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Modified viscocanalostomy in the Chinese population with open angle glaucoma: a 10-year follow-up results

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 429-435页

作者： Ya Liang Hong Sun Jie Shuai Kai Xu Fang-Fang Ji Sucijanti zhi-Lan yuan Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical University Department of Ophthalmology Eye & ENT Hospital of Fudan University

AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients with medically uncontrolled OAG. All the patients underwent modified viscocanalostomy with injection of viscoelastic material in the surgically created ostia of Schlemm's canal(SC). The modifications included peeling of the inner wall of SC and the juxtacanalicular meshwork, use of mitomycin C, and loosely suturing the superficial scleral flap. Intraocular pressure(IOP), visual acuity, number of medications, laser goniopuncture data and complications were recorded. The definition of complete(qualified) success was an IOP equal to or lower than 21, 18, 16 mm Hg without(with or without) anti-glaucoma medications. RESULTS: The mean IOP was 33.5±9.9 mm Hg before surgery, 15.2±3.6 mm Hg(mean IOP reduction of 51%) at 5 y after surgery, and 15.6±2.8 mm Hg(mean IOP reduction of 49.9%) at 10 y after surgery(P<0.001). The number of anti-glaucoma medications dropped from 2.39±0.5 preoperatively to 0.47±0.8 at 5 y and 0.67±0.8 at 10 y postoperatively(P<0.001). The follow-up period was 104.5±37.0 mo. The qualified success rate for an IOP of 21, 18 or 16 mm Hg or less was 84% [95% confidence interval(CI): 0.80-0.88], 73%(95%CI: 0.68-0.78), and 59%(95%CI: 0.52-0.66) after 5 y, and 80%(95%CI: 0.76-0.84), 69%(95%CI: 0.64-0.74), 51%(95%CI: 0.44-0.58) after 10 y, respectively. There was a relationship between age, preoperative IOP and success rate(P<0.01, P<0.05). A total of 31 eyes(31.3%)in 31 patients underwent laser goniopuncture, decreasing the IOP from 22.9±4.3 mm Hg to 16.3±2.5 mm Hg(P<0.01). Neither blebitis nor endophthalmitis ***: Modified viscocanalostomy could be performed to lower IOP, decrease multiple anti-glaucoma drops use as well. It's a safe procedure with less complications over 10 y in Chinese individuals with OAG.

关键词： non-penetrating glaucoma surgery viscocanalostomy Schlemm’s canal open angle glaucoma laser goniopuncture

Unaxisymmetric Non-Fused Electron Acceptors for Efficient Polymer Solar Cells

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Chinese Journal of Polymer Science 2022年第8期40卷 944-950,I0009页

作者： Si-Ya Liu Di Wang Tian-Jiao Wen Guan-Qing Zhou Hai-Ming zhu Hong-Zheng Chen Chang-zhi Li State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry Zhejiang UniversityHangzhou310027China

To develop photovoltaics embracing the both features of high performance and low cost has drawn attentions of researchers,yet representing the significant *** this work,two non-fused ring acceptors(NFRAs),namely p-PTIC4Cl and t-PTIC4Cl,were developed via a short synthetic *** tethering unaxisymmetric aromatic chains to thienyl bridge of NFRAs,we revealed that the tuning of aromatic chains allows modulating the self-assembly and stacking of NFRAs in solid,hence influencing their optoelectronic and photovoltaic *** results,p-PTIC4Cl,consisting of 3-hexylbenzene with large axial angle to backbone,can achieve superior PCE of 11.30%than that of t-PTIC4Cl with 2-hexylthiophene chains(PCE of 6.49%),when pairing with polymer donor *** of the only subtle structural difference,the p-PTIC4Cl based blend films possess better exciton dissociation and charge transfer rates,as well as photostability,to those of t-PTIC4Cl based blends.

关键词： Polymer solar cells Non-fused ring acceptor Unaxisymmetric aromatic chains Photostability

Empagliflozin ameliorates diabetic cardiomyopathy probably via activating AMPK/PGC-1αand inhibiting the RhoA/ROCK pathway

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World Journal of Diabetes 2023年第12期14卷 1862-1876页

作者： Na Li Qiu-Xiao zhu Gui-zhi Li Ting Wang Hong Zhou Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Diabetic cardiomyopathy(DCM)increases the risk of hospitalization for heart failure(HF)and mortality in patients with diabetes ***,no specific therapy to delay the progression of DCM has been *** dysfunction,oxidative stress,inflammation,and calcium handling imbalance play a crucial role in the pathological processes of DCM,ultimately leading to cardiomyocyte apoptosis and cardiac ***,a novel glucoselowering agent,has been confirmed to reduce the risk of hospitalization for HF in diabetic ***,the molecular mechanisms by which this agent provides cardioprotection remain *** To investigate the effects of empagliflozin on high glucose(HG)-induced oxidative stress and cardiomyocyte apoptosis and the underlying molecular *** Twelve-week-old db/db mice and primary cardiomyocytes from neonatal rats stimulated with HG(30 mmol/L)were separately employed as in vivo and in vitro *** was used to evaluate cardiac *** cytometry and TdT-mediated dUTP-biotin nick end labeling staining were used to assess apoptosis in myocardial *** function was assessed by cellular ATP levels and changes in mitochondrial membrane ***,intracellular reactive oxygen species production and superoxide dismutase activity were ***-time quantitative PCR was used to analyze Bax and Bcl-2 mRNA *** blot analysis was used to measure the phosphorylation of AMP-activated protein kinase(AMPK)and myosin phosphatase target subunit 1(MYPT1),as well as the peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)and active caspase-3 protein *** the in vivo experiment, db/db mice developed DCM. However, the treatment of db/db mice with empagliflozin(10 mg/kg/d) for 8 wk substantially enhanced cardiac function and significantly reduced myocardial apoptosis,accompanied by an increase in the phosphorylatio

关键词： Empagliflozin Diabetic cardiomyopathy AMPK ROCK Apoptosis Oxidative stress

Ultrafast photoionization of ions and molecules by orthogonally polarized intense laser pulses: Effects of the time delay

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Chinese Physics B 2021年第1期30卷 207-214页

作者： Si-Qi Zhang zhi-Jie Yang zhi-Xian Lei Wei Feng Sheng-Peng Zhou Kai-Jun yuan Xue-Shen Liu Jing Guo Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

We present the photoelectron momentum distributions(PMDs) and the photoelectron angular distributions(PADs) of He+ ions, aligned H2+ molecules and N2 molecules by intense orthogonally polarized laser pulses. Simulations are performed by numerically solving the corresponding two-dimensional time-dependent Schr?dinger equations(TDSEs) within the single-electron approximation frame. Photoelectron momentum distributions and photoelectron angular distributions present different patterns with the time delays Td, illustrating the dependences of the PMDs and PADs on the time delays by orthogonally polarized laser pulses. The evolution of the electron wavepackets can be employed to describe the intensity of the PADs from the TDSE simulations for N2 molecules.

关键词： photoelectron momentum distributions photoelectron angular distributions intense orthogonally polarized laser pulses ultrafast photoionization model

LAPAROSCOPIC SURGERY IN PATIENTS WITH HYPOVOLEMIC SHOCK DUE TO ECTOPIC PREGNANCY

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Chinese Medical Sciences Journal 2005年第1期20卷 40-43,页

作者： zhi-gangLi Jin-huaLeng Jing-heLang zhu-fengLiu Da-weiSun zhuLan DepartmentofObstetricsandGynecology GuangdongProvincialPeople＇sHospitalGuangzhou510080 DepartmentofObstetricsandGynecology PekingUnionMedicalCollegeHospitalChineseAcademyofMedicalSciences＆PekingUnionMedicalCollegeBeijing100730

Objective To evaluate the feasibility and safety of operative laparoscopy for ectopic pregnancy with hypovolemic shock. Methods Two hundred and fifteen women with ectopic pregnancy underwent operative laparoscopy. These patients were divided into two groups. The study group included 21 patients with shock and intraperitoneal hemorrhage more than 1000 mL, and control group included 194 patients, hemodynamically stable, with blood loss less than 1000 mL. Clinical data of perio-perative periods in two groups were retrospectively analyzed. Results All patients were tubal pregnancies. The occurrence rate of tubal rupture was higher in study group than in control group (80.95% vs. 15.98%, P < 0.001). Intraabdominal blood loss was significantly higher in study group than in control group (1900 mL vs. 300 mL, P < 0.001), and autologous blood transfusions were given to 95.24% and 9.3% of patients in study and control group, respectively (P < 0.001). Laparoscopic salpingectomy was performed on 85.7 % and 50.5% of patients in study and control group (P < 0.001). The operative time was somewhat longer in study group than that in control group (60 minutes vs. 45 minutes), but with no significant difference. All patients had no perioperative complications. Conclusion Operative laparoscopy in patients with hopovolemic shock can be safely and effectively performed by experi-enced laparoscopists with the aid of optimal anesthesia, advanced cardiovascular monitoring, and autologous blood transfusion.

关键词： laparoscopic surgery ectopic pregnancy hypovolemic shock gynecologic surgical procedures

超声引导下胸椎旁神经阻滞复合全身麻醉对胸腔镜手术患者的影响及其可能机制

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实用临床医药杂志 2024年第14期28卷 44-48,53页

作者：朱肖萌范飒康磊张懿兰袁超黄飞河北省保定市第二医院麻醉科河北保定071000 河北省保定市第二医院手术室河北保定071000 河北省保定市第二医院胸外科河北保定071000

目的探讨超声引导下胸椎旁神经阻滞(TPVB)复合全身麻醉(简称全麻)对胸腔镜手术患者的影响及其可能机制。方法选取122例胸腔镜手术患者作为研究对象,随机分为对照组和研究组,每组61例。对照组接受全麻,研究组接受超声引导下TPVB复合全麻... 详细信息

目的探讨超声引导下胸椎旁神经阻滞(TPVB)复合全身麻醉(简称全麻)对胸腔镜手术患者的影响及其可能机制。方法选取122例胸腔镜手术患者作为研究对象,随机分为对照组和研究组,每组61例。对照组接受全麻,研究组接受超声引导下TPVB复合全麻。记录并比较2组患者的临床资料、围术期指标;比较2组术前以及术后24、72 h的平均动脉压(MAP)、心率(HR)、视觉模拟评分法(VAS)评分,以及术前、术后72 h的炎性因子[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)]水平;统计2组术后不良反应发生情况;采用实时荧光定量聚合酶链反应检测2组患者外周血中Nrf2/Keap1/ARE通路关键分子mRNA表达。结果2组手术时间、术中出血量比较,差异无统计学意义(P>0.05);研究组术毕至拔管时间、引流管留置时间短于对照组,总引流量、术后36 h自控静脉镇痛(PCIA)总用药量、PCIA有效按压次数少于对照组,差异有统计学意义(P<0.05)。术后24、72 h,对照组MAP、HR、VAS评分高于术前,研究组VAS评分高于术前,但研究组MAP、HR、VAS评分低于对照组,差异有统计学意义(P<0.05)。术后72 h,2组血清IL-6、IL-10、TNF-α、MDA水平高于术前,SOD、GSH-Px水平低于术前,且研究组血清IL-6、TNF-α、MDA水平低于对照组,IL-10、SOD、GSH-Px水平高于对照组,差异有统计学意义(P<0.05)。研究组患者术后不良反应总发生率为4.92%(3/61),低于对照组的21.31%(13/61),差异有统计学意义(P<0.05)。术后72 h,研究组患者外周血中Nrf2 mRNA、ARE mRNA表达量低于对照组,Keap1 mRNA表达量高于对照组,差异有统计学意义(P<0.05)。结论相较于全麻,超声引导下TPVB复合全麻可显著提升早期肺癌患者胸腔镜手术后的血流动力学稳定性和镇痛效果,减轻机体炎症反应和氧化应激反应,降低术后不良反应发生率,其分子机制可能与抑制Nrf2/Keap1/ARE信号通路的激活有关。

关键词：肺癌胸腔镜胸椎旁神经阻滞全身麻醉术后镇痛 Nrf2/Keap1/ARE信号通路

Simulation of the erosion of casing and perforation under staged sand fracturing conditions in horizontal sections

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Journal of Hydrodynamics 2022年第4期34卷 725-743页

作者： Bao-cheng Wu Si-song Zhang Jian-min Li Yu-ting Pan De-zhi Zeng Hui-yong Yu Hong-jun zhu Research Institute of Engineering Technology PetroChina Xinjiang Oilfield CompanyKaramay 834000China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

The new fracturing technology of intensive stages and high-intensity proppant injection shows significant advantages of cost reduction and high efficiency in the volume fracturing of unconventional reservoirs,but it also intensifies the erosion of the casing and the perforations,with a perforation diameter expansion and the casing wall *** solve this problem,in view of the applications of the perforation fracturing technology under the construction conditions in Mahu Area in Xinjiang,China,the structure parameters of the downhole strings are measured and a calculation model of the perforation casing erosion is established for the large-displacement sand fracturing process in horizontal *** software ANSYS-FLUENT is used to simulate the casing and perforation erosion under different conditions of the displacement,the sand content,the proppant particle size,and the fracturing fluid viscosity in the sand fracturing *** particle size of the proppant and the viscosity of the fracturing fluid mainly affect the erosion area,but they have little influence on the erosion *** sand content and the displacement significantly affect the erosion *** these factors,the sand content has a more significant effect on the erosion rate and the displacement has a more significant effect on the erosion *** to the influence of gravity,the perforation erosion rate is larger when the phase angle ranges from 120°to 240°.

关键词： Sand fracturing erosion numerical simulation perforated casing solid-liquid flow

Non-associative learning behavior in mixed proton and electron conductor hybrid pseudo-diode

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Journal of Materials Science & Technology 2023年第29期160卷 204-213页

作者： zhi Wen Shi Wei Sheng Wang Ling Ai Yan Li Xin Li Chen Hui Xiao Yu Heng Zeng Li Qiang zhu School of Physical Science and Technology Ningbo UniversityNingbo 315211China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China

With inherent ionic priorities, mixed ion and electron conductor hybrid devices have been proposed for brain-inspired neuromorphic system applications, demonstrating interesting neuromorphic functions. Here, mixed proton and electron conductor (MPEC) hybrid oxide neuromorphic transistor is proposed by adopting aqueous solution-processed mesoporous silica coating (MSC)-based electrolyte as gate dielec- tric. With optical and electrical synergetic coupling behaviors, the device demonstrates typical synap- tic responses and transition between short-term plasticity and long-term plasticity. With unique field- configurable proton self-modulation behaviors, a pseudo-diode operation mode is demonstrated on the MPEC hybrid transistor. Moreover, the device demonstrates interesting non-associative learning, including habituation and sensitization behavior. The results show that the proposed MPEC hybrid oxide neuromor- phic transistor has great potential in the field of neuromorphic engineering and would have potential in the bionic visual perception platform .

关键词： Mixed proton and electron conductor hybrid Oxide neuromorphic transistors Non-associative learning Pseudo-diode

基于主成分分析和聚类分析的李子果实品质综合评价

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食品工业科技 2024年第8期45卷 293-300页

作者：李可林籽汐刘佳廖茂雯袁怀瑜梁钰梅潘翠萍郭南滨朱永清张国薇李华佳四川省农业科学院农产品加工研究所四川成都610000 四川省农业科学院园艺研究所四川成都610000 四川省葡萄酒与果酒行业协会四川成都610000

为了解不同品种李子的品质特性,本文选取12个品种李子作为研究对象,分别从外观、理化及糖酸组成等方面对果实品质进行了对比分析,同时采用主成分分析和聚类分析对李子品质性状进行综合评价。结果表明,不同品种李子外观、理化和糖酸组成... 详细信息

为了解不同品种李子的品质特性,本文选取12个品种李子作为研究对象,分别从外观、理化及糖酸组成等方面对果实品质进行了对比分析,同时采用主成分分析和聚类分析对李子品质性状进行综合评价。结果表明,不同品种李子外观、理化和糖酸组成等指标均表现出丰富的多样性。糖酸组成、色泽、单果重、果实密度和果形指数等是评价李子综合品质的关键性指标。12个品种中‘紫皇’(ZH)‘圣雪珀’(SXP)‘爱丽丝’(ALS)‘香李’(XL)‘香甜李’(XTL)5个品种综合评分为正值,品质较好。其中,ZH和SXP品质特征为出汁率、可溶性固形物、总糖含量及色泽品质高;ALS品质特征为总糖、总甜度、甜酸比和糖酸比最高;XL和XTL品质特征为可溶性固形物含量、糖酸比、甜酸比高,但出汁率低。该研究结果可作为不同用途李子品种筛选的重要参考依据。

关键词：李子品质主成分分析聚类分析综合评价

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