再灌注损伤的机制

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中国组织工程研究 2025年第13期29卷 2706-2712页

作者：李灵玉魏华锋罗豪王浩贺佳辉姚雅韡吕兴华兰州大学第一临床医学院甘肃省兰州市730000 兰州大学第一医院日间手术中心甘肃省兰州市730000

背景:人脐带间充质干细胞来源外泌体参与多种损伤修复过程,其对肾缺血再灌注损伤的影响以及具体机制还没有完全阐明。目的:探讨人脐带间充质干细胞来源外泌体治疗肾缺血再灌注损伤的分子机制。方法:①培养人脐带间充质干细胞,使用外泌... 详细信息

背景:人脐带间充质干细胞来源外泌体参与多种损伤修复过程,其对肾缺血再灌注损伤的影响以及具体机制还没有完全阐明。目的:探讨人脐带间充质干细胞来源外泌体治疗肾缺血再灌注损伤的分子机制。方法:①培养人脐带间充质干细胞,使用外泌体提取试剂盒获取外泌体并鉴定;②采用活体荧光成像技术检测外泌体在肾缺血再灌注损伤小鼠肾脏中的分布;③C57/BL6雄性小鼠30只,按随机数字表法分为5组:假手术组、肾缺血再灌注组、假手术组+Compound C组、肾缺血再灌注+外泌体组、肾缺血再灌注+外泌体+Compound C组,每组6只。除假手术组外,其余组均夹闭双侧肾蒂45 min,再灌注24 h建立肾缺血再灌注小鼠模型;假手术组+Compound C组和外泌体+Compound C组于造模前30 min腹腔注射AMPK抑制剂Compound C;外泌体组和外泌体+Compound C组在肾蒂夹闭前15 min经尾静脉注射外泌体。再灌注24 h检测各组小鼠血清肌酐和尿素氮水平、肾组织白细胞介素6和肿瘤坏死因子α水平、肾组织凋亡相关因子的表达。结果与结论:①人脐带间充质干细胞外泌体具有典型的茶托形态,直径分布在40-160 nm范围内,表达外泌体表面特异性标志膜蛋白;②与假手术组相比,肾缺血再灌注损伤小鼠肾脏更易聚集人脐带间充质干细胞外泌体;③外泌体预处理可减轻肾缺血再灌注小鼠肾损伤,降低肾小管上皮细胞凋亡水平,并且这种保护作用可被AMPK抑制剂所逆转。结果表明,人脐带间充质干细胞来源外泌体发挥肾缺血再灌注损伤的保护作用可能与激活AMPK/YAP1通路抗细胞凋亡有关。

关键词：人脐带间充质干细胞外泌体 AMPK-YAP1通路凋亡肾缺血再灌注损伤

Landslide data mosaicking based on an airborne laser point cloud and multi-beam sonar images

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Journal of Mountain Science 2020年第9期17卷 2068-2080页

作者： JI hao-wei luo Xian-qi ZHOU Yong-jun School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Landslides are one of the most disastrous geological hazards in southwestern *** a landslide becomes unstable,it threatens the lives and safety of local ***,empirical studies on landslides have predominantly focused on landslides that occur on *** this end,we aim to investigate ashore and underwater landslide data *** study proposes an optimized mosaicking method for ashore and underwater landslide *** method fuses an airborne laser point cloud with multi-beam depth sounder *** to their relatively high efficiency and large coverage area,airborne laser measurement systems are suitable for emergency investigations of *** on the airborne laser point cloud,the traversal of the point with the lowest elevation value in the point set can be used to perform rapid extraction of the crude channel *** meticulous extraction of the channel boundaries is then implemented using the probability mean value optimization *** addition,synthesis of the integrated ashore and underwater landslide data angle is realized using the spatial guide line between the channel boundaries and the underwater multibeam sonar images.A landslide located on the right bank of the middle reaches of the Yalong River is selected as a case study to demonstrate that the proposed method has higher precision thantraditional *** experimental results show that the mosaicking method in this study can meet the basic needs of landslide modeling and provide a basis for qualitative and quantitative analysis and stability prediction of landslides.

关键词： Laser point cloud Airborne laser measurement Mosaicking method Multi-beam sonar images Shipborne Channel boundaries

NUMERICAL SIMULATION AND EXPERIMENTAL STUDY OF DRAGREDUCING SURFACE OF A REAL SHARK SKIN

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Journal of Hydrodynamics 2011年第2期23卷 204-211页

作者： ZHANG De-yuan luo Yue-hao LI Xiang CHEN Hua-wei School of Mechanical Engineering and Automation Beihang University Beijing 100191 China

It is well known that shark skin surface can effectively inhabit the occurrence of turbulence and reduce the wall friction, but in order to understand the mechanism of drag reduction, one has to solve the problem of the turbulent flow on grooved-scale surface, and in that respect, the direct numerical simulation is an important tool. In this article, based on the real biological shark skin, the model of real shark skin is built through high-accurate scanning and data processing. The turbulent flow on a real shark skin is comprehensively simulated, and based on the simulation, the drag reduction mechanism is discussed. In addition, in order to validate the drag-reducing effect of shark skin surface, actual experiments were carried out in water tunnel, and the experimental results are approximately consistent with the numerical simulation.

关键词： numerical simulation experimental study biomimetic surface shark skin drag reduction mechanism

Zinc modification of Ni-Ti as efficient Ni_(x)Zn_(y)Ti_(1)catalysts with both geometric and electronic improvements for hydrogenation of nitroaromatics

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Frontiers of Chemical Science and Engineering 2022年第4期16卷 461-474页

作者： Pingle Liu Yu Liu Yang Lv wei Xiong Fang hao Hean luo College of Chemical Engineering National&Local United Engineering Research Center for Chemical Process Simulation and IntensificationXiangtan UniversityXiangtan 411105China

The catalytic hydrogenation of nitroaromatics is an environmentally friendly technology for aniline production,and it is crucial to develop noble-metal-free catalysts that can achieve chemoselective hydrogenation of nitroaromatics under mild reaction *** this work,zinc-modified Ni-Ti catalysts(Ni_(x)Zn_(y)Ti_(1))were fabricated and applied for the hydrogenation of nitroaromatics *** was found that the introduction of zinc effectively increases the surface Ni density,enhances the electronic effect,and improves the interaction between Ni and TiO_(2),resulting in smaller Ni particle size,more oxygen vacancies,higher dispersion and greater concentration of Ni on the catalyst ***,the electron-rich Ni^(δ-) obtained by electron transfer from Zn and Ti to Ni effectively adsorbs and dissociates *** results reveal that Ni_(x)Zn_(y)Ti_(1)(Ni_(0.5)Zn_(0.5)Ti_(1))shows excellent catalytic performance under mild conditions(70℃and 6 bar).These findings provide a rational strategy for the development of highly active non-noble-metal hydrogenation catalysts.

关键词： bimetal strategy oxygen vacancy non-noble metal catalyst hydrogenation aromatic nitro compounds