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Neighbor Sum Distinguishing Total Coloring of Triangle Free IC-planar Graphs

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Acta Mathematica Sinica,English Series 2020年第3期36卷 292-304页

作者： Wen Yao SONG yuan yuan duan Lian Ying MIAO School of Mathematics and Statistics Zaozhuang UniversityZaozhuang 277160P.R.C hina School of Mathematics China University of Mining and TechnologyXuzhou 221116P.R.C hina

A graph is IC-planar if it admits a drawing in the plane such that each edge is crossed at most once and two crossed edges share no common end-vertex.A proper total-k-coloring of G is called neighbor sum distinguishing if∑_c(u)≠∑_c(v)for each edge uv∈E(G),where∑_c(v)denote the sum of the color of a vertex v and the colors of edges incident with *** least number k needed for such a total coloring of G,denoted byχ∑"is the neighbor sum distinguishing total chromatic *** and Wozniak conjecturedχ∑"(G)≤Δ(G)+3 for any simple graph with maximum degreeΔ(G).By using the famous Combinatorial Nullstellensatz,we prove that above conjecture holds for any triangle free IC-planar graph with△(G)≥***,it holds for any triangle free planar graph withΔ(G)≥6.

关键词： Neighbor sum distinguishing total coloring Combinatorial Nullstellensatz triangle free IC-planar graph maximum degree

肝脏类器官在肝脏疾病模型与移植治疗中的应用潜力

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中国组织工程研究 2025年第8期29卷 1684-1692页

作者：袁维勃刘婵余丽梅遵义医科大学附属医院贵州省细胞工程重点实验室贵州省遵义市563003 遵义医科大学教育部省部共建组织损伤修复与再生医学协同创新中心贵州省遵义市563000 遵义医科大学附属医院贵州省干细胞临床应用与新药研发工程研究中心贵州省遵义市563003 遵义医科大学附属医院贵州省生物治疗人才基地贵州省遵义市563003 遵义医科大学附属医院遵义市干细胞与再生医学工程研究中心贵州省遵义市563003

背景:肝脏类器官对阐明肝脏疾病的确切病理机制及对肝脏疾病的治疗具有重要的意义。目的:总结目前国内外该领域的基础研究,回顾以往肝脏类器官的构建、疾病建模和移植治疗的重要研究进展,探讨肝脏类器官联合组织工程技术的应用前景。方... 详细信息

背景:肝脏类器官对阐明肝脏疾病的确切病理机制及对肝脏疾病的治疗具有重要的意义。目的:总结目前国内外该领域的基础研究,回顾以往肝脏类器官的构建、疾病建模和移植治疗的重要研究进展,探讨肝脏类器官联合组织工程技术的应用前景。方法:检索PubMed数据库及中国知网数据库收录的相关文献,英文检索词为“liver,organoids,liver diseases”,中文检索词为“肝,类器官,肝脏疾病”,主要检索时限为2018年4月至2024年4月,通过人工阅读排除重复文献等,最终纳入94篇文献进行归纳分析。结果与结论:①肝脏类器官构建的种子细胞主要集中于成体细胞和多能干细胞,通过辅助各种细胞因子参与信号引导作用和细胞外基质提供3D微环境,促进类器官的产生,但是整体成熟度不高,有望通过结合组织工程技术改善这一问题;②体外疾病建模方面主要在简单疾病和单基因遗传病领域研究较多,类器官高度保留患者遗传特性,有望通过结合CRISPR-Cas9基因矫正和其他新兴技术模拟更复杂的肝脏疾病并阐明更深层次的病理机制;③体内移植治疗方面,肝脏类器官能够安全有效的植入,表现出惊人的肝功能替代潜力及组织再生能力,并且还可能通过与其他组织工程材料结合达到治疗目的。

关键词：肝脏类器官干细胞种子细胞肝脏疾病疾病建模体内移植综述

Gallic Acid: A Potential Anti-Cancer Agent

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Chinese Journal of Integrative Medicine 2022年第7期28卷 661-671页

作者： JIANG yuan PEI Jin ZHENG Yan MIAO yu-jing duan Bao-zhong HUANG Lin-fang Key Laboratory of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu 611137China College of Pharmaceutical Science Dali UniversityDaliYunnan Province 761000China

Cancer is one of the most devastating diseases worldwide and definitive therapeutics for treating cancer are not yet available despite extensive research efforts. The key challenges include limiting factors connected with traditional chemotherapeutics, primarily drug resistance, low response rates, and adverse side-effects. Therefore, there is a high demand for novel anti-cancer drugs that are both potent and safe for cancer prevention and treatment. Gallic acid(GA), a natural botanic phenolic compound, can mediate various therapeutic properties that are involved in anti-inflammation, anti-obesity, and anti-cancer activities. More recently, GA has been shown to exert anti-cancer activities via several biological pathways that include migration, metastasis, apoptosis, cell cycle arrest, angiogenesis, and oncogene expression. This review discusses two aspects, one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms, the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma may become a hot topic in further research. Overall, this review provides evidence that GA represents a promising novel, potent, and safe anti-cancer drug candidate for treating cancer.

关键词： gallic acid cancer tumor bibliometric application

Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii

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Chinese Journal of Natural Medicines 2022年第2期20卷 133-138页

作者： duan Hai-Yan WANG Jian ZHA Liang-Ping PENG Hua-Sheng ZHAO yu-Ping yuan yuan HUANG Lu-Qi School of Pharmacy Anhui University of Chinese MedicineHefei 230012China State Key Laboratory Breeding Base of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Research Unit of DAO-DI Herbs Chinese Academy of Medical SciencesBeijing 100700China

Pueraria thomsonii has long been used in traditional Chinese *** are the principle pharmacologically active components,which are primarily observed as glycosyl-conjugates and accumulate in *** ***,the molecular mechanisms underlying the glycosylation processes in(iso)flavonoid biosynthesis have not been thoroughly *** the current study,an O-glucosyltransferase(PtUGT8)was identified in the medicinal plant *** from RNA-seq *** assays of the recombinant PtUGT8 showed that it was able to glycosylate chalcone(isoliquiritigenin)at the 4-OH position and glycosylate isoflavones(daidzein,formononetin,and genistein)at the 7-OH or 4′-OH position,exhibiting no enzyme activity to flavonones(liquiritigenin and narigenin)in *** identification of PtUGT8 may provide a useful enzyme catalyst for efficient biotransformation of isoflavones and other natural products for food or pharmacological applications.

关键词： Flavonone Isoflavone Glucosyltransferase 4′-O-glucosylation 7-O-glucosylation

A Smart Obfuscation Approach to Protect Software in Cloud

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Computers, Materials & Continua 2023年第9期76卷 3949-3965页

作者： Lei yu yucong duan Department of Computer Science Inner Mongolia UniversityHohhotChina Department of Computer Science Hainan UniversityHaikouChina

Cloud computing and edge computing brought more software,which also brought a new danger of malicious software *** synchronization mechanisms of software can further help reverse data *** on the mechanisms,attackers can cover themselves behind the network and modify data *** knowledge of software reverse engineering can be organized as rules to accelerate the attacks,when attackers intrude cloud server to access the source or binary ***,we proposed a novel method to resist this kind of reverse engineering by breaking these *** method is based on software obfuscations and encryptions to enhance the security of distributed software and cloud services in the 5G *** method is capable of(1)replacing theoriginal assembly codes of theprotectedprogramwithequivalent assembly instructions inan iteration way,(2)obfuscating the control flow of the protected program to confuse attackers meanwhile keeps the program producing the same outputs,(3)encrypting data to confuse *** addition,the approach can periodically and automatically modify the protected software binary codes,and the binary codes of the protected software are encrypted to resist static analysis and dynamic ***,a simplified virtual machine is implemented to make the protected codes unreadable to *** game is one of the specific scenarios which needs low latency and strong data *** engine,Ollydbg,and Interactive Disassembler Professional(IDA)are used prevalently for *** improved methods can protect the software from the most vulnerable *** improved dynamic code swapping and the simplified virtual machine technologies for cloud games are the main *** inductively learned that our methods have been working well according to the security mechanisms and time complexity *** show that hidden dangers can be eliminated with efficient methods:Execution time and file sizes of

关键词： Obfuscation self-modification encryption edge computing

Spatial Density Distributions and Correlations in a Quasi-one-Dimensional Polydisperse Granular Gas

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Communications in Theoretical Physics 2009年第2期51卷 259-264页

作者： CHEN Zhi-yuan ZHANG duan-Ming School of Electronic and Information Engineering Xianning College Xianning 437100 China Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

By Monte Carlo simulations, the effect of the dispersion of particle size distribution on the spatial density distributions and correlations of a quasi one-dimensional polydisperse granular gas with fractal size distribution is investigated in the same inelasticity. The dispersive degree of the particle size distribution can be measured by a fractal dimension dr, and the smooth particles are constrained to move along a circle of length L, colliding inelastically with each other and thermalized by a viscosity heat bath. When the typical relaxation time τ of the driving Brownian process is longer than the mean collision time To, the system can reach a nonequilibrium steady state. The average energy of the system decays exponentially with time towards a stable asymptotic value, and the energy relaxation time τB to the steady state becomes shorter with increasing values of df. In the steady state, the spatial density distribution becomes more clusterized as df increases, which can be quantitatively characterized by statistical entropy of the system. Furthermore, the spatial correlation functions of density and velocities are found to be a power-law form for small separation distance of particles, and both of the correlations become stronger with the increase of df. Also, tile density clusterization is explained from the correlations.

关键词： granular gas inelasticity fractal dimension df spatial density distributions spatial correlationsof density and velocities

Role of the NLRP3 inflammasome in neurodegenerative diseases and therapeutic implications

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Neural Regeneration Research 2020年第7期15卷 1249-1250页

作者： Yanhui duan Nathan Kelley yuan He Department of Biochemistry Microbiology and Immunology Wayne State University School of Medicine

Neurodegenerative diseases are a group of neuronal disorders caused by progressive neuronal cell death in different regions of the human ***'s disease(AD)and Parkinson's disease(PD)are the most common types of neurodegenerative diseases that affect millions of people *** is no cure available for either *** of the pathological hallmarks of neurodegenerative diseases is the abnormal protein aggregation in the central nervous system.

关键词： NLRP3 diseases degenerative

Edge sensor based real-time calculation method for active panel position of QTT

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Research in Astronomy and Astrophysics 2020年第11期20卷 273-282页

作者： Cong-Si Wang yue-Fei Yan Qian Xu Na Wang yuan-Peng Zheng Pei-yuan Lian Song Xue Yan Wang yu-Hu duan yu Shi yu Jia Key Laboratory of Electronic Equipment Structure Design of the Ministry of Education Xidian UniversityXi’an 710071China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China CETC No.54 Research Institute Shijiazhuang 050081China School of Information and Control Engineering Xi’an University of Architecture and TechnologyXi’an 710055China CETC No.39 Research Institute Xi’an 710065China Department of Mechanical Engineering University of ChesterChester CH14BJUK School of Engineering and Applied Science Aston UniversityBirmingham B47ETUK

QiTai Telescope(QTT),the world’s biggest full-steerable telescope,will be constructed in Xinjiang,*** extra high operating frequency(115 GHz)imposes strict requirements on the accuracy of the reflector,while its large aperture(110 m)increases the impact of antenna weight and environment on surface ***,the panels of reflector will deform under the influence of gravity and the ***,to compensate for the performance degradation caused by this deformation,a technique called active surface adjustment has been *** existing adjustment methods cannot detect the deformation caused by environment of the reflector surface in real time,which can result in a delay in the ***,it is difficult to achieve an optimal compensating *** solve this problem,a real-time method to estimate the large-aperture reflector antenna surface by calculating the antenna panel position based on edge sensors is proposed in this *** the proposed method,a panel coordinate transfer matrix has been formulated and the data measured from these edge sensors can then be treated as input for the proposed transfer matrix to calculate the actual position of the antenna panel in real time.A numerical simulation has been carried out in the QTT model and the results obtained show that the proposed real-time method is a promising tool to estimate the large reflector surface position in real *** is believed that this active surface adjustment method has laid the foundation for new methods that will be developed to compensate for the reflector electrical performance.

关键词： instrumentation miscellaneous methods miscellaneous telescopes

[Solid-phase extraction coupled with high performance liquid chromatography-triple quadrupole mass spectrometry for simultaneous determination of seven coumarins in water samples from drinking water treatment plants]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 78-86页

作者： Wen-Mei Jiao Jing-Ming Yang Ce Xu Fu-Kang Gao Lu-Yao Shen yu-Bo yuan Zhi-Fen Guo Guang Huang School of Life Sciences and Chemical Engineering Jiangsu Second Normal University Nanjing 211200 China. School of Stomatology Nanjing Medical University Nanjing 210029 China. School of Public Health Nanjing Medical University Nanjing 211166 China. Key Laboratory of Modern Toxicology Ministry of Education School of Public Health Nanjing Medical University Nanjing 211166 China.

Chlorinated coumarins, which are as cytotoxic as highly toxic halobenzoquinones toward CHO-K1 cells, have recently been identified as disinfection byproducts in drinking water disinfection processes. Therefore, detecting coumarins in water samples collected at various stages from drinking water treatment plants helps assess the formation of chlorinated coumarins in drinking water. Hence, a simple, rapid, accurate, and sensitive method for quantifying coumarins in water samples is required. In this study, a method was developed based on solid-phase extraction coupled with high performance liquid chromatography-triple-quadrupole mass spectrometry for analyzing seven coumarins in water samples from drinking water treatment plants, including 6,7-dihydroxycoumarin, 7-hydroxycoumarin, 6-hydroxy-4-methylcoumarin, 8-chloro-7-hydroxycoumarin, coumarin, 7-chloro-6-hydroxy-4-methylcoumarin, and 3,8-dichloro-7-hydroxycoumarin. Sample pretreatment involved solid-phase extraction using HLB columns, followed by elution with water and methanol, each containing 0.25% formic acid. The extracted solution was separated via gradient elution using a Phenomenex Luna C18 column (100 mm×2.0 mm, 3 mm) with 0.1% formic acid aqueous solution and methanol as the mobile phases, with analytes detected by triple-quadrupole mass spectrometry equipped with electrospray ionization source in multiple reaction monitoring mode. The matrix effect, precision, and accuracy of the developed method were investigated using raw and treated water as matrices. Matrix effects of 0.84-1.12 were recorded for the detection of 6,7-dihydroxycoumarin, 7-hydroxycoumarin, 6-hydroxy-4-methylcoumarin, and coumarin in raw water, while values of 0.67-0.70 were recorded for 8-chloro-7-hydroxycoumarin, 7-chloro-6-hydroxy-4-methylcoumarin, and 3,8-dichloro-7-hydroxycoumarin in finished water. The three chlorinated coumarins exhibited matrix effects above 0.80 after the finished water matrix had been diluted four times. These re

关键词： coumarins disinfection byproducts drinking water high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) solid-phase extraction (SPE)