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Journal of Innovative Optical Health Sciences 2019年第3期12卷 32-40页

作者： Hao Xu yubin liu Junle Qu Zhen Yuan College of Optoelectronic Engineering Shenzhen University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province ShenzhenGuangdongP.R.China Faculty of Health Sciences University of Macao TaipaMacao SAR 999078P.R.China

The photosensitizer(PS)as photodynamic therapy(PDT)agent,can also serve as the contrast agent for dual-modalffuorescence imaging(FLI)and photoacoustic imaging(PAI)for precise cancer *** this study,the PAI capability of commercial PS,benzoporphyrin derivative monoacid ring-A(BPD)were examined and compared with that from the other PSs and dyes such as TPPS_(4),Cy5 dye and *** discovered that BPD exhibited its advantage as contrast agent for ***,BPD can also serve as the contrast agent for enhanced *** particular,the PEGylated nanoliposome(PNL)encapsulated BPD(LBPD)was produced for contrast enhanced dual-modal FLI and PAI and imaging-guided high-efficiency *** FLI and PAI results demonstrated the significant accumulation of LBPD both within and among individual tumor during 24 h monitoring for in vivo experiment ***-vitro and in-vivo PDT tests were also performed,which showed that LBPD have higher PDT efficiency and can easily break the blood vessel of tumor tissues as compared to that from *** was discovered that LBPD has great potentials as a diagnosis and treatment agent for dual-modal FLI and PAI-guided PDT of cancer.

关键词： Liposome photosensitizer photodynamic therapy photoacoustic imaging ffuorescence imaging

Numerical Methods for Semilinear Fractional Diffusion Equations with Time Delay

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Advances in Applied Mathematics and Mechanics 2022年第1期14卷 56-78页

作者： Shuiping Yang yubin liu Hongyu liu Chao Wang School of Mathematics and Big Data Science Huizhou UniversityHuizhouGuangdong 516007China Department of Mathematics City University of Hong KongKowloonHong Kong Department of Mathematics Southern University of Science and TechnologyShenzhenGuangdong 518055China Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and TechnologyShenzhenGuangdong 518055China

In this paper,we consider the numerical solutions of the semilinear Riesz space-fractional diffusion equations(RSFDEs)with time delay,which constitute an important class of differential equations of practical *** develop a novel implicit alternating direction method that can effectively and efficiently tackle the RSFDEs in both two and three *** numerical method is proved to be uniquely solvable,stable and convergent with second order accuracy in both space and *** results are presented to verify the accuracy and efficiency of the proposed numerical scheme.

关键词： Semilinear Riesz space fractional diffusion equations with time delay implicit alternating direction method stability and convergence

Preparation of new technetium-99m NNS/X complexes and selection for brain imaging agent

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Science China Chemistry 2004年第6期47卷 499-506页

作者： HE Qiange CHEN Xiangji MIAO yubin liu Boli Chemistry Department Beijing Normal University Beijing 100875 China Chemistry Department Beijing Normal University Beijing 100875 China Chemistry Department Beijing Normal University Beijing 100875 China

Based on excellent experiment results of 99mTcO-MPBDA-CI, two new ligands MPTDA and MPDAA are synthesized. Then series of 99mTcO3+ complexes are prepared through adding different halide anions, followed by tests of physical chemistry qualities and biodistribution experiments. And results of these experiments show that complexes formed with MPTDA and MPDAA have better lipophilicity than those formed with MPBDA, still maintain the good brain retention ability of this type of compounds, but radioactivity uptake in blood is higher than that of 99mTcO-MPBDA and ratios of brain/blood are reduced. Obvious affections are fetched out on brain uptake and retention if fluoride, bromide or iodide anions are added. Results of experiments can be explained in reason with theoretic computation. It is confirmed that 99mTcO-MPBDA-CI has potential to develop a new type of brain imaging agent considering integrated factors such as brain uptake, retention and toxicity.

关键词： 99mTc, brain perfusion imaging agent, MPBDA, MPTDA, MPDAA.

Biomimetic Design and Optimal Swing of a Hexapod Robot Leg

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Journal of Bionic Engineering 2014年第1期11卷 26-35页

作者： Jie Chen yubin liu Jie Zhao He Zhang Hongzhe Jin State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 P. R. China

Biological inspiration has spawned a wealth of solutions to both mechanical design and control schemes in the efforts to develop agile legged machines. This paper presents a compliant leg mechanism for a small six-legged robot, HITCR-ll, based on abstracted anatomy from insect legs. Kinematic structure, relative proportion of leg segment lengths and actuation system were analyzed in consideration of anatomical structure as well as muscle system of insect legs and desired mobility. A spring based passive compliance mechanism inspired by musculoskeletal structures of biological systems was integrated into distal segment of the leg to soften foot impact on touchdown. In addition, an efficient locomotion planner capable of generating natural movements for the legs during swing phase was proposed. The problem of leg swing was formulated as an optimal control procedure that satisfies a series of locomotion task terms while minimizing a biologically-based objective function, which was solved by a Gauss Pseudospectral Method （GPM） based numerical technique. We applied this swing generation algorithm to both a simulation platform and a robot prototype. Results show that the proposed leg structure and swing planner are able to successfully perform effective swing movements on rugged terrains.

关键词： biomimetic design legged robot optimal control biological movement principle Gauss pseudospectral method

Development of a Bionic Hexapod Robot for Walking on Unstructured Terrain

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Journal of Bionic Engineering 2014年第2期11卷 176-187页

作者： He Zhang yubin liu Jie Zhao Jie Chen Jihong Yan State Key Lab of Robotics and System Harbin Institute of Technology Harbin 150080 P. R. China

This paper reports the design methodology and control strategy in the development of a novel hexapod robot HITCR-II that is suitable for walking on unstructured terrain. First, the entire sensor system is designed to equip the robot with the perception of external environment and its internal states. The structure parameters are optimized for improving the dexterity of the robot. Second, a foot-force distribution model and a compensation model are built to achieve posture control. The two models are capable of effectively improving the stability of hexapod walking on unstructured terrain. Finally, the Posture Control strategy based on Force Distribution and Compensation （PCFDC） is applied to the HITCR-II hexapod robot. The experimental results show that the robot can effectively restrain the vibration of trunk and keep stable while walking and crossing over the un- structured terrains.

关键词： hexapod robot structure optimization posture control force distribution force compensation

The HITCR-I:Evaluation on a free gait generation method for the hexapod robot on irregular terrain

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High Technology Letters 2013年第4期19卷 406-412页

作者：张赫 Zhao Jie liu yubin Chen Fu State Key Laboratory of Robotics and System Harbin Institute of Technology

The purpose of this paper is to present and evaluate a method of free gait generation for HITCRI,a hexapod walking *** HITCR-I is designed as a modularized structure of legs that is based upon a four-bar linkage mechanism and with force sensors in the tip of legs,distributed hardware structure and a modular software structure of the control *** on a set of local rules between adjacent legs,finite state machine(FSM) model is built to control the coordination of *** automatic smooth transition of gait pattern is achieved through deriving the mathematical relation between gait pattern and locomotion *** disordered inter-leg phase sequence is adjusted to a regular state smoothly and quickly by the local rules based FSM,and the gait pattern can transform automatically adapting to irregular *** experiment on HITCR-I has demonstrated that it can walk through irregular terrain reliably and expeditiously with the free gait controller designed in this paper.

关键词： robotics hexapod robot irregular terrain walking tree gait gait pattern transition

Colonization and Probiotic Effect of Metschnikowia sp. C14 in the Intestine of Juvenile Sea Cucumber, Apostichopus japonicus

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Journal of Ocean University of China 2020年第1期19卷 225-231页

作者： LI Ming BAO Pengyun SONG Jian DING Jianfeng liu yubin MA Yuexin Key Laboratory of Mariculture and Stock Enhancement in North China’s Sea of Ministry of Agriculture and Rural Affair Dalian Ocean University

Viable cell count was used to determine whether Metschnikowia sp.C14 can colonize the intestine of juvenile sea cucumber Apostichopus *** cucumber individuals were divided into two groups,which were fed the control diet for 38 days or the C14-supplemented diet at 105 cells g−1 diet for 28 days,then the control diet from day 29 to day *** number of C14 cells in the intestine of sea cucumber fed the C14-supplemented diet significantly increased from day 7 to day 28,and decreased from day 29 to day *** cucumber fed with the diet containing C14 showed a significant increase in trypsin activity and lipase activity from day 21 to day 33 compared with the *** C14 significantly improved the phagocytic activity and respiratory burst in coelomocytes from day 21 to day 35 and from day 14 to day 38,*** addition,there was an obvious enhancement in lysozyme activity(from day 21 to day 38 or day 33),phenoloxidase activity(from day 21 to day 28)and total nitric oxide synthase activity(from day 14 to day 38)in coelomic fluid supernatant and/or coelomocyte cell lysate supernatant compared with the *** were significant positive correlations between the number of C14 cells colonizing the intestine and trypsin activity of the intestine,lysozyme activity of the coelomic fluid supernatant and coelomocyte lysate supernatant from sea *** data suggested that the number of C14 cells should be maintained at 105 cfu(colony-forming units)g−1 intestine material for the maximum benefit.

关键词： Apostichopus japonicas feeding duration colonization Metschnikowia sp.C14 digestive enzyme activity immune parameter

Characterization of the bacterial communities associated with biofilters in two full-scale recirculating aquaculture systems

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Journal of Oceanology and Limnology 2021年第3期39卷 1143-1150页

作者： Yuexin MA Xin DU yubin liu Tao ZHANG Yue WANG Saisai ZHANG Key Laboratory of Environment Controlled Aquaculture Ministry of EducationDalian 116023China Dalian Modern Agricultural Production Development Service Center Dalian 116023China Dalian Tianzheng Industry Company Limited Dalian 116011China

Bacteria play a major role in metabolizing ammonia and other metabolites in recirculating aquaculture systems(RASs).To characterize and compare the bacterial communities in the biofilters of two full-scale RASs for the culture of puffer fish,Takifugu rubripes,at different ages and densities were *** overall,47807 optimized reads of the 16 S rRNA gene with V4-V5 region were obtained from four biofilm samples collected after biofilm *** 97%cut-off level,these sequences were clustered into 500 operational taxonomic units,and were classified into 19 bacterial phyla and 138 *** the phylum level,Proteobacteria and Bacteroidetes were the most abundant,followed by Nitrospirae and *** the genus level,Colwellia,Marinifilum,Oceanospirillum,Lutibacter,Winogradskyella,Pseudoalteromonas,Arcobacter,and Phaeobacter were the top *** and Nitrospira were main ammonia-and nitrite-oxidizing *** in bacterial communities at different sampling dates and similarities of both biofilters were revealed in the Venn diagram and cluster *** a good water quality and health offarmed fish in RASs depended on the correct management of the bacterial *** study provides more accurate information on the bacterial communities associated with the bifilters of both RASs.

关键词： biofilters bacterial community recirculating aquaculture system Illumina-MiSeq sequencing

Sulfonated polyaniline/vanadate composite as anode material and its electrochemical property in microbial fuel cells on ocean floor

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Science China Chemistry 2011年第5期54卷 844-849页

作者： FU yubin ZHAO ZhongKai liu Jia LI KuiZhong XU Qian ZHANG ShaoYun Institute of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

A unique sulfonated polyaniline/vanadate composite was synthesized and utilized as a composite anode in microbial fuel cells on ocean floor (BMFCs). X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were employed to characterize its chemical composition and morphology. Wettability of the composite anodes decreases due to the addition of polytetrafluoroethylene (PTFE). The electrochemical behavior of the composite anodes was investigated by means of linear sweep voltammetry and Tafel plot measurements. Compared with the plain graphite anode,the composite anode significantly improves the power density,5.5-fold higher,reaching 187.1 mW/m2 and gives a 27-fold higher exchange current density and a higher kinetic activity. A novel synergistic mechanism between sulfonated polyaniline and vanadate is proposed to explain the excellent electrochemical performance. This composite thus has great potential to be used as an anode material for a high-power BMFC.

关键词： sulfonated polyaniline/vanadate composite anode material microbial fuel cells on ocean floor power density electrochemical property

A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region： Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging

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Nano Research 2017年第1期10卷 64-76页

作者： Jian Zhang Haobin Chen Ting Zhou Limei Wang Duyang Gao Xuanjun Zhang yubin liu Changfeng Wu Zhen Yuan Bioimaging Core Faculty of Health Sciences University of Macao Taipa Macao SAR 999078 China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Jilin 130012 China College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China College of Veterinary Medicine South China Agricultural University Guangzhou 510642 China Center for Drug Non-clinical Evaluation and Research Guangdong Biological Resources Institute Guangdong Academy of Sciences Guangzhou 510900 China

As a hybrid imaging technique, photoacoustic imaging （PAI） can provide multiscale morphological information of tissues, and the use of multi-spectral PAI （MSPAI） can recover the spatial distribution of chromophores of interest, such as hemoglobin within tissues. Herein, we developed a contrast agent that can very effectively combine multiscale PAI with MSPAI for a more comprehensive characterization of complex biological tissues. Specifically, we developed novel PIID-DTBT based semi-conducting polymer dots （Pdots） that show broad and strong optical absorption in the visible-light region （500-700 nm）. The performances of gold nanoparticles （GNPs） and gold nanorods （GNRs）, which have been verified as excellent photoacoustic contrast agents, were compared with that of the Pdots based on the multiscale PAI system. Both ex vivo and in vivo experiments demonstrated that the Pdots have better photoacoustic conversion efficiency at 532 nm than GNPs and showed similar photoacoustic performance with GNRs at 700 nm at the same mass concentration. Photostability and toxicity tests demonstrated that the Pdots are photostable and biocompatible. More importantly, an in vivo MSPAI experiment indicated that the Pdots have better photoacoustic performance than the blood and therefore the signals can be accurately extracted from the background of vascular-rich tissues. Our work demonstrates the great potential of Pdots as highly effective contrast agents for the precise localization of lesions relative to the blood vessels based on multiscale PAI and MSPAI.

关键词： nanoparticles polymer dots contrast agents photoacoustic imaging multiscale imaging multi-spectral imaging