检索结果-南通市图书馆

Efficacy and moderating factors of the Early Start Denver Model in Chinese toddlers with autism spectrum disorder:a longitudinal study

引用

World Journal of Pediatrics 2023年第8期19卷 741-752页

作者： Shi-Huan Wang Hai-Tao Zhang yuan-yuan zou San-Mei Cheng Xiao-Bing zou Kai-Yun Chen Child Developmental and Behavioral Center The Third Affiliated Hospital of Sun Yat-sen UniversityNo.600Tianhe RoadGuangzhou510630China

Background Several studies have shown the effectiveness of the Early Start Denver Model(ESDM),but few studies have explored the long-term efficacy of *** study aimed to explore the efficacy and moderating factors of ESDM in Chinese toddlers with autism spectrum disorder(ASD)in a longitudinal *** A total of 60 toddlers with ASD were recruited and randomly divided into two groups:ESDM group all received 24 weeks intervention;Control group were waiting for *** assessment(T0)was conducted before intervention,including Gesell Developmental Scale(GDS)and Psycho-educational Profile-3rd Edition(PEP-3).All toddlers with ASD were examined in the first assessment(T1)at 6 months and in the second assessment(T2)at 12 *** In T1 assessment,the increments in speech and personal communication development quotient in GDS were significantly larger in the ESDM group than in the control group(P=0.010,0.047).In T2 assessment,the ESDM group had higher elevation in cognitive verbal/preverbal(CVP),social reciprocity and characteristic verbal behaviors assessed by PEP-3(P=0.021,0.046,0.014).In addition,the severity of stereotyped behavior was negatively associated with improvement in *** income was positively associated with improvement in speech and CVP(all P<0.05).Conclusions ESDM can effectively improve speech and communication in toddlers with ASD after 24-week *** importantly,ESDM can promote cognition and social interaction and can reduce stereotyped verbal behavior in toddlers with ASD in longitudinal *** severity of stereotyped behavior and family ecological factors may be considered as affecting the efficacy of ESDM.

关键词： Autism spectrum disorder Efficacy Early Start Denver Model Longitudinal Moderating factors Stereotyped behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?

引用

Acta Pharmacologica Sinica 2019年第8期40卷 1119-1126页

作者： Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang yuan-yuan zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi Hiromichi Yamanishi Hideaki Higashino Haruki Okamura Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine Hirakata Ryoikuen

Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle *** most hypertension guidelines recommend moderate-to high-intensity exercise,we decided to explore a mild yet effective type of exercise to add to hypertension management,especially in populations with complications or *** comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers(km)(3 km/h versus 6 km/h)in young,healthy volunteers,we delivered low-speed walking(low-intensity walking,2.5 metabolic equivalents of task,METs)as exercise therapy in 42 prehypertensive and 43 hypertensive *** found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin *** we prescribed regular low-intensity walking with a target exercise dose(exercise volume)of 500-1000 METs-min/week(50-60 min/day and 5-7 times/week)in hypertensive subjects in addition to their daily *** low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two *** is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.

关键词： hypertension prehypertension exercise medication low-intensity walking metabolic equivalent of task blood pressure heart rate urine β-endorphin

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

光学相干断层扫描结合眼底检查观察产后妊娠高血压疾病眼底病变

引用

中国现代医学杂志 2016年第7期26卷 73-77页

作者：王志学邹媛媛孔令茹河北省沧州市中心医院眼科河北沧州061000 河北省沧州市中心医院麻醉科河北沧州061000

目的通过光学相干断层扫描（OCT）结合眼底检查观察产后妊娠高血压疾病（以下简称妊高征）疾病眼底病变。方法产后妊高征48例患者行眼部检查,包括视力、验光、裂隙灯检查、眼底检查、OCT检查、眼底照相检查;部分患者行眼底荧光血管造影... 详细信息

目的通过光学相干断层扫描（OCT）结合眼底检查观察产后妊娠高血压疾病（以下简称妊高征）疾病眼底病变。方法产后妊高征48例患者行眼部检查,包括视力、验光、裂隙灯检查、眼底检查、OCT检查、眼底照相检查;部分患者行眼底荧光血管造影检查。结果 148例患者96只眼中OCT检查异常72只眼（75.00%）,其中视网膜神经上皮层浆液性脱离40只眼（55.56%）,色素上皮层及椭圆体带改变22只眼（30.56%）,其他改变如视盘水肿、视网膜出血等10只眼（13.88%）。248例患者96只眼眼底检查,其中Ⅰ期4只眼（4.17%）;Ⅱ期12只眼（12.50%）;Ⅲ期80只眼（83.33%）。3将妊高征患者产前妊高征分级和产后眼底检查做等级相关性检验,发现眼底检查结果与妊高征分级呈正相关（C=0.545,χ^2=56.991,P=0.000）;将妊高征患者产后就诊于眼科时的血压分级和眼底检查做等级相关性检验,发现两者无相关性（C=0.117,χ^2=2.633,P=0.853）;眼底检查与OCT检查结果做等级相关性检验,发现两者呈正相关（C=0.324,χ^2=20.130,P=0.000）。结论对妊高征患者行产后眼部检查非常重要,眼底结合OCT检查可以更有效地发现妊高征眼底病变。

关键词：妊娠高血压疾病视网膜病变光学相干断层扫描

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Primary Studies on Burnup Estimation of Irradiated Uranium by Dtermining 236U/238U in Contaminated Environmental Samples JIANG Xiao-yan,ZHANG Ji-long,zou Wei,Chang Zhi-yuan

Primary Studies on Burnup Estimation of Irradiated Uranium b...

引用

作者： JIANG Xiao-yan ZHANG Ji-long zou Wei Chang Zhi-yuan

U/U of the environmental sample can indicate the existence of uranium irradiation,and even can be uesd to estimate the burnup of nuclear spent fuel.A study on the burnup estimation of irradiated uranium which was mixed with natural uranium was carried out by measuring the U/U and U/U in the samples by using MC-ICP-MS. According to the equation(1) and(2),a programme for calculating the burnup of the irradiated

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

水解工艺对苦荞提取物中槲皮素含量的影响及其药代动力学研究

引用

食品工业科技 2018年第10期39卷 231-235,334页

作者：郑瑾卓虹伊宋雨代丽萍邓园源邹亮陈慧娟成都大学四川抗菌素工业研究所四川成都610052 成都大学医学院四川成都610106 成都大学农业部杂粮加工重点实验室四川成都610106 成都中医药大学药学院四川成都611137 成都大学药学与生物工程学院四川成都610106 四川省中医药科学院中医研究所四川成都610031

目的:以苦荞提取物为研究对象,通过正交实验设计优化苦荞提取物中芦丁被酸水解为槲皮素的工艺条件,并结合药代动力学研究探讨酸水解工艺对苦荞提取物中芦丁和槲皮素吸收的影响。方法:以盐酸百分含量、水解时间、乙醇百分含量、水解温度... 详细信息

目的:以苦荞提取物为研究对象,通过正交实验设计优化苦荞提取物中芦丁被酸水解为槲皮素的工艺条件,并结合药代动力学研究探讨酸水解工艺对苦荞提取物中芦丁和槲皮素吸收的影响。方法:以盐酸百分含量、水解时间、乙醇百分含量、水解温度作为因素设计四因素三水平正交实验优化苦荞提取物中芦丁酸水解为槲皮素的工艺条件,以该工艺进行苦荞提取物酸水解,并在水解第1、2、4、6 h取样得到不同槲皮素含量的水解产物1、2、3、4。分别灌胃大鼠200 mg/kg的苦荞提取物及各水解产物,并在不同时间点采血,以黄芩素为内标,高效液相色谱(HPLC)测定血浆中槲皮素的浓度,DAS 2.0计算主要药代动力学参数。结果:苦荞提取物芦丁酸水解的最佳工艺参数为盐酸百分含量0.91%、水解时间6 h、乙醇百分含量50%、水解温度70℃,在该工艺条件下64.11%芦丁转化为槲皮素。苦荞提取物、水解产物1、2、3、4槲皮素的AUC_(0-t)分别为(17.604±5.422)、(42.175±9.435)、(87.917±19.347)、(116.706±46.256)、(178.509±49.478)mg/L·h,C_(max)分别为(2.743±1.217)、(7.109±2.603)、(12.438±3.197)、(15.727±4.68)、(20.044±5.736)mg/L。与苦荞提取物相比,其水解产物1、2、3、4的药代动力学参数AUC_(0-t)、C_(max)具有显著性差异(p<0.05)。结论:苦荞提取物经酸水解后部分芦丁转化为槲皮素,芦丁和槲皮素在大鼠体内的累计吸收量也相应提高。

关键词：苦荞提取物酸水解药代动力学累计吸收量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

儿童牙科患者就诊行为状况和影响因素的分析

引用

牙体牙髓牙周病学杂志 2012年第10期22卷 591-593,596页

作者：吴煜石苡榕冯华玉蒋才谦刘丽魏园园邹丹广西医科大学口腔医院儿童牙科广西南宁530021

目的:调查分析儿童牙科患者就诊行为状况和不合作行为的相关因素。方法:采用问卷调查和改良的合作行为级别评定量表对257名儿童牙科就诊行为状况和相关因素进行调查,采用χ2检验进行单因素分析,并将具有统计学意义的因素进行二元logisti... 详细信息

目的:调查分析儿童牙科患者就诊行为状况和不合作行为的相关因素。方法:采用问卷调查和改良的合作行为级别评定量表对257名儿童牙科就诊行为状况和相关因素进行调查,采用χ2检验进行单因素分析,并将具有统计学意义的因素进行二元logistic回归分析。结果:257例患儿不合作行为的发生率为23.3%。Logistic回归结果提示:儿童牙科患者不合作行为与就诊原因和患儿年龄密切相关。随着年龄增长,不合作行为发生减少。而就诊原因中的尖周炎是不合作行为的危险因素。结论:儿童牙科患者普遍存在不合作行为,就诊原因中的尖周炎和患儿的年龄是不合作行为的重要预测因子。

关键词：牙科行为儿童相关因素 logistic回归分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

引用

Journal of Materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng zou Lifeng Ma Yanchun Zhu Ling Qin yuan yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy Machinery Engineering Research Center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy Magnesium alloy Strengthening mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于CRISPR/Cas9基因编辑技术的RIP1稳定敲除细胞模型的构建及功能研究

引用

军事医学 2017年第2期41卷 96-100,105页

作者：陈瑶刘青邢微微陈惠华张冬冬王园园邹民吉徐东刚刘中成河北大学药学院河北保定071002 军事医学科学院基础医学研究所基因组工程研究室北京100850 河北大学生命科学学院河北保定071002

目的利用CRISPR/Cas9技术构建RIP1稳定敲除的人永生化表皮细胞HaCaT细胞株,在此基础上对RIP1功能进行探究。方法针对GenBank中RIP1基因序列,设计靶向RIP1不同外显子的小指导RNA(sgRNA),并将其克隆至SpCas9-2A-Puro V2.0(PX459)载体中,获... 详细信息

目的利用CRISPR/Cas9技术构建RIP1稳定敲除的人永生化表皮细胞HaCaT细胞株,在此基础上对RIP1功能进行探究。方法针对GenBank中RIP1基因序列,设计靶向RIP1不同外显子的小指导RNA(sgRNA),并将其克隆至SpCas9-2A-Puro V2.0(PX459)载体中,获得PX459-sgRNA基因敲除载体。将上述载体转染HaCaT细胞并通过嘌罗霉素筛选获得阳性克隆,免疫印迹和DNA测序技术进一步鉴定RIP1敲除效果最佳的单克隆。通过CCK-8实验检测RIP1缺失对细胞增殖能力的影响。分别用TNF-α处理HaCaT^(WT)细胞和HaCaT^(R1P1KO)细胞,流式细胞仪检测敲除RIP1对TNF-α诱导细胞死亡的影响,进一步通过胱天蛋白酶(caspase)抑制剂Z-VAD-FMK判断细胞死亡类型。结果与结论利用CRISPR/Cas9系统成功构建RIP1完全敲除的细胞模型,功能分析发现敲除RIP1导致细胞增殖能力减慢;HaCaT^(R1P1KO)对TNF-α诱导的死亡畀常敏感,这种死亡能被Z-VAD-FMK显著抑制,证明为caspase依赖性细胞凋亡。该研究为探究RIP1在皮肤损伤中的作用奠定了基础。

关键词： CRISPR/Cas9系统基因敲除受体相互作用丝/苏氨酸蛋白激酶1 HaCaT细胞凋亡细胞增殖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructural and mechanical response of ZK60 magnesium alloy subjected to radial forging

引用

Journal of Materials Science & Technology 2021年第24期83卷 228-238页

作者： Jingfeng zou Lifeng Ma Weitao Jia Qichi Le Gaowu Qin yuan yuan Heavy Machinery Engineering Research Center Ministry of EducationTaiyuan University of Science and TechnologyTaiyuan030024China School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan030024China Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang110819China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing400044China

Radial forging(RF)is an economical manufacturing forging process,in which four dies arranged radially around the workpiece simultaneously act on the workpiece with high-frequency radial *** this study,a ZK60 magnesium alloy step-shaft bar was processed under different accumulated strains by RF at350℃.The deformation behavior,microstructure evolution,and mechanical responses of this bar were systematically investigated via numerical simulations and *** the early deformation stage of forging,the material undergoes pronounced grain refinement but an inhomogeneous grain structure is formed due to the strain gradient along the radial *** grains in different radial parts were gradually refined by increasing the RF pass,resulting in a bimodal grained structure comprising coarse(~14.1μm)and fine(~2.3μm)*** the RF pass increased,the initial micro-sizeβ-phases were gradually crushed and dissolved into the matrix mostly,eventually evolving to form a higher area fraction of nano-sized Zn2 Zr spheroidal particles uniformly distributed through the grain *** texture changed as the RF strain increased,with the c-axes of most of the deformed grains rotating in the ***,excellent mechanical properties including higher values of tensile strengths and ductility were attained after the three RFed passes,compared to the as-received sample.

关键词： ZK60 magnesium alloy Radial forging Microstructure Texture evolution Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Maximum Surplus Distribution before Ruin in an Erlang（n） Risk Process Perturbed by Diffusion

引用

Acta Mathematica Sinica,English Series 2011年第9期27卷 1869-1880页

作者： Zhen Zhong ZHANG Jie Zhong zou yuan yuan LIU College of Science Donghua University Shanghai 201620 P. R. China andSchool of Mathematics Central South University Changsha 410075 P. R. China School of Mathematics Central South University Changsha 410075 P. R. China

In this paper, we consider the distribution of the maximum surplus before ruin in a generalized Erlang（n） risk process （i.e., convolution of n exponential distributions with possibly different parameters） perturbed by diffusion. It is shown that the maximum surplus distribution before ruin satisfies the integro-differential equation with certain boundary conditions. Explicit expressions are obtained when claims amounts are rationally distributed. Finally, the surplus distribution at the time of ruin and the surplus distribution immediately before ruin are presented.

关键词： Sparre Anderson risk model generalized Erlang(n) inter-claim times integro-differential equation diffusion process maximum surplus distribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：