Preparation and characterization of a metered dose transdermal spray for testosterone

作     者：Wangding Lu Huafei Luo Yubo Wu Zhuangzhi Zhu Hao Wang 

作者机构：National Pharmaceutical Engineering Research CenterChina State Institute of Pharmaceutical IndustryShanghai 201203China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2013年第3卷第6期

页      面：392-399页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported financially by the Major Projects for Drug Innovation and Development from National Science and Technology(2012ZX09304004) 

主　　题：Metered dose transdermal spray Testosterone Transdermal vehicle Azone Permeability Pharmacokinetics Rat 

摘      要：The objective of the present work was to develop a metered dose transdermal spray(MDTS)formulation for transdermal delivery of testosterone and to characterize its *** release from a series of formulations was assessed in *** from hairless mice was used in permeation experiments with Franz diffusion *** spray pattern,pump seal efficiency,average weight per metered dose and dose uniformity were *** optimized formulation containing 10%(w/v)testosterone,9%(v/v)azone and 91%(v/v)ethanol was based on good skin permeation and acceptable drug concentration and permeation enhancer(PE)content.A skin irritation study indicated that the formulation was non-irritating in a rat *** in vivo pharmacokinetic study indicated that the optimized formulation showed a different plasma concentration-time profile from that of the commercially available product *** Testopatchs product demonstrated a more sustainable drug *** evaluation of the testosterone MDTS indicated that it could deliver reproducible amounts of the formulation per *** results obtained showed that the MDTS is a potential alternative therapeutic system for transdermal testosterone delivery.