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Validation of an Algorithm based on parameters in Non-Contrast Computerized Tomogram for selection of upper ureteral stone for shock wave lithotripsy

Validation of an Algorithm based on parameters in Non-Contra...

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第十五届全国泌尿外科学术会议

作者： chi-Fai ng Annie Wong Deyond Siu Kak-tak Wong Eddie Chan Department of Surgery and Department of Diagnostic Radiology and Organ Imaging The Chinese University of Hong Kong

Introduction and Objective: There is increase recognition of the role of various parameters measured by non-contrast computerized tomogram (NCCT) in predicting treatment outcomes of urinary stone by shockwave lithotripsy (SWL). In our previous analysis, a clinical algorithm, based on stone volume (SV), mean stone density (MSD) and skin-to-stone distance (SSD), was formulated. (J Urol 2007;177 supp: A1316) Therefore, we would like to use our subsequent patients to validate the usefulness of this algorithm. Methods: After our first part of study, a further prospective collection of data from patients diagnosed to have solitary upper ureteral stone by NCCT and received primary SWL was performed. The primary outcome was the stone free rate at 3-month after one session of SWL by Sonolith 4000+. Pre-treatment NCCT were reviewed by a single radiologist with SV, MSD and SSD measured. These patient parameters were then applied into our algorithm to assess its validity in predicting treatment outcome. Results: 37 patients (24 males and 13 females) were recruited. The overall stone free rate was 45.9%. By applying the algorithms, for patients with either SV ≤ 0.2cc or MSD ≤600 or SDep ≤ 85mm, the stone free rate was 52.2% (95% CI 31.7%, 72.7%). For those patients without any favourable factors, the stone free rate was 35.7% (95% CI 10.6%, 60.8%). Although the difference was not statistically significant, a trend of difference can still be observed in this small sample. Conclusions: Clinical algorithm based on the measurement of stone volume, mean stone density and skin to stone distance from NCCT can help to predict the treatment outcome of SWL in upper ureteral stone.

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Current and future molecular diagnostics in colorectal cancer and colorectal adenoma

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World Journal of Gastroenterology 2014年第14期20卷 3847-3857页

作者： Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong Department of Health Technology and Informatics Faculty of Health and Social SciencesHong Kong Polytechnic University Department of Surgery Prince of Wales Hospital State Key Laboratory in Oncology in South china Sir Y K Pao Centre for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong Kong

Colorectal cancer(CRC)is one of the most prevalent cancers in developed *** the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or *** CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the *** occult blood test is a widely used non-invasive screening tool for *** fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the *** dysregulations have been found to play an important role in CRC *** better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for *** this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were *** review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma.

关键词： Colorectal cancer Colorectal adenoma Molecular diagnostics Fecal occult blood test Non-invasive

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Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease

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Congenital Heart Disease 2021年第4期16卷 373-381页

作者： Dongdong Zheng chi Shen Wenshi Liu Wenjing Lv Xiaofei Li Department of Cardiovascular Internal Medicine Affiliated Hospital of Nantong UniversityNantong226001China Department of Cardiovascular Internal Medicine Tongzhou People’s Hospital Affiliated to Nantong UniversityNantong226300China

Objectives:Pulmonary arterial hypertension in congenital heart disease(PAH-CHD)is the most common type of PAH and increases morbidity and mortality in patients with *** heart catheterization(RHC)is the standard method to diagnose ***,RHC is an invasive and complicated method with relatively high ***,feasible,and cost-efficient methods are urgently *** objective of this study was to evaluate three potential biomarkers of PAH-CHD:Hepatocyte growth factor(HGF),osteopontin(OPN),and suppression of tumorigenicity 2(ST2).Methods:Plasma samples were collected from patients with CHD(n=46)and healthy individuals(n=22)and divided into four groups according to the severity of *** levels of HGF,OPN,and ST2 were then analyzed using an enzyme-linked immunosorbent *** between HGF,OPN,ST2,and clinical parameters of PAH-CHD were ***:The plasma HGF levels in the moderate to the severe group were significantly higher than those in the mild group,nonPAH group,and healthy control group(png characteristic(ROC)curve analysis,a cut-off value of 356.75 ng/ml for the HGF concentration was able to predict PAH-CHD with 53%sensitivity and 89%*** HGF level was positively related to pulmonary arterial systolic pressure(PASP)(r=0.36,p<0.05)and pulmonary vascular resistance(PVR)(r=0.36,p<0.05).Plasma OPN levels in the mild group were significantly higher than other groups and positively correlated with the pulmonary-systemic shunt ratio(Qp/Qs)(r=0.33,p<0.05).There was no statistically significant between-group difference in plasma soluble ST2(sST2)***:The plasma HGF level was elevated in PAH-CHD patients and can be used as a potential *** plasma OPN level was positively correlated with the Qp/Qs.

关键词： Congenital heart disease pulmonary hypertension hepatocyte growth factor osteopontin suppression of tumorigenicity 2 biomarker

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Enhanced plasma factor Ⅷ activity in mice via cysteine mutation using dual vectors

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Science china(Life Sciences) 2012年第6期55卷 521-526页

作者： ZHU FuXiang LIU ZeLong MIAO Jing QU HuiGe chi XiaoYan Life Science College of Ludong University Yantai 264025China

Hemophilia A is caused by a genetic mutation in coagulation factor VIII （FVIII） gene and gene therapy is considered to be a promising strategy for its treatment. We recently demonstrated that co-delivery of two vectors expressing M662C mutated heavy and D1828C mutated light chain genes of B-domain-deleted coagulation factor VIII （BDD-FVIII） leads to inter-chain disulfide cross-linking and improved heavy chain secretion in vitro. In this study, co-injection of both M662C and D1828C mutated BDD-FVIII gene expression vectors into mice resulted in increased heavy chain secretion and coagulation activity in plasma in vivo. Approximately （239＋_56） ng mL-1 above endogenous levels of transgenic FVIII heavy chain was found in mouse plasma using a chain-specific ELISA. For FVIII coagulation activity, approximately （1.09＋_0.25） IU mL-1 above en- dogenous levels were detected in co-injected transgenic mouse plasma using a chromogenic assay. These data demonstrate that inter-chain disulfide bonds likely increase heavy chain secretion and coagulation activity in the plasma of transgenic mice with an improved efficacy of a dual-vector delivery of BDD-FVIII gene. These findings support our ongoing efforts to develop a gene therapy for hemophilia A treatment using dual-AAV vectors.

关键词： coagulation factor VIII dual-vector gene delivery inter-chain disulfide bonding heavy chain secretion coagulation ac-tivity

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第一家居室

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城市住宅 1998年第3期 50-51页

作者： Benjamin Yung ng chi Wai Win World Engineering Itd.

面积:约102平方米(建筑面积)间隔:二室二厅吧台顶的假天花板和灯槽是旧有的,设计师除了更换灯光外,更在走廊处加插数盏射灯,反映到墙壁上以显层次及立体感。

关键词：居室室内设计室内装饰

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新加坡中央医院针灸门诊的规范化管理

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中国针灸 2014年第2期34卷 179-182页

作者：崔淑丽 Tan Kian Hian Ong Biauw chi Lim Shih hui Yong Yang Seah Cheng ngee Youyi Huang Han Seong ng 新加坡中央医院疼痛中心针灸门诊新加坡169608 杜克.新加坡国大医学研究生院

介绍新加坡中央医院针灸门诊的规范化管理。通过对门诊基础建设逐渐改进,医务人员再培训,操作过程严格消毒,医疗仪器定期检查,病历书写、保存和处理统一管理,开展公众中医知识教育等,逐渐形成了一套与现代化医院相适应的规范化管理制度... 详细信息

介绍新加坡中央医院针灸门诊的规范化管理。通过对门诊基础建设逐渐改进,医务人员再培训,操作过程严格消毒,医疗仪器定期检查,病历书写、保存和处理统一管理,开展公众中医知识教育等,逐渐形成了一套与现代化医院相适应的规范化管理制度,使临床治疗效率和质量不断提高。自1998年4月至2012年12月,治疗患者74 654人次,日诊量渐增,避免了针灸异常状况的发生,多次通过国内外国际医疗卫生机构认证联合委员会定期的严格审查。此外,针灸门诊还承担了3项新加坡健保集团的科研项目。

关键词：针灸门诊规范化管理新加坡

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Probabilistic Models for RFID Detection

Probabilistic Models for RFID Detection

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2011 2nd Asia-Pacific Conference on Wearable Computing Systems

作者： chi-Kong Chan Kam-Shing ng Cho-Tak Wong Henry C.B.Chan Department of Computing The Hong Kong Polytechnic University

Radio Frequency Identification（RFID） technology allows items with an RFID tag to be detected effectively and efficiently for identification and other purposes（e.g., for location management and movement detection）. In this paper, we study two probabilistic models, namely a binomial model and a Markov model for RFID detection. These models make use of RFID signals detected by antennas（i.e., RFID detection events）. Based on these models, the detection events can be analyzed or processed to facilitate the development of RFID applications（e.g., integrated RFID gateway and location management）. Our preliminary experimental results show that the models should be effective.

关键词： RFID RFID gateway RFID location management

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AlH_(3)在GAP/ng/BTTN中的贮存稳定性研究

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固体火箭技术 2024年第3期47卷 348-353页

作者：王榜庆裴宝林池旭辉杨根曹蓉赵程远张峰涛李小娜航天化学动力技术重点实验室襄阳441003 湖北航天化学技术研究所襄阳441003

针对三氢化铝(AlH_(3))在硝酸酯(ng/BTTN)增塑叠氮缩水甘油醚(GAP)高能推进剂中的贮存稳定性问题,采用XRD、SEM、元素分析等研究了不同温度下AlH_(3)在GAP/ng/BTTN中的分解特性。结果表明:相对于XRD,采用元素分析对AlH_(3)的含量进行定... 详细信息

针对三氢化铝(AlH_(3))在硝酸酯(ng/BTTN)增塑叠氮缩水甘油醚(GAP)高能推进剂中的贮存稳定性问题,采用XRD、SEM、元素分析等研究了不同温度下AlH_(3)在GAP/ng/BTTN中的分解特性。结果表明:相对于XRD,采用元素分析对AlH_(3)的含量进行定量表征的测试结果波动较小;AlH_(3)本体及其在GAP/ng/BTTN混合物中的分解释氢都存在诱导期、加速期和衰退期,70℃下诱导期均为6 d左右,GAP/ng/BTTN加快了AlH_(3)的分解释氢速率,在加速期内尤为明显,使得AlH_(3)分解加速期的时间跨度由22 d缩短为9 d;在诱导期内,ng/BTTN是影响AlH_(3)贮存稳定性的主要因素,GAP对AlH_(3)的贮存稳定性影响不明显;诱导期内纯AlH_(3)的分解活化能为197.01 kJ/mol,AlH_(3)/GAP/ng/BTTN混合物中AlH_(3)的分解活化能为199.58 kJ/mol,两者的分解活化能基本一致。

关键词：高能推进剂含能材料 AlH_(3) 活化能硝酸酯

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一种急性胰腺炎腺泡细胞凋亡/坏死体外模型的改良

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四川大学学报（医学版） 2018年第5期49卷 765-770页

作者：陈珂玲陈家乐池俊霖周总光李园四川大学华西医院生物治疗国家重点实验室消化外科研究室成都610041 四川大学华西医院胃肠外科成都610041

目的首次将共培养体系及混合腹水技术应用于急性胰腺炎腺泡细胞凋亡/坏死体外模型,并与常见的雨蛙素及雨蛙素联合脂多糖(LPS)模型进行对比研究,以观察其改良效果。方法体外培养的大鼠胰腺腺泡细胞株AR42J分为4组:对照组(培养液+PBS),雨... 详细信息

目的首次将共培养体系及混合腹水技术应用于急性胰腺炎腺泡细胞凋亡/坏死体外模型,并与常见的雨蛙素及雨蛙素联合脂多糖(LPS)模型进行对比研究,以观察其改良效果。方法体外培养的大鼠胰腺腺泡细胞株AR42J分为4组:对照组(培养液+PBS),雨蛙素组(培养液+10nmol/L雨蛙素),雨蛙素+LPS组(培养液+10nmol/L雨蛙素+10mg/L LPS)及改良腹水组。改良腹水组采用牛黄胆酸钠诱导的重症急性胰腺炎动物模型腹水,混合后加入共培养体系,刺激体外培养的同源腺泡细胞造模。共培养体系的设置为:培养板中置入孔径为1μm的小室,以体积比1∶1于孔板和小室中分别加入培养液及混合腹水。各组刺激24h后收集腺泡细胞,采用流式细胞术检测腺泡细胞的凋亡/坏死率,Western blot检测凋亡/坏死相关蛋白B淋巴瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、受体相互作用蛋白1(RIP1)的表达情况,透射电镜观察腺泡细胞的亚显微结构。结果改良腹水模型中腺泡细胞以坏死特征为主,与其余3组相比,其凋亡率及坏死率均上调,RIP1及BAX蛋白表达水平上调,而Bcl-2蛋白呈下调趋势。透射电镜结果显示改良腹水组腺泡细胞细胞器结构破坏,细胞膜降解。而雨蛙素及雨蛙素+LPS模型与对照组相比,腺泡细胞凋亡率上调,坏死率无改变;促凋亡蛋白Bax表达升高,而RIP1蛋白的表达水平无显著上调。透射电镜结果显示雨蛙素及雨蛙素+LPS组细胞染色质固缩成团,胞质降解,细胞膜完整,呈现出典型的凋亡特征。结论相较于以腺泡细胞凋亡特征为主、研究轻症急性胰腺炎的雨蛙素及雨蛙素+LPS模型,改良的腹水模型以腺泡细胞的坏死特征为主,是研究腺泡细胞坏死及重症急性胰腺炎的良好模型。

关键词：急性胰腺炎体外模型凋亡/坏死腹水

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The effect of a secretion-enhanced heavy chain on improving intein-based dual-vector co-delivery of a full-length factor Ⅷ gene

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chinese Science Bulletin 2011年第2期56卷 158-163页

作者： ZHU FuXiang YAng ShuDe LIU ZeLong MIAO Jing QU HuiGe chi XiaoYan College of Life Sciences Ludong University Yantai 264025 China

Treatment of hemophilia A by gene therapy is adversely affected by inefficient FVIII secretion and the large FVIII gene,which is difficult to package in the promising adeno-associated virus (AAV) *** secretion of FVIII is caused mainly by inefficient secretion of its heavy ***,we have employed a protein splicing-based dual-vector to co-transfer a B-domain-deleted FVIII (BDD-FVIII) gene,suggesting that the light chain,covalently ligated to a co-expressed heavy chain can improve the secretion of spliced ***,its level of secretion was affected by inefficient secretion the heavy ***,we studied the effect of a mutant heavy chain with L303E/F309S substitutions,which enhance FVIII secretion on the heavy chain itself and spliced FVIII when using a protein splicing-based split-delivery of a full-length FVIII *** vectors expressing Ssp DnaB intein-fused mutant heavy and light chains were transiently co-transfected into cultured COS-7 cells.A spliced FVIII protein was seen in co-transfected cells by Western blot *** heavy chain was secreted by cells transfected with the mutant heavy chain gene alone at (39±11) ng/mL and this secretion increased to (123±13) ng/mL when cells were co-transfected with the light chain gene,which was greater than the secretion of wild-type heavy *** amount of spliced FVIII in the culture supernatant of co-transfected cells was (86±14) ng/mL,with an activity of (0.61±0.08) IU/mL,which was greater than that of wild-type FVIII co-transfected *** FVIII and bioactivity were also detected in the combined culture supernatant of cells individually transfected with mutant heavy and light chain gene at a higher level than that of combined wild-type heavy and light chain *** suggested that the heavy chain with improved secretion markedly increased the efficacy of protein splicing-based split delivery of the full-length FVIII gene using a *** result

关键词：分泌作用基因传递因子和内含肽轻链载体基础蛋白质剪接

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