Central visual function and inner retinal structure in primary open-angle glaucoma

作     者：Li-juan XU Sha-ling LI Vance ZEMON Yan-qian XIE Yuan-bo LIANG Li-juan XU;Sha-ling LI;Vance ZEMON;Yan-qian XIE;Yuan-bo LIANG

作者机构：Clinical and Epidemiological Eye Research CenterEye HospitalSchool of Optometry and OphthalmologyWenzhou Medical UniversityWenzhou 325027China Department of OphthalmologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Ferkauf Graduate School of PsychologyAlbert Einstein College of Medicine CampusYeshiva UniversityNew York 10461USA Global Eye HealthCentre for Public HealthQueens UniversityBelfast BT71NNUK 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2020年第21卷第4期

页      面：305-314页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 100212[医学-眼科学] 10[医学] 

基　　金：Project supported by the Wenzhou Medical University(No.QTJ13009) the Health Innovation Talents in Zhejiang Province(2016,No.25) the Eye Hospital of Wenzhou Medical University(the Value of IsolatedCheck Visual Evoked Potential in Glaucoma Diagnosis and Monitoring),China 

主　　题：Isolated-check visual evoked potential(icVEP) Primary open-angle glaucoma(POAG) Optical coherence tomography(OCT) Standard automated perimetry(SAP) 

摘      要：To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma(POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants: isolated-check visual evoked potential(ic VEP) testing, 24-2 standard automated perimetry(SAP), and Cirrus optical coherence tomography(OCT) examinations. Signal-to-noise ratio(SNR) measures obtained from ic VEP responses to isolated checks presented at four depths of modulation(DOMs;8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity(mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness(GCL+IPLT) and peripapillary retinal nerve fiber layer thickness(pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed: SNR, mMS, GCL+IPLT, and pRNFLT. SNR, mMS, GCL+IPLT, and pRNFLT were all more significantly decreased in glaucoma than in controls(P0.001). A significant positive association was found between SNR at 14% DOM and GCL+IPLT at the inferior sector in early glaucoma(r=0.465, P=0.004). In moderate to advanced glaucoma, significant correlations were found between SNR at 32% DOM and mean GCL+IPLT(r=0.364, P=0.023), superior GCL+IPLT(r=0.358, P=0.025), and mean p RNFLT(r=0.396, P=0.025). In addition, in moderate to advanced glaucoma, there were significant correlations between mMS and all relevant measures of retinal thickness(r=0.330–0.663, P 0.010). In early glaucoma, significant correlations were found between mean mMS and minimum GCL+IPLT(r=0.373, P=0.023), and between inferior mMS and superior GCL+IPLT(r=0.470, P=0.003). Linear models provided a good explanation for the relationship between SNR and inner retinal thickness(IRT), whereas nonlinear models better explained the relationship betw