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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 49-63页

作者： Jia Zeng Peng Sun yuanqian zhao Xinning Fang Zhenghong Wu Xiaole Qi Key Laboratory of Modern Chinese Medicines China Pharmaceutical UniversityNanjing 210009China Industrial Technology Innovation Platform Zhejiang Center for Safety Study of Drug SubstancesHangzhou 310018China

Mesenchymal stem cells(MSC)are particularly effective in promoting cartilage regeneration due to their immunomodulatory,anti-inflammatory and regenerative repair functions of tissues and ***,the intra-articular delivery and synergy with other therapeutic drugs have been the key issues driving their further *** report a mussel-inspired multifunctional hydrogel system,which could achieve co-delivery and synergism effect of MSC-derived exosomes(Exos)with icariin(ICA).The ICA and Exos co-delivered articular cavity injection system are expected to retain in the joint cavity and promote cartilage regeneration,due to the thermosensitive,self-healing and adhesion properties of the mussel-inspired multifunctional *** experimental results proved that Exos enhanced the cellular uptake of ICA by more than 2-fold evenly,and the synergism of Exos and ICA efficiently improve the cell proliferation and *** synergic treatment,the content of matrix metalloproteinase 13 in the supernatant and intracellular decreased by 47%and 59%,*** vivo study,ICA-loaded Exos exhibited prolonged retention behavior bymultifunctional hydrogel delivery,thus displayed an increased cartilage *** the model of osteoarthritis,co-delivery hydrogel system relieved the cartilage recession,ensuring appropriate cartilage thickness.

关键词： Osteoarthritis Icariin Exosomes Multifunctional hydrogel

微RNA在恶性胸膜间皮瘤发生发展中的作用机制研究进展

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基因组学与应用生物学 2024年第6期43卷 967-975页

作者：赵丹普元倩熊伟大理大学基础医学院生物化学与分子生物学教研室大理671000 云南省高校临床生物化学检验重点实验室大理671000 云南省昆虫生物医药研发重点实验室大理671000

微RNA(microRNA,miRNA)是近年来发现的最短的内源性非编码RNA(non-coding RNAs,ncRNA)之一,普遍认为其通过调节信使RNA(messenger RNA,mRNA)表达水平来发挥作用,主要功能体现在参与调节生物个体发育、细胞增殖与分化、肿瘤的发生发展等... 详细信息

微RNA(microRNA,miRNA)是近年来发现的最短的内源性非编码RNA(non-coding RNAs,ncRNA)之一,普遍认为其通过调节信使RNA(messenger RNA,mRNA)表达水平来发挥作用,主要功能体现在参与调节生物个体发育、细胞增殖与分化、肿瘤的发生发展等多种病理和生理过程中。miRNA在调控癌基因、抑癌基因的表达和信号通路的活性过程中以及在恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)发生和发展中发挥着重要的作用。本综述对miRNA的生成和miRNA的功能及在MPM发生发展过程中发挥促癌作用和肿瘤抑制作用的相关miRNA进行总结和归纳,以期为MPM的临床诊断以及治疗提供理论参考。

关键词：微RNA 恶性胸膜间皮瘤促癌基因抑癌基因

Recycling arsenic-containing bio-leaching residue after thermal treatment in cemented paste backfill:Structure modification,binder properties and environmental assessment

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2136-2147页

作者： Dengfeng zhao Shiyu Zhang Yingliang zhao Department of Mining Engineering Lyuliang UniversityLvliang 033000China School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083China School of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 00852China

The substantial arsenic(As)content present in arsenic-containing bio-leaching residue(ABR)presents noteworthy environ-mental challenges attributable to its inherent instability and susceptibility to *** its elevated calcium sulfate content,ABR exhibits considerable promise for industrial *** study delved into the feasibility of utilizing ABR as a source of sulfates for producing super sulfated cement(SSC),offering an innovative binder for cemented paste backfill(CPB).Thermal treatment at varying temperatures of 150,350,600,and 800℃ was employed to modify ABR’s *** investigation encompassed the examination of phase transformations and alterations in the chemical composition of As within ***,the hydration characteristics of SSC utilizing ABR,with or without thermal treatment,were studied,encompassing reaction kinetics,setting time,strength development,and *** findings revealed that thermal treatment changed the calcium sulfate structure in ABR,consequently impacting the resultant sample ***,calcination at 600℃ demonstrated optimal modification effects on both early and long-term strength *** enhanced performance can be attributed to the augmented formation of reaction products and a densified ***,the thermal treatment elicited modifications in the chemical As fractions within ABR,with limited impact on the As immobilization capacity of the prepared binders.

关键词： cemented paste backfill bio-leaching residue arsenic immobilization binder hydration calcination

Automatic modeling algorithm of stochastic error for inertial sensors

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Control Theory and Technology 2024年第1期22卷 81-91页

作者： Luodi zhao Long zhao School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Digital Navigation Center Beihang UniversityBeijing100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic algorithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the generalized method of wavelet moments (GMWM), whose estimator was proven to be consistent and asymptotically normally distributed. This algorithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This algorithm further explores the complete stochastic error models and the candidate model ranking criterion to realize automatic model identification and determination. The best model is selected by making the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying dynamic conditions.

关键词： GMWM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

Meeting the challenges of invasive alien species

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National Science Review 2024年第3期11卷 296-298页

作者： Weijie zhao NSR news

The Xinjiang Uygur Autonomous Region of China is famous for its tomato production. Abundant sunshine, large day–night temperature difference and the abundant irrigation by snowmelt from the Tianshan Mountains produce...

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Ling-Ling Chen: RNA has its own features;don't study it as a protein

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National Science Review 2024年第2期11卷 301-305页

作者： Weijie zhao NSR

Non-coding RNA(ncRNA) has been a very active research area over the past 30 years. From small nc RNA – the discovery of RNA interference won the lead researchers the Nobel Prize, to long ncRNA(lncRNA), which has attracted much attention in recent years, various nc RNAs participate in all kinds of biological processes and show a variety of biomedical application prospects.

关键词： RNA

Giant Flexoelectric Effect in Snapping Surfaces Enhanced by Graded Stiffness

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Acta Mechanica Solida Sinica 2024年第4期37卷 528-540页

作者： Chuo zhao Department of Aeronautics Imperial College LondonSouth Kensington CampusLondonSW72AZUK

Flexoelectricity is present in nonuniformly deformed dielectric materials and has size-dependent properties, making it useful for microelectromechanical systems. Flexoelectricity is small compared to piezoelectricity;therefore, producing a large-scale flexoelectric effect is of great interest. In this paper, we explore a way to enhance the flexoelectric effect by utilizing the snap-through instability and a stiffness gradient present along the length of a curved dielectric plate. To analyze the effect of stiffness profiles on the plate, we employ numerical parameter continuation. Our analysis reveals a nonlinear relationship between the effective electromechanical coupling coefficient and the gradient of Young’s modulus. Moreover, we demonstrate that the quadratic profile is more advantageous than the linear profile. For a dielectric plate with a quadratic profile and a modulus gradient of − 0.9, the effective coefficient can reach as high as 15.74 pC/N, which is over three times the conventional coupling coefficient of piezoelectric material. This paper contributes to our understanding of the amplification of flexoelectric effects by harnessing snapping surfaces and stiffness gradient design.

关键词： Functionally graded material Flexoelectricity Numerical continuation Snap-through instability

One dimensional CeO_(2) nanorods/poly(ethylene oxide) solid composite electrolyte for all-solid-state lithium-ion batteries

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Journal of Rare Earths 2024年第3期42卷 570-577,I0005页

作者： Yudi Guo Erqing zhao Xiaofang zhao Shuailei Liu School of Chemistry and Materials Engineering Xinxiang UniversityXinxiang453003China School of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang453003China

The research of poly(ethylene oxide)(PEO)-based solid composite electrolyte with high ionic conductivity and excellent interfacial stability is the key to the development of all-solid-state lithium-ion batteries(ASSLIBs). Herein, uniform nanorod structured CeO_(2) fillers were controllably synthesized by electrospinning, which were subsequently filled into PEO polymer to prepare CeO_(2)/PEO solid composite electrolyte. The addition of CeO_(2) nanorods can reduce both the glass transition temperature and the melting point of PEO polymer, and also interact with PEO and lithium bis(trifluoromethanesulphonyl)imide(LITFSI) by Lewis acid—base reaction. Therefore, the solid composite electrolyte exhibits a high ionic conductivity of 4.52 × 10^(-4)S/cm, a wide electrochemical stability window of about 4.8 V, and a good interfacial stability with Li at 55℃. Moreover, the LiFePO_4/Li ASSLIB divulges the discharging specific capacity of 165, 162, 156 and 146 mA,h/g at 0.2, 0.5, 1 and 2 C, respectively, and achieves the capacity retention of 90.3% after 150 cycles at 0.5 C. Consequently, one dimensional CeO_(2) nanorods can be considered as an alternative filler for polymeric solid electrolyte.

关键词： Poly(ethylene oxide) Solid composite electrolyte CeO_(2)nanorods Ionic conductivity Rare earths

The trajectory of rice from wild to domesticated:A new chapter in the study of origins of agriculture

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Science China Earth Sciences 2024年第9期67卷 3011-3012页

作者： Zhijun zhao Institute of Cultural Heritage Shandong UniversityQingdao 266237China

Rice(Oryza sativa)is one of the most important food crops in the world today,feeding more than one-third of the global *** domestication of rice has always been an international research topic(Gross and zhao,2014).When,where,and how rice was cultivated and eventually domesticated has been a hot issue in many research fields such as archaeology,biology,and agronomy(Fuller et al.,2009).

关键词： sativa Oryza crops

A DIRECT DISCONTINUOUS GALERKIN METHOD FOR TIME FRACTIONAL DIFFUSION EQUATIONS WITH FRACTIONAL DYNAMIC BOUNDARY CONDITIONS

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Journal of Computational Mathematics 2024年第1期42卷 156-177页

作者： Jingjun zhao Wenjiao zhao Yang Xu School of Mathematics Harbin Institute of TechnologyHarbin 150001China

This paper deals with the numerical approximation for the time fractional diffusion problem with fractional dynamic boundary *** well-posedness for the weak solutions is studied.A direct discontinuous Galerkin approach is used in spatial direction under the uniform meshes,together with a second-order Alikhanov scheme is utilized in temporal direction on the graded mesh,and then the fully discrete scheme is ***,the stability and the error estimate for the full scheme are analyzed in *** experiments are also given to illustrate the effectiveness of the proposed method.

关键词： Time fractional diffusion equation Numerical stability Convergence