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Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma Xing-Yao Yin Zhao-Yun Zong yuan-yuan tan Ya-Ming Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

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Neutrophils inhibit CD8^(+)T cells immune response by arginase-1 signaling in patients with sepsis

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World Journal of Emergency Medicine 2022年第4期13卷 266-273页

作者： Xiao-kang Dai Zhen-xing Ding yuan-yuan tan Hua-rui Bao Dong-yao Wang Hong Zhang Department of Emergency the First Affiliated Hospital of Anhui Medical UniversityHefei 230027China Department of Hematology the First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineHefei 230001China Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscalethe Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Immunology in Chronic Diseases Bengbu Medical CollegeBengbu 233030China

BACKGROUND:Patients with sepsis often exhibit an acute inflammatory response,followed by an immunosuppressive phase with a poor immune ***,the underlying mechanisms have not been fully ***:We sought to comprehensively characterize the transcriptional changes in neutrophils of patients with sepsis by transcriptome ***,we conducted a series of experiments,including real-time quantitative polymerase chain reaction(RT-qPCR)and flow cytometry to investigate the role of arginase-1 signaling in ***:Through the analysis of gene expression profiles,we identified that the negative regulation of T cell activation signaling was enriched,and the expression of arginase-1 was high in neutrophils from patients with ***,we conducted flow cytometry and found that the function of CD8^(+)T cells in septic patients was ***,neutrophils from septic patients inhibited the percentage of polyfunctional effector CD8^(+)T cells through ***,the proportions of granzyme B^(+)IFN^(-)γ^(+)CD8^(+)T and TNF^(-)α^(+)IFN^(-)γ^(+)CD8^(+)T cells increased after inhibition of arginase-1 ***:The impaired effector function of CD8^(+)T cells could be restored by blocking arginase-1 signaling in patients with sepsis.

关键词： Sepsis Effector CD8+T cells Neutrophils Arginase-1 Interferon-γ

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Eutectic high entropy alloy syntactic foam

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Journal of Materials Science & Technology 2023年第18期149卷 177-189页

作者： Jin Meng Yu Qiao Tian-Wei Liu yuan-yuan tan Fu-Hua Cao Yan Chen Hai-Ying Wang Lan-Hong Dai State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences(CAS)Beijing 100190China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Engineering Science University of Chinese Academy of SciencesBeijing 101408China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

High-strength metallic foams have a wide range of applications in engineering as lightweight structural and energy-absorbing ***,it is challenging to obtain metallic foam with both good energy absorption performance and high ***,we developed a novel metal matrix syntactic foam fabri-cated with AlCoCrFeNi_(2.1) eutectic high entropy alloy and alumina cenospheres that exhibits a remarkable combination of high strength and energy absorption performance under both quasi-static and dynamic *** porous structure of syntactic foam fully exploits the properties of the AlCoCrFeNi_(2.1) alloy matrix with a unique FCC/B2 dual-phase eutectic microstructure and thus yields exceptional *** discovered that this dual-phase microstructure not only provides high strength but also allows the pores to collapse in a progressive and diffusive way,which enables the formation of a high and smooth energy absorption *** is found that the heterogeneity between the two phases in the matrix can provide back stress strengthening,and it also induces multiple micro shear bands and microcracks as additional energy dissipation modes as the deformation *** unique mechanism ensures the strength of microstructures and makes them fracture promptly,which causes the balance of strengthening and softening on the macro *** work opens the avenue for developing advanced high-strength lightweight structural and energy-absorbing materials.

关键词： Eutectic high entropy alloy Foams Metal matrix composites(MMCs) Energy absorption

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Gene editing: an instrument for practical application of gene biology to plant breeding

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第6期21卷 460-473页

作者： yuan-yuan tan Hao DU Xia WU Yan-hua LIU Meng JIANG Shi-yong SONG Liang WU Qing-yao SHU National Key Laboratory of Rice Biology Institute of Crop SciencesZhejiang UniversityHangzhou 310058China The Rural Development Academy Zhejiang UniversityHangzhou 310058China

Plant breeding is well recognized as one of the most important means to meet food security challenges caused by the ever-increasing world population. During the past three decades, plant breeding has been empowered by both new knowledge on trait development and regulation(e.g., functional genomics) and new technologies(e.g., biotechnologies and phenomics). Gene editing, particularly by clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) and its variants, has become a powerful technology in plant research and may become a game-changer in plant breeding. Traits are conferred by coding and non-coding genes. From this perspective, we propose different editing strategies for these two types of genes. The activity of an encoded enzyme and its quantity are regulated at transcriptional and post-transcriptional, as well as translational and post-translational, levels. Different strategies are proposed to intervene to generate gene functional variations and consequently phenotype changes. For non-coding genes, trait modification could be achieved by regulating transcription of their own or target genes via gene editing. Also included is a scheme of protoplast editing to make gene editing more applicable in plant breeding. In summary, this review provides breeders with a host of options to translate gene biology into practical breeding strategies, i.e., to use gene editing as a mechanism to commercialize gene biology in plant breeding.

关键词： Gene editing Expression regulation Novel allele Trait development Plant breeding

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Tissue-specific expression, developmentally and spatially regulated alternative splicing, and protein subcellular localization of OsLpa1 in rice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第2期17卷 100-109页

作者： Hai-ping LU Wei-qin PANG Wen-xu LI yuan-yuan tan Qing WANG Hai-jun ZHAO Qing-yao SHU State Key Laboratory of Rice Biology Institution of Crop Science Zhejiang University Hangzhou 310029 China Wuxi Hupper Bioseed Technology Academy Ltd. Wuxi 214000 China

The OsLpa1 gene（LOC_Os02g57400） was identified to be involved in phytic acid（PA） metabolism because its knockout and missense mutants reduce PA content in rice grain. However, little is known about the molecular characteristics of OsLpa1 in rice and of its homologues in other plants. In the present study, the spatial pattern of OsLpa1 expression was revealed using OsLpa1 promoter：：GUS transgenic plants（GUS： β-glucuronidase）; GUS histochemical assay showed that OsLpa1 was strongly expressed in stem, leaf, and root tissues, but in floral organ it is expressed mainly and strongly in filaments. In seeds, GUS staining was concentrated in the aleurone layers; a few blue spots were observed in the outer layers of embryo, but no staining was observed in the endosperm. Three OsLpa1 transcripts（OsLpa1.1, OsLpa1.2, OsLpa1.3） are produced due to alternative splicing; quantitative reversetranscriptase polymerase chain reaction（RT-PCR） analysis revealed that the abundance of OsLpa1.3 was negligible compared with OsLpa1.1 and OsLpa1.2 in all tissues. OsLpa1.2 is predominant in germinating seeds（about 5 times that of OsLpa1.1）, but its abundance decreases quickly with the development of seedlings and plants, whereas the abundance of OsLpa1.1 rises and falls, reaching its highest level in 45-d-old plants, with abundance greater than that of OsLpa1.2 in both leaves and roots. In seeds, the abundance of OsLpa1 continuously increases with seed growth, being 27.5 and 15 times greater in 28-DAF（day after flowering） seeds than in 7-DAF seeds for OsLpa1.1 and OsLpa1.2, respectively. Transient expression of chimeric genes with green fluorescence protein（GFP） in rice protoplasts demonstrated that all proteins encoded by the three OsLpa1 transcripts are localized to the chloroplast.

关键词： OsLpa1 Low phytic acid Expression pattern Alternative splicing Subcellular localization

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Numerical investigation of the photo-thermal characteristics of a direct absorption solar collector using Monte Carlo and finite volume methods

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Science China(Technological Sciences) 2024年第8期67卷 2436-2448页

作者： ZHU YanLong LI SuNing FAN JianHua KONG WeiQiang yuan yuan tan HePing School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Civil Engineering and Mechanical Engineering Technical University of DenmarkKoppels AlléBuilding 4042800 Kgs.LyngbyDenmark School of Vehicle and Energy Yanshan UniversityQinhuangdao 066004China

In this study, a novel model of photothermal conversion in a direct absorption solar collector based on the Monte Carlo and finite volume methods was built and validated and the temperatures of the novel and traditional solar collectors were compared. The sensitivity of the parameters to the radiative heat loss was investigated. Finally, the radiative heat transfer characteristics were discussed using the radiative exchange factor. The results of this study validated the advantages of the novel solar collector at both the surface and fluid temperatures. Under the conditions used in this study, the maximum temperature difference of the novel solar collector was 30 K, compared with 193 K for the traditional solar collector. Furthermore, the collector was divided into several units along the flow direction. The radiative exchange factor indicated that with an increase in the attenuation coefficient, the percentage of radiation intensity in the total solar radiation absorbed by the corresponding unit ***, it decreased with an increase in the incident angle and scattering albedo. These results provide a reference for addressing the low efficiency and thermal damage caused by traditional solar collectors at high temperatures.

关键词： direct absorption solar collector radiative heat transfer Monte Carlo

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Lattice distortion and magnetic property of high entropy alloys at low temperatures

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Journal of Materials Science & Technology 2022年第9期104卷 236-243页

作者： yuan-yuan tan Zhong-Jun Chen Ming-Yao Su Gan Ding Min-Qiang Jiang Zhou-Can Xie Yu Gong Tao Wu Zhong-Hua Wu Hai-Ying Wang Lan-Hong Dai State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China Institute of High Energy Physics Chinese Academy of Sciences&GraduateUniversity of Chinese Academy of SciencesBeijing 100049China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Zhejiang Institute of Mechanical&Electrical Engineering Hangzhou 310053China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Deformation mechanisms and magnetic properties of medium and high entropy alloys(MEA/HEAs)closely relate to lattice distortion and are strongly temperature-dependent,in particular,at low temperature ***,little attention has been paid to the evolution of lattice distortion with temperature decreasing and its effects on deformation behavior and magnetic state *** this work,we carry out in situ synchrotron radiation based X-ray powder diffraction(SR-XRD)experiments from 293 to 123 K aiming for determining lattice distortion evolutions of Cr Co Ni MEA,Cr Fe Co Ni and Cr Mn Fe Co Ni *** measurements at corresponding low temperatures and cryogenic ranges are further *** in situ SR-XRD results demonstrate a general reduction of lattice distortion magnitude with temperature decreasing,which shows a similar tendency with that of reported stacking fault energy(SFE)*** is thus suggested that lattice distortion reduction possibly makes a critical contribution to deformation mechanism *** magnetic measurement results show a clear ferromagnetic transition of Cr Fe Co Ni HEA when temperature is below 173 ***,no obvious magnetic state transition is observed for Cr Co Ni MEA and Cr Mn Fe Co Ni *** present findings on lattice distortion evolutions will pave the way for designing targeted HEAs with particular properties.

关键词： High entropy alloy Lattice distortion Magnetic property Low temperature In situ SR-XRD

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A comparative study on design standards of screw conveyors in China,Germany,and the USA-Part Ⅱ:Discrete element method

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颗粒学报（英文版） 2024年第9期92卷 113-125页

作者： yuan tan Michael Rackl Weijie Yang Johannes Fottner Wenjun Meng Stephan Kessler Technical University of Munich Chair for Materials HandlingMaterial FlowLogisticsGarchingGermany Ibracon-Ingenieurbüro Dr.-Ing.Rackl ZornedingGermany School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuanChina

This part of the study aims to evaluate the advantages and disadvantages of technical standards of screw conveyors in China,Germany,and the USA for industrial *** source or determination method of empirical coefficients as well as the theoretical foundation of dimensioning-relevant diagrams in these standards is not explicitly documented in the ***,instead of less efficient on-site tests,the numerical simulation by discrete element method is *** on the geometrical and operational designs determined in three standards for horizontal,slightly inclined,and vertical conveyance of three representative bulk solids(barley,lignite,and sand),the potential influencing factors are *** constant particle and contact parameters,the potential deviations caused by particle models are ***,the accuracy of power consumption calculation of each standard and the divergence between accessible and required mass flows is comprehensively assessed based on the analysis of simulated *** main conclusions are drawn:(1)Particle fall back is barely considered by all three standards and leads to overestimated mass throughput;(2)The decrease in mass throughput caused by an increasing degree of filling can be compensated by slowing down the rotational speed.

关键词： Bulk solid Design standard Discrete element method Screw auger Screw conveyor

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A model for aircraft cabin evacuation considering passenger type

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Journal of Safety Science and Resilience 2024年第1期5卷 83-90页

作者： Yaping Ma Jinfeng yuan Lingling tan Quanyi Liu Mengling Li Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province Civil Aviation Flight University of ChinaGuanghan 618307China School of Safety Science and Emergency Management Wuhan University of TechnologyWuhan 430070China

Pedestrian safety evacuation in aircraft cabins has been a challenging problem because of the aircraft’s unique characteristics,such as the diversity of passengers and the restricted evacuation *** is difficult to reproduce evacuation activities in aircraft cabin due to safety concerns and cost *** fill this gap,an improved cellular automaton model of crowd evacuation for aircraft cabin is established by incorporating the characteristics of cabin space structures and passenger *** are divided into healthy individual passengers and disabled-healthy group passengers,whose movement mechanisms are *** on the constructed model,simulation experiments are conducted using the configuration cabin layout of B737-800 as an *** results show that the evacuation time is prolonged with increased passenger density and the number of disabled ***,the overall evacuation time is insignificantly affected by whether disabled-healthy group passengers’seats are close to the aisle or window,and the evacuation efficiency is best when their seats are evenly distributed in the *** evacuation time is the shortest when all cabin doors are open,and pedestrians are evacuated the slowest when the central emergency doors are *** study pro-vides valuable insights into effective strategies for pedestrian evacuation and crowd emergency management of civil aircraft.

关键词： Aircraft cabin evacuation Passenger type Cellular automaton model Pedestrian distribution Evacuation efficiency

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Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

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Chemical Research in Chinese Universities 2024年第2期40卷 173-189页

作者： ZHAO Long HU Haolan MA Xiaoqian LYU Yifan yuan Quan tan Weihong Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha410082P.R.China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou310022P.R.China Institute of Molecular Medicine(IMM) Renji HospitalSchool of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240P.R.China Furong Laboratory Changsha410082P.R.China

Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular *** of membrane proteins is of paramount importance for studying molecular events inside cells and organisms and holds promising prospects for early disease diagnosis and treatment *** from obvious merits including high affinity,high specificity and ease of modification,aptamers have been regarded as ideal molecular recognition elements in membrane protein analysis and molecular diagnostics *** review summarised recent advances in membrane protein-specific aptamer screening,aptamer-based static and dynamic membrane protein analysis,and aptamer-based molecular diagnostic *** and challenges were also discussed.

关键词： Membrane protein Aptamer DNA nanotechnology Bioanalysis Molecular diagnostics

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