检索结果-南通市图书馆

Whole-genome resequencing reveals recent signatures of selection in five populations of largemouth bass(Micropterus salmoides)

引用

Zoological Research 2023年第1期44卷 78-89页

作者： Cheng-Fei Sun Xin-Hui Zhang Jun-Jian Dong Xin-Xin You yuan-yuan tian Feng-Ying Gao He-Tong Zhang Qiong Shi Xing Ye Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation Ministry of Agriculture and Rural AffairsPearl River Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong 510380China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineShenzhenGuangdong 518081China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Largemouth bass(Micropterus salmoides) is an economically important fish species in North America, Europe, and China. Various genetic improvement programs and domestication processes have modified its genome sequence through selective pressure, leaving nucleotide signals that can be detected at the genomic level. In this study,we sequenced 149 largemouth bass fish, including protospecies(imported from the US) and improved breeds(four domestic breeding populations from China). We detected genomic regions harboring certain genes associated with improved traits, which may be useful molecular markers for practical domestication, breeding, and selection. Subsequent analyses of genetic diversity and population structure revealed that the improved breeds have undergone more rigorous genetic changes. Through selective signal analysis, we identified hundreds of putative selective sweep regions in each largemouth bass line. Interestingly, we predicted 103 putative candidate genes potentially subjected to selection,including several associated with growth(psst1 and grb10), early development(klf9, sp4, and sp8), and immune traits(pkn2, sept2, bcl6, and ripk2). These candidate genes represent potential genomic landmarks that could be used to improve important traits of biological and commercial interest. In summary, this study provides a genome-wide map of genetic variations and selection footprints in largemouth bass, which may benefit genetic studies and accelerate genetic improvement of this economically important fish.

关键词： Largemouth bass Whole-genome resequencing Signatures of selection Growth Immunity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Associations of Saposin C,Src,and Androgen Receptor Upregulate Expression and Function of Androgen Receptor in Human Prostate Cancer Cells

Associations of Saposin C,Src,and Androgen Receptor Upregula...

引用

2008年全国生物化学与分子生物学学术大会

作者： Hui-qing yuan Yan Ding Xiao-ling Wang Ai-hui Xu yuan-yuan tian (Department of Biochemistry and Molecular Biology,School of Medicine,Shandong University,Jinan 250012,China)

Saposin C,one of the sphingolipid activator proteins involved in lysosomal hydrolysis of sphingolipids,is a novel androgen-response gene in prostate cancer *** is proposed that a putative G protein-coupled receptor interacts with saposin C and results in activation of saposin ***,we demonstrated that ectopic expres-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

引用

Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： tian Qin Yuxin Jin Yiming Qin Feifei yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

内蒙古自治区电信产品全面质量管理浅谈

引用

移动通信 2015年第5期39卷 44-48页

作者：袁天远中国移动通信集团内蒙古有限公司内蒙古呼和浩特010010

经济全球化与信息化是当今世界经济发展的2种趋势,也是知识经济的2个重要特征。随着知识经济时代的来临,企业经营正从生产经营型向创新管理型转变,技术创新成为企业日常的、重要的活动并呈现出新的特点。文章从全面质量管理的背景和现... 详细信息

经济全球化与信息化是当今世界经济发展的2种趋势,也是知识经济的2个重要特征。随着知识经济时代的来临,企业经营正从生产经营型向创新管理型转变,技术创新成为企业日常的、重要的活动并呈现出新的特点。文章从全面质量管理的背景和现状出发,探讨全面质量管理在电信运营商质量管理中的运用。

关键词：内蒙古移动全面质量管理(TQM) 供应商客户满意度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于工效学的机车显示、控制器界面计算机辅助优化设计

引用

铁道学报 2004年第6期26卷 20-24页

作者：方卫宁徐媛媛田生彩北京交通大学机械与电子控制工程学院北京100044

应用优化匹配(CSP)技术,根据操作任务、功能和工效学要求,在机车操纵显示和控制单元之间建立约束条件,构造目标函数,进行优化计算。论文对CSP模型进行了改进,提出了一种适用于多面板显示、控制器界面的计算机辅助设计方法,并有效地对机... 详细信息

应用优化匹配(CSP)技术,根据操作任务、功能和工效学要求,在机车操纵显示和控制单元之间建立约束条件,构造目标函数,进行优化计算。论文对CSP模型进行了改进,提出了一种适用于多面板显示、控制器界面的计算机辅助设计方法,并有效地对机车多面板显示、控制器界面进行了优化设计,在我国铁路机车司机室规范化设计工作中得到了较好的应用。

关键词：工效学机车操纵显示、控制器界面优化匹配计算机辅助设计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The essential role of dopaminergic system in the food-anticipatory activity in mice

The essential role of dopaminergic system in the food-antici...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： yuan-yuan LIU~1,tian-Ya LIU~2,Zong-yuan HONG~2,Wei-Min QU~1,Zhi-Li HUANG~(1,*) 1 Department of Pharmacology,State Key Laboratory of Medical Neurobiology,Shanghai Medical College,Institute of Brain Science,Fudan University,Shanghai 200032,China 2 Institute of Quantitative Pharmacology,Department of Pharmacology,Wannan Medical College,Wuhu 241001, China

Objective When food is available during a restricted and predictable time of the day,mammals exhibit food-anticipatory activity(FAA),a daily increase in locomotor activity preceding the presentation of *** many studies attempted to locate the food-entrainable circadian oscillator in the central nervous system,the mechanisms for FAA are a matter of *** present study was designed to clarify the role of dopaminergic and histaminergic systems in *** The mice were given access to food for 2 h(CT19-CT21) in ICR mice and for 4 h(CT 17-CT21) in gene-manipulated *** was monitored by infrared locomotor activity sensors and defined as the locomotor activity occurred 2 h before the availability of *** D,receptor(R),D2R,and histamine H,R-specific antagonists,and DR- and HR-knockout(KO) mice were used to clarify the role of dopamine and histamine receptors in FAA induced by food restriction(FR).In addition,brain monoamine concentrations on the 14 day of FR were determined by *** Pretreatment with DR antagonist SCH23390 at 1,3,or 10μg/kg significantly decreased FAA by 19%,26%or 19%,respectively,and DR antagonist raclopride at 22,67,or 200μg/kg significantly decreased FAA by 16%,36%or 41%,respectively,as compared with vehicle ***,co-administration of SCH23390 and raclopride synergistically inhibited FAA by 57%.Consistently,the levels of dopamine and its metabolites in the striatum and midbrain were significantly increased during FR-induced FAA,even in the mice pretreated with DR and DR ***,DR KO mice exhibited attenuated ***,pretreatment with pyrilamine at 2.5,5,or 10 mg/kg did not significantly decrease FAA,although it decreased the locomotor activity during the dark period in ad libitum mice,and H,R KO did not affect *** These results strongly indicate that dopaminergic system plays an essential role in the food-anticipatory activity in mice.

关键词： antagonist dopamine D1 receptor D2 receptor food restriction histamine H1 receptor food-anticipatory activity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

动物药材分子鉴别现状与策略

引用

中国现代中药 2017年第1期19卷 1-10页

作者：黄璐琦袁媛蒋超田晓轩道地药材国家重点实验室培育基地中国中医科学院中药资源中心北京100700 天津中医药大学天津300193

笔者于2011年提出的动物药分子鉴定的策略与目标已初步完成,即先后提出中药分子鉴定原则、研制推出动物药材分子鉴定试剂盒、发展中国动物药材DNA条形码及其标准鉴定数据库。本文在此基础上,进一步对近5年动物药材分子鉴别的科研、技术... 详细信息

笔者于2011年提出的动物药分子鉴定的策略与目标已初步完成,即先后提出中药分子鉴定原则、研制推出动物药材分子鉴定试剂盒、发展中国动物药材DNA条形码及其标准鉴定数据库。本文在此基础上,进一步对近5年动物药材分子鉴别的科研、技术、产业化发展现状与问题进行总结,提出进一步加强动物分类学基础研究、扩大研究品种,完善基础数据库建设,针对关键技术难点开发更为有效、快速的检测方法,促进标准制定或修订和产业化发展等策略。

关键词：动物药材分子鉴定关键问题核心技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抽动症患者语言研究的最新进展

引用

徐州医科大学学报 2017年第9期37卷 623-626页

作者：冯延琴燕浩袁苑田梅西安电子科技大学外国语学院语言认知与脑科学实验室陕西西安710126 西安电子科技大学人文学院心理系陕西西安710032 西安电子科技大学西京医院儿科陕西西安710032

抽动症是发病于儿童时期的一种神经发育性障碍，发病率为0．6％～1％，男孩是女孩的3～4倍。该病对患者在学习、社会交往、生活和心理等方面造成极大影响，但发病初期症状易被家长忽视，且很多人误认为其可以自愈，导致病情延误，治疗... 详细信息

抽动症是发病于儿童时期的一种神经发育性障碍，发病率为0．6％～1％，男孩是女孩的3～4倍。该病对患者在学习、社会交往、生活和心理等方面造成极大影响，但发病初期症状易被家长忽视，且很多人误认为其可以自愈，导致病情延误，治疗困难。语言作为最直观便捷的方式对该病的发现、辅助诊断有重要作用。作者从发声抽动、流利障碍、非发声抽动语言3个方面对抽动症语言研究的进展作一综述，以期有助于相关研究及临床语言学在国内的发展。

关键词：抽动症语言障碍临床语言学发声抽动流利障碍

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

引用

Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen Meng tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

时间序列分析在北京市东城区艾滋病病毒感染者和艾滋病患者发病率预测中的应用

引用

疾病监测 2017年第9期32卷 731-734页

作者：王媛媛田飞刘晶磊北京市东城区疾病预防控制中心北京100050

目的探讨应用时间序列差分自回归移动平均模型(ARIMA)预测北京市东城区艾滋病病毒感染者/艾滋病患者(HIV/AIDS)发病率的可行性。方法应用SAS 9.3软件对北京市东城区2005 2014年HIV/AIDS月发病率构建ARIMA模型,用得到的模型对2015年HIV/A... 详细信息

目的探讨应用时间序列差分自回归移动平均模型(ARIMA)预测北京市东城区艾滋病病毒感染者/艾滋病患者(HIV/AIDS)发病率的可行性。方法应用SAS 9.3软件对北京市东城区2005 2014年HIV/AIDS月发病率构建ARIMA模型,用得到的模型对2015年HIV/AIDS月发病率进行预测,评价模型的拟合和预测效果。结果 ARIMA(0,1,1)×(0,1,1)12模型拟合效果较好,但仍有优化的空间,月发病率的实际值均在预测值的95%可信区间内,预测值与实际值拟合趋势一致。结论 ARIMA模型可以对北京市东城区HIV/AIDS月发病率进行预测,为艾滋病疫情预测提供依据。

关键词：时间序列差分自回归移动平均模型预测获得性免疫缺陷综合征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：