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Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing

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Journal of Geriatric Cardiology 2013年第4期10卷 361-368页

作者： Yan-Jun Jia Jun Liu yuan-lin guo Rui-Xia Xu Jiang Sun Jian-Jun Li Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College BeiLiShi Road 167 Beijing 100037 China

BACKGROUND: Obesity is associated with unfavorable alternations in plasma lipid profile and a broad spectrum of cardio-metabolic disorders。 Proprotein convestase subtilisin kexin type 9 (PCSK9) is a novel circulating protein that promotes hypercholesterolemia by decreasing hepatic low lipoprotein density receptor (LDLR) protein。 However, the relationship between PCSK9 concentration and lipid profile in an obesity condition has less been investigated。 OBJECTIVE: To examine the changes of plasma PCSK9 concentration in a rat model fed with high fat diet (HFD) and its correlation to lipid profile, body weight and ageing。 METHODS: Twenty male Sprague Dawley (SD) rats were divided into two groups, control group (fed with normal pellet for 4 weeks), and high-fat diet group (fed with 3% cholesterol enrich diet for 4 weeks)。 Blood samples of rats were obtained before and at days 14, 21, and 28 in both groups。 The body weight, plasma metabolic parameters (glucose, lipid profile) and PCSK9 were determined at indicated time points。 RESULTS: The body weights were significantly increased in rats fed with HFD compared to that in rats with normal pellets at day 28。 Additionally, total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) levels in rat fed with HFD were also higher than that in rats fed with control diet while decreased high density lipoprotein cholesterol (HDL-C) levels were found in rats with HFD at day 28。 More interesting, there were no differences of plasma PCSK9 concentrations as well as hepatic expression of LDLR between the two groups at day 28。 CONCLUSIONS: Although the body weight and LDL-C were significantly increased in rats fed with HFD at 4 weeks, there were no differences of changes in plasma PCSK9 concentration and LDLR expression of liver tissue in both groups at baseline and day 28, suggesting that dyslipidemia in the rat model with HFD appears not to be associated with PCSK9-LDLR pathway but ageing。

关键词： Ageing Dyslipidemia High fat diet PCSK9

Spatiotemporal changeof vegetationcoverage recovery and its driving factors in the Wenchuan earthquake-hit areas

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Journal of Mountain Science 2021年第11期18卷 2854-2869页

作者： SUN Xiao-fei yuan lin-guo ZHOU Ying-zhi SHAO Huai-yong LI Xian-feng ZHONG Ping Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China College of Earth Science Chengdu University of TechnologyChengdu 610059China Natural Resources and Planning Bureau of Nanchong Nanchong 637000China Department of Geography National University of SingaporeKent Ridge 117570Singapore

Vegetation coverage recovery after the Wenchuan earthquake has important implications for preventing post-seismic geohazards and soil ***,spatiotemporal changes in vegetation coverage recovery and its driving factors have not been sufficiently studied in the quake-hit *** paper aims to analyze vegetation coverage recovery and its driving factors in the quake-hit areas using monadic linear regression,coefficient of variation,and geographical ***,we used Moderate-resolution Imaging Spectroradiometer(MODIS)data to calculate the vegetation coverage from 2008 to 2018 in the quake-hit ***,we assessed the trend and stability of vegetation recovery in the quake-hit areas based on vegetation ***,combined with topography,climate,soil type,vegetation type,and human activities in the quake-hit areas,the driving factors affecting vegetation coverage recovery were *** results showed that the vegetation coverage level in the quake-hit areas recovered about 90%of that before the *** coverage recovery was mainly improved in a stepwise manner:increasing and then stabilizing,then increasing and stabilizing ***,soil type,and road density were the main factors affecting vegetation coverage recovery,and the interaction among all factors positively strengthened their impacts on vegetation coverage *** addition,the results also revealed the categories that were conducive to vegetation coverage recovery among the same environmental factors and can provide a scientific reference for vegetation coverage recovery in the quake-hit areas.

关键词： Wenchuan earthquake Vegetation coverage recovery Geographical detector Driving factors

Association of serum lipoprotein(a) level with the severity and prognosis of calcific aortic valve stenosis: a Chinese cohort study

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Journal of Geriatric Cardiology 2020年第3期17卷 133-140页

作者： Shuo-lin LIU Rynat Rozi Hui-Wei SHI Ying GAO yuan-lin guo Yi-Da TANG Jian-Jun LI Na-Qiong WU Endocrinology&Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background There was a causal relationship between elevated lipoprotein(a)[Lp(a)]levels and increased risk of calcific aortic valve stenosis(CAVS)in whites and *** present study aimed to investigate whether Lp(a)levels were associated with aortic stenosis(AS)severity and clinical events in Chinese *** Levels of serum Lp(a)were measured in 652 patients with CAVS,whom all underwent baseline echocardiographic *** clinical endpoint was defined as a composite of aortic valve replacement(AVR)and cardiac *** Patients in the tertile 3 of Lp(a)had a higher percentage of severe AS compared with those in the tertile 1 and 2 of Lp(a)(46.2%vs.33.9%,P=0.005).Moreover,the top tertile of Lp(a)was an independent predictor of severe AS(OR=1.78,95%CI:1.18-2.66,P=0.006).However,there was no significant association between tertile 3 of Lp(a)and clinical events(hazard ratio:0.73;95%CI:0.43-1.24;P=0.239)in the multivariate Cox regression analysis during a mean follow-up time of 3.16±2.74 *** Elevated Lp(a)level was an independent predictor of severe AS by echocardiography in the Chinese population,but was not associated with the increased risk of AVR and cardiac death,suggesting that Lp(a)levels might be helpful in the risk stratification of patients with CAVS.

关键词： Aortic stenosis Calcification Severity Lipoprotein(a) Prognosis

Effects of Pitavastatin on Lipoprotein Subfractions and Oxidized Low-density Lipoprotein in Patients with Atherosclerosis

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Current Medical Science 2020年第5期40卷 879-884页

作者： Rui-xia XU Yan ZHANG Yue ZHANG Ya-ru WU Xiao-lin LI yuan-lin guo Geng LIU Qian DONG Jian-jun LI State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

It has been demonstrated that pitavastatin can significantly reduce low-density lipoprotein(LDL)cholesterol(LDL-C),but its impact on lipoprotein subfractions and oxidized low-density lipoprotein(oxLDL)has not been *** aim of the present study was to investigate the potential effects of pitavastatin on subfractions of LDL and high-density lipoprotein(HDL)as well as oxLDL in untreated patients with coronary atherosclerosis(AS).Thirty-six subjects were enrolled in this study.O f them,18 patients with AS were administered pitavastatin 2 mg/day for 8 weeks and 18 healthy subjects without therapy served as *** plasma lipid profile,lipoprotein subfractions and circulating oxLDL were determined at baseline and 8 weeks *** results showed that pitavastatin treatment indeed not only decreased LDL-C,total cholesterol(TC),triglycerides(TG)and apolipoprotein B(ApoB)levels,and increased HDL cholesterol(HDL-C),but also reduced the cholesterol concentration of all of the LDL subfractions and the percentage of intermediate and small LDL ***,pitavastatin could decrease plasma oxLDL ***,a more close correlation was found between oxLDL and LDL-C as well as LDL subfractions after pitavastatin *** concluded that a moderate dose of pitavastatin therapy not only decreases LDL-C and oxLDL concentrations but also improves LDL subfractions in patients with AS.

关键词： pitavastatin atherosclerosis lipoprotein subfraction low-density lipoprotein

Free triiodothyronine in relation to coronary severity at different ages： Gensini score assessment in 4206 euthyroid patients

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Journal of Geriatric Cardiology 2016年第12期13卷 978-983页

作者： Bing-Yang ZHOU yuan-lin guo Na-Qiong WU Cheng-Gang ZHU Ying GAO Ping QING Xiao-lin LI Yao WANG Geng LIU Qian DONG Jian-Jun LI Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academyof Medical Sciences and Peking Union Medical College Beifing China

Objective To study whether free triiodothyronine （FT3） within normal range has effects on the presence and severity of coronary ar- tery disease （CAD） in different gender and age groups. Methods A total of 4206 euthyroid patients were consecutively enrolled and di- vided into CAD group （n = 3306） and non-CAD group （n = 900）. All patients underwent coronary angiography （CAG）. Gensini score （GS） was used to determine the severity of coronary artery stenosis. Severe CAD was defined as GS 〉 32 and mild CAD was defined as GS 〈 32. Logistic regression analysis and linear regression analysis were conducted to determine the association of FT3 with CAD in patients with different gender and ages. Results Concentration of FT3 was lower in patients with CAD than that in angiography-normal control group （P 〈 0.05）. In addition, concentration of FT3 was lower in severe CAD than that in mild CAD. After adjusting for traditional cardiovascular risk factors and potential confounders, FT3 was negatively correlated with the presence of CAD, but not in the old patients （〉 65 years old）. Mul- tivariable linear regression analysis showed that FT3 was negatively associated with GS in male and young patients with stable CAD, but not in the old patients. Conclusions Low FT3 within normal range was negatively associated with the presence and severity of CAD in young patients, but not in the old ones. Further studies are needed to confirm our findings.

关键词： Coronary angiography Coronary artery disease Euthyroidism Free triiodothyronine Gensini score

2023 China Guidelines for Lipid Management

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Journal of Geriatric Cardiology 2023年第9期20卷 621-663页

作者： Jian-Jun LI Shui-Ping ZHAO Dong ZHAO guo-Ping LU Dao-Quan PENG Jing LIU Zhen-Yue CHEN yuan-lin guo Na-Qiong WU Sheng-Kai YAN Zeng-Wu WANG Run-lin GAO National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijingChina The Second Xiangya Hospital of Central South University ChangshaHunanChina Beijing Anzhen Hospital Capital Medical UniversityBeijingChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina Affiliated Hospital of Zunyi Medical University School of Laboratory Medicine of Zunyi Medical UniversityZunyiGuizhouChina

Atherosclerotic cardiovascular disease(ASCVD)is the leading cause of death among urban and rural residents in China,and elevated low-density lipoprotein cholesterol(LDL-C)is a risk factor for *** the increasing burden of ASCVD,lipid management is of the utmost *** recent years,research on blood lipids has made breakthroughs around the world,hence a revision of China guidelines for lipid management is imperative,especially since the target lipid levels in the general population vary in respect to the risk of *** level of LDL-C,which can be regarded as appropriate in a population without frisk factors,can be considered abnormal in people at high risk of developing *** a result,the“Guidelines for the prevention and treatment of dyslipidemia”were adapted into the“China Guidelines for Lipid Management”(henceforth referred to as the new guidelines)by an Experts’committee after careful *** new guidelines still recommend LDL-C as the primary target for lipid control,with CVD risk stratification to determine its target *** guidelines recommend that moderate intensity statin therapy in adjunct with a heart-healthy lifestyle,be used as an initial line of treatment,followed by cholesterol absorption inhibitors or/and proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors,as *** new guidelines provide guidance for lipid management across various age groups,from children to the *** aim of these guidelines is to comprehensively improve the management of lipids and promote the prevention and treatment of ASCVD by guiding clinical practice.

关键词： Lipid prevention hence

Clinical features of coronary artery ectasia in the elderly

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Journal of Geriatric Cardiology 2014年第3期11卷 185-191页

作者： Qiao-Juan HUANG Yan ZHANG Xiao-lin LI Sha LI yuan-lin guo Cheng-Gang ZHU Rui-Xia XU Li-Xin JIANG Meng-Hua CHEN Jian-Jun LI Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College BeiLiShi Road 167 Beijing 100037 China Department of Cardiology Institute of Cardiovascular Diseases the First Affiliated Hospital Guangxi Medical University Nanning Guangxi 530021 China

Objective To investigate the incidence, imaging and clinical characteristics in elderly patients with coronary artery ectasia （CAE）. Methods A retrospective analysis was conducted on patients with CAE who underwent coronary angiography between January 2006 and December 2012. According to age, the enrolled patients were divided into two groups （elderly group, age≥ 65 years; non-elderly group, age 〈 65 years）. The clinical feature, imaging characteristics and the 5-year survival rate of the two groups were *** The preva-lence of CAE in elderly patients was 0.33%. Patients in elderly group were found to have significantly higher proportion of female （30.1%vs. 10.1%,P〈 0.001）, three-vessel disease （60.5%vs. 45.2%,P = 0.003） and localized ectasia （55.0%vs. 40.2%,P = 0.003）. In addition, body mass index （20.90 ± 2.71 kg/m2vs. 22.31 ± 2.98 kg/m2,P 〈 0.001） and percentage of current smokers （45.0%vs. 64.6%,P 〈 0.001） were significantly lower in elderly group. Cumulative survival curves demonstrated reduced 5-year cumulative survival at the follow-up in the elderly group compared with the non-elderly group （88.0%vs. 96.0%,P = 0.002）. But the 5-year event free survival rate failed to show a significant difference between the two groups （31.0%vs. 35.0%,P= 0.311）.ConclusionThe prevalence of CAE in elderly patients was 0.33%, which was about 1/3 of the entire numbers of CAE patients. There were significant differences between the elderly and the non-elderly patients with CAE in terms of coronary artery disease risk factors and coronary artery ectatic characteristics. CAE might be asso-ciated with increased mortality risk in the elderly.

关键词： Coronary artery ectasia Elderly patients Clinical feature

Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第3期21卷 349-358页

作者： Hui-Hui LIU Meng ZHANG yuan-lin guo Cheng-Gang ZHU Na-Qiong WU Ying GAO Rui-Xia XU Jie QIAN Ke-Fei DOU Jian-Jun LI Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are ***,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with *** In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were *** admission,ABG,SHR,and GG were assessed and all participants were classified according to their ***-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term *** During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were ***-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and *** adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term ***,we observed similar associations of these acute glycemic parameters with 30-day *** Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.

关键词： admitted infarction shaped

Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics

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Journal of Geriatric Cardiology 2016年第8期13卷 685-692页

作者： Ying DU Juan CHEN Man-Hua CHEN Sheng-Hua YANG Sha LI yuan-lin guo Cheng-Gang ZHU Rui-Xia XU Qian DONG Jian-Jun LI Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academyof Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology the Central Hospital of Wuhan Wuhan Hubei China

Background Diabetes mellitus （DM） is associated with coronary artery disease （CAD） progression. Although previous studies have demonstrated the association of lipid and lipoprotein ratios with CAD, no data are currently available concerning the relationship between lipid and lipoprotein ratios and the severity of new on-set CAD in diabetics. Therefore, the aim of the present study was to investigate the usefulness of lipid and lipoprotein ratios in predicting the severity of CAD in patients with type 2 DM （T2DM）. Methods A total of 380 consecutive T2DM patients with new on-set CAD were enrolled in the present study. Then, they were classified into the three groups ac-cording to Gensini score （GS） tertiles. The relationship between lipid and lipoprotein ratios currently used and the GS was investigated. Results Positive correlations of natural log-transformed GS （lnGS） with apolipoprotein B to apoA-I ratio （apoB/apoA-I）, non-high-density lipoprotein cholesterol to apoA-I ratio （non-HDL-C/apoA-I）, and low-density lipoprotein cholesterol to apoA-I ratio （LDL-C/apoA-I） were found （r = 0.18, 0.13, 0.12, respectively, all P 〈 0.05）. Multivariate logistic analysis indicated apoB/apoA-I as the strongest predictor for high GS （OR = 5.67, 95% CI： 1.45-23.92, P = 0.003）. Area under receivers operating characteristic curve of apoB/apoA-I was 0.63 （95% CI： 0.60-0.66, P = 0.001） for predicting high GS. The optimal cutoff value of apoB/apoA-I to predict high GS was 0.72 with the sensitivity of 61.2% and the specificity of 62.1%. Conclusions Lipid and lipoprotein ratios might be useful for predicting the severity of new on-set CAD in T2DM patients, and the apoB/apoA-I appeared as the most significant predictor in this population.

关键词： Coronary artery disease Lipid Lipoprotein Type 2 diabetes mellitus