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Size analysis of slag eye formed by gas blowing in ladle refining

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Journal of Iron and Steel Research International 2017年第3期24卷 243-250页

作者： Ning-ning Lv Liu-shun Wu Hai-chuan Wang yuan-chi dong Chang Su School of Metallurgical Engineering Anhui University of Technology Ma'anshan 243032 Anhui China Key Laboratory of Metallurgical Emission Reduction & Resources Recycling Ministry of Education Ma' anshan 243002 AnhuiChina

The formation of slag eye in a gas stirred ladle was studied through cold models and industrial trials. In the cold model,water and sodium tungstate solution were employed to simulate liquid steel,and silicon oil was employed to simulate slag. The simulation results revealed that the gas flow rate and bath height had strong effects on the slag eye size. In particular,the thickness of slag layer played a strong role in the slag eye size. In addition,the slag eye could not be formed when the thickness of the top layer was more than 4 cm in water-silicone oil ***,the section area of vessel had a great impact on the slag eye size. Industrial trials results showed a similar trend that the gas flow rate was very significant on the slag eye size. The predictions of the existing models showed larger predictions deviations compared with the experimental data. Moreover,a new model without fitting parameters was developed based on force balance and mathematical derivation,and verified by the experimental data. The new model provides the prediction with small deviations by comparing with the data acquired from cold models and industrial trials.

关键词： Slag eye Cold model Industrial trial Gas blowing Ladle refining

Effect of high Na2O addition on distribution of phosphorus in lowbasicity converter slag

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Journal of Iron and Steel Research International 2019年第1期26卷 42-51页

作者： Chang Su Ning-ning Lv Jin-xing Yang Liu-shun Wu Hai-chuan Wang yuan-chi dong School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Anhui University of Technology) Ministry of EducationMa'anshan 243002AnhuiChina

In order to improve the dephosphorization efficiency of low-basicity converter slag and decrease the consumption of solid CaO,the effect of high Na2O addition(0-15 mass%)on the distribution of P2O5 between solid solution and matrix phase was *** thermodynamic properties of slag samples were calculated by FactSage 7.0 ***,the dissolution behavior of phosphorus element from slag was *** results show that the mass fraction of 2CaO*SiO2-2CaO*Na2O*P2O5 solid solution increases when the Na2O content is increased in ***,the amount of formed solid solution changes little when the Na2O addition is more than 10 mass%.Moreover,the content of Na2O in solid solution would reach saturation when adding 15 mass%Na2O into the *** the increase in Na2O content in slag,the distribution ratio of P2O5 between solid solution and matrix phase *** values are evidently higher than the results reported in the ***,the activity of P2O5 in matrix phase and the activity coefficient of P2O5 in solid solution are decreased with increasing the Na2O content in ***,the dissolution ratio of phosphorus in citric acid solution could be improved by adding Na2O into slag,but the increment of dissolution ratio would decrease when the Na2O content exceeds 10 mass%in slag.

关键词： Na2O addition-Low-basicity converter slag Phosphorus distribution ratio Thermodynamic property Phosphorus dissolution behavior

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

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china Foundry 2025年

作者： Gang Huang Qian Dang Cong-cong Su Jing Zhao chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern University School of Materials Science and Engineering Shenyang University of Technology

The grain size of TiAl alloy castings prepared by traditional casting process is coarse, thus showing poor mechanical properties. In this study, a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was introduced. This research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings, employing both experimental approaches and ProCast simulation methodologies. The findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed grains. Under the condition of pouring temperature of 1,600 °C, rotation speed of 800 r·min-1and pouring time of 6 s, the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa, and the tensile strength at 800 °C reaches 705 MPa, which is significantly higher than that of traditional as-cast Ti-Al alloy.

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Insight into the particle shape on the impact of dry granular flow against a rigid barrier: A DEM study

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Journal of Earth Science 2025年

作者： Rui-Xiao Zhan dong Su Xiang-Sheng Chen yuan-Jun Jiang Guo-Ping Lei Jing-Jing Yu Key Laboratory for Resilient Infrastructures of Coastal Cities (MOE)， Shenzhen University College of Civil and Transportation Engineering， Shenzhen University School of Architecture and Urban Planning， Shenzhen University Shenzhen Key Laboratory of Green， Efficient and Intelligent Construction of Underground Metro Station， Shenzhen University Institute of Mountain Hazards and Environment， chinese Academy of Sciences School of Transportation， Civil Engineering & Architecture， Foshan University

The effect of particle shape on the impact of dry granular flow remains an open area for further investigation. Five distinct particle shapes were examined in this study using discrete element simulations after calibrating the numerical model using a published work. The findings indicated that the particle shape had a significant influence on granular mobility. With negligible variations in normalized kinetic energy between particles of different shapes， the effect of particle shape on the increasing rate of kinetic energy became more obvious. All irregular particle scenarios had longer accumulated particle lengths down the channel than spherical particles. Variations in particle shape led to adjustments in the distribution of impact forces on the barrier. These findings substantially enhance our understanding of the distinctive effects of particle shapes on the impact mechanism of dry granular flow.

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LED显示屏支撑结构分析与设计

建筑技术 2015年第5期46卷 429-432页

作者：姚云龙阎勇琦池远东屈海宁华信咨询设计研究院有限公司杭州310014

LED显示屏支撑结构分为落地式、壁挂式和楼顶式3种,各类型的支撑结构体系应力应变特点不同。通过对3种支撑结构体系进行有限元分析比较,得出相应支撑结构的优化方案。结果表明,落地式支撑体系悬臂柱宜采用圆形截面,壁挂式水平向支撑体... 详细信息

LED显示屏支撑结构分为落地式、壁挂式和楼顶式3种,各类型的支撑结构体系应力应变特点不同。通过对3种支撑结构体系进行有限元分析比较,得出相应支撑结构的优化方案。结果表明,落地式支撑体系悬臂柱宜采用圆形截面,壁挂式水平向支撑体系宜采用组合桁架,楼顶式支撑结构宜采用空间桁架体系。针对支撑结构关键节点进行优化设计,通过设置抗剪键或十字形加劲肋等构造措施优化节点应力状态,提高支撑结构的安全性能。

关键词： LED显示屏支撑结构结构选型有限元分析节点

新、旧荷载规范对通信单管塔风荷载计算的比较和分析

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江苏建筑 2014年第3期 59-60,82页

作者：竹影张珩池远东华信邮电咨询设计研究院有限公司浙江杭州310014

文章结合新、旧荷载规范,对通信单管塔的风荷载进行了计算与对比,通过比较,发现新荷载规范的计算结果有所增大,并结合实际工程,分析挂载、塔基高度、塔高等因素对增大系数的影响。

关键词：荷载规范风荷载单管塔比较

TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

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Science china Life Sciences 2025年

作者： yuan dong Li Su Sin Man Lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

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