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Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang Su-Jie Fan Zuo-HongWu Su-Mian Cheng Li-Jun Zhao Qin-Hua Cai Shao-Dan Zhang Shan-Shan Liu Ai-Guo Lyu Ying Zhang Hong Chen Dan-Ni Jiang Wu-liang Li Nathan Congdon Clement C Tham Ming-Guang He yuan-bo liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of Suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1wk,1,3,6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 34 eyes received *** IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(P<0.001)with 2.9±1.6 medications(P=0.046)at 1d,and 17.4±6.7 mm Hg(P<0.001)with 1.3±1.7 medications(P<0.001)at *** ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo,respectively.A total of 32(94.1%)eyes achieved initial anatomical *** follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 12-month anatomical success rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success

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Central visual function and inner retinal structure in primary open-angle glaucoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第4期21卷 305-314页

作者： Li-juan XU Sha-ling LI Vance ZEMON Yan-qian XIE yuan-bo liang Clinical and Epidemiological Eye Research Center Eye HospitalSchool of Optometry and OphthalmologyWenzhou Medical UniversityWenzhou 325027China Department of Ophthalmology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Ferkauf Graduate School of Psychology Albert Einstein College of Medicine CampusYeshiva UniversityNew York 10461USA Global Eye Health Centre for Public HealthQueens UniversityBelfast BT71NNUK

To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma(POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants: isolated-check visual evoked potential(ic VEP) testing, 24-2 standard automated perimetry(SAP), and Cirrus optical coherence tomography(OCT) examinations. Signal-to-noise ratio(SNR) measures obtained from ic VEP responses to isolated checks presented at four depths of modulation(DOMs;8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity(mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness(GCL+IPLT) and peripapillary retinal nerve fiber layer thickness(pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed: SNR, mMS, GCL+IPLT, and pRNFLT. SNR, mMS, GCL+IPLT, and pRNFLT were all more significantly decreased in glaucoma than in controls(P<0.001). A significant positive association was found between SNR at 14% DOM and GCL+IPLT at the inferior sector in early glaucoma(r=0.465, P=0.004). In moderate to advanced glaucoma, significant correlations were found between SNR at 32% DOM and mean GCL+IPLT(r=0.364, P=0.023), superior GCL+IPLT(r=0.358, P=0.025), and mean p RNFLT(r=0.396, P=0.025). In addition, in moderate to advanced glaucoma, there were significant correlations between mMS and all relevant measures of retinal thickness(r=0.330–0.663, P< 0.010). In early glaucoma, significant correlations were found between mean mMS and minimum GCL+IPLT(r=0.373, P=0.023), and between inferior mMS and superior GCL+IPLT(r=0.470, P=0.003). Linear models provided a good explanation for the relationship between SNR and inner retinal thickness(IRT), whereas nonlinear models better explained the relationship betw

关键词： Isolated-check visual evoked potential(icVEP) Primary open-angle glaucoma(POAG) Optical coherence tomography(OCT) Standard automated perimetry(SAP)

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Proposing new indicators for glaucoma healthcare service

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Eye and Vision 2017年第1期4卷 26-29页

作者： yuan bo liang Ye Zhang David C.Musch Nathan Congdon Clinical and Epidemiological Eye Research Center The Eye Hospital of Wenzhou Medical UniversityWenzhouChina Centre for Public Health Queens UniversityBelfastUK Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Kellogg Eye Center University of MichiganAnn ArborMIUSA Eye Hospital School of Optometry and OphthalmologyWenzhou Medical CollegeNo.270Xue Yuan Xi RoadWenzhouZhejiang 3250027China

Glaucoma is the first leading cause of irreversible blindness worldwide with increasing importance in public *** of glaucoma care quality as well as efficiency would benefit public health assessments,but are *** propose three such ***,the glaucoma coverage rate(GCR),which is the number of people known to have glaucoma divided by the total number of people with glaucoma as estimated from population-based studies multiplied by 100%.Second,the glaucoma detection rate(GDR),which is number of newly diagnosed glaucoma patients in one year divided by the population in a defined area in ***,the glaucoma follow-up adherence rate(GFAR),calculated as the number of patients with glaucoma who visit eye care provider(s)at least once a year over the total number of patients with glaucoma in given eye care provider(s)in a specific *** tracking and reporting these three indicators may help to improve the healthcare system performance at national or regional levels.

关键词： Glaucoma coverage rate Glaucoma detection rate Glaucoma follow-up adherence rate Healthcare indicator

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Regarding successful use of 23G cutter for anterior vitrectomy and scleral-fixated intraocular lens implantation

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1947-1948页

作者： koushik tripathy yuan bo liang yoly fong alvin young ICARE Eye Hospital&Postgraduate Institute Uttar Pradesh 201301India Clinical and Epidemiological Eye Research Center the Affiliated Eye HospitalSchool of Optometry and OphthalmologyWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology&Visual Sciences.the Chinese University of Hong Kong Prince of Wales HospitalShatinHong KongChina

Citation： Tripathy K. Regarding successful use of 23G cutter for anterior vitrectomy and scleral-fixated intraocular lens implantation. IntJ Ophthalmol 2017;10（12）：1947-1948

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Association of peripheral anterior synechia,intraocular pressure,and glaucomatous optic neuropathy in primary angle-closure diseases

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1533-1538页

作者： Ming Zhang Guang-Yun Mao Cong Ye Su-Jie Fan yuan-bo liang Ning-Li Wang Department of Ophthalmology ZhongDa HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Glaucoma Institute Eye HospitalSchool of Optometry and OphthalmologyWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Center of Evidence-Based Medicine&Clinical Epidemiological Research School of Public HealthWenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Handan Eye Hospital Handan 056001Hebei ProvinceChina Beijing Tongren Hospital Beijing Institute of OphthalmologyCapital Medical UniversityBeijing 100730China

AIM:To investigate the association of peripheral anterior synechiae(PAS)with intraocular pressure(IOP)and glaucomatous optic neuropathy(GON)in primary angle closure(PAC)and primary angle-closure glaucoma(PACG).METHODS:Totally 355 eyes(238 PAC and 117 PACG)of 181 patients were included in this retrospective analysis of baseline data from a randomized clinical *** patients had undergone a comprehensive ophthalmic *** extent of PAS in clock hours as determined on gonioscopy was *** independent effect of the extent of PAS on IOP and the prevalence of GON were determined using multivariable generalized estimating equation(GEE)***:The frequency of GON increased with the extent of PAS and a higher *** were more extensive(8 vs 1 clock hour,Pboth PAS≥6 clock hours and IOP≥21 mm Hg had the highest risk of GON compared to eyes with both PAS<6 clock hours and IOP<21 mm Hg(OR=18.0,95%CI:7.5-43.4;P<0.001).CONCLUSION:The extent of PAS in PAC and PACG is an important predictor of higher IOP and is linearly associated with GON independent of IOP,suggesting other factors related to PAS formation may be involved in the development of GON in PACG.

关键词： primary angle-closure glaucoma peripheral anterior synechiae intraocular pressure

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Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1179-1184页

作者： Da-Peng Mou yuan-bo liang Su-Jie Fan Yi Peng Ning-Li Wang Ravi Thomas Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing 100730China Handan Eye Hospital Handan 056001Hebei ProvinceChina Queensland Eye Institute Brisbane 4343Australia University of Queensland Brisbane 4343Australia

AIM:To report the progression rate(PR)to primary angle closure(PAC)following laser peripheral iridotomy(LPI)in PAC suspects(PACS).METHODS:Prospective,randomized controlled interventional clinical trial conducted at the Handan Eye Hospital,*** 134 bilateral PACS,defined as non-visibility of the posterior trabecular meshwork for≥180 degrees on gonioscopy were randomly assigned to undergo LPI in one *** and Goldmann applanation tonometry were performed prior to,on day 7 and 12 mo post ***:Eighty of 134 patients(59.7%)could be followed up at one *** mean intraocular pressure(IOP)in treated eyes was 15.9±2.6 mm Hg at baseline,15.4±3.0 mm Hg on day 7;16.5±2.9 mm Hg at one month,and 15.5±2.9 mm Hg at 12 mo;the IOP in untreated eyes was similar(P=0.834).One or more quadrants of the angle opened in 93.7%of the LPI treated eyes,but 67.0%(53/79)remained closed in two or more *** PR to PAC in untreated eyes was 3.75%and one developed acute angleclosure glaucoma(AACG);the PR to PAC in treated eyes was 2.5%and none had developed peripheral anterior synechia(PAS)or ***:LPI can open some of the occludable angle in the majority of eyes with PACS,but 67%continue to have non-visibility of the trabecular meshwork for over 180 degrees.

关键词： primary angle-closure suspects anterior chamber angle laser peripheral iridotomy intraocular pressure

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Prevalence of and risk factors for diabetic macular edema in a northeastern Chinese population

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 320-326页

作者： Zhong Lin Feng-Hua Wang liang Wen Yu Wang Dong Li Xiao-Xia Ding Yu Dou Gang Zhai yuan-bo liang The Eye Hospital School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Wenzhou 325027Zhejiang ProvinceChina Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing 100730China Fushun Eye Hospital Fushun 113006Liaoning ProvinceChina

AIM:To estimate the prevalence of diabetic macular edema(DME) and clinically significant macular edema(CSME),and to assess their risk factors in a population with type 2 diabetic mellitus(T2DM) located in northeast ***:Patients were included from the Fushun Diabetic Retinopathy Cohort Study(FS-DIRECT),a community-based study conducted in northeast *** presence of DME and CSME was determined by the Early Treatment Diabetic Retinopathy Study(ETDRS) retinopathy scale of fundus *** age-standardized prevalence of DME and CSME was *** association between DME/CSME and risk factors was analyzed in a multivariate Logistical ***:A total of 292(15.4%) and 166(8.8%) patients were diagnosed as DME and CSME,yielding the age and sex standardized prevalence of 13.5%(95%CI:11.9%-15.0%),and 7.1%(95%CI:5.9%-8.3%),*** patients had a higher prevalence of DME compared to their male counterparts(15.7% vs 10.4%,P=0.03).Multivariable Logistic regression analysis showed that younger age,insulin use,proteinuria,longer duration of diabetes,and higher glycosylated hemoglobin A1c,were associated with the prevalence of DME and *** with higher fasting plasma glucose,systolic blood pressure,and blood urea nitrogen were also found to be associated with ***:Early fundus screening in diabetic patients is invaluable and given the relatively high prevalence of DME and CSME in this study cohort,those with a high risk of sight threatening maculopathy would invariably benefit from earlier detection.

关键词： diabetic macular edema clinically significant macular edema diabetic retinopathy

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High speed small gauge anterior vitrectomy cutter for scleral fixated intraocular lens implantation

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 77-80页

作者： yuan bo liang Yoly Y.Y. FonG Lulu L. Cheng Alvin L. Young Clinical and Epidemiological Eye Research Center the Affiliated Eye Hospital School of Optometry and OphthalmologyWenzhou Medical University Wenzhou 325027 ZhejiangProvince China Department of Ophthalmology ＆ Visual Sciences the ChineseUniversity of Hong Kong Prince of Wales Hospital ShatinHong Kong China

AIM： To report the outcomes of anterior vitrectomy using high speed cutter for scleral fixated intraocular lens （SFIOL） implantation in patients with posterior capsular rupture .METHODS： Medical records of 51 patients with posterior capsular rupture who received high speed cutter anterior vitrectomy via limbal incision with SFIOL implantation from June 2011 to December 2013 were reviewed retrospectively for visual outcomes and ***： Totally 51 eyes of 51 patients were identified （23 males and 28 females）. Mean age at surgery was 67.2±15y （range 27-91y）, with mean follow-up of 23±8.2mo （range 12-40mo）. The 49 （96.1%） eyes had improvement or unchanged of final postoperative visual acuity. The most common complication was vitreous haemorrhage （5.9%） and transient rise in intraocular pressure （5.9%） which all spontaneously resolved CONCLUSION： High speed cutter anterior vitrectomy via limbal incision is a safe and effective method for those with posterior capsular rupture for SFIOL implantation.

关键词： cataract aphakia posterior capsular rupture intraocular lens scleral fixation

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Observation seasonal variation of intraocular pressure in young healthy volunteers

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 59-64页

作者： Na Liao Yan-Qian Xie Guang-Yun Mao Fan-Jun Bao Zhong Lin Hui-Lyu Jiang yuan-bo liang The Eye Hospital School of Optometry and OphthalmologyWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate fluctuation of intraocular pressure(IOP)and seasonal variation of 24-hour IOP during one year in healthy participantsMETHODS:Totally 13 young healthy volunteers participated in this *** was measured with Canon TX-20 at about 8:00-9:00 *** Monday to Friday every week for a whole *** also underwent 24-hour IOP examination every three *** pressure,heart rate,temperature,humidity,atmosphere pressure,sunshine duration and other environment parameters were ***:The yearly fluctuation curve showed IOP in the summer months were lower than other *** the multivariable generalized estimating equation analysis,IOP had a negative correlation with both temperature and sunshine duration(Pboth environmental temperature and duration of *** a season-to-season basis,24-hour IOP is not highly reproducible in healthy volunteers.

关键词： intraocular pressure season temperature sunshine duration

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Effect of low dose laser cycloplasty on deepening anterior chamber in chronic angle-closure glaucoma

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2011-2017页

作者： Xuan-Li Zheng Hai-Shuang Lin Xiao-Jie Wang Jia-Qian Li Yan-Qian Xie Shao-Dan Zhang yuan-bo liang Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case *** charts of CACG patients who underwent LCP in the Eye Hospital of Wenzhou Medical University were *** main outcomes included intraocular pressure(IOP),the number of glaucoma medication,anterior segment parameters and surgery-related ***:A total of 7 eyes of 7 CACG patients(age 38.9±11.0y)underwent LCP with a mean follow-up of 27.1±13.7mo(range 16-48mo).Following LCP,mean IOP and glaucoma medications decreased from 26.1±6.1 mm Hg with 3.1±1.1 glaucoma medications pre-treatment to 14.9±3.1 mm Hg(P=0.027)with 0.4±1.1 glaucoma medications(P=0.001)at final *** anterior chamber depth(ACD),angle opening distance500 and trabecular-iris angle increased from 1.65±0.33 mm,0.05 mm(range 0-0.30 mm)and 5.1°(range,0-31.97°)at baseline to 1.98±0.43 mm(P=0.073),0.53 mm(range 0.42-0.91 mm,P=0.015),45.9°(range,40.2°-59.4°),(P=0.015)in the long-term follow-up,*** deepening of ACD and reopening of anterior chamber angle(ACA)was observed in 6 eyes(85.7%).CONCLUSION:LCP is a promising treatment option for patients with CACG via reducing IOP and glaucoma medication without serious *** addition,LCP can bring a significant deepening in ACD and reopening of ACA.

关键词： chronic angle-closure glaucoma low dose laser cycloplasty anterior chamber depth intraocular pressure

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